Cited by 1,916Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

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Polyphenols and disease risk in epidemiologic studies

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Arts, Ilja CW, Hollman, Peter CH·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/81.1.317s

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Abstract

Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.

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Chakraborty, S. B. (2012) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2012.21209 · Cited by 30
“Phytochemicals are a large group of plant-derived compounds that are commonly found in fruits, vegetables, beans, cereals and plantbased beverages like tea and wine (Arts and Hollman, 2005).”
Background
Vascular effect of red wine polyphenols in chronic stress-exposed Wistar-kyoto rats
Púzserová, A., Csizmadiova, Z., Andriantsitohaina, R., & Bernátová, I. (2006) · Physiological Research · doi:10.33549/physiolres.930000.55.s1.39 · Cited by 30
Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role ofLoranthus micranthus
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“One of the mechanisms to support this claim is that flavonoids have the ability to scavenge free radicals [11].”
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Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes
Gimblet, C. J., Kruse, N. T., Geasland, K. M., Michelson, J., Sun, M., Mandukhail, S. R., Wendt, L. H., Eyck, P. T., Pierce, G. L., & Jalal, D. I. (2023) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000000000337 · Cited by 32
“Polyphenols are naturally occurring compounds found in various fruits and plants that attenuate atherosclerotic vascular disease, 15 likely because of their ability to limit oxidative stress and in ﬂ ammation in endothelial cells.”
Background
Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk
Lu, D., Pan, C., Ye, C., Duan, H., Xu, F., Li, Y., Tian, W., & Zhang, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-03692-y · Cited by 29
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“Moreover, polyphenols are the most abundant bioactive compounds reaching values of 1 g/day in the diet, approximately 10-times higher than vitamin C intake (Arts and Hollman, 2005; Scalbert et al., 2005) .”
Antilipoxygenase and Anti-Inflammatory Activities of Streblus asper Leaf Extract on Xylene-Induced Ear Edema in Mice
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“Many studies reported that phenolic compounds inhibit the inflammatory process via inhibiting lipoxygenase enzyme involved in transformation of arachidonic acid to inflammatory mediators and involved free radical scavenging in arachidonic acid metabolism [18, 24].”
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Gut microbiota axis: potential target of phytochemicals from plant-based foods
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“Polyphenol serves as a free radical scavenger and is related to reduction of inflammatory responses and modulation of immune function (3).”
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Borah, A., Paul, R. K., Mazumder, M. K., & Bhattacharjee, N. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1330-2 · Cited by 29
Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by resveratrol
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“A growing number of studies suggest that dietary intake or supplementation of natural products have an ability to prevent or delay the incidence of age-related neurological disorders (Bastianetto and Quirion, 2002; Arts and Hollman, 2005).”
Background
Preventive or Potential Therapeutic Value of Nutraceuticals against Ionizing Radiation-Induced Oxidative Stress in Exposed Subjects and Frequent Fliers
Giardi, M. T., Touloupakis, E., Bertolotto, D., & Mascetti, G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140817168 · Cited by 30
Infusions of artichoke and milk thistle represent a good source of phenolic acids and flavonoids
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Antioxidant capacity and colour stability of texture-improved canned strawberries as affected by the addition of rose (Rosa damascena Mill.) petal extracts
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Effect of marjoram extract treatment on the cytological and biochemical changes induced by cyclophosphamide in mice
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Selaginella uncinata flavonoids ameliorated ovalbumin-induced airway inflammation in a rat model of asthma
