Cited by 1,916Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

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Polyphenols and disease risk in epidemiologic studies

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Arts, Ilja CW, Hollman, Peter CH·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/81.1.317s

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Abstract

Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.

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Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men
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“Epidemiological data suggest that polyphenols within fruits and vegetables may contribute to this observed reduction in CVD risk (4, 13).”
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Differential pH-Induced Biosynthesis of Steviol Glycosides and Biochemical Parameters in Submerge Root Cultures of Stevia rebaudiana (Bert.)
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Therapeutic Strategies to Protect the Central Nervous System against Shiga Toxin from Enterohemorrhagic Escherichia coli
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“meta-analysis studies strongly suggest that long-term consumption of diets rich in plant polyphenols offers protection against cancer, cardiovascular disease, diabetes, osteoporosis, neurodegenerative diseases and infections [171-173].”
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Dietary Polyphenols Inhibit the Cytochrome P450 Monooxygenase Branch of the Arachidonic Acid Cascade with Remarkable Structure-Dependent Selectivity and Potency
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Using Rosemary Essential Oil as a Potential Natural Preservative during Stirred-like Yogurt Making
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“Therefore, natural antioxidants can protect the human body from free radicals and could retard the progress of many chronic diseases, as well as lipid oxidative rancidity in foods [33].”
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Monomeric and oligomeric flavan-3-ols and antioxidant activity of leaves from different Laurus sp.
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Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells
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“Many studies [7] [31] [32] have reported that consumption of polyphenol rich foods exert various biological effects.”
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Isolation of isoflavones from Iris kashmiriana Baker as potential anti proliferative agents targeting NF-kappaB
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The Effects of Drying Processes on Organoleptic Characteristics and the Health Quality of Food Ingredients Obtained from Goldenberry Fruits (Physalis peruviana)
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A validated method for the quantification of enterodiol and enterolactone in plasma using isotope dilution liquid chromatography with tandem mass spectrometry
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Breeding for Fruit Nutritional and Nutraceutical Quality
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Blood brain barrier inflammation and potential therapeutic role of phytochemicals
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The Exogenous Application of Abscisic Acid Induce Accumulation of Anthocyanins and Phenolic Compounds of the ‘Rubi’ Grape
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Agitated shoot cultures of Aronia arbutifolia and Aronia × prunifolia: biotechnological studies on the accumulation of phenolic compounds and biotransformation capability
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Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder
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4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis
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“The dietary consumption of foods rich in phenols has been attributed to numerous health benefits, including lowering rates of chronic diseases, such as Alzheimer’s disease, Parkinson’s disease, diabetes, cardiovascular disease, and inflammation [6, 7].”
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Plant stem tissue modeling and parameter identification using metaheuristic optimization algorithms
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Background
Activation of muscarinic receptors by a hydroalcoholic extract of Dicksonia sellowiana Presl. HooK (Dicksoniaceae) induces vascular relaxation and hypotension in rats
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“increased intake of these compounds may help to protect against chronic diseases, such as cardiovascular pathologies (Yochum et al., 2000; Arts and Hollman, 2005; Taubert et al., 2007).”
