Cited by 1,916Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 72 of the 74 references it cites were found in a registry or an index.

Polyphenols and disease risk in epidemiologic studies

Open access

Arts, Ilja CW, Hollman, Peter CH·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/81.1.317s

Open this paper in CoChat — free account Open PDF

Abstract

Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/ajcn/81.1.317s

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
Flavonoids: a review of probable mechanisms of action and potential applications.
Nijveldt, R., van Nood, E., van Hoorn, D. V., Boelens, P., van Norren, K., & van Leeuwen, P. V. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,232
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Phyto-oestrogens and Western Diseases
Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282
Flavonoid intake and coronary mortality in Finland: a cohort study
Knekt, P., Jarvinen, R., Reunanen, A., & Maatela, J. (1996) · BMJ · doi:10.1136/bmj.312.7029.478 · Cited by 1,268
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke: The Zutphen Study
Keli, S., Hertog, M. G., Feskens, E., & Kromhout, D. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060059007 · Cited by 914
Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
Hertog, M. G. L., Hollman, P. C. H., & van de Putte, B. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00032a015 · Cited by 899

Show all 74 references

Sorted by citations

Items 601–700 of 1,001

Diversity of Antioxidant Content and Its Relationship to Grain Color and Morphological Characteristics in Winter Wheat Grains
Ma, D., Sun, D., Yi, Z. U. O., Wang, C., Zhu, Y., & Guo, T. (2014) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(13)60573-0 · Cited by 54
Phenolic compounds in berries and flowers of a natural hybrid between bilberry and lingonberry (Vaccinium×intermedium Ruthe)
Primetta, A. K., Riihinen, K., & Jaakola, L. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.02.015 · Cited by 54
Cocoa Polyphenols: Can We Consider Cocoa and Chocolate as Potential Functional Food?
Ačkar, Đ., Lendić, K. V., Valek, M., Šubarić, D., Miličević, B., Babić, J., & Nedić, I. (2013) · Journal of Chemistry · doi:10.1155/2013/289392 · Cited by 58
Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats
Sanches, J. R., França, L. M., Chagas, V. T., Gaspar, R. S., dos Santos, K. A., Gonçalves, L. M., Sloboda, D. M., Holloway, A. C., Dutra, R. P., Carneiro, E. M., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00048 · Cited by 56
“Flavonoids and polyphenolic-related compounds, abundant in fruits, and vegetables are used for dietary and medicinal purposes, and increasing evidence supports the beneficial effects of such compounds on gluco-lipid homeostasis and the prevention of metabolic diseases (Arts and Hollman, 2005).”
Background
Valorization of Olive Mill Wastewater by Membrane Processes to Recover Natural Antioxidant Compounds for Cosmeceutical and Nutraceutical Applications or Functional Foods
Alfano, A., Corsuto, L., Finamore, R., Savarese, M. F., Ferrara, F., Falco, S., Santabarbara, G., ROSA, M. D., & Schiraldi, C. (2018) · Antioxidants · doi:10.3390/antiox7060072 · Cited by 54
“In addition, the long-term consumption of diets rich in plant polyphenols offers some protection against the development of cancers, cardiovascular diseases, diabetes, osteoporosis, and neurodegenerative diseases [3,4].”
Background
Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion
Andrade, J. M. D. M., & Fasolo, D. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00020-7 · Cited by 60
Protocatechuic acid from chicory is bioavailable and undergoes partial glucuronidation and sulfation in healthy humans
Zheng, J., Xiong, H., Li, Q., He, L., Weng, H., Ling, W., & Wang, D. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1168 · Cited by 53
“Regular consumption of polyphenols has been associated with a reduced risk of a number of chronic diseases including cancer and atherosclerotic diseases (Arts & Hollman, 2005; Fraga, Croft, Kennedy, & Tomas‐Barberan, 2019; Gonzalez et al., 2018).”
