Cited by 1,916Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 72 of the 74 references it cites were found in a registry or an index.

Polyphenols and disease risk in epidemiologic studies

Open access

Arts, Ilja CW, Hollman, Peter CH·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/81.1.317s

Open this paper in CoChat — free account Open PDF

Abstract

Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/ajcn/81.1.317s

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
Flavonoids: a review of probable mechanisms of action and potential applications.
Nijveldt, R., van Nood, E., van Hoorn, D. V., Boelens, P., van Norren, K., & van Leeuwen, P. V. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,232
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Phyto-oestrogens and Western Diseases
Adlercreutz, H., & Mazur, W. (1997) · Annals of Medicine · doi:10.3109/07853899709113696 · Cited by 1,282
Flavonoid intake and coronary mortality in Finland: a cohort study
Knekt, P., Jarvinen, R., Reunanen, A., & Maatela, J. (1996) · BMJ · doi:10.1136/bmj.312.7029.478 · Cited by 1,268
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke: The Zutphen Study
Keli, S., Hertog, M. G., Feskens, E., & Kromhout, D. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060059007 · Cited by 914
Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
Hertog, M. G. L., Hollman, P. C. H., & van de Putte, B. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00032a015 · Cited by 899

Show all 74 references

Sorted by citations

Items 701–800 of 1,001

Chemical and nutritional characterization of Chenopodium pallidicaule (cañ ihua) and Chenopodium quinoa (quinoa) seeds
Villa, D., Russo, L., Kerbab, K., Landi, M., & Rastrelli, L. (2014) · Emirates Journal of Food and Agriculture · doi:10.9755/ejfa.v26i7.18187 · Cited by 44
“For example, plant polyphenols, natural antioxidants, are ideal candidates linked to the protective effects of vegetables and fruits against cancer and cardiovascular diseases (Arts and Hollman, 2005).”
Background
Poly (ADP-ribose) Polymerase-1–Inhibiting Flavonoids Attenuate Cytokine Release in Blood from Male Patients with Chronic Obstructive Pulmonary Disease or Type 2 Diabetes
Weseler, A. R., Geraets, L., Moonen, H. J. J., MANDERS, R. J. F., van Loon, L. J. C., Pennings, H.-J., Wouters, E. F. �., Bast, A., & Hageman, G. J. (2009) · Journal of Nutrition · doi:10.3945/jn.108.102756 · Cited by 45
Chemical Composition, In Vitro Bioaccessibility and Antioxidant Activity of Polyphenolic Compounds from Nutraceutical Fennel Waste Extract
Castaldo, L., Izzo, L., Pascale, S. D., Narváez, A., Rodríguez-Carrasco, Y., & Ritieni, A. (2021) · Molecules · doi:10.3390/molecules26071968 · Cited by 46
“In this line, a wealth of data from epidemiological studies support an inverse association between polyphenol-rich diets and the incidence of several age-related diseases [11].”
Background
Screening of phenolic compounds in australian grown grapes and their potential antioxidant activities
Vo, G. T., Liu, Z., Chou, O., Zhong, B., Barrow, C. J., Dunshea, F. R., & Suleria, H. A. R. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101644 · Cited by 44
Solubilities of p-coumaric and caffeic acid in ionic liquids and organic solvents
Alevizou, E. I., & Voutsas, E. C. (2013) · The Journal of Chemical Thermodynamics · doi:10.1016/j.jct.2013.02.013 · Cited by 44
Anti–bacterial studies on Hemigraphis colorata (Blume) H.G. Hallier and Elephantopus scaber L.
Anitha, V. T., Antonisamy, J. M., & Jeeva, S. (2011) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(11)60245-9 · Cited by 44
A Pharmacokinetic Study of Different Quercetin Formulations in Healthy Participants: A Diet‐Controlled, Crossover, Single‐ and Multiple‐Dose Pilot Study
Solnier, J., Zhang, Y., Roh, K., Kuo, Y. C., Du, M., Wood, S., Hardy, M. L., Gahler, R. J., & Chang, C. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/9727539 · Cited by 51
“In general, favonols and favones have shown protective efects against cancer and cardiovascular diseases in epidemiological studies [6, 7].”
