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Cited by 397

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI

McCarthy, Gregory, Puce, Aina, Constable, Todd, Krystal, John H., Gore, John C., Goldman-Rakic, Patricia·1996·Cerebral Cortex
DOI 10.1093/cercor/6.4.600
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Abstract

Separate working memory domains for spatial location, and for objects, faces, and patterns, have been identified in the prefrontal cortex (PFC) of nonhuman primates. We have used functional magnetic resonance imaging to examine whether spatial and nonspatial visual working memory processes are similarly dissociable in human PFC. Subjects performed tasks which required them to remember either the location or shape of successive visual stimuli. We found that the mnemonic component of the working memory tasks affected the hemispheric pattern of PFC activation. The spatial (LOCATION) working memory task preferentially activated the middle frontal gyrus (MFG) in the right hemisphere, while the nonspatial (SHAPE) working memory task activated the MFG in both hemispheres. Furthermore, the area of activation in the left hemisphere extended into the inferior frontal gyrus for nonspatial SHAPE task. A perceptual target (DOT) detection task also activated the MFG bilaterally, but at a level approximately half that of the working memory tasks. The activation in the MFG occurred within 3-6 s of task onset and declined following task offset. Time-course analysis revealed a different pattern for cingulate gyrus, in which activation occurred upon task completion. Cingulate gyrus activation was greatest following the SHAPE task and was greater in the left hemisphere. The present results support the prominent role of the PFC and, specifically, the MFG in working memory, and indicate that the mnemonic content of the task affects the relative weighting of hemispheric activation.

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Metadata

Authors
McCarthy, G., Puce, A., Constable, T., Krystal, J. H., Gore, J. C., & Goldman-Rakic, P.
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
1996
Volume
6
Issue
4
Pages
600-611
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/6.4.600
OpenAlex
W2073147266
Cited by
397
References
6
FWCI
13.26
Type
journal article
Language
en
Open access
closed

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