Cited by 514Regulation of Appetite and ObesityBody Composition Measurement TechniquesThyroid Disorders and Treatments

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Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine

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Johnstone, Alexandra M, Murison, Sandra D, Duncan, Jackie S, Rance, Kellie A, Speakman, John R·2005·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/82.5.941

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Abstract

Background Basal metabolic rate (BMR) is the largest component of daily energy demand in Western societies. Previous studies indicated that BMR is highly variable, but the cause of this variation is disputed. All studies agree that variation in fat-free mass (FFM) plays a major role, but effects of fat mass (FM), age, sex, and the hormones leptin, triiodothyrionine (T3), and thyroxine (T4) remain uncertain.Objective We partitioned the variance in BMR into within- and between-subject effects and explored the roles of FFM, FM, bone mineral content, sex, age, and circulating concentrations of plasma leptin, T3, and T4.Design This was a cross-sectional study of 150 white adults from northeast Scotland, United Kingdom.Results Only 2% of the observed variability in BMR was attributable to within-subject effects, of which 0.5% was analytic error. Of the remaining variance, which reflected between-subject effects, 63% was explained by FFM, 6% by FM, and 2% by age. The effects of sex and bone mineral content were not significant (P > 0.05). Twenty-six percent of the variance remained unexplained. This variation was not associated with concentrations of circulating leptin or T3. T4 was not significant in women but explained 25% of the residual variance in men.Conclusions Our data confirm that both FFM and FM are significant contributors to BMR. When the effect of FM on BMR is removed, any association with leptin concentrations disappears, which suggests that previous links between circulating leptin concentrations and BMR occurred only because of inadequate control for the effects of FM.

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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Predicting basal metabolic rate, new standards and review of previous work.
Wn, S. (1985) · PubMed · Cited by 2,955
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Energy and protein requirements*
Pacey, A., & Payne, P. (2019) · Routledge eBooks · doi:10.4324/9780429036279-4 · Cited by 2,545
Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain
Ravussin, E., Lillioja, S., Knowler, W. C., Christin, L., Freymond, D., Abbott, W. G. H., Boyce, V., Howard, B. V., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802253180802 · Cited by 1,215
Body size and tissue respiration
Krebs, H. A. (1950) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(50)90032-1 · Cited by 810
On body size and tissue respiration
Davies, M. (1961) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030570302 · Cited by 764
Untitled work
(1996) · PubMed · Cited by 705

Show all 65 references

Research works printed but not linked: 1

Scrimshaw, 1996, Proceedings of an IDECG Workshop 31 October to 4 November 1994, Eur J Clin Nutr, 50, S1

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Authors: Johnstone, A. M., Murison, S. D., Duncan, J. S., Rance, K. A., & Speakman, J. R.
Affiliations: University of Aberdeen (GB)
Corresponding author: Johnstone, Alexandra M
ORCID: Johnstone, Alexandra M
Speakman, John R
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2005-11
Volume: 82
Issue: 5
Pages: 941-948
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/82.5.941
OpenAlex: W2132499198
Cited by: 514
References: 65
Citations by year: 2026: 23 · 2025: 30 · 2024: 27 · 2023: 29 · 2022: 60 · 2021: 36 · 2020: 30 · 2019: 27 · 2018: 18 · 2017: 28 · 2016: 27 · 2015: 36 · 2014: 21 · 2013: 23 · 2012: 21
FWCI: 3.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6333 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords: basal metabolic rate, fat-free mass, fat mass, age, sex differences, bone mineral content, thyroxine, triiodothyronine, leptin, daily energy expenditure
MeSH terms: Adipose Tissue, Adult, Age Factors, Basal Metabolism, Body Composition, Body Constitution, Calorimetry, Indirect, Cross-Sectional Studies, Humans, Male, Middle Aged, Oxygen Consumption, Scotland, Sex Factors, Thyroxine, Triiodothyronine, Absorptiometry, Photon, Muscle, Skeletal, Leptin

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Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine

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