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Polyphenols and disease risk in epidemiologic studies
Open accessAbstract
Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.
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“In humans, it was shown that there is a correlation between dietary phenolic compound intake and a reduced incidence of chronic diseases such as cancers, cardiovascular and neurodegenerative diseases (Arts and Hollman, 2005)”
From Cannabis sativa: The Plant of the Thousand and One Molecules (2016) · cites this paper as Arts and Hollman, 2005
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“epidemiological investigations revealed an inverse correlation between the intake of flavanol-containing foods and coronary artery disease (CAD) mortality (1).”
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Citations
Cites
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
Flavonoids: a review of probable mechanisms of action and potential applications.
Nijveldt, R., van Nood, E., van Hoorn, D. V., Boelens, P., van Norren, K., & van Leeuwen, P. V. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,232
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Phyto-oestrogens and Western Diseases
Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282
Flavonoid intake and coronary mortality in Finland: a cohort study
Knekt, P., Jarvinen, R., Reunanen, A., & Maatela, J. (1996) · BMJ · doi:10.1136/bmj.312.7029.478 · Cited by 1,268
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke: The Zutphen Study
Keli, S., Hertog, M. G., Feskens, E., & Kromhout, D. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060059007 · Cited by 914
Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
Hertog, M. G. L., Hollman, P. C. H., & van de Putte, B. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00032a015 · Cited by 899
Cited by
Sorted by citations
Items 401–500 of 1,001
Lignans: Quantitative Analysis of the Research Literature
Yeung, A. W. K., Tzvetkov, N. T., Balacheva, A. A., Georgieva, M. G., Gan, R., Jóźwik, A., Pyzel, B., Horbańczuk, J. O., Novellino, E., Durazzo, A., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00037 · Cited by 87
Composition, characteristics and health promising prospects of black wheat: A review
Dhua, S., Kumar, K., Kumar, Y., Singh, L., & Sharanagat, V. S. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.04.037 · Cited by 91
Systematic analysis of the polyphenol metabolome using the Phenol‐Explorer database
Rothwell, J. A., Urpí-Sardà, M., Boto‐Ordóñez, M., Llorach, R., Farrán-Codina, A., Barupal, D. K., Neveu, V., Manach, C., Andrés‐Lacueva, C., & Scalbert, A. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500435 · Cited by 88
“Polyphenol consumption may protect against cardiovascular diseases, cancers, and a range of other diseases [3, 4].”
BackgroundBarreca, D., Bellocco, E., Leuzzi, U., & Gattuso, G. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.10.096 · Cited by 84
“…has occurred because of their potential health-promoting properties, supported also by a well documented epidemiological and literature data (Arts & Hollman, 2005; Barreca, Laganà, Bruno, Magazù, & Bellocco, 2013b; Benavente-García & Castillo, 2008; Galtieri et al., 2010; Grosso et al.,…”
BackgroundAnticoagulant effect of polyphenols-rich extracts from black chokeberry and grape seeds
Bijak, M., Bobrowski, M., Borowiecka, M., Podsędek, A., Golański, J., & Nowak, P. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.04.017 · Cited by 84
Tradtrantip, L., Zhang, H., Anderson, M. O., Saadoun, S., Phuan, P., Papadopoulos, M. C., Bennett, J. L., & Verkman, A. S. (2012) · The FASEB Journal · doi:10.1096/fj.11-201608 · Cited by 84
“Quercetin is a widely available neutraceutical with reported beneficial effects in cardiovascular diseases (42, 43).”
BackgroundZamora‐Ros, R., Rabassa, M., Cherubini, A., Urpí-Sardà, M., Bandinelli, S., Ferrucci, L., & Andrés‐Lacueva, C. (2013) · Journal of Nutrition · doi:10.3945/jn.113.177121 · Cited by 85
“The underlying mechanisms by which high TUP concentrations can contribute to a reduction of all-cause mortality are still unknown but may be due to their cardiovascular-protective and anticarcinogenic effects, because CVDs and cancer are the 2 main causes of mortality in this section of the population (6,9).”
