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Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Open accessAbstract
Brain aging research relies mostly on cross-sectional studies, which infer true changes from age differences. We present longitudinal measures of five-year change in the regional brain volumes in healthy adults. Average and individual differences in volume changes and the effects of age, sex and hypertension were assessed with latent difference score modeling. The caudate, the cerebellum, the hippocampus and the association cortices shrunk substantially. There was minimal change in the entorhinal and none in the primary visual cortex. Longitudinal measures of shrinkage exceeded cross-sectional estimates. All regions except the inferior parietal lobule showed individual differences in change. Shrinkage of the cerebellum decreased from young to middle adulthood, and increased from middle adulthood to old age. Shrinkage of the hippocampus, the entorhinal cortices, the inferior temporal cortex and the prefrontal white matter increased with age. Moreover, shrinkage in the hippocampus and the cerebellum accelerated with age. In the hippocampus, both linear and quadratic trends in incremental age-related shrinkage were limited to the hypertensive participants. Individual differences in shrinkage correlated across some regions, suggesting common causes. No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment.
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“Possibly, at some level, the burden of pathology becomes great enough to overcome this protective mechanism, resulting in rapid cognitive decline31,53.”
From Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing (2018) · cites this paper as [53]
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“Because longitudinal studies show that posterior association regions, e.g., inferior parietal lobule, are just as sensitive to aging as prefrontal regions (Raz et al., 2005)”
From Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed (2009) · cites this paper as Raz et al., 2005
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“Most have revealed prominent GM loss in prefrontal regions [40,59,65,71,76] with smaller but significant decline in other regions, notably in mesial temporal areas.”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [65]
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“Although a longitudinal PET-MR combined study would obviously be of considerable interest, the advantage of this approach relative to cross-sectional designs has been occasionally [40,65], but not consistently [27,75], shown.”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [65]
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Metadata
- Authors
- Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D.
- Affiliations
- Wayne State University (US)
- Max Planck Society (DE)
- University of Washington (US)
- University of Memphis (US)
- Baptist Memorial Hospital (US)
- Corresponding author
- Raz, Naftali
- ORCID
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-09
- Volume
- 15
- Issue
- 11
- Pages
- 1676-1689
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2103069600
- Cited by
- 2,875
- References
- 61
- Citations by year
- 2026: 90 · 2025: 115 · 2024: 138 · 2023: 108 · 2022: 144 · 2021: 198 · 2020: 171 · 2019: 188 · 2018: 170 · 2017: 192 · 2016: 171 · 2015: 172 · 2014: 174 · 2013: 163 · 2012: 139
- FWCI
- 35.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wayne State University
- National Institute on Aging (AG-11230)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- brain aging, individual differences, hippocampus, cerebellum, caudate nucleus, entorhinal cortex, inferior parietal lobule, hypertension, sex differences, educational attainment, neuroprotection, healthy older adults
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Body Constitution, Brain, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Sensitivity and Specificity, Sex Factors, Reproducibility of Results, Imaging, Three-Dimensional
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