Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations
Alexander, Barbara D., Johnson, Melissa D., Pfeiffer, Christopher D., Jiménez-Ortigosa, Cristina, Catania, Jelena, Booker, Rachel, Castanheira, Mariana, Messer, Shawn A. +2 more·2013·Clinical Infectious Diseases
Cited by (133)
Items 101–133 of 133
- Antifungal resistance to fluconazole and echinocandins is not emerging in yeast isolates causing fungemia in a Spanish tertiary care center.Marcos-Zambrano, Laura Judith, Escribano, Pilar, Sánchez, Carlos, Muñoz, Patricia, Bouza, Emilio, Guinea, Jesús · 2014 · Antimicrobial Agents and Chemotherapy
- Set of Classical PCRs for Detection of Mutations in
<i>Candida glabrata FKS</i>
Genes Linked with Echinocandin ResistanceDudiuk, Catiana, Gamarra, Soledad, Leonardeli, Florencia, Jimenez-Ortigosa, Cristina, Vitale, Roxana G., Afeltra, Javier, Perlin, David S., Garcia-Effron, Guillermo · 2014 · Journal of Clinical Microbiology
- We can do better: a fresh look at echinocandin dosingBader, Justin C, Bhavnani, Sujata M, Andes, David R, Ambrose, Paul G · 2018 · Journal of Antimicrobial Chemotherapy
- The novel oral glucan synthase inhibitor SCY-078 shows in vitro activity against sessile and planktonic Candida sppMarcos-Zambrano, Laura Judith, Gómez-Perosanz, Marta, Escribano, Pilar, Bouza, Emilio, Guinea, Jesús · 2017 · Journal of Antimicrobial Chemotherapy
- Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrataWiederhold, Nathan P, Najvar, Laura K, Jaramillo, Rosie, Olivo, Marcos, Pizzini, Jason, Catano, Gabriel, Patterson, Thomas F · 2018 · Journal of Antimicrobial Chemotherapy
- Novel
<i>FKS1</i>
and
<i>FKS2</i>
modifications in a high-level echinocandin resistant clinical isolate of
<i>Candida glabrata</i>Hou, Xin, Healey, Kelley R., Shor, Erika, Kordalewska, Milena, Ortigosa, Cristina Jiménez, Paderu, Padmaja, Xiao, Meng, Wang, He, Zhao, Ying, Lin, Li-Yan et al. · 2019 · Emerging Microbes & Infections
- Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?Kuchler, Karl, Jenull, Sabrina, Shivarathri, Raju, Chauhan, Neeraj · 2016 · PLOS Pathogens
- Antifungal susceptibility testing in Candida, Aspergillus and Cryptococcus infections: are the MICs useful for clinicians?Bassetti, M., Vena, A., Bouza, E., Peghin, M., Muñoz, P., Righi, E., Pea, F., Lackner, M., Lass-Flörl, C. · 2020 · Clinical Microbiology and Infection
- Review of T-2307, an Investigational Agent That Causes Collapse of Fungal Mitochondrial Membrane PotentialWiederhold, Nathan P. · 2021 · Journal of Fungi
- Antifungals in Clinical Use and the PipelineJohnson, Melissa D. · 2021 · Infectious Disease Clinics of North America
- CD101, a novel echinocandin, possesses potent antibiofilm activity against early and mature Candida albicans biofilmsChandra, Jyotsna, Ghannoum, Mahmoud A. · 2018 · Antimicrobial Agents and Chemotherapy
- Critical Assessment of Cell Wall Integrity Factors Contributing to in vivo Echinocandin Tolerance and Resistance in Candida glabrataGarcia-Rubio, Rocio, Hernandez, Rosa Y., Clear, Alissa, Healey, Kelley R., Shor, Erika, Perlin, David S. · 2021 · Frontiers in Microbiology
- Comparative Genomics of Serial
<i>Candida glabrata</i>
Isolates and the Rapid Acquisition of Echinocandin Resistance during TherapyBarber, Amelia E., Weber, Michael, Kaerger, Kerstin, Linde, Jörg, Gölz, Hanna, Duerschmied, Daniel, Markert, Antonie, Guthke, Reinhard, Walther, Grit, Kurzai, Oliver · 2019 · Antimicrobial Agents and Chemotherapy
- Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant CellsGarcia-Rubio, Rocio, Jimenez-Ortigosa, Cristina, DeGregorio, Lucius, Quinteros, Christopher, Shor, Erika, Perlin, David S. · 2021 · mBio
- <i>Candida glabrata</i>
: new tools and technologies—expanding the toolkitHo, Hsueh-lui, Haynes, Ken · 2015 · FEMS Yeast Research
- Biofilm production and antibiofilm activity of echinocandins and liposomal amphotericin B in echinocandin-resistant yeast speciesMarcos-Zambrano, Laura Judith, Gómez-Perosanz, Marta, Escribano, Pilar, Zaragoza, Oscar, Bouza, Emilio, Guinea, Jesús · 2016 · Antimicrobial Agents and Chemotherapy
- Attenuating the emergence of anti-fungal drug resistance by harnessing synthetic lethal interactions in a model organismUsher, Jane, Haynes, Ken · 2019 · PLOS Genetics
- Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1Healey, Kelley R., Paderu, Padmaja, Hou, Xin, Jimenez Ortigosa, Cristina, Bagley, Nicole, Patel, Biren, Zhao, Yanan, Perlin, David S. · 2020 · Journal of Fungi
- A Novel, Drug Resistance-Independent, Fluorescence-Based Approach To Measure Mutation Rates in Microbial PathogensShor, Erika, Schuyler, Jessica, Perlin, David S. · 2019 · mBio
- Treatment practices for adults with candidemia at 9 active surveillance sites—United States, 2017–2018.Gold, Jeremy A W, Seagle, Emma E, Nadle, Joelle, Barter, Devra M, Czaja, Christopher A, Johnston, Helen, Farley, Monica M, Thomas, Stepy, Harrison, Lee H, Fischer, Jill et al. · 2021 · Clinical Infectious Diseases
- Echinocandin resistance among Candida isolates at an academic medical centre 2005–15: analysis of trends and outcomesMcCarty, Todd P, Lockhart, Shawn R, Moser, Stephen A, Whiddon, Jennifer, Zurko, Joanna, Pham, Cau D, Pappas, Peter G · 2018 · Journal of Antimicrobial Chemotherapy
- Epidemiology and risk factors for invasive fungal disease in liver transplant recipients in a tertiary transplant centerLum, Lionel, Lee, Andie, Vu, Monica, Strasser, Simone, Davis, Rebecca · 2020 · Transplant Infectious Disease
- Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant<i>Candida glabrata</i>Ceballos-Garzon, Andres, Monteoliva, Lucia, Gil, Concha, Alvarez-Moreno, Carlos, Vega-Vela, Nelson E, Engelthaler, David M, Bowers, Jolene, Le Pape, Patrice, Parra-Giraldo, Claudia M · 2022 · Journal of Antimicrobial Chemotherapy
- Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus
<i>Candida glabrata</i>Arastehfar, Amir, Daneshnia, Farnaz, Floyd, Daniel J., Jeffries, Nathan Elias, Salehi, Mostafa, Perlin, David S., Ilkit, Macit, Lass-Flöerl, Cornelia, Mansour, Michael K. · 2024 · mBio
- Enhanced Efflux Pump Activity in Old Candida glabrata CellsBhattacharya, Somanon, Fries, Bettina C. · 2018 · Antimicrobial Agents and Chemotherapy
- Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological MalignanciesSfeir, Maroun M., Jiménez-Ortigosa, Cristina, Gamaletsou, Maria N., Schuetz, Audrey N., Soave, Rosemary, Van Besien, Koen, Small, Catherine B., Perlin, David S., Walsh, Thomas J. · 2020 · Journal of Fungi
- Novel Sulfones with Antifungal Properties: Antifungal Activities and Interactions with Candida spp. Virulence FactorsGizińska, Małgorzata, Staniszewska, Monika, Ochal, Zbigniew · 2018 · Mini-Reviews in Medicinal Chemistry
- Treatment of invasive candidiasis: between guidelines and daily clinical practiceTagliaferri, Enrico, Menichetti, Francesco · 2015 · Expert Review of Anti-infective Therapy
- Echinocandins Susceptibility Patterns of 2,787 Yeast Isolates: Importance of the Thresholds for the Detection of FKS MutationsDesnos-Ollivier, Marie, Bretagne, Stéphane, Lortholary, Olivier, Dromer, Françoise, the French Mycoses Study Group N. Brieu CH Aix, T. Chouaki , C. Damiani , A. Totet CHU Amiens, J. P. Bouchara , D. Chabasse , M. Pihet CHU Angers, S. Bland CH Annecy, V. Blanc CH Antibes, S. Branger CH Avignon, A. P. Bellanger , L. Millon CHU Besançon, C. Plassart CH Beauvais, I. Poilane Hôpital Jean Verdier, Bondy, I. Accoceberry , L. Delhaes , B. Couprie , F. Gabriel CH Bordeaux, J. Dunand , A. L. Roux , V. Sivadon-Tardy Hôpital Ambroise Paré, Boulogne Billancourt, F. Laurent CH, Bourg en Bresse, S. Lega · 2022 · Antimicrobial Agents and Chemotherapy
- The impact of new epidemiological cutoff values on Candida glabrata resistance rates and concordance between testing methodsBen-Ami, Ronen, Hilerowicz, Yuval, Novikov, Anna, Giladi, Michael · 2014 · Diagnostic Microbiology and Infectious Disease
- Multidrug-resistant Candida glabrata strains obtained by induction of anidulafungin resistance in planktonic and biofilm cellsHatwig, Camila, Balbueno, Eduardo A., Bergamo, Vanessa Z., Pippi, Bruna, Fuentefria, Alexandre M., Silveira, Gustavo P. · 2019 · Brazilian Journal of Pharmaceutical Sciences
- Expression of 1,3-β-glucan synthase subunits in
<i>Candida glabrata</i>
is regulated by the cell cycle and growth conditions and at both transcriptional and post-transcriptional levelsGonzalez-Jimenez, Irene, Keniya, Mikhail V., Aptekmann, Ariel A., Quinteros, Christopher, Wilkerson, Alexis, Arastehfar, Amir, Daneshnia, Farnaz, Perlin, David S., Shor, Erika · 2025 · Antimicrobial Agents and Chemotherapy
- Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in
<i>Candida Glabrata</i>Su, Yanyu, Li, Yi, Xiao, Meng, Guo, Dan, Perlin, David S., Shor, Erika, Xu, Yingchun, Li, Yingxing · 2026 · Advanced Science