Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice
Open accessAbstract
The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composition and proteolysis in a well-established model of experience-dependent plasticity in the visual cortex. We describe a rapid change in ECM protein composition during Ocular Dominance Plasticity (ODP) in adolescent mice, and a loss of ECM remodeling in mice that lack the extracellular protease, matrix metalloproteinase-9 (MMP9). Loss of MMP9 also attenuated functional ODP following monocular deprivation (MD) and reduced excitatory synapse density and spine density in sensory cortex. While we observed no change in the morphology of existing dendritic spines, spine dynamics were altered, and MMP9 knock-out (KO) mice showed increased turnover of dendritic spines over a period of 2 days. We also analyzed the effects of MMP9 loss on microglia, as these cells are involved in extracellular remodeling and have been recently shown to be important for synaptic plasticity. MMP9 KO mice exhibited very limited changes in microglial morphology. Ultrastructural analysis, however, showed that the extracellular space surrounding microglia was increased, with concomitant increases in microglial inclusions, suggesting possible changes in microglial function in the absence of MMP9. Taken together, our results show that MMP9 contributes to ECM degradation, synaptic dynamics and sensory-evoked plasticity in the mouse visual cortex.
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In Mmp9−/− mice, there is no increase in the strength of the non-deprived input following monocular deprivation.
“However, we did not observe an increase in the strength of the non-deprived input in Mmp9−/− mice, consistent with previous reports (Spolidoro et al., 2012; Kelly et al., 2015; Pielecka-Fortuna et al., 2015)”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Kelly et al., 2015
RS neurons in Mmp9−/− visual cortex have elevated excitability and reduced dendritic spine density.
“However, RS neurons in Mmp9−/− visual cortex have elevated excitability and reduced dendritic spine density, as previously reported (Murase et al., 2016; Kelly et al., 2015).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Kelly et al., 2015
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Preparation of Mouse Brain Tissue for Immunoelectron Microscopy
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Self-citationKaliszewska, A., Bijata, M., Kaczmarek, L., & Kossut, M. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr303 · Cited by 55 · see citing works
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Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus
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α-Actinin-dependent cytoskeletal anchorage is important for ICAM-5-mediated neuritic outgrowth
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Differences in lesion-induced hippocampal plasticity between mice and rats
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Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice
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Self-citationEphA4 is localized in clathrin‐coated and synaptic vesicles in adult mouse brain
Bouvier, D. S., Tremblay, M., Riad, M., Corera, A. T., Gingras, D., Horn, K. E., Fotouhi, M., Girard, M., Murai, K. K., Kennedy, T. E., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06582.x · Cited by 19 · see citing works
Critical period for the whisker-barrel system
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Postsynaptic Deregulation in GAP-43 Heterozygous Mouse Barrel Cortex
Kelly, E. A., Tremblay, M., McCasland, J. S., & Majewska, A. K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp231 · Cited by 8 · see citing works
Self-citationLoss of Prestin Does Not Alter the Development of Auditory Cortical Dendritic Spines
Bogart, L. J., Levy, A. D., Gladstone, M. B., Allen, P. D., Zettel, M. L., Ison, J. R., Luebke, A. E., & Majewska, A. K. (2011) · Neural Plasticity · doi:10.1155/2011/305621 · Cited by 5 · see citing works
Self-citation
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- Authors
- Kelly, E. A., Russo, A. S., Jackson, C. D., Lamantia, C. E., & Majewska, A. K.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Majewska, Ania K.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-09-22
- Volume
- 9
- Pages
- 369-369
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4585116
- OpenAlex
- W1918225643
- Cited by
- 48
- References
- 110
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Eye Institute (EY019277, P30EY001319)
- National Institute of Environmental Health Sciences (T32 ES 7026-34)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- MMP-9, extracellular matrix, synaptic plasticity, ocular dominance plasticity, monocular deprivation, primary visual cortex, dendritic spines, microglia, experience-dependent plasticity, proteolysis, excitatory synapses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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