CoChat
Sign Up
Cited by 90Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

Role of protein and amino acids in promoting lean mass accretion with resistance exercise and attenuating lean mass loss during energy deficit in humans

Churchward-Venne, Tyler A., Murphy, Caoileann H., Longland, Thomas M., Phillips, Stuart M.·2013·Amino Acids
DOI 10.1007/s00726-013-1506-0
Open this paper in CoChat — free account

Abstract

Amino acids are major nutrient regulators of muscle protein turnover. After protein ingestion, hyperaminoacidemia stimulates increased rates of skeletal muscle protein synthesis, suppresses muscle protein breakdown, and promotes net muscle protein accretion for several hours. These acute observations form the basis for strategized protein intake to promote lean mass accretion, or prevent lean mass loss over the long term. However, factors such as protein dose, protein source, and timing of intake are important in mediating the anabolic effects of amino acids on skeletal muscle and must be considered within the context of evaluating the reported efficacy of long-term studies investigating protein supplementation as part of a dietary strategy to promote lean mass accretion and/or prevent lean mass loss. Current research suggests that dietary protein supplementation can augment resistance exercise-mediated gains in skeletal muscle mass and strength and can preserve skeletal muscle mass during periods of diet-induced energy restriction. Perhaps less appreciated, protein supplementation can augment resistance training-mediated gains in skeletal muscle mass even in individuals habitually consuming 'adequate' (i.e., >0.8 g kg⁻¹ day⁻¹) protein. Additionally, overfeeding energy with moderate to high-protein intake (15-25 % protein or 1.8-3.0 g kg⁻¹ day⁻¹) is associated with lean, but not fat mass accretion, when compared to overfeeding energy with low protein intake (5 % protein or ~0.68 g kg⁻¹ day⁻¹). Amino acids represent primary nutrient regulators of skeletal muscle anabolism, capable of enhancing lean mass accretion with resistance exercise and attenuating the loss of lean mass during periods of energy deficit, although factors such as protein dose, protein source, and timing of intake are likely important in mediating these effects.

Integrity signals

Registry

Crossref · 10.1007/s00726-013-1506-0

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Protein consumption directly after resistance exercise is an effective way to acutely promote a positive muscle protein balance.

    “It is widely reported that protein consumption directly after resistance exercise is an effective way to acutely promote a positive muscle protein balance [31, 55, 67], which if repeated over time should translate into a net gain or hypertrophy of muscle [68].”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [67]

  • Rates of myofibrillar protein synthesis were optimized throughout the day of recovery by the consumption of 20 g protein every three hours compared to large (2 × 40 g), less frequent servings or smaller but more frequent (8 × 10 g) patterns of protein intake.

    “the rates of myofibrillar protein synthesis were optimized throughout the day of recovery by the consumption of 20 g protein every three hours compared to large (2 × 40 g), less frequent servings or smaller but more frequent (8 × 10 g) patterns of protein intake [67].”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [67]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Churchward-Venne, T. A., Murphy, C. H., Longland, T. M., & Phillips, S. M.
Affiliations
McMaster University (CA)
Corresponding author
Phillips, Stuart M.
ORCID
Venue
Amino Acids
Publisher
Springer Science and Business Media LLC
Published
2013-05-05
Volume
45
Issue
2
Pages
231-240
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
DOI
10.1007/s00726-013-1506-0
OpenAlex
W1970978609
Cited by
90
References
25
Citations by year
2026: 5 · 2025: 6 · 2024: 8 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 6 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 15 · 2013: 1
FWCI
6.38
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
protein supplementation, lean mass loss, resistance training, negative energy balance, caloric restriction, muscle protein turnover, skeletal muscle anabolism, protein dose, protein sources, overfeeding, muscle strength
MeSH terms
Amino Acids, Diet, Dietary Proteins, Eating, Humans, Muscle Proteins, Thinness, Weight Loss, Muscle, Skeletal, Dietary Supplements, Caloric Restriction, Resistance Training

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review