The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Interventions for sarcopenia and muscle weakness in older people
Abstract
OBJECTIVE: three major strategies have been tested for combating the losses in muscle mass and strength that accompany ageing. Those strategies are testosterone replacement for men, growth hormone replacement and resistance exercise training. This review will cover the risks and benefits associated with each of these interventions. METHODS: searches of PubMed and Web of Science through May 2004 yielded 85 relevant citations for the following descriptors: sarcopenia, aging/ageing, elderly, testosterone, hormone replacement, growth hormone, resistance training, exercise, muscle mass, nutrition and strength. RESULTS AND CONCLUSIONS: testosterone replacement in elderly hypogonadal men produces only modest increases in muscle mass and strength, which are observed in some studies and not in others. Higher doses have not been given for fear of accelerating prostate cancer. Growth hormone replacement in elderly subjects produces a high incidence of side-effects, does not increase strength and does not augment strength gains resulting from resistance training. Some alternate strategies for stimulating the growth hormone/insulin-like growth factor (IGF) pathway continue to hold promise. The latter include growth hormone releasing hormone (GHRH) and the complex of IGF-I with its major circulating binding protein (IGF-I/IGFBP-3). Resistance training remains the most effective intervention for increasing muscle mass and strength in older people. Elderly people have reduced food intake and increased protein requirements. As a result, adequate nutrition is sometimes a barrier to obtaining full benefits from resistance training in this population.
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Cites
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Ferrando, A. A., Sheffield-Moore, M., Yeckel, C. W., Gilkison, C., Jiang, J., Achacosa, A., Lieberman, S. A., Tipton, K., Wolfe, R. R., & Urban, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2001 · Cited by 522
Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability
Papadakis, M. A., Grady, D., Black, D., Tierney, M. J., Gooding, G. A. W., Schambelan, M., & Grunfeld, C. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-8-199604150-00002 · Cited by 474
Kenny, A. M., Prestwood, K. M., Gruman, C. A., Marcello, K. M., & Raisz, L. G. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.5.m266 · Cited by 456
Brose, A., Parise, G., & Tarnopolsky, M. A. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.1.b11 · Cited by 274
Cited by
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives
Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071
Sarcopenic obesity: A new category of obesity in the elderly
Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.10.002 · Cited by 953
Exercise, brain, and cognition across the life span.
Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T., & Kramer, A. F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00210.2011 · Cited by 601
Kim, H. K., Suzuki, T., Saito, K., Yoshida, H., Kobayashi, H., Kato, H., & Katayama, M. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03776.x · Cited by 551
Thomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521
Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., Morton, R. A., & Steiner, M. S. (2011) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-011-0034-6 · Cited by 403
Exercise interventions for the prevention and treatment of sarcopenia. A systematic umbrella review.
Beckwée, D., Delaere, A., Aelbrecht, S., Baert, V., Beaudart, C., Bruyere, O., de Saint-Hubert, M., & Bautmans, I. (2019) · The Journal of nutrition, health and aging · doi:10.1007/s12603-019-1196-8 · Cited by 330
Live strong and prosper: the importance of skeletal muscle strength for healthy ageing
McLeod, M., Breen, L., Hamilton, D. L., & Philp, A. (2016) · Biogerontology · doi:10.1007/s10522-015-9631-7 · Cited by 274
Fragala, M. S., Kenny, A. M., & Kuchel, G. A. (2015) · Sports Medicine · doi:10.1007/s40279-015-0305-z · Cited by 246
Exercise dosing to retain resistance training adaptations in young and older adults
BICKEL, C. S., CROSS, J. M., & BAMMAN, M. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318207c15d · Cited by 203
Exercise and cognition in older adults: is there a role for resistance training programmes?
Liu-Ambrose, T., & Donaldson, M. G. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.055616 · Cited by 202
Luo, L., Lu, A.-M., Wang, Y., Hong, A., Chen, Y., Hu, J., Li, X., & Qin, Z.-H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.009 · Cited by 192
Waters, D. L., & Baumgartner, R. N. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.007 · Cited by 185
Zhu, L.-Y., Chan, R., Kwok, T., Cheng, K. C.-C., Ha, A., & Woo, J. (2019) · Age and Ageing · doi:10.1093/ageing/afy179 · Cited by 179
Androgen Treatment and Muscle Strength in Elderly Men: A Meta‐Analysis
Ottenbacher, K. J., Ottenbacher, M. E., Ottenbacher, A. J., Acha, A. A., & Ostir, G. V. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00938.x · Cited by 173
Sarcopenia in the elderly: basic and clinical issues
Wang, C., & Bai, L. (2012) · Geriatrics & Gerontology International · doi:10.1111/j.1447-0594.2012.00851.x · Cited by 170
the Sarcopenia Guidelines Development group of the Belgian Society of Gerontology and Geriatrics (BSGG), De Spiegeleer, A., Beckwée, D., Bautmans, I., & Petrovic, M. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0566-y · Cited by 160
Modifying muscle mass – the endocrine perspective
Solomon, A. M., & Bouloux, P. M. G. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06837 · Cited by 156
Bouillanne, O., Curis, E., Hamon-Vilcot, B., Nicolis, I., Chrétien, P., Schauer, N., Vincent, J.-P., Cynober, L., & Aussel, C. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.015 · Cited by 152
Attenuation of sarcopenia by dietary restriction in rhesus monkeys
Colman, R. J., Beasley, T. M., Allison, D. B., & Weindruch, R. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.6.556 · Cited by 141
Abbatecola, A. M., Paolisso, G., Fattoretti, P., Evans, W. J., Fiore, V., Dicioccio, L., & Lattanzio, F. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-011-0366-0 · Cited by 137
Meng, X., Zhu, K., Devine, A., Kerr, D. A., Binns, C. W., & Prince, R. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090513 · Cited by 123
Bergamin, M., Ermolao, Tolomio, S., Berton, Sergi, & Zaccaria (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s44198 · Cited by 118
Bradlee, M. L., Mustafa, J., Singer, M. R., & Moore, L. L. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx070 · Cited by 116
Watanabe, Y., Madarame, H., Ogasawara, R., Nakazato, K., & Ishii, N. (2014) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12117 · Cited by 110
National Athletic Trainers' Association Position Statement: Anabolic-Androgenic Steroids
Kersey, R. D., Elliot, D. L., Goldberg, L., Kanayama, G., Leone, J. E., Pavlovich, M., & Pope, H. G. (2012) · Journal of Athletic Training · doi:10.4085/1062-6050-47.5.08 · Cited by 73
Adunsky, A., Chandler, J., Heyden, N., Lutkiewicz, J., Scott, B. B., Berd, Y., Liu, N., & Papanicolaou, D. A. (2011) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.10.004 · Cited by 67
Cooke, M. B., Brabham, B., Buford, T. W., Shelmadine, B. D., McPheeters, M., Hudson, G. M., Stathis, C., Greenwood, M., Kreider, R., & Willoughby, D. S. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2866-1 · Cited by 58
Wood, R. J., Gregory, S. M., Sawyer, J., Milch, C. M., Matthews, T. D., & Headley, S. A. E. (2012) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0104 · Cited by 32
Gray, M., Powers, M., Boyd, L., & Garver, K. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-0929-6 · Cited by 20
Metadata
- Authors
- Borst, S. E.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-09-22
- Volume
- 33
- Issue
- 6
- Pages
- 548-555
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2117547584
- Cited by
- 350
- References
- 5
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
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