BackgroundRole of Rutin on Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells
Ugusman, A., Zakaria, Z., Chua, K. H., Nordin, N. A. M. M., & Mahdy, Z. A. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/169370 · Cited by 84
Dávalos, A., Fernandez-Hernando, C. F., Cerrato, F., Martı́nez-Botas, J., Gómez‐Coronado, D., Gómez‐Cordovés, C., & Lasunción, M. A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.7.1766 · Cited by 85
Papillo, V. A., Vitaglione, P., Graziani, G., Gökmen, V., & Fogliano, V. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500695a · Cited by 83
Pierre, J. F., Heneghan, A. F., Feliciano, R. P., Shanmuganayagam, D., Roenneburg, D. A., Krueger, C. G., Reed, J. D., & Kudsk, K. A. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607112463076 · Cited by 84
Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes
Rivera-Yañez, N., Rodriguez-Canales, M., Nieto-Yañez, O., Jimenez-Estrada, M., Ibarra-Barajas, M., Canales-Martinez, M. M., & Rodriguez-Monroy, M. A. (2018) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2018/4360356 · Cited by 83
“Flavonoids have the ability to scavenge free radicals and chelate metals [36].”
Ardekani, M. R. S., Hajimahmoodi, M., Oveisi, M. R., Sadeghi, N., Jannat, B., Ranjbar, A. M., Gholam, N., & Moridi, T. (2011) · Europe PMC (PubMed Central) · Cited by 83
Dietary Iron-Initiated Lipid Oxidation and Its Inhibition by Polyphenols in Gastric Conditions
Lorrain, B., Dangles, O., Loonis, M., Armand, M., & Dufour, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302348s · Cited by 83
McDougall, G. J., Martinussen, I., & Stewart, D. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.06.032 · Cited by 83
Wang, D., Zou, T., Yang, Y., Yan, X., & Ling, W. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.04.007 · Cited by 83
Morrison, M. C., van der Heijden, R. A., Heeringa, P., Kaijzel, E. L., Verschuren, L., Blomhoff, R., Kooistra, T., & Kleemann, R. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.027 · Cited by 87
Barbosa, P. O., Pala, D., Silva, C. T., de Souza, M. O., do Amaral, J. F., Vieira, R. A. L., Folly, G. A. D. F., Volp, A. C. P., & de Freitas, R. N. (2015) · Nutrition · doi:10.1016/j.nut.2015.12.030 · Cited by 83
“Regular intake of fruits, vegetables, and other antioxidant-rich foods is associated with numerous beneficial health effects, reducing the incidence of these diseases [42,43].”
BackgroundRacial disparities in cardiovascular disease risk: mechanisms of vascular dysfunction
Brothers, R. M., Fadel, P. J., & Keller, D. M. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00126.2019 · Cited by 82
“Specifically, flavanol consumption is inversely correlated with coronary artery disease and incidence of stroke (4, 71).”
BackgroundChensom, S., Okumura, H., & Mishima, T. (2019) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2019.24.2.171 · Cited by 82
Biopolymers for food packaging applications
Fabra, M. J., López‐Rubio, A., & Lagaron, J. M. (2014) · Elsevier eBooks · doi:10.1533/9780857097026.2.476 · Cited by 82
“Amongst the broad group of antioxidants, carotenoids and polyphenols have attracted a great deal of research due to the possible health benefi ts of both groups of compounds (Arts and Hollman, 2005).”