Background
Nutraceutical potential, phytochemistry of hemp seed (Cannabis sativa L.) and its application in food and feed: A review
Kamle, M., Mahato, D. K., Sharma, B., Gupta, A., Shah, A. K., Mahmud, M. M. C., Agrawal, S., Singh, J., Rasane, P., Shukla, A. C., et al. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100671 · Cited by 47
Jabuticaba as a source of functional pigments.
dos Santos, D. T., & Meireles, M. A. A. (2009) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · Cited by 43
Effects of red grape juice polyphenols in NADPH oxidase subunit expression in human neutrophils and mononuclear blood cells
Dávalos, A., de la Peña, G., Sánchez-Martín, C. C., Guerra, M. T., Bartolomé, B., & Lasunción, M. A. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509382148 · Cited by 44
“Plant polyphenols comprise a large group of natural antioxidants that are serious candidates to explain the protective effects of vegetables and fruits against CVD and certain types of cancer (13,14) .”
Validating polyphenol intake estimates from a food-frequency questionnaire by using repeated 24-h dietary recalls and a unique method-of-triads approach with 2 biomarkers
Burkholder-Cooley, N. M., Rajaram, S., Haddad, E. H., Oda, K., Fraser, G. E., & Jaceldo‐Siegl, K. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.137174 · Cited by 43
Impact of UV-C irradiation on the quality, safety, and cytotoxicity of cranberry-flavored water using a novel continuous flow UV system
Gopisetty, V. V. S., Patras, A., Kilonzo‐Nthenge, A., Yannam, S. K., Bansode, R. R., Sasges, M., Burns, M., Vergne, M. J., Pan, C., & Xiao, H. (2018) · LWT · doi:10.1016/j.lwt.2018.04.042 · Cited by 43
Barley grass juice (Hordeum vulgare L.) inhibits obesity and improves lipid profile in high fat diet-induced rat model
Jhansyrani, T., Dodoala, S., Koganti, B., & Prasad, K. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.111843 · Cited by 43
Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome
Beavers, K. M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s142 · Cited by 45
Flavonoids of Piper sarmentosum and its cytoprotective effects against oxidative stress.
Ugusman, A., Zakaria, Z., Hui, C. K., Nordin, N. A. M. M., & Mahdy, Z. A. (2012) · PubMed Central · Cited by 43
Development of a food frequency questionnaire for the assessment of quercetin and naringenin intake
Ranka, S., Gee, J. M. W., Bíró, L., Brett, G. M., Saha, S., Kroon, P. A., Skinner, J. S., Hart, A. R., Cassidy, A., Rhodes, M. A., et al. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602827 · Cited by 43
“There is a considerable interest in the possibility that flavonoids function as natural anticarcinogens, but their true biological significance remains controversial (Nijveldt et al., 2001; Arts and Hollman, 2005; Lin et al., 2006).”
Background
Dietary patterns associated with hypertension prevalence in the Cameroon defence forces
Nkondjock, A., & Bizome, E. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.109 · Cited by 42
“In a setting where awareness of CVD is very low, such a dietary pattern may have great clinical significance, suggesting that consuming a diet rich in fruits, vegetables, tubers and legumes may reduce CVD risk through lowering BP. Additional studies assessing the influence of overall diet in the aetiology of hypertens…”
BackgroundInfluential
The key role of grape variety for antioxidant capacity of red wines
Kondrashov, A., Ševčík, R., Benaková, H., Kostirova, M., & Štípek, S. (2008) · e-SPEN the European e-Journal of Clinical Nutrition and Metabolism · doi:10.1016/j.eclnm.2008.10.004 · Cited by 43
Antioxidative Effects of Plant Polyphenols
Jefremov, V., Zilmer, M., Zilmer, K., Bogdanović, N., & Karelson, E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.048 · Cited by 44
Phenolics in the bran of waxy wheat and triticale lines
Jonnala, R. S., Irmak, S., MacRitchie, F., & Bean, S. R. (2010) · Journal of Cereal Science · doi:10.1016/j.jcs.2010.07.013 · Cited by 43
“Increased consumption of phenolic compounds has been correlated with a reduced risk of cardiovascular diseases and certain types of cancers (Arts and Hollman, 2005; Jacobs et al., 1998; Kris-Etherton et al., 2002).”
