Cited by 1,916Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 72 of the 74 references it cites were found in a registry or an index.

Polyphenols and disease risk in epidemiologic studies

Open access

Arts, Ilja CW, Hollman, Peter CH·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/81.1.317s

Open this paper in CoChat — free account Open PDF

Abstract

Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/ajcn/81.1.317s

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
Flavonoids: a review of probable mechanisms of action and potential applications.
Nijveldt, R., van Nood, E., van Hoorn, D. V., Boelens, P., van Norren, K., & van Leeuwen, P. V. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,232
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Phyto-oestrogens and Western Diseases
Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282
Flavonoid intake and coronary mortality in Finland: a cohort study
Knekt, P., Jarvinen, R., Reunanen, A., & Maatela, J. (1996) · BMJ · doi:10.1136/bmj.312.7029.478 · Cited by 1,268
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke: The Zutphen Study
Keli, S., Hertog, M. G., Feskens, E., & Kromhout, D. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060059007 · Cited by 914
Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
Hertog, M. G. L., Hollman, P. C. H., & van de Putte, B. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00032a015 · Cited by 899

Show all 74 references

Sorted by citations

Items 101–200 of 1,001

The development of fruit‐based functional foods targeting the health and wellness market: a review
Sun-Waterhouse, D. (2011) · International Journal of Food Science & Technology · doi:10.1111/j.1365-2621.2010.02499.x · Cited by 264
Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women
Wang, L., Lee, I.-M. M., Zhang, S. M., Blumberg, J. B., Buring, J. E., & Sesso, H. D. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26913 · Cited by 285
Phenolic Compounds from Blueberries Can Inhibit Colon Cancer Cell Proliferation and Induce Apoptosis
Yi, W., Fischer, J. G., Krewer, G. W., & Akoh, C. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051333o · Cited by 280
Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (−)-epigallocatechin gallate
Dube, A., Nicolazzo, J. A., & Larson, I. C. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.06.010 · Cited by 279
Effect of Cocoa and Tea Intake on Blood Pressure
Taubert, D. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.7.626 · Cited by 282
“7 (20-73), 15 dropouts (intention-totreat analysis) 10, Tea Packers Association, London, England Black tea (minimum of 6 cups/d) vs placebo (matched to water, milk, sugar, and caffeine intake); polyphenol and energy intake: NR Tea: 119.”
BackgroundInfluential
Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls
Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.006 · Cited by 279
Adherence to Mediterranean diet and risk of cancer: A systematic review and meta-analysis of observational studies: Mediterranean diet and cancer risk
Schwingshackl, L., & Hoffmann, G. (2014) · International Journal of Cancer · doi:10.1002/ijc.28824 · Cited by 269
In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers
Boots, A. W., Wilms, L. C., Swennen, E. L. R., Kleinjans, J. C. S., Bast, A., & Haenen, G. R. M. M. (2008) · Nutrition · doi:10.1016/j.nut.2008.03.023 · Cited by 271
Fruit polyphenols and CVD risk: a review of human intervention studies
Chong, M. F., Macdonald, R., & Lovegrove, J. A. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003922 · Cited by 273
Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: The PREDIMED study
Tresserra‐Rimbau, A., Medina‐Remón, A., Pérez‐Jiménez, J., Martínez‐González, M. Á., Covas, M.-I., Corella, D., Salas‐Salvadó, J., Gómez‐Gracia, E., Lapetra, J., Arós, F., et al. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.10.008 · Cited by 282
Common tea formulations modulate in vitro digestive recovery of green tea catechins
Green, R. J., Murphy, A. S., Schulz, B., Watkins, B. A., & Ferruzzi, M. G. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700086 · Cited by 261
“A limiting factor is the poor bioavailability of tea catechins resulting from instability under digestive conditions, poor transcellular transport, and rapid metabolism followed by excretion [13–15].”
