Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations

Alexander, Barbara D., Johnson, Melissa D., Pfeiffer, Christopher D., Jiménez-Ortigosa, Cristina, Catania, Jelena, Booker, Rachel, Castanheira, Mariana, Messer, Shawn A. +2 more·2013·Clinical Infectious Diseases

Cited by (133)

Items 101–133 of 133

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  2. Set of Classical PCRs for Detection of Mutations in <i>Candida glabrata FKS</i> Genes Linked with Echinocandin Resistance
    Dudiuk, Catiana, Gamarra, Soledad, Leonardeli, Florencia, Jimenez-Ortigosa, Cristina, Vitale, Roxana G., Afeltra, Javier, Perlin, David S., Garcia-Effron, Guillermo · 2014 · Journal of Clinical Microbiology
  3. We can do better: a fresh look at echinocandin dosing
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  4. The novel oral glucan synthase inhibitor SCY-078 shows in vitro activity against sessile and planktonic Candida spp
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  5. Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata
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  6. Novel <i>FKS1</i> and <i>FKS2</i> modifications in a high-level echinocandin resistant clinical isolate of <i>Candida glabrata</i>
    Hou, Xin, Healey, Kelley R., Shor, Erika, Kordalewska, Milena, Ortigosa, Cristina Jiménez, Paderu, Padmaja, Xiao, Meng, Wang, He, Zhao, Ying, Lin, Li-Yan et al. · 2019 · Emerging Microbes &amp; Infections
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    Kuchler, Karl, Jenull, Sabrina, Shivarathri, Raju, Chauhan, Neeraj · 2016 · PLOS Pathogens
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  10. Antifungals in Clinical Use and the Pipeline
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  11. CD101, a novel echinocandin, possesses potent antibiofilm activity against early and mature Candida albicans biofilms
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  12. Critical Assessment of Cell Wall Integrity Factors Contributing to in vivo Echinocandin Tolerance and Resistance in Candida glabrata
    Garcia-Rubio, Rocio, Hernandez, Rosa Y., Clear, Alissa, Healey, Kelley R., Shor, Erika, Perlin, David S. · 2021 · Frontiers in Microbiology
  13. Comparative Genomics of Serial <i>Candida glabrata</i> Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy
    Barber, Amelia E., Weber, Michael, Kaerger, Kerstin, Linde, Jörg, Gölz, Hanna, Duerschmied, Daniel, Markert, Antonie, Guthke, Reinhard, Walther, Grit, Kurzai, Oliver · 2019 · Antimicrobial Agents and Chemotherapy
  14. Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells
    Garcia-Rubio, Rocio, Jimenez-Ortigosa, Cristina, DeGregorio, Lucius, Quinteros, Christopher, Shor, Erika, Perlin, David S. · 2021 · mBio
  15. <i>Candida glabrata</i> : new tools and technologies—expanding the toolkit
    Ho, Hsueh-lui, Haynes, Ken · 2015 · FEMS Yeast Research
  16. Biofilm production and antibiofilm activity of echinocandins and liposomal amphotericin B in echinocandin-resistant yeast species
    Marcos-Zambrano, Laura Judith, Gómez-Perosanz, Marta, Escribano, Pilar, Zaragoza, Oscar, Bouza, Emilio, Guinea, Jesús · 2016 · Antimicrobial Agents and Chemotherapy
  17. Attenuating the emergence of anti-fungal drug resistance by harnessing synthetic lethal interactions in a model organism
    Usher, Jane, Haynes, Ken · 2019 · PLOS Genetics
  18. Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1
    Healey, Kelley R., Paderu, Padmaja, Hou, Xin, Jimenez Ortigosa, Cristina, Bagley, Nicole, Patel, Biren, Zhao, Yanan, Perlin, David S. · 2020 · Journal of Fungi
  19. A Novel, Drug Resistance-Independent, Fluorescence-Based Approach To Measure Mutation Rates in Microbial Pathogens
    Shor, Erika, Schuyler, Jessica, Perlin, David S. · 2019 · mBio
  20. Treatment practices for adults with candidemia at 9 active surveillance sites—United States, 2017–2018.