Background
Sorghum distillers dried grain lipid extract increases cholesterol excretion and decreases plasma and liver cholesterol concentration in hamsters
Hoi, J. T., Weller, C. L., Schlegel, V. L., Cuppett, S. L., Lee, J., & Carr, T. P. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2009.09.005 · Cited by 43
CH 6 Dietary Flavonoids and Health — Broadening the Perspective
Andersen, O. M., & Markham, K. R. (2005) · CRC Press eBooks · doi:10.1201/9781420039443-10 · Cited by 43
Antioxidant and antiinflammatory activity of new water-soluble sulfur-containing phenolic compounds
Зенков, Н. К., Брониславовна, М. Е., Кандалинцева, Н. В., Oleynik, A. S., Prosenko, A. E., Gusachenko, O. N., Shklyaeva, O. A., Андреевич, В. В., & Lyakhovich, V. V. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907060077 · Cited by 42
Management of Peripheral Arterial Disease
Steffen, L. M., Duprez, D. A., Boucher, J. L., Ershow, A. G., & Hirsch, A. T. (2008) · Diabetes Spectrum · doi:10.2337/diaspect.21.3.171 · Cited by 41
Quercetin supplementation and its effect on human monocyte gene expression profiles in vivo
Boomgaarden, I., Egert, S., Rimbach, G. H., Wolffram, S., Müller, M. J., & Döring, F. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000711 · Cited by 42
Co-spray dried resveratrol and budesonide inhalation formulation for reducing inflammation and oxidative stress in rat alveolar macrophages
Trotta, V., Lee, W., Loo, C., Young, P. M., Traini, D., & Scalia, S. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.02.018 · Cited by 42
“The anti-oxidant activity of this polyphenol is due to its ability to scavenge free radicals (Arts and Hollman 2005).”
Application of Dietary Phenolic Biomarkers in Epidemiology: Past, Present, and Future
Zamora‐Ros, R., Rabassa, M., Llorach, R., Gonzalez, C. A., & Andrés‐Lacueva, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204742e · Cited by 43
Rauvolfia serpentina L. Benth. ex Kurz.: Phytochemical, Pharmacological and Therapeutic Aspects
Kumari, R., Rathi, B., Rani, A., & Bhatnagar, S. (2013) · Cited by 42
In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions
Thomford, N. E., Dzobo, K., Chopera, D., Wonkam, A., Maroyi, A., Blackhurst, D., & Dandara, C. (2016) · Molecules · doi:10.3390/molecules21070891 · Cited by 42
“Epidemiological studies of polyphenols suggest that consumption of polyphenol-rich herbs and beverages may contribute to the prevention of diseases including cancers, cardiovascular diseases, osteoporosis, neurodegenerative diseases, and diabetes [38,39].”
Background
Effect of sea buckthorn (Hippophae rhamnoides L.) on blood lipid profiles: A systematic review and meta-analysis from 11 independent randomized controlled trials
Guo, X., Yang, B., Cai, W., & Li, D. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.11.007 · Cited by 42
Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer’s disease
Sawmiller, D. R., Li, S., Mori, T., Habib, A., Rongo, D., Delic, V., Bradshaw, P. C., Shytle, R. D., Sanberg, C. D., Bickford, P. C., et al. (2017) · Heliyon · doi:10.1016/j.heliyon.2017.e00279 · Cited by 42
“In light of recent failures in clinical trials of more than a dozen single-target antiamyloidogenic drugs for the treatment of AD, recent studies have focused on the potential effectiveness of nutritional supplements, or nutraceuticals, with multiple therapeutic targets [12, 13, 14, 15].”
Background
A Possible Role for Singlet Oxygen in the Degradation of Various Antioxidants. A Meta-Analysis and Review of Literature Data
Petrou, A. L., Petrou, P., Ntanos, T., & Liapis, A. (2018) · Antioxidants · doi:10.3390/antiox7030035 · Cited by 44
“By still undefined mechanisms, flavonoids and other polyphenols may reduce the risk of cancer and cardiovascular disease [46].”
Background
Polyphenol estimated intake and dietary sources among older adults from Mallorca Island
Karam, J., Bibiloni, M. D. M., & Tur, J. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191573 · Cited by 42
Metabolic Syndrome and Neuroprotection
Etchegoyen, M., Nobile, M. H., Báez, F., Posesorski, B., González, J., Lago, N. R., Milei, J., & Losada, M. E. O. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00196 · Cited by 44
“Several subclasses of flavonoids are free radical scavengers found in plants (Nijveldt et al., 2001; Arts and Hollman, 2005; Nettleton et al., 2006; Lukačínová et al., 2008).”