Background
Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians
Habauzit, V., & Morand, C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311430006 · Cited by 260
“Based on epidemiological studies suggesting that diets rich in flavonoids can reduce the risk of arterial thrombosis [Arts and Hollman, 2005], it seems interesting to investigate the ability of these bioactives to inhibit platelet activation.”
Background
Application of FT-IR and Raman spectroscopy for the study of biopolymers in breads fortified with fibre and polyphenols
Sivam, A. S., Sun‐Waterhouse, D., Perera, C. O., & Waterhouse, G. I. N. (2011) · Food Research International · doi:10.1016/j.foodres.2011.03.039 · Cited by 258
Hydroxycinnamates and their in vitro and in vivo antioxidant activities
Shahidi, F., & Chandrasekara, A. (2009) · Phytochemistry Reviews · doi:10.1007/s11101-009-9142-8 · Cited by 257
“Evidence from in vivo and epidemiological studies suggest that phenolic compounds through their antioxidant properties may exert a myriad of health benefits thus ameliorating chronic diseases associated with oxidative damage (Kris-Etherton et al. 2002; Slavin 2003; Arts and Hollman 2005).”
Background
Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western‐style diet in C57/BL6J mice
Kobori, M., Masumoto, S., Akimoto, Y., & Oike, H. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000392 · Cited by 264
Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
Yang, J., Della‐Fera, M. A., Rayalam, S., Ambati, S., Hartzell, D. L., Park, H. J., & Baile, C. A. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.03.003 · Cited by 253
“Quercetin is a plant-derived, dietary flavonoid with potentially beneficial effects on cardiovascular diseases (Arts and Hollman, 2005; Hertog et al., 1993).”
Background
Improving public health?: The role of antioxidant-rich fruit and vegetable beverages
Wootton-Beard, P. C., & Ryan, L. (2011) · Food Research International · doi:10.1016/j.foodres.2011.09.015 · Cited by 258
Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science
Baron, E. P. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13345 · Cited by 268
Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation
Cione, E., Torre, C. L., Cannataro, R., Caroleo, M. C., Plastina, P., & Gallelli, L. (2019) · Molecules · doi:10.3390/molecules25010063 · Cited by 263
“EGCG from green tea and green tea extracts is widely used in traditional Chinese medicine, so it is considered safe even in huge dosages (>1–3 g per day) it can be a pro-oxidant bringing negative effects such reactive oxygen species (ROS) production [54,57].”
Background
Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity
Virgili, F., & Marino, M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.001 · Cited by 249
“cardiovascular disease [60], but significant differences have been reported between the effects of the intake of complex food matrices”
Flavonoids, Flavonoid Subclasses and Breast Cancer Risk: A Meta-Analysis of Epidemiologic Studies
Hui, C., Qi, X., Qianyong, Z., Xiaoli, P., Jundong, Z., & Mantian, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054318 · Cited by 245
Antioxidant Potential Overviews of Secondary Metabolites (Polyphenols) in Fruits
Swallah, M. S., Sun, H., Affoh, R., Fu, H., & Yu, H. (2020) · International Journal of Food Science · doi:10.1155/2020/9081686 · Cited by 273
Nutrition for the ageing brain: Towards evidence for an optimal diet
Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.010 · Cited by 241
“A number of studies have observed protective associations etween dietary polyphenols and the prevention of age-related hronic diseases such as CVD, diabetes, cancers, osteoporosis and eurodegenerative diseases (Arts and Hollman, 2005; Scalbert t al., 2005; van Dam et al., 2013).”
Molecular targets of tea polyphenols in the cardiovascular system
Stangl, V., Dreger, H., Stangl, K., & Lorenz, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.022 · Cited by 240
Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl
Ahmed, S. I., Hayat, M. Q., Tahir, M. N., Mansoor, Q., Ismail, M., Keck, K. S., & Bates, R. B. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1443-z · Cited by 239
“According to many research reports, the consumption of medicinal plants either in the form of raw extracts or chemical constituents is largely associated with lower risk of degenerative diseases caused by oxidative stress because they contain antioxidants such as phenolics, flavonoids, vitamins and carotenoids [10].”