    Gold, Jeremy A W, Seagle, Emma E, Nadle, Joelle, Barter, Devra M, Czaja, Christopher A, Johnston, Helen, Farley, Monica M, Thomas, Stepy, Harrison, Lee H, Fischer, Jill et al. · 2021 · Clinical Infectious Diseases
  21. Echinocandin resistance among Candida isolates at an academic medical centre 2005–15: analysis of trends and outcomes
    McCarty, Todd P, Lockhart, Shawn R, Moser, Stephen A, Whiddon, Jennifer, Zurko, Joanna, Pham, Cau D, Pappas, Peter G · 2018 · Journal of Antimicrobial Chemotherapy
  22. Epidemiology and risk factors for invasive fungal disease in liver transplant recipients in a tertiary transplant center
    Lum, Lionel, Lee, Andie, Vu, Monica, Strasser, Simone, Davis, Rebecca · 2020 · Transplant Infectious Disease
  23. Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant<i>Candida glabrata</i>
    Ceballos-Garzon, Andres, Monteoliva, Lucia, Gil, Concha, Alvarez-Moreno, Carlos, Vega-Vela, Nelson E, Engelthaler, David M, Bowers, Jolene, Le Pape, Patrice, Parra-Giraldo, Claudia M · 2022 · Journal of Antimicrobial Chemotherapy
  24. Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus <i>Candida glabrata</i>
    Arastehfar, Amir, Daneshnia, Farnaz, Floyd, Daniel J., Jeffries, Nathan Elias, Salehi, Mostafa, Perlin, David S., Ilkit, Macit, Lass-Flöerl, Cornelia, Mansour, Michael K. · 2024 · mBio
  25. Enhanced Efflux Pump Activity in Old Candida glabrata Cells
    Bhattacharya, Somanon, Fries, Bettina C. · 2018 · Antimicrobial Agents and Chemotherapy
  26. Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies
    Sfeir, Maroun M., Jiménez-Ortigosa, Cristina, Gamaletsou, Maria N., Schuetz, Audrey N., Soave, Rosemary, Van Besien, Koen, Small, Catherine B., Perlin, David S., Walsh, Thomas J. · 2020 · Journal of Fungi
  27. Novel Sulfones with Antifungal Properties: Antifungal Activities and Interactions with Candida spp. Virulence Factors
    Gizińska, Małgorzata, Staniszewska, Monika, Ochal, Zbigniew · 2018 · Mini-Reviews in Medicinal Chemistry
  28. Treatment of invasive candidiasis: between guidelines and daily clinical practice
    Tagliaferri, Enrico, Menichetti, Francesco · 2015 · Expert Review of Anti-infective Therapy
  29. Echinocandins Susceptibility Patterns of 2,787 Yeast Isolates: Importance of the Thresholds for the Detection of FKS Mutations
    Desnos-Ollivier, Marie, Bretagne, Stéphane, Lortholary, Olivier, Dromer, Françoise, the French Mycoses Study Group N. Brieu CH Aix, T. Chouaki , C. Damiani , A. Totet CHU Amiens, J. P. Bouchara , D. Chabasse , M. Pihet CHU Angers, S. Bland CH Annecy, V. Blanc CH Antibes, S. Branger CH Avignon, A. P. Bellanger , L. Millon CHU Besançon, C. Plassart CH Beauvais, I. Poilane Hôpital Jean Verdier, Bondy, I. Accoceberry , L. Delhaes , B. Couprie , F. Gabriel CH Bordeaux, J. Dunand , A. L. Roux , V. Sivadon-Tardy Hôpital Ambroise Paré, Boulogne Billancourt, F. Laurent CH, Bourg en Bresse, S. Lega · 2022 · Antimicrobial Agents and Chemotherapy
  30. The impact of new epidemiological cutoff values on Candida glabrata resistance rates and concordance between testing methods
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  31. Multidrug-resistant Candida glabrata strains obtained by induction of anidulafungin resistance in planktonic and biofilm cells
    Hatwig, Camila, Balbueno, Eduardo A., Bergamo, Vanessa Z., Pippi, Bruna, Fuentefria, Alexandre M., Silveira, Gustavo P. · 2019 · Brazilian Journal of Pharmaceutical Sciences
  32. Expression of 1,3-β-glucan synthase subunits in <i>Candida glabrata</i> is regulated by the cell cycle and growth conditions and at both transcriptional and post-transcriptional levels
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  33. Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in <i>Candida Glabrata</i>
    Su, Yanyu, Li, Yi, Xiao, Meng, Guo, Dan, Perlin, David S., Shor, Erika, Xu, Yingchun, Li, Yingxing · 2026 · Advanced Science