BackgroundConsumer attitudes towards enhanced flavonoid content in fruit
Lampila, P., van Lieshout, M., Gremmen, B., & Lähteenmäki, L. (2008) · Food Research International · doi:10.1016/j.foodres.2008.09.002 · Cited by 82
Sharabani, H., Izumchenko, E., Wang, Q., Kreinin, R., Steiner, M., Barvish, Z., Kafka, M., Sharoni, Y., Levy, J., Uskoković, M. R., et al. (2006) · International Journal of Cancer · doi:10.1002/ijc.21736 · Cited by 82
“over, both serum levels of vitamin D3 at the high end of the physiological range(21,22) and consumption of polyphenol-rich diets are consistent with lower risk of certain cancers.(32,33) This is supported by the findings that both VDDs and rosemary extract and its purified components suppressed experimental carcinogen…”
ResultPhytochemica: a platform to explore phytochemicals of medicinal plants
Pathania, S., Ramakrishnan, S. M., & Bagler, G. (2015) · Database · doi:10.1093/database/bav075 · Cited by 83
Advances in Genomic Interventions for Wheat Biofortification: A Review
Saini, D. K., Devi, P., & Kaushik, P. (2020) · Agronomy · doi:10.3390/agronomy10010062 · Cited by 82
Rana, J. N., Gul, K., & Mumtaz, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157381 · Cited by 87
Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract
Kalus, U. J., Grigorov, A., Kadecki, O., Jansen, J., Kiesewetter, H., & Radtke, H. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.10.001 · Cited by 81
“Various reports exist on antiviral and antibacterial potential (Cos et al., 2004; Urquiaga and Leighton, 2000; Arts and Hollman, 2005; Halliwell et al., 2005; Simeray et al., 1982; Chinou et al., 1994; Bouamama et al., 1999) including an antiviral activity of polyphenols against influenza virus (Nakayama et al.”
BackgroundBiologically Active Components and Nutraceuticals in Peanuts and Related Products: Review
Isanga, J., & Guo-nong, Z. (2007) · Food Reviews International · doi:10.1080/87559120701224956 · Cited by 85
Kardum, N., Takić, M. M., Šavikin, K., Zec, M. M., Zdunić, G. M., Spasić, S., & Konić‐Ristić, A. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.04.019 · Cited by 82
Murota, K., & Terao, J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.08.060 · Cited by 81
“[1–5].”
Flores, G., Dastmalchi, K., Wu, S., Whalen, K., Dabo, A. J., Reynertson, K. A., Foronjy, R., D'Armiento, J. M., & Kennelly, E. J. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.025 · Cited by 81
Rudnicki, M., Silveira, M. M., Pereira, T. V., de Oliveira, M. R., Reginatto, F. H., Dal‐Pizzol, F., & Moreira, J. C. F. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.10.022 · Cited by 81
“Furthermore, epidemiological studies suggest a significant inverse correlation between polyphenol consumption and cardiovascular risk (Arts and Hollman, 2005; Peters et al., 2001).”
BackgroundRanilla, L. G., Apostolidis, E., Genovese, M. I., Lajolo, F. M., & Shetty, K. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0122 · Cited by 81
“7 Among Andean grains, flavonoids such as kaempferol and quercetin glycosides were found in the ‘‘Kancolla’’ variety of C. quinoa seeds.”
Wright, M. E., Park, Y., Subar, A. F., Freedman, N. D., Albanes, D., Hollenbeck, A. R., Leitzmann, M. F., & Schatzkin, A. G. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn212 · Cited by 81
“Several prospective studies have shown an inverse association between flavonoid intake (particularly quercetin, which is concentrated in apples) and lung cancer risk (40).”