Background
Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response
Álvarez, A. I., Real, R., Pérez, M., Mendoza, G., Prieto, J. G., & Merino, G. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21851 · Cited by 236
Fruit and vegetable intakes, dietary antioxidant nutrients, and total mortality in Spanish adults: findings from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain)
Agudo, A., Cabrera, L., Amiano, P., Ardanáz, E., Barricarte, A., Berenguer, T., Chirlaque, M. D., Dorronsoro, M., Jakszyn, P. G., Larrañaga, N., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1634 · Cited by 235
The relationship between phenolic compounds from diet and microbiota: impact on human health
Valdés, L., Cuervo, A. J. V., Salazar, N., Ruas‐Madiedo, P., Gueimonde, M., & González, S. (2015) · Food & Function · doi:10.1039/c5fo00322a · Cited by 243
Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity
Kimura, Y., Ito, H., Ohnishi, R., & Hatano, T. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.10.041 · Cited by 234
Citrus Flavanones: What Is Their Role in Cardiovascular Protection?
Chanet, A., Milenković, D., Manach, C., Mazur, A., & Morand, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300669s · Cited by 233
Dietary Flavonoids and the Risk of Colorectal Cancer
Τheodoratou, E., Kyle, J., Cetnarskyj, R., Farrington, S. M., Tenesa, A., Barnetson, R. A., Porteous, M. E., Dunlop, M. G., & Campbell, H. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0785 · Cited by 232
“The main dietary sources of these flavonoids differ widely among subgroups (14-17).”
Background
Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NFκB) Signaling in Cardiovascular Diseases: A Mini Review
Choy, K. W., Murugan, D. D., Leong, X.-F., Abas, R., Alias, A., & Mustafa, M. R. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01295 · Cited by 250
“Flavonoids have shown promising results in reducing atherosclerosis in several animal experimental models; however, conflicting results were reported in human clinical trials (Arts and Hollman, 2005; Zordoky et al., 2015).”
Result
Antioxidant Capacity, Phenolic Content, and Profiling of Phenolic Compounds in the Seeds, Skin, and Pulp ofVitis rotundifolia(Muscadine Grapes) As Determined by HPLC-DAD-ESI-MSn
Sandhu, A. K., & Gu, L. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf904211q · Cited by 228
Polyphenol content and antioxidant capacity in organic and conventional plant foods
Faller, A. L. K., & Fialho, E. (2010) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2010.01.003 · Cited by 226
Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links
Burton‐Freeman, B. M., Sandhu, A. K., & Edirisinghe, I. (2016) · Advances in Nutrition · doi:10.3945/an.115.009639 · Cited by 234
Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors
Pérez‐Jiménez, J., Serrano, J. C. E., Tabernero, M., Arranz, S., Diaz-Rubio, M. E., García‐Diz, L., Goñi, I., & Saura-Calixto, F. D. (2008) · Nutrition · doi:10.1016/j.nut.2008.03.012 · Cited by 230
Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP Activation in Hypercholesterolemic Individuals
Zhu, Y., Xia, M., Yang, Y., Liu, F., Li, Z., Hao, Y., Mi, M., Jin, T., & Ling, W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.167361 · Cited by 233
Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules
Lee, J., Zhou, H. Y., Cho, S. Y., Kim, Y. S., Lee, Y. S., & Jeong, C. S. (2007) · Archives of Pharmacal Research · doi:10.1007/bf02980273 · Cited by 220
A comprehensive review on the determination of enzymatic assay and nonenzymatic antioxidant activities
Haida, Z., & Hakiman, M. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1012 · Cited by 220
“The two major subclasses of polyphenols are phenolic acids and flavonoids (Arts & Hollman, 2005; Yazaki, Sasaki, & Tsurumaru, 2009).”