Background
Phenolic Compounds from Apples: Reviewing their Occurrence, Absorption, Bioavailability, Processing, and Antioxidant Activity – a Review
Starowicz, M., Piskuła, M. K., Achrem–Achremowicz, B., & Zieliński, H. (2020) · Polish Journal of Food and Nutrition Sciences · doi:10.31883/pjfns/127635 · Cited by 50
Hyperoside from Z. bungeanum leaves restores insulin secretion and mitochondrial function by regulating pancreatic cellular redox status in diabetic mice
Zhang, Y., Yu, X.-M., Wang, M., Ding, Y. P., Guo, H., Liu, J., & Cheng, Y. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.320 · Cited by 44
In vitro biological activity of resveratrol using a novel inhalable resveratrol spray-dried formulation
Trotta, V., Lee, W., Loo, C., Haghi, M., Young, P. M., Scalia, S., & Traini, D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.06.033 · Cited by 42
“Specifically, in lungs it has been shown at this compound is capable of scavenging oxygen-derived free dicals (Arts and Hollman, 2005) and therefore has the potential be used as a adjunct therapy in the treatment of COPD (Knobloch al.”
Background
Enhanced anti-inflammatory effect of resveratrol and EPA in treated endotoxin-activated RAW 264.7 macrophages
Pallarès, V., Calay, D., Cedó, L., Castell‐Auví, A., Raes, M. J., Pinent, M., Ardèvol, A., Arola, L., & Blay, M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007057 · Cited by 42
Optimization of the extraction of phenolic compounds from purple corn cob (Zea mays L.) by sequential extraction using supercritical carbon dioxide, ethanol and water as solvents
Monroy, Y. M., Rodrigues, R. A. F., Sartoratto, A., & Cabral, F. A. (2016) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2016.04.011 · Cited by 42
Azuki Bean Juice Lowers Serum Triglyceride Concentrations in Healthy Young Women
Maruyama, C., Araki, R., Kawamura, M., Kondo, N., Kigawa, M., Kawai, Y., Takanami, Y., Miyashita, K., & Shimomitsu, T. (2008) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2008039 · Cited by 40
“Tel: +81-3-5981-3428 Fax: 81-3-5981-3428 E-mail: maruyama@fc.jwu.ac.jp Received 8 January, 2008; Accepted 24 January, 2008 Copyright © 2008 JCBNSummary Effects of azuki bean juice supplementation, prescribed according to a Kanpo medicine regimen, on serum lipid concentrations were studied.”
Method
Grape juice concentrate prevents oxidative DNA damage in peripheral blood cells of rats subjected to a high-cholesterol diet
Aguiar, O., Gollücke, A. P. B., de Moraes, B. B., Pasquini, G., Catharino, R. R., Riccio, M. F., Ihara, S. S. M., & Ribeiro, D. A. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510004368 · Cited by 41
Late chronic catechin antioxidant treatment is deleterious to the endothelial function in aging mice with established atherosclerosis
Gendron, M.-È., Théorêt, J., Mamarbachi, A. M., Drouin, A., Nguyen, A. Q., Bolduc, V., Thorin‐Trescases, N., Merhi, Y., & Thorin, É. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00532.2009 · Cited by 44
Effects of flavonoid-rich Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit extract on regulating glucose and lipid metabolism in diabetic KK-A y mice
Zhang, X., Lv, Q., Jia, S., Chen, Y., Sun, C., Li, X., & Chen, K. (2016) · Food & Function · doi:10.1039/c6fo00397d · Cited by 41
Bush tea (Athrixia phylicoides): A review of the traditional uses, bioactivity and phytochemistry
Lerotholi, L. J., Chaudhary, S. K., Combrinck, S., & Viljoen, A. M. (2016) · South African Journal of Botany · doi:10.1016/j.sajb.2016.06.005 · Cited by 41
Phenolic compound profiles and their seasonal variations in new red-phenotype head-forming Chinese cabbages
Lee, H., Oh, I.-N., Kim, J., Jung, D.-H., Cuong, N. P., Kim, Y., Lee, J., Kwon, O., Park, S. U., Lim, Y.-P., et al. (2017) · LWT · doi:10.1016/j.lwt.2017.12.056 · Cited by 41
Neuroinflammation in CNS diseases: Molecular mechanisms and the therapeutic potential of plant derived bioactive molecules
Welcome, M. O. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100176 · Cited by 41
A comparative phytochemical analysis of cocoa and green tea
Subhashini, R. (2010) · Indian Journal of Science and Technology · doi:10.17485/ijst/2010/v3i2.3 · Cited by 41
Production of Genistein from Naringenin Using Escherichia coli Containing Isoflavone Synthase-Cytochrome P450 Reductase Fusion Protein
Kim, D. H. (2009) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.0905.05043 · Cited by 41
“Polyphenols, one group of plant secondary metabolites, include the (iso)flavonoids, cumarins, stilbenes, and lignins [2].”
Background
Role of quercetin in modulating rat cardiomyocyte gene expression profile
Angeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., & Hrelia, S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01091.2007 · Cited by 41
“Various epidemiological studies have shown an inverse correlation between the consumption of flavonoid-rich foods and cardiovascular disease risk (6, 28, 37).”
Background
Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme
Bae, M., Le, C., Mehta, R. S., Dong, X., Pieper, L. M., Ramirez, L., Alexander, M., Kiamehr, S., Turnbaugh, P. J., Huttenhower, C., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.10.002 · Cited by 42
Mechanistic insights into the role of microRNAs in cancer: influence of nutrient crosstalk
Shah, M. S., Davidson, L. A., & Chapkin, R. S. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00305 · Cited by 41
“Several clinical, experimental, and epidemiological studies have suggested an inverse association between polyphenol-rich food consumption and the prevention of chronic diseases (Arts and Hollman, 2005; Scalbert et al., 2005; Schroeter et al., 2006; Spencer et al., 2008).”
Background
Thermal degradation of green tea flavan-3-ols and formation of hetero- and homocatechin dimers in model dairy beverages
Song, B. J., Manganais, C., & Ferruzzi, M. G. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.10.026 · Cited by 40
Popular naturally occurring antioxidants as potential anticoagulant drugs
Bijak, M., Saluk, J., Szelenberger, R., & Nowak, P. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.07.022 · Cited by 42
Flavonoids as Nutraceuticals
Kaleem, M., & Ahmad, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814625-5.00008-x · Cited by 40
Sources, Chemistry, and Biological Potential of Ellagitannins and Ellagic Acid Derivatives
Lorenzo, J. M., Munekata, P. E. S., Putnik, P., Kovačević, D. B., Muchenje, V., & Barba, F. J. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64181-6.00006-1 · Cited by 42
Structure and Dynamics of Wheat Starch in Breads Fortified with Polyphenols and Pectin: an ESEM and Solid-State CP/MAS 13C NMR Spectroscopic Study
Sivam, A. S., Waterhouse, G. I. N., Zujovic, Z. D., Perera, C. O., & Sun‐Waterhouse, D. (2011) · Food and Bioprocess Technology · doi:10.1007/s11947-011-0699-z · Cited by 40
“…from apples, kiwifruits, and berries have demonstrated health-promoting properties such as antioxidant capacity, anti-neurodegenerative effect, anti-carcinogenic effect and anti-inflammatory activity (Bravo 1998; Boyer and Liu 2004; Arts and Hollman 2005; Lauren et al. 2009; Lyall et al. 2009).”
Background
Evaluation of tolerable levels of dietary quercetin for exerting its antioxidative effect in high cholesterol-fed rats
Azuma, K., Ippoushi, K., & Terao, J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.02.005 · Cited by 40
Comparison of separation power of ultra performance liquid chromatography and comprehensive two‐dimensional liquid chromatography in the separation of phenolic compounds in beverages
Kivilompolo, M., & Hyötyläinen, T. (2008) · Journal of Separation Science · doi:10.1002/jssc.200800287 · Cited by 39
Ectonucleotidase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of streptozotocin-induced diabetic rats and treated with resveratrol
Schmatz, R., Mazzanti, C. M. D. A., Spanevello, R. M., Stefanello, N., Gutierres, J. M., Maldonado, P., Corrêa, M., da Rosa, C. S., Becker, L. V., Bagatini, M. D., et al. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.08.019 · Cited by 39
“[4] I.”
Background
Dietary functional benefits of Bartlett and Starkrimson pears for potential management of hyperglycemia, hypertension and ulcer bacteria Helicobacter pylori while supporting beneficial probiotic bacterial response
Sarkar, D., Ankolekar, C., Pinto, M., & Shetty, K. (2014) · Food Research International · doi:10.1016/j.foodres.2014.12.014 · Cited by 39
Nero d’Avola and Perricone cultivars: determination of polyphenols, flavonoids and anthocyanins in grapes and wines
Gervasi, T., Oliveri, F., Gottuso, V., Squadrito, M., Bartolomeo, G., Cicero, N., & Dugo, G. (2016) · Natural Product Research · doi:10.1080/14786419.2016.1174229 · Cited by 39
Luteolin decreases atherosclerosis in LDL receptor‑deficient mice via a mechanism including decreasing AMPK‑SIRT1 signaling in macrophages
Jiang, L., Dong, J., Ren, Y., Zhu, J., Cao, J., Zhang, J., & Pan, L. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6499 · Cited by 39
Preliminary studies on anti-tumor activity of 2′,4′-dihydroxychalcone isolated from Herba Oxytropis in human gastric cancer MGC-803 cells
Lou, C., Wang, M., Yang, G., Cai, H., Yu, L., Zhao, F., Yang, H., Li, T., & Cai, B. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.05.002 · Cited by 39
Effect of Drying Treatment on the Content of Antioxidants in Enicostemma littorale Blume
Lakshmi, P. T. V., Sathishkum, R., & Annamalai, A. (2009) · Research Journal of Medicinal Plant · doi:10.3923/rjmp.2009.93.101 · Cited by 39
Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega.
Raju, G. S., Moghal, M. R., Dewan, S. M. R., Amin, M. N., & Billah, M. M. (2013) · Europe PMC (PubMed Central) · Cited by 39
Inhibitory effect of blue honeysuckle extract on high-fat-diet-induced fatty liver in mice
Liu, M., Tan, J., He, Z., He, X., Hou, D., He, J., & Wu, S. (2018) · Animal nutrition · doi:10.1016/j.aninu.2018.06.001 · Cited by 39
Dietary Flavonoids and Health — Broadening the Perspective
Clifford, M. N., & Brown, J. E. (2005) · CRC Press eBooks · doi:10.1201/9781420039443.ch6 · Cited by 40
Optimization of a high-performance liquid chromatography method for the analysis of complex polyphenol mixtures and application for sainfoin extracts (Onobrychis viciifolia)
Regos, I., & Treutter, D. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.07.075 · Cited by 38
Comparison of three drying processes to obtain an apple peel food ingredient
Henríquez, C., Almonacid, S., Mariane Lutz, R., Simpson, R., & Valdenegro, M. (2012) · CyTA - Journal of Food · doi:10.1080/19476337.2012.703693 · Cited by 41
Absorption, Metabolism, and Effects at Transcriptome Level of a Standardized French Oak Wood Extract, Robuvit, in Healthy Volunteers: Pilot Study
Natella, F., Leoni, G., Maldini, M., Natarelli, L., Comitato, R., Schönlau, F., Virgili, F., & Canali, R. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf403493a · Cited by 38
Natural plant polyphenols for alleviating oxidative damage in man: Current status and future perspectives
Li, J., Liu, X.-D., Shen, L., Zeng, W.-M., & Qiu, G. (2016) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v15i5.27 · Cited by 38
“Epidemiological studies have repeatedly shown that polyphenols, as antioxidants may protect cell constituents against oxidative damage and therefore limit the risk of various degenerative diseases associated with oxidative stress [53].”
Background
Blackcurrant anthocyanins modulate CCL11 secretion and suppress allergic airway inflammation
Shaw, O. M., Nyanhanda, T., McGhie, T. K., Harper, J. L., & Hurst, R. D. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600868 · Cited by 38
“Studies also link fruit and vegetable phytochemical compounds, including anthocyanins and proanthocyanins, with the attenuation of lung inflammation [12, 1619].”
Background
Exogenous Glycine Nitrogen Enhances Accumulation of Glycosylated Flavonoids and Antioxidant Activity in Lettuce (Lactuca sativa L.)
Yang, X., Cui, X., Zhao, L., Guo, D., Feng, L., Wei, S., Zhao, C., & Huang, D. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.02098 · Cited by 38
“…and diabetes; the protective effects of fruit and vegetable consumption are mainly attributed to the presence of bioactive phytochemicals such as polyphenols, vitamin C and vitamin E (Arts and Hollman, 2005; Hooper and Cassidy, 2006; Russo et al., 2012; Chen and Chen, 2013; Wang et al., 2017).”
Background
Bioactives from Millet: Properties and Effects of Processing on Bioavailability
Akanbi, T. O., Timilsena, Y. P., & Dhital, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-6167-8_10 · Cited by 38
Stability of Hydroxytyrosol in Aqueous Solutions at Different Concentration, Temperature and with Different Ionic Content: A Study Using UPLC-MS
Zafra‐Gómez, A., Luzón-Toro, B., Capel-Cuevas, S., & Morales, J. C. (2011) · Food and Nutrition Sciences · doi:10.4236/fns.2011.210149 · Cited by 38
Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells
Yu, Y., Lin, C.-H., Chan, H., & Tsai, H.-D. (2009) · European Journal of Nutrition · doi:10.1007/s00394-008-0768-x · Cited by 37
Role of flavonoids and nitrates in cardiovascular health
Lovegrove, J. A., Stainer, A. R., & Hobbs, D. A. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116002871 · Cited by 40
Analysis of Environmental Conditions Effect in the Phytochemical Composition of Potato (Solanum tuberosum) Cultivars
Samaniego, I., Espín, S., Subía, H. X. C., Arias, V., Rubio, A., Llerena, W., Angós, I., & Carrillo, W. (2020) · Plants · doi:10.3390/plants9070815 · Cited by 43
Synthesis, Characterization, X-ray Crystallography, Acetyl Cholinesterase Inhibition and Antioxidant Activities of Some Novel Ketone Derivatives of Gallic Hydrazide-Derived Schiff Bases
Gwaram, N. S., Ali, H. M., Abdulla, M. A., Buckle, M. J. C., Sukumaran, S. D., Chung, L. Y., Othman, R., Alhadi, A. A., Yehye, W. A., Hadi, A. H. A., et al. (2012) · Molecules · doi:10.3390/molecules17032408 · Cited by 37
“Therefore, the risk of AD disease might be decreased by intake of antioxidants that neutralize the unfavorable effects of oxidative stress [16].”
Chocolate, well-being and health among elderly men
Strandberg, T., Strandberg, A., Pitkälä, K., Salomaa, V., Tilvis, R., & Miettinen, T. (2008) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602707 · Cited by 37
“These cardiovascular effects of chocolate are usually related to flavonoids (flavanols), which have been associated with less cardiovascular risk in epidemiological studies (Hertog et al., 1993; Keli et al., 1996; Arts and Hollman, 2005).”
Background
Comparison of Various Easy-to-Use Procedures for Extraction of Phenols from Apricot Fruits
Zítka, O., Sochor, J., Rop, O., Skalíčková, S., Šobrová, P., Zehnálek, J., Beklová, M., KRŠKA, B., Adam, V., & Kizek, R. (2011) · Molecules · doi:10.3390/molecules16042914 · Cited by 37
“Quercetin also protects the organism against coronary diseases [54,55], lung cancer and asthma [56].”
Background
Influence of Accelerated Solvent Extraction and Ultrasound-Assisted Extraction on the Anthocyanin Profile of Different Vaccinium Species in the Context of Statistical Models for Authentication
Heffels, P., Weber, F., & Schieber, A. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02255 · Cited by 37
Cocoa Flavanol Cardiovascular Effects Beyond Blood Pressure Reduction
Jumar, A., & Schmieder, R. E. (2015) · Journal of Clinical Hypertension · doi:10.1111/jch.12715 · Cited by 38
“of flavanol-rich foods and decreased incidence of CV events,(7,48,49) especially stroke and myocardial infarction (Table II).(53,54) Epidemiological investigations have consistently revealed an inverse relationship between high dietary intake of flavanol-containing foods and reduced risk of coronary heart disease (CHD…”
Background
Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity
Willenberg, I., Meschede, A. K., Gueler, F., Jang, M.-S., Shushakova, N., & Schebb, N. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139147 · Cited by 36
“Health promoting effects are discussed for secondary plant metabolites in particular for polyphenols: Epidemiological studies suggest beneficial effects of polyphenols on cardiovascular diseases and the risk for the development of cancer [1, 2].”
Background
Additive, antagonistic, and synergistic effects of procyanidins and polyunsaturated fatty acids over inflammation in RAW 264.7 macrophages activated by lipopolysaccharide
Pallarès, V., Calay, D., Cedó, L., Castell‐Auví, A., Raes, M. J., Pinent, M., Ardèvol, A., Arola, L., & Blay, M. (2011) · Nutrition · doi:10.1016/j.nut.2011.07.027 · Cited by 37
Phenolic compounds and their health benefits: A rev iew
Kumar, H., Choudhary, N., Kumar, N., & Seth, R. (2014) · Cited by 36
Association between Mediterranean diet and head and neck cancer: results of a large case–control study in Italy
Giraldi, L., Panić, N., Cadoni, G., Boccia, S., & Leoncini, E. (2016) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000277 · Cited by 36
“…and vegetables may be explained through the biological effects of flavonoids, including antioxidant activity, inhibition of inflammation, antimutagenic, and antiproliferative properties as well as involvement in cell signaling, cell-cycle regulation, and angiogenesis (Arts and Hollman, 2005).”
Background
Tissue specific effects of feeds supplemented with grape pomace or olive oil mill wastewater on detoxification enzymes in sheep
Kerasioti, E., Terzopoulou, Z., Komini, O., Kafantaris, I., Makri, S., Stagos, D., Gerasopoulos, K., Анисимов, Н., Tsatsakis, A. M., & Kouretas, D. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.06.007 · Cited by 36
Antioxidant and Antigenotoxic Activities of Purple Grape Juice—Organic and Conventional—in Adult Rats
Dani, C., Oliboni, L. S., Umezu, F. M., Pasquali, M. A. D. B., Salvador, M. M., Moreira, J. C. F., & Henriques, J. A. P. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0256 · Cited by 36
“Epidemiological studies have suggested an inverse relation between the consumption of polyphenol-rich foods and beverages and the risk of degenerative diseases, particularly cancers and cardiovascular diseases, mainly by their antioxidant capacity.(1,2) Some researches have also shown that diets rich in fruits and veg…”
Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle
Jin, Y., Han, X., Zhang, Y., Lee, J., Lim, Y. H., Kim, T., Yoo, H., & Yun, Y. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21592 · Cited by 36
Application of raw and differently dried Pineapple ( Ananas comosus ) pulp on Rasgulla (sweetened Casein Ball) to enhance its phenolic profile, shelf life, and in‐vitro digestibility characteristics
Sarkar, T., Salauddin, M., Pati, S., Sheikh, H. I., & Chakraborty, R. (2021) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.15233 · Cited by 35
The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc
Hegedüs, I., Andreidesz, K., Szentpéteri, J. L., Kaleta, Z., Szabó, L. G., Szigeti, K., Gulyás, B. Z., Padmanabhan, P., Budán, F., & Máthé, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911165 · Cited by 35
“Diets high in tannins may show a protein absorption-reducing effect [148].”
Background
Extraction and Purification of Catechins from Tea Leaves: An Overview of Methods, Advantages, and Disadvantages
Cioancă, O., Lungu, I. I., Mita-Baciu, I., Robu, S., Burlec, A. F., Hăncianu, M., & Crivoi, F. (2024) · Separations · doi:10.3390/separations11060171 · Cited by 38
Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis
Giacoppo, S., Galuppo, M., Lombardo, G. E., Ulaszewska, M., Mattivi, F., Bramanti, P., Mazzon, E., & Navarra, M. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.04.003 · Cited by 35
Apigenin inhibits TGF-β1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations
Wójcik‐Pszczoła, K., Skoda, M., Koczurkiewicz, P., Sanak, M., Czyż, J., & Michalik, M. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)70974-5 · Cited by 35
Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration
Kim, H. J., Cha, B., Choi, B., Lim, J. S., Woo, J., & Kim, J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002571 · Cited by 35
Dietary flavonoid intake, total antioxidant capacity and lipid oxidative damage: A cross-sectional study of Iranian women
Alipour, B., Rashidkhani, B., & Edalati, S. (2015) · Nutrition · doi:10.1016/j.nut.2015.11.011 · Cited by 35
Antidiabetic dietary materials and animal models
Wang, S., & Zhu, F. (2016) · Food Research International · doi:10.1016/j.foodres.2016.04.028 · Cited by 35
Molecular Insights Reveal Psy1, SGR, and SlMYB12 Genes are Associated with Diverse Fruit Color Pigments in Tomato (Solanum lycopersicum L.)
Kang, S.-I., Hwang, I., Goswami, G., Jung, H., Nath, U. K., Yoo, H.-J., Lee, J. M., & Nou, I. (2017) · Molecules · doi:10.3390/molecules22122180 · Cited by 35
Cyanidin-3-O-β-glucoside attenuates allergic airway inflammation by modulating the IL-4Rα-STAT6 signaling pathway in a murine asthma model
Ma, B., Wu, Y., Chen, B., Yao, Y., Wang, Y., Bai, H., Li, C., Yang, Y., & Chen, Y. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.008 · Cited by 35

Authors: Arts, I. C., & Hollman, P. C.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Arts, Ilja CW
ORCID: Arts, Ilja CW
Hollman, Peter CH
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-01
Volume: 81
Issue: 1
Pages: 317S-325S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/81.1.317s
OpenAlex: W2129133439
Cited by: 1,916
References: 74
Citations by year: 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
FWCI: 6.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6628 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: ZonMw
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
MeSH terms: Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polyphenols and disease risk in epidemiologic studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks