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Do children really recover better? Neurobehavioural plasticity after early brain insult
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Plasticity is an intrinsic property of the central nervous system, reflecting its capacity to respond in a dynamic manner to the environment and experience via modification of neural circuitry. In the context of healthy development, plasticity is considered beneficial, facilitating adaptive change in response to environmental stimuli and enrichment, with research documenting establishment of new neural connections and modification to the mapping between neural activity and behaviour. Less is known about the impact of this plasticity in the context of the young, injured brain. This review seeks to explore plasticity processes in the context of early brain insult, taking into account historical perspectives and building on recent advances in knowledge regarding ongoing development and recovery following early brain insult, with a major emphasis on neurobehavioural domains. We were particularly interested to explore the way in which plasticity processes respond to early brain insult, the implications for functional recovery and how this literature contributes to the debate between localization of brain function and neural network models. To this end we have provided an overview of normal brain development, followed by a description of the biological mechanisms associated with the most common childhood brain insults, in order to explore an evidence base for considering the competing theoretical perspectives of early plasticity and early vulnerability. We then detail these theories and the way in which they contribute to our understanding of the consequences of early brain insult. Finally, we examine evidence that considers key factors (e.g. insult severity, age at insult, environment) that may act, either independently or synergistically, to influence recovery processes and ultimate outcome. We conclude that neither plasticity nor vulnerability theories are able to explain the range of functional outcomes from early brain insult. Rather, they represent extremes along a 'recovery continuum'. Where a child's outcome falls along this continuum depends on injury factors (severity, nature, age) and environmental influences (family, sociodemographic factors, interventions).
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“TBI during these critical developmental stages can have lasting negative impacts on cognitive abilities, learning, language acquisition, social development, and overall psychosocial functioning (Anderson et al., 2011; Beauchamp & Anderson, 2010; Catroppa & Anderson, 2005; Crowe et al., 2012, 2014; Ryan, 2017).”
From Psychosocial outcomes in young adults with childhood traumatic brain injury: A 20‐year follow‐up study (2026) · cites this paper as Anderson et al., 2011
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“, 2013), in particular at early stages of the disorder, in young people, where it is likely to be most effective (Anderson et al., 2011).”
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Metadata
- Authors
- Anderson, V., Spencer-Smith, M., & Wood, A.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-07-22
- Volume
- 134
- Issue
- 8
- Pages
- 2197-2221
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2102622410
- Cited by
- 584
- References
- 22
- FWCI
- 19.67
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.