Background
Exploring the multifocal role of phytochemicals as immunomodulators
Behl, T., Kumar, K., Brisc, C., Rus, M., Nistor-Cseppento, C. D., Bustea, C., Aron, R. A. C., Pantiș, C., Zengin, G., Sehgal, A., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110959 · Cited by 244
The complex links between dietary phytochemicals and human health deciphered by metabolomics
Manach, C., Hubert, J., Llorach, R., & Scalbert, A. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800516 · Cited by 218
Flavonoids Attenuate Cardiovascular Disease, Inhibit Phosphodiesterase, and Modulate Lipid Homeostasis in Adipose Tissue and Liver
Peluso, M. R. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100802 · Cited by 218
Flavonols and Pancreatic Cancer Risk: The Multiethnic Cohort Study
Nöthlings, U., Murphy, S. P., Wilkens, L. R., Henderson, B. E., & Kolonel, L. N. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm172 · Cited by 217
“Recent reviews of epidemiologic studies concluded that the evidence was limited for an inverse association between polyphenol intake and cancer risk (8, 9).”
Background
New cellulose–lignin hydrogels and their application in controlled release of polyphenols
Ciolacu, D. E., Oprea, A., Anghel, N., Cazacu, G., & Cazacu, M. (2011) · Materials Science and Engineering C · doi:10.1016/j.msec.2011.11.018 · Cited by 217
Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI‐SANI study
Bonaccio, M., Pounis, G., Cerletti, C., Donati, M. B., Iacoviello, L., de Gaetano, G., & on behalf of the MOLI‐SANI Study Investigators (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12924 · Cited by 220
Polyphenols in Fruits and Vegetables and Its Effect on Human Health
Lima, G. P. P., Vianello, F., Corrêa, C. R., Campos, R. A. D. S., & Borguini, M. G. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.511117 · Cited by 226
Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target
Gothai, S., Ganesan, P., Park, S., Fakurazi, S., Choi, D., & Arulselvan, P. (2016) · Nutrients · doi:10.3390/nu8080461 · Cited by 226
“Growing evidence from epidemiological studies suggests a positive association between reduction in the incidence diabetes and the consumption of a diet rich in phenols [128].”
Background
Mechanisms of flavonoid protection against myocardial ischemia–reperfusion injury
Akhlaghi, M., & Bandy, B. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.12.003 · Cited by 212
“their abundance in fruit and vegetables they may partly contribute to the currently-known health benefits of plant foods [21].”
Background
Effect οf Genotype and Growing Year on the Nutritional, Phytochemical, and Antioxidant Properties of Industrial Hemp (Cannabis sativa L.) Seeds
Irakli, M., Tsaliki, E., Kalivas, A., Kleisiaris, F., Sarrou, E., & Cook, C. M. (2019) · Antioxidants · doi:10.3390/antiox8100491 · Cited by 212
“Phenolic compounds play an important role in human health due to their role in the prevention of cancer and several chronic diseases, by acting as radical scavengers [35].”
Gene expression changes related to the production of phenolic compounds in potato tubers grown under drought stress.
André, C. M., Schafleitner, R., Legay, S., Lefèvre, I., Aliaga, C. A. A., Nomberto, G., Hoffmann, L., Hausman, J.-F., Larondelle, Y., & Evers, D. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.07.008 · Cited by 237
Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms
Masella, R., Santangelo, C., D’Archivio, M., Volti, G. L., Giovannini, C., & Galvano, F. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800672102 · Cited by 216
“The consumption of a diet rich in vegetables and fruit seems to exert beneficial healthy effects because of the high content in fibers, mineral salts, vitamins, and a large number of non-nutrient phytochemicals such as polyphenols [1,2].”
Background
Effects of Nitrogen Fertilization on the Phenolic Composition and Antioxidant Properties of Basil ( Ocimum basilicum L.)
Nguyen, P. M., & Niemeyer, E. D. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801485u · Cited by 213
“Introduction Epidemiological evidence increasingly suggests that consumption of a diet rich in plant foods has a protective effect against cardiovascular disease and certain forms of cancer (1-3).”