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Potential Benefits on Impairment of Endothelial Function after a High‐Fat Meal of 4 Weeks of Flavonoid Supplementation
Barringer, T. A., Hatcher, L. F., & Sasser, H. C. (2008) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nen048 · Cited by 24
Nutrition, Epigenetic Mechanisms, and Human Disease
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Red Raspberry Phenols Inhibit Angiogenesis: A Morphological and Subcellular Analysis Upon Human Endothelial Cells
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A review on the utilization of sesame as functional food
Asghar, A., Majeed, M. N., & Akhtar, M. N. (2014) · Cited by 22
Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells
Sakurai, T., Kitadate, K., Nishioka, H., Fujii, H., Ogasawara, J., Kizaki, T., Sato, S., Fujiwara, T., Akagawa, K., Izawa, T., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s000711451300086x · Cited by 22
PHYTOCHEMICALS AS CANDIDATE THERAPEUTICS: AN OVERVIEW
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Flavonoid classes and risk of peripheral arterial occlusive disease: a case–control study in Greece
Λάγιου, Π., Samoli, E., Lagiou, A., Skalkidis, Y., Katsouyanni, K., Petridou, E. T., & Trichopoulos, D. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602291 · Cited by 22
“Several studies have examined the intake of flavonoids in relation to coronary heart disease (CHD) (Hertog et al., 1993; Hertog et al., 1995; Knekt et al., 1996; Rimm et al., 1996; Yochum et al., 1999; Huxley and Neil, 2003; Lagiou et al., 2004; Arts and Hollman, 2005).”
BackgroundInfluential
Inhibitory modulation of ATP-sensitive potassium channels by gallate-ester moiety of (−)-epigallocatechin-3-gallate
Baek, W., Jang, B., Lim, J. H., Kwon, T., Lee, H. Y., Cho, C., Kim, D.-K., Shin, D.-H., Park, J.-G., Lim, J.-G., et al. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.09.005 · Cited by 22
Plant Polyphenols: Natural and Potent UV-Protective Agents for the Prevention and Treatment of Skin Disorders
Farjadmand, F., Karimpour‐Razkenari, E., Nabavi, S. M., Ardekani, M. R. S., & Saeedi, M. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666201109121246 · Cited by 21
Ripening Changes of the Chemical Composition, Proteolysis, and Lipolysis of a Hair Sheep Milk Mexican Manchego-Style Cheese: Effect of Nano-Emulsified Curcumin
Sardiñas-Valdés, M., Garcia, H. S., Chay‐Canul, A. J., Velázquez-Martínez, J. R., Hernández-Becerra, J. A., & Ochoa-Flores, A. A. (2021) · Foods · doi:10.3390/foods10071579 · Cited by 21
“Moreover, some studies have evidenced that the polyphenol ingestion of more than 1 g/day is correlated with diminished onset and progress of chronic diseases related to oxidative stress, such as type 2 diabetes mellitus and several forms of cancer [6,7].”
Background
The effect of malting on phenolic compounds and radical scavenging activity in grains and breakfast cereals
Vingrys, K., Mathai, M. L., Ashton, J., Stojanovska, L., Vasiljevic, T., McAinch, A. J., & Donkor, O. N. (2022) · Journal of Food Science · doi:10.1111/1750-3841.16271 · Cited by 21
Synergic interactions between berry polyphenols and gut microbiota in cardiovascular diseases
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“Enor-mous experimental and epigenetics research have shown the intense link between consumption of foods enriched in polyphenolic compounds for long term and various chronic diseases including diabetes mellitus, hypertension, cardiovascular diseases, cancer and many other disorders [17–19 , 157].”
Polyphenols as novel treatment options for dermatological diseases: A systematic review of clinical trials
Tuong, W., Walker, L., & Sivamani, R. K. (2015) · Journal of Dermatological Treatment · doi:10.3109/09546634.2014.991675 · Cited by 17
“We excluded studies that (1) evaluated products that contained polyphenols in addition to other phytochemicals, (2) did not explicitly describe polyphenol type and content/concentration of therapy, (4) had less than 10 subjects and (3) were not published in English.”
BackgroundMethodInfluential

Authors: Arts, I. C., & Hollman, P. C.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Arts, Ilja CW
ORCID: Arts, Ilja CW
Hollman, Peter CH
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-01
Volume: 81
Issue: 1
Pages: 317S-325S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/81.1.317s
OpenAlex: W2129133439
Cited by: 1,916
References: 74
Citations by year: 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
FWCI: 6.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6628 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: ZonMw
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
MeSH terms: Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols

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Polyphenols and disease risk in epidemiologic studies

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