A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time
Open accessAbstract
Voxel-based morphometry (VBM) was used to examine the relation between age and gray matter density cross-sectionally and to study the association between gray matter density and longitudinal decline in performance on cognitive tests in healthy, non-demented elderly individuals. Participants were neuropsychologically tested at baseline and again after 3 years. Thirty-seven subjects (mean age 72.5 years) who showed a decline in cognitive test performance at follow-up were compared with 38 individually matched control subjects (mean age 71.8 years) whose performance did not change over time. Magnetic resonance imaging scans were acquired at follow-up and individual differences in regional gray matter density were examined with VBM. The largest age effects were found in various regions in the prefrontal cortex, the (medial) temporal lobes and the striate cortex. Longitudinal cognitive decline was associated with decreased gray matter density in prefrontal areas, the (medial) temporal lobes and the posterior parietal cortex. These findings suggest that prefrontal and temporal cortical regions are of particular relevance both in aging and age-related cognitive decline in healthy elderly individuals.
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Studies using ROI or VBM have yielded contradictory results regarding whether the hippocampus is preserved or deteriorates with aging.
“In spite of the objectivity of this method, studies led to somewhat contradictory results regarding the hippocampus: some authors have found this structure to be preserved with aging [29,31], whereas others have reported structural deterioration [38,81,84,87].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [81]
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- Authors
- Tisserand, D. J.
- Affiliations
- Baycrest Centre for Geriatric Care (CA)
- Corresponding author
- Tisserand, D. J.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-04-27
- Volume
- 14
- Issue
- 9
- Pages
- 966-973
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2105250545
- Cited by
- 271
- References
- 62
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 14 · 2018: 16 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 15 · 2013: 14 · 2012: 15
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- gray matter density, brain aging, age-related cognitive decline, healthy older adults, prefrontal cortex, medial temporal lobe, posterior parietal cortex, longitudinal cognitive change, individual differences, neuroimaging of aging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Cerebral Cortex, Cognition, Female, Humans, Individuality, Magnetic Resonance Imaging, Male, Middle Aged, Time Factors, Chi-Square Distribution, Linear Models, Statistics, Nonparametric
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