Background
Estimation of Dietary Sources and Flavonoid Intake in a Spanish Adult Population (EPIC-Spain)
Zamora‐Ros, R., Andrés‐Lacueva, C., Lamuela-Raventós, R. M., Berenguer, T., Jakszyn, P. G., Barricarte, A., Ardanáz, E., Amiano, P., Dorronsoro, M., Larrañaga, N., et al. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2009.11.024 · Cited by 205
Sustained Increase in Flow-Mediated Dilation After Daily Intake of High-Flavanol Cocoa Drink Over 1 Week
Heiß, C., Finis, D., Kleinbongard, P., Hoffmann, A., Rassaf, T., Kelm, M., & Sies, H. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31802d0001 · Cited by 207
“An inverse association between mortality from cardiovascular disease and daily intake of flavonoids was previously noted by various investigators.(1,2) The calculated intake of flavonoids, mainly from tea, onions, and apples, ranged from very low amounts to about 100 mg/d.”
Background
Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin‐induced disturbance of hepatic gene expression in mice
Kobori, M., Masumoto, S., Akimoto, Y., & Takahashi, Y. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800310 · Cited by 213
Biosynthesis of Natural Flavanones in Saccharomyces cerevisiae
Yan, Y., Kohli, A., & Koffas, M. A. G. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.9.5610-5613.2005 · Cited by 205
“Flavonoids are a diverse family of plant polyphenols that demonstrate great potential in the treatment of various human pathological conditions (1, 10).”
Background
Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions
Gallardo, C., Jiménez, L., & García‐Conesa, M. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.07.053 · Cited by 204
Adherence to the Healthy Eating Index and Alternative Healthy Eating Index dietary patterns and mortality from all causes, cardiovascular disease and cancer: a meta‐analysis of observational studies
Onvani, S., Haghighatdoost, F., Surkan, P. J., Larijani, B. A., & Azadbakht, L. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12415 · Cited by 223
Improvement of Endothelial Function With Dietary Flavanols Is Associated With Mobilization of Circulating Angiogenic Cells in Patients With Coronary Artery Disease
Heiss, C., Jahn, S., Taylor, M., Real, W. M., Angeli, F. S., Wong, M. L., Amabile, N., Prasad, M., Rassaf, T., Ottaviani, J. I., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.039 · Cited by 202
“Heiss), and an unrestricted research grant from 2 f flavanol-containing foods and coronary artery disease CAD) mortality (1).”
Background
Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus
Hajiaghaalipour, F., Khalilpourfarshbafi, M., & Arya, A. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.11241 · Cited by 215
“Some epidemiological studies have suggested some undesirable effects on the consumption of flavonoid-rich diets and development of certain ailments [62, 63].”
Background
Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations
Peterson, J. J., Dwyer, J. T., Jacques, P. F., & McCullough, M. L. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00508.x · Cited by 203
Analysis of Nonextractable Phenolic Compounds in Foods: The Current State of the Art
Pérez‐Jiménez, J., & Torres, J. L. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203372w · Cited by 201
Dietary Flavonoids Attenuate Tumor Necrosis Factor α-induced Adhesion Molecule Expression in Human Aortic Endothelial Cells
LOTITO, S. B., & Frei, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606804200 · Cited by 200
Antioxidant and Anticancer Activities of Chenopodium Quinoa Leaves Extracts—In Vitro Study
Gawlik-Dziki, U., Świeca, M., Sułkowski, M., Dziki, D., Baraniak, B., & Czyż, J. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.03.023 · Cited by 196
“At the epidemiological level, plant polyphenols have been suggested to reduce the risk of cardiovascular diseases, neurodegenerative disorders and diabetes (Arts and Hollman, 2005).”