Background
Sustainable Single-Stage Solid–Liquid Extraction of Hesperidin and Rutin from Agro-Products Using Cyrene
Milescu, R. A., Segatto, M. L., Stahl, A. M., McElroy, C. R., Farmer, T. J., Clark, J. H., & Zuin, V. G. (2020) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c06751 · Cited by 53
Bioactive components in Bambara groundnut (Vigna subterraenea (L.) Verdc) as a potential source of nutraceutical ingredients
Okafor, J. N. C., Jideani, V. A., Meyer, M., & Roes‐Hill, M. L. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09024 · Cited by 53
Structure-Functional Study of Tyrosine and Methionine Dipeptides: An Approach to Antioxidant Activity Prediction
Torkova, A. A., Королева, О. В., Khrameeva, E. E., Федорова, Т. В., & Tsentalovich, M. Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025353 · Cited by 53
Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil
Morrison, M. C., Mulder, P., Stavro, P. M., Suárez, M., Arola‐Arnal, A., van Duyvenvoorde, W., Kooistra, T., Wielinga, P. Y., & Kleemann, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139196 · Cited by 54
“Polyphenols are widely recognised for their anti-inflammatory effects [48–50], and have frequently been reported to be protective against the development of NAFLD and cardiovascular disease, both in epidemiological and experimental studies [51, 52].”
Background
Uric Acid but Not Apple Polyphenols Is Responsible for the Rise of Plasma Antioxidant Activity after Apple Juice Consumption in Healthy Subjects
Godycki-Ćwirko, M., Król, M., Król, B., Zwolińska, A., Kołodziejczyk, K., Kasielski, M., Padula, G., Grębocki, J., Kazimierska, P., Miatkowski, M., et al. (2010) · Journal of the American College of Nutrition · doi:10.1080/07315724.2010.10719857 · Cited by 53
“Numerous epidemiological studies indicate that diets rich in fresh fruits and vegetables may decrease the risk of cardiovascular disease and variety of different cancers [1–4].”
Background
Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease
Tse, H. N., & Tseng, C. Z. S. (2014) · International Journal of COPD · doi:10.2147/copd.s51057 · Cited by 53
“Polyphenols, another dietary supplement, were also demonstrated to be beneficial in patients with COPD.(53) In an epidemiological study, polyphenols such as catechin (eg, green tea, epigallocatechin gallate), flavonol, and flavone were positively associated with FEV 1 and inversely associated with COPD symptoms, sugge…”
Background
Procyanidins Improve some Disrupted Glucose Homoeostatic Situations: An Analysis of Doses and Treatments According to Different Animal Models
Pinent, M., Cedó, L., Montagut, G., Blay, M., & Ardèvol, A. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.501533 · Cited by 53
“Arts and Hollman (2005) estimated that the mean intake of flavan-3-ol monomers in the Netherlands was 50 ± 56 mg/day, although the intake of oligomeric forms was not analyzed in that study.”
Background
A food pattern that is predictive of flavonol intake and risk of pancreatic cancer
Nöthlings, U., Murphy, S. P., Wilkens, L. R., Boeing, H., Schulze, M. B., Bueno-de-Mesquita, H. B., Michaud, D. S., Roddam, A., Rohrmann, S., Tjønneland, A. M., et al. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26398 · Cited by 55
“Evidence of a reduced risk of cancer from epidemiologic studies with increasing consumption of these plant constituents is scarce (5), with our recent study (1) being 1 of 2 prospective investigations examining associations between dietary intake of 3 specific flavonols— quercetin, kaempferol, and myricetin—and pancre…”
Antidiabetic effects of Mangifera indica Kernel Flour‐supplemented diet in streptozotocin‐induced type 2 diabetes in rats
Irondi, E. A., Oboh, G., & Akindahunsi, A. A. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.348 · Cited by 53
Apigenin affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line
Bruno, A., Siena, L., Gerbino, S., Ferraro, M., Chanez, P., Giammanco, M., Gjomarkaj, M., & Pace, E. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.03.034 · Cited by 53
Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2013
Maraldi, T., Vauzour, D., & Angeloni, C. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/576363 · Cited by 55
Differential Neuroprotective Activity of Two Different Grape Seed Extracts
Narita, K., Hisamoto, M., Okuda, T., & Takeda, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014575 · Cited by 56
“Epidemiological studies suggest that increased consumption of vegetables and fruits has beneficial effects on human health, for which the natural polyphenols have been considered as the major responsible elements [1].”
Background
Supercritical fluid extraction with a modifier of antioxidant compounds from jabuticaba (Myrciaria cauliflora) byproducts: economic viability
Cavalcanti, R. N., Veggi, P. C., & Meireles, M. A. A. (2011) · Procedia Food Science · doi:10.1016/j.profoo.2011.09.247 · Cited by 52
“It has been suggested that diets high in fruits and vegetables are linked to a reduced incidence of heart disease, cancer and some neurodegenerative disorders [1-4].”