Gutiérrez‐Díaz, I., Fernández-Navarro, T., Salazar, N., Bartolomé, B., Moreno-Arribas, M. V., deAndrés‐Galiana, E. J., Fernández‐Martínez, J. L., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & González, S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04408 · Cited by 90
Pradeep, P. M., & Sreerama, Y. N. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.033 · Cited by 80
Sakurai, T., NISHIOKA, H., Fujii, H., Nakano, N., Kizaki, T., Radak, Z. O., Izawa, T., Haga, S., & Ohno, H. (2008) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70567 · Cited by 80
Chanet, A., Milenković, D., Claude, S., Maier, J. A. M., Khan, M. K., Rakotomanomana, N., Shinkaruk, S., Bérard, A. M., Bennetau‐Pelissero, C., Mazur, A., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512005454 · Cited by 82
Barreca, D., Laganà, G., Ficarra, S., Tellone, E., Leuzzi, U., Galtieri, A., & Bellocco, E. (2011) · Food Research International · doi:10.1016/j.foodres.2011.02.031 · Cited by 80
The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function
Giuliani, C., Bucci, I., Santo, S. D., Rossi, C., Grassadonia, A., Piantelli, M., Monaco, F., & Napolitano, G. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.01.016 · Cited by 80
Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention
Izzo, S., Naponelli, V., & Bettuzzi, S. (2020) · Nutrients · doi:10.3390/nu12041010 · Cited by 81
Actis‐Goretta, L., Dew, T. P., Lévèques, A., Pereira‐Caro, G., Rein, M. J., Teml, A., Schäfer, C., Hofmann, U., Schwab, M. G., Eichelbaum, M. F., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500202 · Cited by 79
Selected Aspects of Mediterranean Diet and Cancer Risk
Pelucchi, C., Bosetti, C., Rossi, M., Negri, E., & Vecchia, C. L. (2009) · Nutrition and Cancer · doi:10.1080/01635580903285007 · Cited by 79
Dietary Flavonol and Flavone Intakes and Their Major Food Sources in Chinese Adults
Zhang, Y., Li, Y., Cao, C., Cao, J., Chen, W., Zhang, Y., Wang, C., Wang, J., Zhang, X., & Zhao, X. (2010) · Nutrition and Cancer · doi:10.1080/01635581.2010.513800 · Cited by 78
“com Flavones are present in relatively small quantities in grains, leafy vegetables, and herbs (5,6).”
BackgroundImportance of Phytochemicals in Nutraceuticals
Prakash, D., Gupta, C., & Sharma, G. D. (2012) · Cited by 79
Ouerghemmi, S., Sebei, H., Siracusa, L., Ruberto, G., Saija, A., Cimino, F., & Cristani, M. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2016.08.019 · Cited by 79
Antihypertensive Role of Polyphenols
Rodrigo, R., Gil, D., Miranda-Merchak, A., & Kalantzidis, G. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394383-5.00014-x · Cited by 78
Vitale, M., Vaccaro, O., Masulli, M., Bonora, E., Prato, S. D., Giorda, C. B., Nicolucci, A., Squatrito, S., Auciello, S., Babini, A. C., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.002 · Cited by 78
Cvetanović, A. D., Zengin, G., Zeković, Z. P., Švarc‐Gajić, J., Ražić, S., Damjanović, A., Mašković, P., & Mitić, M. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.09.045 · Cited by 80
Ancient apple varieties from Croatia as a source of bioactive polyphenolic compounds
Jakobek, L., & Barron, A. R. (2015) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2015.09.007 · Cited by 78
“Polyphenols are studied intensively due to many positive effects like their anticancerogenic properties (Veeriah et al., 2007; Yang and Liu, 2009), and effect on the prevention of cardiovascular diseases and cancer (Arts and Hollman, 2005; Hollman et al., 2011).”
BackgroundAlqurashi, R. M., Alarifi, S. N., Walton, G., Costabile, A., Rowland, I. R., & Commane, D. M. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.04.164 · Cited by 76
“A high intake of fruit and vegetables reduces the risk of age related disease (Arts & Hollman, 2005).”