Background
Antioxidative properties and flavonoid composition of Chenopodium quinoa seeds cultivated in Japan
Hirose, Y., Fujita, T., Ishii, T., & Ueno, N. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.09.008 · Cited by 197
Wine by-Products: Phenolic Characterization and Antioxidant Activity Evaluation of Grapes and Grape Pomaces from Six Different French Grape Varieties
Ky, I., Lorrain, B., Kolbas, N., Crozier, A., & Teissèdre, P. (2014) · Molecules · doi:10.3390/molecules19010482 · Cited by 197
“For instance, polyphenolic compound in grapes are known to lower oxidative stress [16], to modulate the inflammatory cascade [17], to reduce the oxidation of LDL-c [18] and to induce protection against atherothrombotic episodes including myocardial ischemia and inhibition of platelet aggregation [19,20].”
Background
Biochemical and antimicrobial activity of phloretin and its glycosilated derivatives present in apple and kumquat
Barreca, D., Bellocco, E., Laganà, G., Ginestra, G., & Bisignano, C. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.03.118 · Cited by 196
Flavanols and cardiovascular disease prevention
Heiß, C., Keen, C. L., & Kelm, M. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq332 · Cited by 202
“A review of 15 cohort studies examined the relationship between dietary flavonoid intakes and the risk for developing CAD.(10) Thirteen of these prospective studies demonstrated a protective effect of flavanols, procyanidins, flavones, and flavanones in the context of deadly and non-deadly CAD with a reduction of mort…”
BackgroundInfluential
The effects of oxidative stress on the development of atherosclerosis
Khosravi, M., Poursaleh, A., Ghasempour, G., Shaikhnia, F., & Najafi, M. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0397 · Cited by 195
Inflammaging and Cancer: A Challenge for the Mediterranean Diet
Ostan, R., Lanzarini, C., Pini, E., Scurti, M., Vianello, D., Bertarelli, C., Fabbri, C., Izzi, M., Palmas, M. G., Biondi, F., et al. (2015) · Nutrients · doi:10.3390/nu7042589 · Cited by 198
“As described in previous paragraphs, many studies showed that the consumption of foods rich in polyphenols was associated with the prevention of chronic diseases [175–178].”
Result
Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients
Castilla, P., Dávalos, A., Teruel, J. L., Cerrato, F., Fernández‐Lucas, M., Merino, J. L., Sánchez-Martín, C. C., Ortuño, J. Á., & Lasunción, M. A. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1053 · Cited by 194
Phenolic Acid Content and Composition in Leaves and Roots of Common Commercial Sweetpotato ( Ipomea batatas L.) Cultivars in the United States
Truong, V., McFeeters, R. F., Thompson, R. T., Dean, L. L., & Shofran, B. G. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00415.x · Cited by 193
The cardiovascular health benefits of apples: Whole fruit vs. isolated compounds
Bondonno, N. P., Bondonno, C. P., Ward, N. C., Hodgson, J. M., & Croft, K. D. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.04.012 · Cited by 192
“Polyphenol-rich foods are a major research focus due to epidemiological studies showing a correlation between high polyphenol intake and decreased CVD risk (Arts & Hollman, 2005; Knekt et al., Fig.”
Background
Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IΚBα/NF-κB signaling pathway
Jia, Z., Nallasamy, P., Liu, D., Shah, H., Li, J. Z., Chitrakar, R., Si, H., McCormick, J., Zhu, H., Wei, Z., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.11.008 · Cited by 192
“Luteolin is a bioflavonoid present in many medicinal plants as well as in some commonly consumed fruits and vegetables including green leafy spices such as parsley, sweet peppers and celery [11–13].”