Background
Role of red grape polyphenols as antidiabetic agents
Pandey, K. B., & Rizvi, S. I. (2014) · Integrative Medicine Research · doi:10.1016/j.imr.2014.06.001 · Cited by 54
Potential medicinal benefits of Cosmos caudatus (Ulam Raja): A scoping review
Yusof, B. N. M., Cheng, S.-H., Anthony, J., & Ismail, A. (2015) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.172796 · Cited by 57
“[6] Polyphenol-rich foods are potent anti-oxidants,[34] which protect cells against oxidative stress and reduce the risk of chronic disease.[35] The anti-oxidant properties of C.”
Background
Inhibition of Breast Cancer Resistance Protein and Multidrug Resistance Associated Protein 2 by Natural Compounds and Their Derivatives
Sjöstedt, N., Holvikari, K., Tammela, P., & Kidron, H. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00754 · Cited by 53
Phenolic constituents and modulatory effects of Raffia palm leaf ( Raphia hookeri ) extract on carbohydrate hydrolyzing enzymes linked to type-2 diabetes
Dada, F. A., Oyeleye, S. I., Ogunsuyi, O. B., Olasehinde, T. A., Adefegha, S. A., Oboh, G., & Boligon, A. A. (2017) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2017.01.003 · Cited by 52
3-O-Glucosylation of quercetin enhances inhibitory effects on the adipocyte differentiation and lipogenesis
Lee, C. W., Seo, J. Y., Lee, J., Choi, J. W., Cho, S., Bae, J. Y., Sohng, J. K., Kim, S. O., Kim, J., & Park, Y. I. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.002 · Cited by 53
Improving Fenton-like system with Catechin, an environmental-friendly polyphenol: Effects and mechanism
Fang, Z., Zhao, J., Li, Y., Wang, Y., Qiu, T., Wu, Y., Dong, W., & Mailhot, G. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127946 · Cited by 51
Dual association between polyphenol intake and breast cancer risk according to alcohol consumption level: a prospective cohort study
Touvier, M., Druesne‐Pecollo, N., Kesse‐Guyot, E., Andreeva, V. A., Fezeu, L., Galan, P., Herçberg, S., & Latino‐Martel, P. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2323-y · Cited by 51
“These studies were reviewed in 2005 [3, 5], showing no evidence of an association of flavonoid intake with breast cancer risk; lignans, however, were associated with decreased breast cancer risk in several case–control, but not in prospective studies.”
BackgroundResultInfluential
Green Tea Consumption and the Risk of Pancreatic Cancer in Japanese Adults
Lin, Y., Kikuchi, S., Tamakoshi, A., Yagyu, K., Obata, Y., Kurosawa, M., Inaba, Y., Kawamura, T., Motohashi, Y., & Ishibashi, T. (2008) · Pancreas · doi:10.1097/mpa.0b013e318160a5e2 · Cited by 51
“13 In contrast to animal and cell studies, epidemiologic studies have shown mixed results regarding an association between green tea and cancer risk.(14) Among digestive tract cancers, an inverse association has been observed for gastric, gallbladder, and pancreatic cancer in several case-control studies, whereas seve…”
Result
Encapsulation of betacyanins and polyphenols extracted from leaves and stems of beetroot in Ca(II)-alginate beads: A structural study
Aguirre‐Calvo, T. R., Perullini, M., & Santagapita, P. R. (2018) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2018.04.015 · Cited by 52
Comprehensive evaluation of effective polyphenols in apple leaves and their combinatory antioxidant and neuroprotective activities
Lu, Y., Du, Y., Qin, X., Wu, H., Huang, Y., Cheng, Y., & Wei, Y. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.12.013 · Cited by 51
Acute Effects of Hibiscus sabdariffa Calyces on Postprandial Blood Pressure, Vascular Function, Blood Lipids, Biomarkers of Insulin Resistance and Inflammation in Humans
Abubakar, S. M., Ukeyima, M. T., Spencer, J. P. E., & Lovegrove, J. A. (2019) · Nutrients · doi:10.3390/nu11020341 · Cited by 55
The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols
Man, A. W. C., Xia, N., Daiber, A., & Li, H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14850 · Cited by 52
“…end of the 20th century, a large number of clinical trials and epigenetics studies have strongly correlated the long‐term consumption of a polyphenol‐rich diet with protection against chronic diseases such as cancers and CVDs (Arts & Hollman, 2005; Mitjavila & Moreno, 2012; Pounis et al., 2018).”