Ahmad, N., Ahmad, R., Alrasheed, R. A., Almatar, H. M. A., Al-Ramadan, A., Amir, M., & Sarafroz, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030203 · Cited by 78
RetractedHuang, L., Zhang, X., Zhang, H., & Wang, J. (2018) · LWT · doi:10.1016/j.lwt.2018.01.027 · Cited by 77
Flavonoids and ovarian cancer risk: A case–control study in Italy
Rossi, M., Negri, E., Λάγιου, Π., Talamini, R., Maso, L. D., Montella, M., Franceschi, S., & Vecchia, C. L. (2008) · International Journal of Cancer · doi:10.1002/ijc.23549 · Cited by 78
Leonardo, C. C., & Doré, S. (2011) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000013 · Cited by 77
Quercetin and Its In Vivo Metabolites Inhibit Neutrophil-Mediated Low-Density Lipoprotein Oxidation
Loke, W. M., Proudfoot, J. M., McKinley, A. J., Needs, P. W., Kroon, P. A., Hodgson, J. M., & Croft, K. D. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8003042 · Cited by 77
Flavonoids and risk of squamous cell esophageal cancer
Rossi, M., Garavello, W., Talamini, R., Vecchia, C. L., Franceschi, S., Λάγιου, Π., Zambon, P., Maso, L. D., Bosetti, C., & Negri, E. (2006) · International Journal of Cancer · doi:10.1002/ijc.22499 · Cited by 77
Phytochemical studies on Azolla pinnata R. Br., Marsilea minuta L. and Salvinia molesta Mitch
Mithraja, M. J., Antonisamy, J. M., Mahesh, M., Paul, Z. M., & Jeeva, S. (2011) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(11)60116-0 · Cited by 77
Wätjen, W., Weber, N., Lou, Y., Wang, Z.-Q., Chovolou, Y., Kampkötter, A., Kahl, R., & Proksch, P. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.08.008 · Cited by 77
Ozone-elicited secondary metabolites in shoot cultures of Melissa officinalis L.
Tonelli, M., Pellegrini, E., D’Angiolillo, F., Petersen, M., Nali, C., Pistelli, L., & Lorenzini, G. (2014) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-014-0628-8 · Cited by 77
“…the attention was focused on the ingestion of natural phenolic antioxidants and essential oils that may decrease the risk of cardiovascular disease, cancer, and inflammation (Arts and Hollman 2005) and, in general, exhibit good antioxidant activities (Marongiu et al. 2004; Kamdem et al. 2013).”
Flavonoids and mitochondrial pharmacology: A new paradigm for cardioprotection
Testai, L. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.04.017 · Cited by 77
Cancer Protective Properties of Cocoa: A Review of the Epidemiologic Evidence
Maskarinec, G. (2009) · Nutrition and Cancer · doi:10.1080/01635580902825662 · Cited by 76
“A 2005 review of the epidemiologic literature on polyphenols summarized some of the limited research in the area of catechin intake and cancer risk (13).”
BackgroundKardum, N., Milovanović, B., Šavikin, K., Zdunić, G. M., Mutavdžin, S., Gligorijević, T., & Spasić, S. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.0171 · Cited by 79
“4,5 Among various plant foods, berry fruits have been found to have the greatest antioxidant potential due to the high presence of polyphenols.”
Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland)
Bobe, G., Weinstein, S. J., Albanes, D., Hirvonen, T., Ashby, J., Taylor, P. R., Virtamo, J. R. K., & Stolzenberg‐Solomon, R. Z. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2523 · Cited by 76
“In support of this biological mechanism, flavonol intake has shown the greatest protective association for lung cancer (18, 46, 47).”
BackgroundDelosière, M., Rémond, D., Loonis, M., Buffière, C., Santé-Lhoutellier, V., & Dufour, C. (2014) · Food & Function · doi:10.1039/c4fo00269e · Cited by 79
Gotti, R., Furlanetto, S., Pinzauti, S., & Cavrini, V. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.11.058 · Cited by 92
Flavonoids and cardiovascular health: which compounds, what mechanisms?
Geleijnse, J. M., & Hollman, P. C. H. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.12 · Cited by 76
“Epidemiologic studies of flavonoids and cardiovascular mortality have also been performed in other countries, and in most, although not all, studies, a protective association was found (3, 8).”
ResultHagen, S. F., Solhaug, K. A., Bengtsson, G., Borge, G. I. A., & Bilger, W. (2006) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2006.04.003 · Cited by 75
Alias, L. M., Manoharan, S., Vellaichamy, L., Balakrishnan, S., & Ramachandran, C. R. (2008) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2008.09.001 · Cited by 75
CHAPTER 7: Micronutrients and Phytochemicals in Wheat Grain
Piironen, V. I., & Salmenkallio‐Marttila, M. (2009) · AACC International eBooks · doi:10.1094/9781891127557.007 · Cited by 75
Liu, Y., Wang, X., Pang, J., Zhang, H., Luo, J., Qian, X., Chen, Q., & Ling, W. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05719 · Cited by 75
Dietary antioxidants in inflammatory arthritis: do they have any role in etiology or therapy?