Yu, B., Cai, W., Zhang, H., Zhong, Y.-S., Fang, J., Zhang, W., Li, M., Wang, L.-C., & Yu, C.-H. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.11.049 · Cited by 29
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Saponara, S., Sgaragli, G., & Fusi, F. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.08.016 · Cited by 29
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“Green tea may also help to prevent chronic conditions such as cardiovascular diseases, cancer and kidney stones.(9) It can also be hypothesized that polyphenol-containing beverages may have a positive effect on lung cancer risk.”
Background
Heavy metal levels and flavonoid intakes are associated with chronic obstructive pulmonary disease: an NHANES analysis (2007–2010 to 2017–2018)
Yan, Z., Xu, Y., Li, K., & Liu, L. (2023) · BMC Public Health · doi:10.1186/s12889-023-17250-x · Cited by 28
“These numerous advantages highlight the high feasibility of using flavonoids for COPD prevention [24].”
Background
Antioxidant, Hepatoprotective, and Ameliorative Effects of Methanolic Extract of Leaves of Grewia mollis Juss. on Carbon Tetrachloride–Treated Albino Rats
Asuku, O., Atawodi, S. E.-O., & Onyike, E. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0285 · Cited by 28
Comparative Studies of the Phytochemical, Antioxidant and Antimicrobial Properties of Cashew Leaf, Bark and Fruits Extracts
Onuh, J. O., Idoko, G., Yusufu, P., & Onuh, F. (2017) · American Journal of Food and Nutrition · doi:10.12691/ajfn-5-4-1 · Cited by 28
“Consumption of foods rich in polyphenols have been reported to offer protection against cardiovascular diseases, cancers, and osteoporosis, neurodegenerative diseases and diabetes mellitus [31,32].”
Background
Evaluation of Yield, Processing Quality, and Nutritional Quality in Different‐Colored Wheat Grains under Nitrogen and Phosphorus Fertilizer Application
Ma, D., Zhang, J., Hou, J., Li, Y., Huang, X., Wang, C., Lü, H., Zhu, Y., & Guo, T. (2017) · Crop Science · doi:10.2135/cropsci2017.03.0152 · Cited by 28
Enrichment of Bread with Olive Oil Industrial By-Product
Cedola, A., Cardinali, A., Nobile, M. A. D., & Conte, A. (2019) · Journal of Agricultural Science and Technology B · doi:10.17265/2161-6264/2019.02.005 · Cited by 28
“At the epidemiological level, plant polyphenols have been suggested to reduce the risk of cardiovascular diseases, neurodegenerative disorders, cancer and diabetes [4].”
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Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota
Gomes, A., Oudot, C., Macià, A., Foito, A., Carregosa, D., Stewart, D., de Wiele, T. V., Berry, D., Motilva, M., Brenner, C., et al. (2019) · Nutrients · doi:10.3390/nu11112634 · Cited by 29
“Several epidemiological studies have suggested an association between (poly)phenol-enriched diets (fruits and vegetables) and a lower risk of CVDs [9].”
BackgroundInfluential
Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols
Bankole, V. O., Osungunna, M. O., Souza, C. R. F., Salvador, S. L. D. S., & OLIVEIRA, W. P. D. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01668-2 · Cited by 28
Strategies for the discovery of anti-aging compounds
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Effect of Germination and UV‐C Radiation on the Accumulation of Flavonoids and Saponins in Black Bean Seed Coats
Guajardo‐Flores, D., Guerrero, D. A. S., Serna-Saldivar, S. O., & Jacobo‐Velázquez, D. A. (2013) · Cereal Chemistry · doi:10.1094/cchem-08-13-0172-r · Cited by 28
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Genistein Inhibits Rat Aortic Smooth Muscle Cell Proliferation Through the Induction of p27kip1
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The Anti-angiogenic Effect of Chlorogenic Acid on Choroidal Neovascularization
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Authors: Arts, I. C., & Hollman, P. C.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Arts, Ilja CW
ORCID: Arts, Ilja CW
Hollman, Peter CH
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-01
Volume: 81
Issue: 1
Pages: 317S-325S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/81.1.317s
OpenAlex: W2129133439
Cited by: 1,916
References: 74
Citations by year: 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
FWCI: 6.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6628 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: ZonMw
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
MeSH terms: Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols

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Polyphenols and disease risk in epidemiologic studies

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