Cited by 204Neuroscience and Neural EngineeringElectrochemical sensors and biosensorsConducting polymers and applications

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Chronic in vivo stability assessment of carbon fiber microelectrode arrays

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Patel, Paras R, Zhang, Huanan, Robbins, Matthew T, Nofar, Justin B, Marshall, Shaun P, Kobylarek, Michael J, Kozai, Takashi D Y, Kotov, Nicholas A, Chestek, Cynthia A·2016·Journal of Neural Engineering

DOI 10.1088/1741-2560/13/6/066002PMC PMC5118062

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Abstract

OBJECTIVE: Individual carbon fiber microelectrodes can record unit activity in both acute and semi-chronic (∼1 month) implants. Additionally, new methods have been developed to insert a 16 channel array of carbon fiber microelectrodes. Before assessing the in vivo long-term viability of these arrays, accelerated soak tests were carried out to determine the most stable site coating material. Next, a multi-animal, multi-month, chronic implantation study was carried out with carbon fiber microelectrode arrays and silicon electrodes. APPROACH: Carbon fibers were first functionalized with one of two different formulations of PEDOT and subjected to accelerated aging in a heated water bath. After determining the best PEDOT formula to use, carbon fiber arrays were chronically implanted in rat motor cortex. Some rodents were also implanted with a single silicon electrode, while others received both. At the end of the study a subset of animals were perfused and the brain tissue sliced. Tissue sections were stained for astrocytes, microglia, and neurons. The local reactive responses were assessed using qualitative and quantitative methods. MAIN RESULTS: Electrophysiology recordings showed the carbon fibers detecting unit activity for at least 3 months with average amplitudes of ∼200 μV. Histology analysis showed the carbon fiber arrays with a minimal to non-existent glial scarring response with no adverse effects on neuronal density. Silicon electrodes showed large glial scarring that impacted neuronal counts. SIGNIFICANCE: This study has validated the use of carbon fiber microelectrode arrays as a chronic neural recording technology. These electrodes have demonstrated the ability to detect single units with high amplitude over 3 months, and show the potential to record for even longer periods. In addition, the minimal reactive response should hold stable indefinitely, as any response by the immune system may reach a steady state after 12 weeks.

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2011, 10.1520/F1980-07R11 · DOI
Kozai, 2014, Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes, Biomaterials, 35, 9255, 10.1016/j.biomaterials.2014.07.039 · DOI · Paper page

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Authors: Patel, P. R., Zhang, H., Robbins, M. T., Nofar, J. B., Marshall, S. P., Kobylarek, M. J., Kozai, T. D. Y., Kotov, N. A., & Chestek, C. A.
Affiliations: University of Michigan (US)
University of Pittsburgh (US)
Corresponding author: Patel, Paras R
Zhang, Huanan
Robbins, Matthew T
Nofar, Justin B
Marshall, Shaun P
Kobylarek, Michael J
Kozai, Takashi D Y
Kotov, Nicholas A
Chestek, Cynthia A
ORCID: Patel, Paras R
Zhang, Huanan
Kozai, Takashi D Y
Kotov, Nicholas A
Chestek, Cynthia A
Venue: Journal of Neural Engineering
Publisher: IOP Publishing
Published: 2016-10-05
Volume: 13
Issue: 6
Pages: 066002
ISSN: 1741-2552 (ISSN-L)
1741-2560
DOI: 10.1088/1741-2560/13/6/066002
PMC: PMC5118062
OpenAlex: W2529123936
Cited by: 204
References: 77
Citations by year: 2026: 11 · 2025: 14 · 2024: 17 · 2023: 18 · 2022: 16 · 2021: 34 · 2020: 34 · 2019: 24 · 2018: 24 · 2017: 9 · 2016: 2
FWCI: 11.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: publishingsupport.iopscience.iop.org/iop-standard/v1 (vor)
iopscience.iop.org/info/page/text-and-data-mining (tdm)
Locations: Journal of Neural Engineering (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: McKnight Foundation
National Institute of Neurological Disorders and Stroke (1R01NS094396)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
Keywords: chronic neural recording, electrode stability, PEDOT coating, accelerated aging, glial scar, silicon electrodes, single-unit recording
MeSH terms: Carbon Fiber, Animals, Astrocytes, Carbon, Cell Count, Electrodes, Implanted, Microcomputers, Microelectrodes, Motor Cortex, Neurons, Silicon, Microglia, Rats, Electrophysiological Phenomena, Signal-To-Noise Ratio

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Chronic in vivo stability assessment of carbon fiber microelectrode arrays

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