Pattison, D. J., & Winyard, P. G. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0920 · Cited by 74
El‐Hadary, A. E., & Ramadan, M. F. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2015.1078381 · Cited by 74
“Epidemiological studies suggested an inverse relation between the consumption of phenol-rich foods and the risk of degenerative diseases, particularly cancers and cardiovascular diseases (Arts & Hollman, 2005).”
BackgroundUptake and metabolism of enterolactone and enterodiol by human colon epithelial cells
Jansen, G. H. E., Arts, I. C. W., Nielen, M. W. F., Müller, M. M., Hollman, P. C. H., & Keijer, J. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.12.015 · Cited by 74
Guo, X., Tresserra‐Rimbau, A., Estruch, R., Martínez‐González, M. Á., Medina‐Remón, A., Castañer, O., Corella, D., Salas‐Salvadó, J., & Lamuela-Raventós, R. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2572606 · Cited by 76
Ishida, K., Yamamoto, M., Misawa, K., Nishimura, H., Misawa, K., Ota, N., & Shimotoyodome, A. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.05.001 · Cited by 76
In vitro digestion of polysaccharide including whey protein isolate hydrogels
Özel, B., Aydin, Ö., & Öztop, M. H. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115469 · Cited by 73
Dutta, G., & Sugumaran, A. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102853 · Cited by 74
Chen, R., Lin, J., Hong, J., Han, D., Zhang, A. D., Lan, R., Fu, L., Wu, Z., Lin, J., Zhang, W., et al. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.07.014 · Cited by 73
Panickar, K. S., & Anderson, R. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12118181 · Cited by 73
Kojadinović, M., Arsić, A., Debeljak-Martačić, J., Konić‐Ristić, A., Kardum, N., Popović, T. B., & Glibetić, M. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7977 · Cited by 73
Apetrei, I. M., Rodrı́guez-Méndez, M. L., Apetrei, C., & de Saja, J. A. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2012.10.131 · Cited by 72
Li, Q., Chen, J., Xiao, Y., Di, P., Zhang, L., & Chen, W. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-388 · Cited by 72
“Lariciresinol is a kind of lignan which has been widely studied and reported to possess a number of biological activities, including antimicrobial, antioxidant, anti-inflammatory and anti-estrogenic properties, which may reduce the risk of cardiovascular diseases, as well as certain types of cancer [4-9].”
BackgroundZamora‐Ros, R., Rabassa, M., Cherubini, A., Urpí-Sardà, M., Llorach, R., Bandinelli, S., Ferrucci, L., & Andrés‐Lacueva, C. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.07.035 · Cited by 72
“These beneficial effects are due to their antioxidant, antiviral, anti-inflammatory and chemopreventive activities [2,3].”
Stewart, D., McDougall, G. J., Sungurtas, J., Verrall, S. R., Graham, J., & Martinussen, I. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700056 · Cited by 72
Polyphenols: Potential Future Arsenals in the Treatment of Diabetes
Solayman, M., Ali, Y., Alam, F., Islam, M. A., Alam, N., Khalil, M. I., & Gan, S. H. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151125001111 · Cited by 76
Izuegbuna, O., Otunola, G. A., & Bradley, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209682 · Cited by 72
Current Trends in Enrichment of Wheat Pasta: Quality, Nutritional Value and Antioxidant Properties
Dziki, D. (2021) · Processes · doi:10.3390/pr9081280 · Cited by 71
Yi, W., Akoh, C. C., Fischer, J. G., & Krewer, G. W. (2006) · Food Research International · doi:10.1016/j.foodres.2006.01.001 · Cited by 71
Grujić-Letić, N. N., Lepojević, Ž., Čonić, B. S., Vladić, J., & Sudji, J. (2012) · Molecules · doi:10.3390/molecules17032518 · Cited by 71
“Recent studies showed a high correlation between consumption of polyphenol-rich food and beverages and the prevention of many human diseases [5,6].”