Background
Evaluation of the nutraceutical, antioxidant and cytoprotective properties of ripe pistachio ( Pistacia vera L., variety Bronte) hulls
Barreca, D., Laganà, G., Leuzzi, U., Smeriglio, A., Trombetta, D., & Bellocco, E. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.09.077 · Cited by 191
Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals
Rothwell, J. A., Urpi-Sarda, M., Boto-Ordonez, M., Knox, C., Llorach, R., Eisner, R., Cruz, J., Neveu, V., Wishart, D., Manach, C., et al. (2012) · Database · doi:10.1093/database/bas031 · Cited by 188
Plant Phenolics – Secondary Metabolites with Diverse Functions
Lattanzio, V., Kroon, P. A., Quideau, S., & Treutter, D. (2008) · Wiley eBooks · doi:10.1002/9781444302400.ch1 · Cited by 186
Antioxidant Strategies in the Management of Diabetic Neuropathy
Oyenihi, A. B., Ayeleso, A. O., Mukwevho, E., & Masola, B. (2015) · BioMed Research International · doi:10.1155/2015/515042 · Cited by 192
Beneficial roles of honey polyphenols against some human degenerative diseases: A review
Hossen, M. S., Ali, M. Y., Jahurul, M. H. A., Abdel‐Daim, M. M., Gan, S. H., & Khalil, M. I. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.07.002 · Cited by 185
Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together
Rogers, P. J., Smith, J. E., Heatherley, S. V., & Pleydell-Pearce, C. W. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0938-1 · Cited by 183
Alpha-Glucosidase Inhibitory and Antioxidant Activities of Vietnamese Edible Plants and Their Relationships with Polyphenol Contents
Tuyết, T., Thu, N. N., Tien, P. G., & Chuyên, N. V. (2007) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.53.267 · Cited by 179
Overview of polyphenols and their properties
Belščak‐Cvitanović, A., Durgo, K., Huđek, A., Bačun‐Družina, V., & Komes, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813572-3.00001-4 · Cited by 204
Effects of exogenous abscisic acid on antioxidant capacities, anthocyanins, and flavonol contents of muscadine grape (Vitis rotundifolia) skins
Sandhu, A. K., Gray, D. J., Lu, J., & Gu, L. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.11.105 · Cited by 178
Absorption of Anthocyanins from Blueberry Extracts by Caco-2 Human Intestinal Cell Monolayers
Yi, W., Akoh, C. C., Fischer, J. G., & Krewer, G. W. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0531959 · Cited by 180
Estimated Daily Intake and Seasonal Food Sources of Quercetin in Japan
Nishimuro, H., Ohnishi, H., Sato, M., Ohnishi‐Kameyama, M., Matsunaga, I., Naito, S., Ippoushi, K., Oike, H., Nagata, T., Akasaka, H., et al. (2015) · Nutrients · doi:10.3390/nu7042345 · Cited by 177
“Epidemiological studies have suggested that flavonoids, including quercetin, have a protective effect against cardiovascular diseases, cancers, and other chronic diseases [1–7].”
BackgroundMethod
The role of sugars and sweeteners in food, diet and health: Alternatives for the future
Edwards, C. H., Rossi, M., Corpe, C. P., Butterworth, P., & Ellis, P. R. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.07.008 · Cited by 190
Nutrition, Well-Being and Health
(2012) · doi:10.5772/1864 · Cited by 178
Storage Stability of Microencapsulated Cloudberry (Rubus chamaemorus) Phenolics
Laine, P., Kylli, P., Heinonen, M., & Jouppila, K. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801868h · Cited by 176
Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: A study on the Spanish diet
Arranz, S., Silván, J. M., & Saura-Calixto, F. D. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900580 · Cited by 175
“Polyphenols (PP) are the most abundant phytochemicals in the human diet and their biological properties, bioavailability, metabolism, and effects on the prevention of chronic diseases risk are nowadays the focus of a wide and intense research [1–4].”
Background
Protocatechuic Acid, a Metabolite of Anthocyanins, Inhibits Monocyte Adhesion and Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice
Wang, D., Wei, X., Xiao, Y., Jin, T., & Ling, W. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103427j · Cited by 176
Tannins improve dough mixing properties through affecting physicochemical and structural properties of wheat gluten proteins
Wang, Q., Li, Y., Sun, F., Li, X., Wang, P., Sun, J., Zeng, J., Wang, C., Hu, W., Chang, J., et al. (2014) · Food Research International · doi:10.1016/j.foodres.2014.12.012 · Cited by 174
Modulation of miRNA Expression by Dietary Polyphenols in apoE Deficient Mice: A New Mechanism of the Action of Polyphenols
Milenković, D., Deval, C., Gouranton, E., Landrier, J., Scalbert, A., Morand, C., & Mazur, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029837 · Cited by 174
“Epidemiological, clinical or animal studies have suggested an inverse association between the consumption of polyphenol and polyphenol-rich foods or beverages and the prevention of diseases [14,15,16,17].”
Ferulic Acid and Naturally Occurring Compounds Bearing a Feruloyl Moiety: A Review on Their Structures, Occurrence, and Potential Health Benefits
Silva, E. D. O., & Batista, R. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12266 · Cited by 177
Dietary flavonoid intake and risk of cancer in postmenopausal women: The Iowa Women's Health Study
Cutler, G. J., Nettleton, J. A., Ross, J. A., Harnack, L., Jacobs, D. R., Scrafford, C., Barraj, L. M., Mink, P. J., & Robien, K. (2008) · International Journal of Cancer · doi:10.1002/ijc.23564 · Cited by 173
“Exposure measurement error is an important limitation of all flavonoid studies, including ours, that rely on data from a single FFQ because of underreporting of dietary intake or missing information on certain flavonoid containing foods.(2) Unfortunately, for most flavonoid compounds there are no biomarkers that accur…”
BackgroundInfluential
Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity
Hosseinzade, A., Sadeghi, O., Biregani, A. N., Soukhtehzari, S., Brandt, G. S., & Esmaillzadeh, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00051 · Cited by 186
Evaluation of nutritional and antioxidant properties of the tropical fruits banana, litchi, mango, papaya, passion fruit and pineapple cultivated in Réunion French Island
Septembre‐Malaterre, A., Stanislas, G., Quessary, E. D., & Gonthier, M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.147 · Cited by 172
Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss
Rupasinghe, H. P. V., Sekhon-Loodu, S., Mantso, T., & Panayiotidis, M. I. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.005 · Cited by 178
“, 2001) in addition to activating the AMPK pathway which 428 regulates glucose and lipid metabolism (Arts and Hollman, 2005; Kurlandsky and Stote, 2006).”
Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults
McKay, D. L., Chen, C.-Y. O., Zampariello, C. A., & Blumberg, J. B. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.07.062 · Cited by 179
“…have consistently shown the consumption of fruits and vegetables is inversely associated with the risk of developing chronic diseases, such as cardiovascular diseases (CVD), certain forms of cancer, and neurodegenerative diseases. contribute substantially to this benefit (Arts & Hollman, 2005).”
Background
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid
Fiorani, M., Guidarelli, A., Blasa, M., Azzolini, C., Candiracci, M., Piatti, E., & Cantoni, O. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.014 · Cited by 171
“Quercetin is a naturally occurring flavonoid producing beneficial effects for the human health [1–3], via scavenging of reactive oxygen species/metal chelation and stimulation/inhibition of enzyme activities/signal transduction pathways [4–7].”
Background
Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity
Loke, W. M., Proudfoot, J. M., Stewart, S. G., McKinley, A. J., Needs, P. W., Kroon, P. A., Hodgson, J. M., & Croft, K. D. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.11.002 · Cited by 172

Authors: Arts, I. C., & Hollman, P. C.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Arts, Ilja CW
ORCID: Arts, Ilja CW
Hollman, Peter CH
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-01
Volume: 81
Issue: 1
Pages: 317S-325S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/81.1.317s
OpenAlex: W2129133439
Cited by: 1,916
References: 74
Citations by year: 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
FWCI: 6.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6628 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: ZonMw
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
MeSH terms: Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polyphenols and disease risk in epidemiologic studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks