Cited by 1,916Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

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Polyphenols and disease risk in epidemiologic studies

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Arts, Ilja CW, Hollman, Peter CH·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/81.1.317s

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Abstract

Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.

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“The lower likelihood of CRC observed in participants who drank red wine might be explained by the multiple biological effects of flavonoids, including antioxidant activity, inflammation inhibition, antimutagenic and antiproliferative properties, and involvement in cell signaling, cell cycle regulation, and angiogenesi…”
Background
A look beyond dietary (poly)phenols: The low molecular weight phenolic metabolites and their concentrations in human circulation
Carregosa, D., Pinto, C., Ávila‐Gálvez, M. Á., Bastos, P., Berry, D., & dos Santos, C. N. (2022) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13006 · Cited by 62
Extracts deriving from olive mill waste water and their effects on the liver of the goldfishCarassius auratusfed with hypercholesterolemic diet
Alesci, A., Cicero, N., Salvo, A., Palombieri, D., Zaccone, D., Dugo, G., Bruno, M., Vadalà, R., Lauriano, E. R., & Pergolizzi, S. (2014) · Natural Product Research · doi:10.1080/14786419.2014.903479 · Cited by 59
Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice
RASTOGI, S., Shukla, Y., PAUL, B., Chowdhuri, D. K., Khanna, S., & DAS, M. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.05.020 · Cited by 59
The effect of anthocyanin supplementation on body composition, exercise performance and muscle damage indices in athletes.
Askari, G., Ghiasvand, R., Paknahad, Z., Karimian, J., Rabiee, K., Gh.R., S., & Feizi, A. (2013) · Europe PMC (PubMed Central) · Cited by 57
Electrochemical Tools for Determination of Phenolic Compounds in Plants. A Review
Dobes, J., Zítka, O., Sochor, J., Ruttkay-Nedecký, B., Babula, P., Beklová, M., Kynický, J., Hubálek, J., Klejdus, B., Kizek, R., et al. (2013) · International Journal of Electrochemical Science · doi:10.1016/s1452-3981(23)14619-0 · Cited by 59
Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.)
Commisso, M., Bianconi, M., Carlo, F. D., Poletti, S., Bulgarini, A., Munari, F., Negri, S., Stocchero, M., Ceoldo, S., Avesani, L., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180889 · Cited by 59
Host–Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols
Anhê, F. F., Choi, B. S.-Y., Dyck, J. R. B., Schertzer, J. D., & Marette, A. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.04.002 · Cited by 60
“Since his initial discovery, a wealth of epidemiological studies has documented an inverse correlation between the intake of polyphenol-rich foods and the incidence of cardiometabolic diseases (see Glossary) and cancer [1].”
Background
Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats
Rodriguez-Mateos, A., Ishisaka, A., Mawatari, K., Vidal-Diez, A., Spencer, J. P. E., & Terao, J. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512003911 · Cited by 58
Phenolic Compounds in Rosaceae Fruit and Nut Crops
Ogah, O., Watkins, C. S., Ubi, B. E., & Oraguzie, N. C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf501574q · Cited by 59
Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications
Oh, Y. S. (2016) · Nutrients · doi:10.3390/nu8080472 · Cited by 59
“Luteolin (31,41,5,7-tetrahydroxyflavone) is a flavonoid present in many medicinal plants, as well as in some commonly-consumed fruits and vegetables, including green leafy spices, such as parsley, sweet peppers and celery [101].”
Background
Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats
Son, H.-Y., Lee, M.-S., Chang, E., Kim, S.-Y., Kang, B., Ko, H.-M., Kim, I.-H., Zhong, Q., Jo, Y.-H., Kim, C., et al. (2019) · Nutrients · doi:10.3390/nu11020244 · Cited by 58
“Plant polyphenols or flavonoid, rich in vegetables and fruits has been suggested to be the candidates for decreasing cardiovascular disease risk [13,14].”
Background
Ecology and Physiology of the Intestinal Tract
Blaut, M. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_192 · Cited by 57
“Purported beneficial effects include the protection against sex-hormone-dependent cancers and cardiovascular diseases (Arts and Hollman 2005).”
Background
Acerola and cashew apple as sources of antioxidants and dietary fibre
Rufino, M. D. S. M., Pérez‐Jiménez, J., Tabernero, M., Alves, R. E., de Brito, E. S., & Saura-Calixto, F. D. (2010) · International Journal of Food Science & Technology · doi:10.1111/j.1365-2621.2010.02394.x · Cited by 57
“In many studies, all these constituents have been related to the prevention of several chronic diseases, such as cardiovascular disease or certain cancers (Bingham et al., 2003; Arts & Hollman, 2005).”
Background
Protection of Dietary Polyphenols against Oral Cancer
Ding, Y., Yao, H., Yao, Y., Fai, L. Y., & Zhang, Z. (2013) · Nutrients · doi:10.3390/nu5062173 · Cited by 57
“The action of polyphenols has been investigated in various cancers including lung, skin, oral cavity, ovarian, esophagus, stomach, liver, pancreas, endometrial, thyroid, testicular bladder, small intestine, colon, urinary tract, and prostate [5,6].”
Background
Evaluation of spectrophotometric methods for antioxidant compound measurement in relation to total antioxidant capacity in beverages
Tabart, J., Kevers, C., Pincemail, J., Defraigne, J.-O., & Dommès, J. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.10.031 · Cited by 57
The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ)
Beekmann, K., Rubió, L., de Haan, L. H. J., Actis‐Goretta, L., van der Burg, B., van BLADEREN, P. J., & Rietjens, I. M. C. M. (2015) · Food & Function · doi:10.1039/c5fo00076a · Cited by 57
Phytochemical and antioxidant characterization of mamey (Pouteria sapota Jacq. H.E. Moore & Stearn) fruit
Yahia, E. M., Gutiérrez‐Orozco, F., & Leon, C. A.-D. (2010) · Food Research International · doi:10.1016/j.foodres.2010.11.029 · Cited by 58
“…the consumption of fruits and vegetables and the development of these disorders (Yahia and Ornelas-Paz, 2010; Ames, Shigenaga, & Hagen, 1993; Arts & Hollman, 2005; Dillard & German, 2000; Eastwood, 1999; Esterbauer, Dieber-Rotheneder, Striegl, & Waeg, 1991; Ness & Powles, 1997; Prior & Cao,…”
Polyphenol‐Rich Beverages Enhance Zinc Uptake and Metallothionein Expression in Caco‐2 Cells
Kilari, S., Pullakhandam, R., & Nair, K. M. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01582.x · Cited by 57
Anti-Inflammatory Activity of A Polyphenolic Extract from Arabidopsis thaliana in In Vitro and In Vivo Models of Alzheimer’s Disease
Mattioli, R., Francioso, A., D’Erme, M., Trovato, M., Mancini, P., Piacentini, L., Casale, A. M., Wessjohann, L. A., Gazzino, R., Costantino, P., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030708 · Cited by 58
Enterodiol and Enterolactone Modulate the Immune Response by Acting on Nuclear Factor-κB (NF-κB) Signaling
Corsini, E., Dell’Agli, M., Facchi, A., Fabiani, E. D., Lucchi, L., Boraso, M., Marinovich, M., & Galli, C. L. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100471n · Cited by 57
Multidimensional Comparative Analysis of Bioactive Phenolic Compounds of Honeys of Various Origin
Gośliński, M., Nowak, D., & Szwengiel, A. (2021) · Antioxidants · doi:10.3390/antiox10040530 · Cited by 56
Dietary Flavanols and Platelet Reactivity
Holt, R. R., Actis‐Goretta, L., Momma, T. Y., & Keen, C. L. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200606001-00014 · Cited by 56
“The consumption of diets rich in 1 widely distributed class of phytochemical, the flavonoids, has been inversely associated with cardiovascular disease risk in several epidemiologic studies.(3,4) It is reasonable to suggest that the inverse association observed between the consumption of flavonoid-rich foods and the r…”
Background
An assessment of dietary flavonoid intake in the UK and Ireland
Beking, K., & Vieira, A. V. (2010) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2010.511165 · Cited by 56
“(2004), Arts et al. (1999), Kamath et al. (2004), Holtekjolen et al. (2006), Trade Data and Analysis per-capita wine consumption (The Wine Institute, San Francisco, 2007), Kirin per-capita beer consumption (Tokyo, 2004), Adom and Liu (2002), Adom et al.”
Background
Protective effect of dry olive leaf extract in adrenaline induced DNA damage evaluated using in vitro comet assay with human peripheral leukocytes
Pirković, A., Živković, L., Žukovec, D., Djelić, N., Bajić, V., Dekanski, D., & Spremo‐Potparević, B. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.12.014 · Cited by 56
Alterations of Na+/K+-ATPase, cholinergic and antioxidant enzymes activity by protocatechuic acid in cadmium-induced neurotoxicity and oxidative stress in Wistar rats
Adefegha, S. A., Oboh, G., Omojokun, O. S., & Adefegha, O. M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.07.017 · Cited by 56
The role of nutraceuticals, functional foods and value added food products in the prevention and treatment of chronic diseases
Olaiya, C. O., Soetan, K. O., & Esan, A. M. (2016) · African Journal of Food Science · doi:10.5897/ajfs2015.1402 · Cited by 56
Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults
Larmo, P. S., Yang, B., Hurme, S. A. M., Alin, J., Kallio, H. P. T., Salminen, E. K., & Tahvonen, R. L. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0011-4 · Cited by 56
“Epidemiological studies suggest the beneficial effects of flavonoids on cardiovascular disease risks [2].”
Background
Photodegradation of (−)-epigallocatechin-3-gallate in topical cream formulations and its photostabilization
Bianchi, A., Marchetti, N., & Scalia, S. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2011.07.007 · Cited by 56
Natural Compounds Extracted from Medicinal Plants and Their Applications
Saboon, Chaudhari, S. K., Arshad, S., Amjad, M. S., & Akhtar, M. S. (2019) · Springer eBooks · doi:10.1007/978-981-13-7154-7_7 · Cited by 59
Comparative Study of Early- and Mid-Ripening Peach (Prunus persica L.) Varieties: Biological Activity, Macro-, and Micro- Nutrient Profile
Mihaylova, D. S., Popova, A. T., Desseva, I., Petkova, N. T., Stoyanova, M., Vrancheva, R., Slavov, A. M., Slavchev, A., & Lante, A. (2021) · Foods · doi:10.3390/foods10010164 · Cited by 55
“It has been widely reported that a menu rich in fruits and vegetables can reduce the risk of chronic disease such as cancer and cardiovascular disease [2,3].”
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Bread enriched with Chenopodium quinoa leaves powder – The procedures for assessing the fortification efficiency
Gawlik‐Dziki, U., Dziki, D., Świeca, M., Sęczyk, Ł., Różyło, R., & Szymanowska, U. (2015) · LWT · doi:10.1016/j.lwt.2015.02.007 · Cited by 55
Antioxidant properties and polyphenol contents of trembling aspen bark extracts
Diouf, P. N., Stevanović, T., & Cloutier, A. (2009) · Wood Science and Technology · doi:10.1007/s00226-009-0240-y · Cited by 55
“The interest for polyphenols is ever growing especially due to the beneficial health effects that are attributed to several classes of polyphenols (Arts and Hollman 2005).”
Background
Extractability of polyphenols from black currant, red currant and gooseberry and their antioxidant activity
Zöld, E. L., Komlósi, A., Ülkei, T., Fogarasi, E., Croitoru, M., FÜLÖP, I. Z., Domokos, E., Ștefănescu, R., & Varga, E. (2018) · Acta Biologica Hungarica · doi:10.1556/018.69.2018.2.5 · Cited by 55
“Acta Biologica Hungarica 69, 2018 Epidemiological studies suggest that a polyphenol rich diet may provide protection against coronary heart disease [1, 8, 14] and lung cancer [15].”
Background
Disponibilidade de polifenóis em frutas e hortaliças consumidas no Brasil
Faller, A. L. K., & Fialho, E. (2009) · Revista de Saúde Pública · doi:10.1590/s0034-89102009005000010 · Cited by 80
Mathematical modeling of nutritional, color, texture, and microbial activity changes in fruit and vegetables during drying: A critical review
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“Polyphenol-rich foods such as fruits and fruits juices are capable of preventing various diseases and have been considered with much attention in recent time (Arts and Hollman 2005; Scalbert, Johnson, and Saltmarsh 2005).”
Background
Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review
Drețcanu, G., Ştirbu, I., Leoplold, N., Cruceriu, D., Danciu, C., Stănilă, A., Fărcaș, A. C., Borda, I. M., Iuhas, C. I., & Diaconeasa, Z. M. (2022) · Plants · doi:10.3390/plants11091117 · Cited by 54
“Polyphenols are a group of phytochemical substances, characterized by the presence of more than one phenol group per molecule [5].”
Background
Effect of nitrogen fertilisation and irrigation on phenolic content, phenolic acid composition, and antioxidant activity of winter wheat grain
Ma, D., Sun, D., Li, Y., Wang, C., Xie, Y., & Guo, T. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6790 · Cited by 54
Comprehensive two-dimensional liquid chromatography in the analysis of antioxidant phenolic compounds in wines and juices
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Authors: Arts, I. C., & Hollman, P. C.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Arts, Ilja CW
ORCID: Arts, Ilja CW
Hollman, Peter CH
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-01
Volume: 81
Issue: 1
Pages: 317S-325S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/81.1.317s
OpenAlex: W2129133439
Cited by: 1,916
References: 74
Citations by year: 2026: 20 · 2025: 37 · 2024: 72 · 2023: 55 · 2022: 66 · 2021: 82 · 2020: 77 · 2019: 106 · 2018: 107 · 2017: 103 · 2016: 130 · 2015: 119 · 2014: 138 · 2013: 132 · 2012: 114
FWCI: 6.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6628 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: ZonMw
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: plant polyphenols, flavonoids, flavonols, flavones, catechins, lignans, cardiovascular disease, cancer risk, lung cancer, stroke, asthma, chronic obstructive pulmonary disease, dietary exposure assessment, residual confounding, prospective study design
MeSH terms: Adult, Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Epidemiologic Methods, Female, Flavonoids, Humans, Male, Neoplasms, Phenols, Prospective Studies, Risk Factors, Polyphenols

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Polyphenols and disease risk in epidemiologic studies

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