BackgroundLi, W., Liang, H. B., Zhang, M., Zhang, R., Deng, Y., Wei, Z., Zhang, Y., & Tang, X. (2012) · Molecules · doi:10.3390/molecules171214954 · Cited by 73
“Accumulating epidemiological studies have demonstrated that increased consumption of fruits and vegetables can reduce risk of chronic diseases associated with oxidative stress, such as cardiovascular disease, cancer, diabetes and neurodegenerative diseases [2–4].”
BackgroundCefali, L. C., Ataide, J. A., Fernandes, A. R., Sousa, I. M. D. O., Gonçalves, F. C. D. S., Eberlin, S., Dávila, J. L., Jozala, Â. F., Chaud, M. V., Sánchez‐López, E., et al. (2019) · Antioxidants · doi:10.3390/antiox8100443 · Cited by 71
Plant Polyphenols as Antioxidants Influencing the Human Health
Vladimir-Kneevic, S., Blaekovi, B., Bival, M., & Babac, M. (2012) · InTech eBooks · doi:10.5772/27843 · Cited by 74
Sun‐Waterhouse, D., Zhou, J., & Wadhwa, S. S. (2011) · Food and Bioprocess Technology · doi:10.1007/s11947-011-0563-1 · Cited by 70
Flavanols, the Kuna, cocoa consumption, and nitric oxide
Hollenberg, N. K., Fisher, N. D. L., & McCullough, M. L. (2009) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2008.11.001 · Cited by 70
“Several epidemiologic studies have specifically examined the relationship between flavan-3-ols or their food sources and CVD outcomes.(24,28,29) Cross-sectional and hospital-based case-control studies suggest inverse associations between these compounds and various CVD outcomes, but have study design limitations.”
Jia, E., Yan, Y., Zhou, M., Li, X., Jiang, G., Liu, W., & Zhang, D. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.114268 · Cited by 70
Premathilaka, R. W., Rashidinejad, A., Golding, M., & Singh, J. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2022.107567 · Cited by 69
Disorders of Endogenous and Exogenous Antioxidants in Neurological Diseases
Korczowska-Łącka, I., Słowikowski, B. K., Piekut, T., Hurła, M., Banaszek, N., Szymanowicz, O., Jagodziński, P. P., Kozubski, W. P., Permoda-Pachuta, A., & Dorszewska, J. (2023) · Antioxidants · doi:10.3390/antiox12101811 · Cited by 84
“The study of Arts and Hollman [178] proved that increased consumption of polyphenols (quercetine, kaempferol, myricetine, apigenine, and luteolin) may lower potential stroke risk.”
Preliminary study of the effect of ultrasound on physicochemical properties of red wine
Zhang, Q., Shen, Y., Fan, X., & Martín, J. F. G. (2015) · CyTA - Journal of Food · doi:10.1080/19476337.2015.1045036 · Cited by 69
“…compounds are beneficial and important to health as they play a significant role in reducing the risk of many diseases originating from the oxidative stress in the human body (Arts & Hollman, 2005; Duthie et al., 2006; Pace-Asciak, Hahn, Diamandis, Soleas, & Goldberg, 1995; Vinson & Hontz, 1995).”
BackgroundEndothelial Function, Nitric Oxide, and Cocoa Flavanols
Heiß, C., Schroeter, H., Balzer, J., Kleinbongard, P., Matern, S., Sies, H., & Kelm, M. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200606001-00007 · Cited by 69
“Epidemiologic studies indicate that diets rich in fruit and vegetables are associated with a decreased incidence of adverse cardiovascular events, such as CAD and stroke.(36) This effect was ascribed, at least in part, to the high content of antioxidants, in particular polyphenolic compounds, such as flavonoids, in pl…”
Background
Metadata
- Authors
- Arts, I. C., & Hollman, P. C.
- Affiliations
- Wageningen University & Research (NL)
- Corresponding author
- Arts, Ilja CW
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 81
- Issue
- 1
- Pages
- 317S-325S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2129133439
- Cited by
- 1,916
- References
- 74
- Citations by year
- 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- ZonMw
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
- MeSH terms
- Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols
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