BackgroundInfluential
Characterization of piñon seed (Araucaria araucana (Mol) K. Koch) and the isolated starch from the seed
Henríquez, C., Escobar, B., Figuerola, F., Italo Chiffelle, G., Speisky, H., & Estévez, A. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.08.040 · Cited by 49
“…therefore different studies have suggested that they play a preventive role in the development of various degenerative diseases, such as cardiovascular disease, various types of cancer and neurological diseases (Arts & Hollman, 2005; Kaur & Kapoor, 2001; Scalbert, Manach, Morand, & Rémésy, 2005).”
Background
Diet and endothelial function
Landberg, R., Naidoo, N., & van Dam, R. M. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328351123a · Cited by 50
“In the Zutphen Elderly Study, an intake of subclasses of flavonoids was associated with a lower risk of coronary heart disease [34] and these results have been supported by some, but not all subsequent studies [35].”
Result
From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport
Dávalos, A., & Fernandez-Hernando, C. F. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.02.005 · Cited by 52
Quercetin decreases high-fat diet induced body weight gain and accumulation of hepatic and circulating lipids in mice
den Hil, E. F. H.-V., van Schothorst, E. M., van der Stelt, I., Swarts, H. J. M., Venema, D. P., Sailer, M., Vervoort, J. J. M., Hollman, P. C. H., Rietjens, I. M. C. M., & Keijer, J. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0418-2 · Cited by 50
“Moreover, epidemiological studies have shown that the intake of the flavonoid quercetin is associated with a reduction of CVD risk (Arts and Hollman 2005; Hertog et al. 1993; Hollman et al. 2010).”
Background
Oxidative stress and cardiovascular health: therapeutic potential of polyphenols
Khurana, S., Piché, M., Hollingsworth, A., Venkataraman, K., & Tai, T. C. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0252 · Cited by 51
“Numerous epidemiological studies assessing the relationship between nutrition and disease states have demonstrated positive outcomes in cardiovascular health to be linked with diets rich in polyphenols (Arts and Hollman 2005).”
Background
Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract
Bock, C., Waldmann, K.-H., & Ternes, W. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.08.001 · Cited by 50
“Studies support the hypothesis that regular consumption of flavonoid-containing foods can reduce the risk of cardiovascular disease [1,2] and improve endothelial function, as well as reducing blood pressure in humans [3].”
Background
Antioxidant activity guided separation of major polyphenols of marjoram (Origanum majorana L.) using flash chromatography and their identification by liquid chromatography coupled with electrospray ionization tandem mass spectrometry†
Hossain, M. B., Camphuis, G., Aguiló‐Aguayo, I., Gangopadhyay, N., & Rai, D. K. (2014) · Journal of Separation Science · doi:10.1002/jssc.201400597 · Cited by 50
Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans
Perche, O., Vergnaud, J., Morand, C., Dubray, C., Mazur, A., & Vasson, M. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.03.012 · Cited by 50
Characterization and evaluation of a macroporous adsorbent for possible use in the expanded bed adsorption of flavonoids from Ginkgo biloba L.
Li, J., & Chase, H. A. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.02.092 · Cited by 50
Histone Deacetylase Inhibition Activity and Molecular Docking of (E )‐Resveratrol: Its Therapeutic Potential in Spinal Muscular Atrophy
Erden, D. D., Bora, G., Ayhan, P., Kocaefe, Ç., Dalkara, S., Yelekçi, K., DEMİR, A. S., & Erdem‐Yurter, H. (2009) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2009.00781.x · Cited by 50
“They are famous for their antioxidant properties and health benefits (26).”
Background
The Cardioprotective Effect of Protocatechuic Acid on Myocardial Ischemia/Reperfusion Injury
Tang, X., Liu, J., Dong, W., Li, P., Li, L., Lin, C.-R., Zheng, Y., Cong, W., & Hou, J.-C. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13247fp · Cited by 50
The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells.
Giuliani, C., Noguchi, Y., Harii, N., Napolitano, G., Tatone, D., Bucci, I., Piantelli, M., Monaco, F., & Kohn, L. (2008) · Endocrinology · doi:10.1210/en.2007-0618 · Cited by 52
Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats
Galindo, P., González‐Manzano, S., Zarzuelo-Romero, M. J., Gómez‐Guzmán, M., Quintela, A. M., Paramás, A. M. G., Santos‐Buelga, C., Pérez‐Vizcaíno, F., Duarte, J., & Jiménez, R. (2012) · Food & Function · doi:10.1039/c2fo10268d · Cited by 50
Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis
Aliomrani, M., Sepand, M., Mirzaei, H., Kazemi, A., Nekonam, S., & Sabzevari, O. (2016) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-016-0154-9 · Cited by 52
“Beside antioxidant activity, certain polyphenols possess a potent anticarcinogenic activity through enzyme modulation, upregulation of gap junction communication, gene expression, apoptosis and P-glycoprotein activation in cell culture and animal models [51–53].”
Background
Phenolic Composition, Antioxidant Capacity and in vitro Cytotoxicity Assessment of Fruit Wines
Ljevar, A., Ćurko, N., Tomašević, M., Radošević, K., Srček, V. G., & Ganić, K. K. (2015) · Food Technology and Biotechnology · doi:10.17113/ftb.54.02.16.4208 · Cited by 51
“against the development of several chronic diseases such as cardiovascular, cancer, diabetes, osteoporosis and neurodegenerative diseases (5,6).”
Background
POLYPHENOLS AND HUMAN HEALTH- A REVIEW
Wani, S. M. (2013) · Cited by 50
Natural antioxidant ice cream acutely reduces oxidative stress and improves vascular function and physical performance in healthy individuals
Sanguigni, V., Manco, M., Sorge, R. P., Gnessi, L., & Francomano, D. (2016) · Nutrition · doi:10.1016/j.nut.2016.07.008 · Cited by 53
Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases
Rahim, R. A., Jayusman, P. A., Muhammad, N., Ahmad, F., Mokhtar, N. M., Mohamed, I. N., Mohamed, N., & Shuid, A. N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16244962 · Cited by 49
“development of various diseases, including cancers, cardiovascular diseases, diabetes, osteoporosis, and neurodegenerative diseases [3].”
Background
Flavonoids and gastrointestinal health: single molecule for multiple roles
Lan, H., Wang, H., Chen, C., Hu, W., Ai, C., Chen, L., & Teng, H. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2230501 · Cited by 48
“…contains polyphenols, which need to withstand food processing, released from the food matrix after ingestion, and can be bioaccessible in the gastrointestinal tract, playing a role in promoting health, preventing disease and improving performance (Arts and Hollman 2005; Kussmann et al. 2007).”
Evolution of major phenolic components and radical scavenging activity of grape juices through concentration process and storage
Gollücke, A. P. B., Catharino, R. R., de Souza, J. C., Eberlin, M. N., & Tavares, D. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.06.060 · Cited by 49
Inhibition of Vascular Smooth Muscle Cell Proliferation by Gentiana lutea Root Extracts
Kesavan, R., Potunuru, U. R., Nastasijević, B. J., Avaneesh, T., Joksiċ, G., & Dixit, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061393 · Cited by 49
“proliferative diseases such as cancer and atherosclerosis [25].”
Background
Effect ofMoringa oleiferaLam. Seed Extract on Toluene Diisocyanate-Induced Immune-Mediated Inflammatory Responses in Rats
Mahajan, S. G., Mali, R. G., & Mehta, A. A. (2007) · Journal of Immunotoxicology · doi:10.1080/15476910701337472 · Cited by 52
“A beneficial link between polyphenol intake and lower disease risk is likely, with many of the clinical benefits being attributed to both their antioxidant and anti-inflammatory properties (Arts and Hollman, 2005).”
Background
Development of a novel microextraction by packed sorbent-based approach followed by ultrahigh pressure liquid chromatography as a powerful technique for quantification phenolic constituents of biological interest in wines
Gonçalves, J. L., Mendes, B., Silva, C. L., & Câmara, J. S. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.01.023 · Cited by 49
Stimulation of Postprandial Fat Utilization in Healthy Humans by Daily Consumption of Chlorogenic Acids
Soga, S., Ota, N., & Shimotoyodome, A. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130147 · Cited by 49
Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities
Wang, S. W. J., Kulkarni, K. H., Tang, L. Y., Wang, J. R., Yin, T., Daidoji, T., Yokota, H., & Hu, M. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.147371 · Cited by 49
In vitro antioxidant and cholinesterase inhibitory activities of methanolic fruit extract of Phyllanthus acidus
Moniruzzaman, M., Asaduzzaman, M., Hossain, M. S., Sarker, J., Rahman, S. M. A., Rashid, M., & Rahman, M. M. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0930-y · Cited by 53
“Total antioxidant capacity of methanol and water extracts of Phyllanthus niruri and Phyllanthus urinaria leaves were performed in a previous study showing that MEPA has less activity than two extracts of these plants [52].”
Background
Urinary excretion rate and bioavailability of chlorogenic acid, caffeic acid, p-coumaric acid, and ferulic acid in non-fasted rats maintained under physiological conditions
Kishida, K., & Matsumoto, H. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02708 · Cited by 49
“Epidemiological studies have suggested that dietary phenolic compounds from plant products contribute to the prevention of degenerative diseases such as cardiovascular disease and cancer [1, 2, 3].”
Background
Analysis of prominent flavonoid aglycones by high-performance liquid chromatography using a monolithic type column
Repollés, C., Herrero‐Martínez, J. M., & Ràfols, C. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.07.012 · Cited by 49
Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats
Choi, J. H., Hwang, Y. P., Choi, C. Y., Chung, Y., & Jeong, H. G. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.08.009 · Cited by 49
Bioactive Compounds in small Fruits and their Influence on Human Health
Badjakov, I. K., Nikolova, M. T., Gevrenova, R., Kondakova, V., Todorovska, E., & Atanassov, A. I. (2008) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2008.10817517 · Cited by 52
The influence of TDZ concentrations on in vitro growth and production of secondary metabolites by the shoot and callus culture of Lallemantia iberica
Pourebad, N., Motafakkerazad, R., Kosari‐Nasab, M., Akhtar, N. F., & Movafeghi, A. (2015) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-015-0769-4 · Cited by 48
Hydroxycinnamic acids loaded in lipid-core nanocapsules
Granata, G., Consoli, G. M. L., Nigro, R. L., & Geraci, C. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.10.106 · Cited by 48
Protective activity of caffeic acid and sinapic acid against UVB-induced photoaging in human fibroblasts
Jeon, J., Sung, J., Lee, H., Kim, Y., Jeong, H. S., & Lee, J. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12701 · Cited by 49
Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits
Frederiksen, H. W., Mortensen, A., Schrøder, M., Frandsen, H. L., Bysted, A., Knuthsen, P., & Rasmussen, S. E. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700009 · Cited by 48
Effect of Processing of Black Currant Press-Residue on Polyphenol Composition and Cell Proliferation
Holtung, L., Grimmer, S., & Aaby, K. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf104427r · Cited by 48
Proanthocyanidin: Chemistry and Biology: From Phenolic Compounds to Proanthocyanidins
Zuiter, A. S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.11046-7 · Cited by 52
Management of diabetic complications through fruit flavonoids as a natural remedy
Tanveer, A., Akram, K., Farooq, U., Hayat, Z., & Shafi, A. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.1000482 · Cited by 48
“Epidemiological studies and meta-analyses described the use of fruits rich in flavonoids decreases diabetes (Arts and Hollman, 2005; Graf et al., 2005).”
Background
EuroFIR eBASIS: application for health claims submissions and evaluations
Kiely, M. E., Black, L. J., Plumb, J. A., Kroon, P. A., Hollman, P. C. H., Larsen, J. C., Speijers, G. J. A., Kapsokefalou, M., Sheehan, D., Gry, J., et al. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.219 · Cited by 47
“In animal models and in vitro systems, polyphenols, for instance, not only trap and scavenge free radicals but they also regulate nitric oxide, induce apoptosis, inhibit cell proliferation and angiogenesis and exhibit phytoestrogenic activity (Arts and Hollman, 2005).”
Background
Flavonoids and laryngeal cancer risk in Italy
Garavello, W., Rossi, M., McLaughlin, J. K., Bosetti, C., Negri, E., Λάγιου, Π., Talamini, R., Franceschi, S., Parpinel, M. T., Maso, L. D., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm078 · Cited by 47
“In fact, flavonoids have been inversely associated with risk of several cancers [11, 12], including those of the lung, digestive tract and breast [13–16].”
Background
Phenolic Acids
Chandrasekara, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22395-0 · Cited by 47
Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review
Clemente‐Suárez, V. J., Redondo-Flórez, L., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025) · Nutrients · doi:10.3390/nu17050884 · Cited by 52
“Polyphenols are a diverse group of phytochemicals found in high concentrations in fruits, vegetables, tea, coffee, and wine [81].”
Detection and degradation of phenolic compounds based on metal-organic complexes
Chai, T.-Q., Chen, G.-Y., Luo, M.-L., Zhu, H., Li, T., Li, J.-X., Xu, L., Dai, J.-J., Li, L., & Yang, F. Q. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216721 · Cited by 47
Utilisation Potential of Feijoa Fruit Wastes as Ingredients for Functional Foods
Sun‐Waterhouse, D., Wang, W., Waterhouse, G. I. N., & Wadhwa, S. S. (2012) · Food and Bioprocess Technology · doi:10.1007/s11947-012-0978-3 · Cited by 46
“Accordingly, fruit-derived materials represent a logical source of functional food ingredients (Bravo 1998; Starling 2004; Arts and Hollman 2005; Slavin and Green 2007; Scott et al. 2008; Lauren et al. 2009).”
Background
Comparing the metabolism of quercetin in rats, mice and gerbils
Yeh, S.-L., Lin, Y., Lin, Y., Li, C., & Chuang, C. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0862-9 · Cited by 46
“Epidemiologic studies show that high quercetin intakes are associated with a lower risk of heart disease, stroke [1, 2], and several types of cancers including lung, breast and prostate [3, 4].”
Background
Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines
Actis‐Goretta, L., Romanczyk, L. J., Rodriguez, C. A., Kwik-Uribe, C. L., & Keen, C. L. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.10.004 · Cited by 46
“diets rich in flavonoids, as well as flavanols, is associated with a reduced risk for a number of chronic diseases, including cancer [10–13].”
Background
Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo
Shu, G., Lu, N., Zhu, X., Xu, Y., Min-qing, D. U., Xie, Q., Zhu, C., Xu, Q., Wang, S., Wang, L., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.07.007 · Cited by 46
“Phloretin, enriched in apples [11], strawberries [12] and other fruits, was shown to reduce risk of major chronic diseases [13].”
Background
Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat
Akhtar, M., Maikiyo, A., Najmi, A. K., Khanam, R., Mujeeb, M., & Aqil, M. (2013) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.111825 · Cited by 46
“[37,38] The present study observed a significant decrease in GSH levels ( P 0.001) in MCA occluded rats as compared to pretreated groups.”
Influential
Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936
Corley, J., Kyle, J. A. M., Starr, J. M., McNeill, G., & Deary, I. J. (2015) · British Journal Of Nutrition · doi:10.1017/s000711451500210x · Cited by 51
Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents
Penczynski, K. J., Krupp, D., Bring, A., Bolzenius, K., Remer, T., & Buyken, A. E. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1121-9 · Cited by 46
Nitrogen, phosphorus, and potassium effects on the physiology and biomass yield of baby spinach (Spinacia oleracea L.)
Nemadodzi, L. E., Araya, H., Nkomo, M., Ngezimana, W., & Mudau, F. N. (2017) · Journal of Plant Nutrition · doi:10.1080/01904167.2017.1346121 · Cited by 46
Investigations on Antioxidant Potential of Phenolic Acids and Flavonoids: The Common Phytochemical Ingredients in Plants
Singh, D. P., Verma, S., & Prabha, R. (2018) · Journal of Plant Biochemistry & Physiology · doi:10.4172/2329-9029.1000219 · Cited by 46
Review: Natural products from Genus Selaginella (Selaginellaceae)
SETYAWAN, A. D. (2014) · Nusantara Bioscience · doi:10.13057/nusbiosci/n030107 · Cited by 46
Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization
Clemente‐Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025) · Bioengineering · doi:10.3390/bioengineering12020208 · Cited by 49
Protective role of quercetin against cisplatin-induced hair cell damage in zebrafish embryos
Lee, S., Oh, K., Chung, A., Park, H.-C., Lee, S., Kwon, S., & Choi, J. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327114567766 · Cited by 45
EFFECT OF DIETARY SUPPLEMENTATION WITH NIGELLA SATIVA L. ON SERUM LIPID PROFILE, LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE SYSTEM IN HYPERLIPIDEMIC RABBITS
Gargari, B. P., Attari, V. E., Rafraf, M., & Gorbani, A. (2009) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000474 · Cited by 45
Comparison of plasma and intake levels of antioxidant nutrients in patients with chronic obstructive pulmonary disease and healthy people in Taiwan: a case-control study.
Lin, Y., Wu, T., Chen, P., Hsieh, L.-Y., & Yeh, S.-L. (2010) · PubMed · Cited by 45
Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice
Lauro, F., Giancotti, L. A., Ilari, S., Dagostino, C., Gliozzi, M., Morabito, C., Malafoglia, V., Raffaeli, W., Muraca, M., Goffredo, B. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156039 · Cited by 45
“Their bioactivity has been associated to their antioxidant properties that are involved in the onset development of many of the chronic degenerative diseases such as cancer and inflammation [29, 30].”
Background
Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner
Pellegrini, G., Morales, C. C., Wallace, T. C., Plotkin, L. I., & Bellido, T. (2016) · Nutrients · doi:10.3390/nu8070423 · Cited by 45
“Increasing evidence, including epidemiological, clinical, and animal experimentation, suggests that consumption of plant foods, containing polyphenols helps to protect against the development of oxidative stress pathologies, including cancer, cardiovascular diseases, diabetes, neurodegenerative diseases, and osteoporo…”
Background
Interaction between olanzapine and human serum albumin and effect of metal ions, caffeine and flavonoids on the binding: A spectroscopic study
Mrkalić, E., Jelić, R., Stojanović, S., & Sovrlić, M. (2020) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2020.119295 · Cited by 45
Using Phytochemicals to Enhance Health Benefits of Milk: Impact of Polyphenols on Flavor Profile
Axten, L. G., Wohlers, M. W., & Wegrzyn, T. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00808.x · Cited by 45
Cost Effective Natural Antioxidants
Prakash, D., & Kumar, N. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-308-4_12 · Cited by 45
Cytometric Analysis of Cytotoxicity of Polyphenols and Related Phenolics to Rat Thymocytes: Potent Cytotoxicity of Resveratrol to Normal Cells
Fujimoto, A., Sakanashi, Y., Matsui, H., Oyama, T. B., Nishimura, Y. H., Masuda, T., & Oyama, Y. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00386.x · Cited by 44
Absorption and Bioavailability of Antioxidant Phytochemicals and Increase of Serum Oxidation Resistance in Healthy Subjects Following Supplementation with Raisins
Kanellos, P. T., Kaliora, A. C., Gioxari, A., Christopoulou, G. O., Kalogeropoulos, N., & Karathanos, V. Τ. (2013) · Plant Foods for Human Nutrition · doi:10.1007/s11130-013-0389-2 · Cited by 44
“dence of non-communicable diseases [1], especially the phenolic compounds contained in fresh fruits and vegetables [2].”
Background
Acute treatment with polyphenol quercetin improves postischemic recovery of isolated perfused rat hearts after global ischemia
Barteková, M., Čarnická, S., Pancza, D., Ondrejčáková, M., Breier, A., & Ravíngerová, T. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y10-025 · Cited by 44
“Quercetin (3,5,7,3’,4’-pentahydroxyflavone) is an important member of the flavonoid family with proposed beneficial effects on the cardiovascular system (Duarte et al. 2001; Brookes et al. 2002; Arts and Hollman 2005; Edwards et al. 2007).”
Background
Dietary intake of polyphenols and major food sources in an institutionalised elderly population
González, S., Fernández, M., Cuervo, A. M., & Lasheras, C. (2013) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12058 · Cited by 44
Effect of genetic variation on phenolic acid and policosanol contents of Pegaso wheat lines
Irmak, S., Jonnala, R. S., & MacRitchie, F. (2007) · Journal of Cereal Science · doi:10.1016/j.jcs.2007.07.007 · Cited by 44
Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial
Soriano‐Maldonado, A., Hidalgo, M., Arteaga, P., de Pascual‐Teresa, S., & Nova, E. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0670-7 · Cited by 45
“Several epidemiological studies have shown that fruit and vegetable-rich diets may decrease the risk 2 of chronic diseases, such as cardiovascular diseases [1,2], metabolic syndrome [3-5], diabetes [6] 3 and different types of cancer [7-9].”
Recombinant expression and functional characterisation of regiospecific flavonoid glucosyltransferases from Hieracium pilosella L.
Witte, S., Moco, S., Vervoort, J. J. M., Matern, U., & Martens, S. (2009) · Planta · doi:10.1007/s00425-009-0902-x · Cited by 44

Authors: Arts, I. C., & Hollman, P. C.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Arts, Ilja CW
ORCID: Arts, Ilja CW
Hollman, Peter CH
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-01
Volume: 81
Issue: 1
Pages: 317S-325S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/81.1.317s
OpenAlex: W2129133439
Cited by: 1,916
References: 74
Citations by year: 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
FWCI: 6.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6628 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: ZonMw
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
MeSH terms: Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polyphenols and disease risk in epidemiologic studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks