Establishment and development of lactic acid bacteria and bifidobacteria microbiota in breast-milk and the infant gut
Abstract
The initial establishment of lactic acid bacteria (LAB) and bifidobacteria in the newborn and the role of breast-milk as a source of these microorganisms are not yet well understood. The establishment of these microorganisms during the first 3 months of life in 20 vaginally delivered breast-fed full-term infants, and the presence of viable Bifidobacterium in the corresponding breast-milk samples was evaluated. In 1 day-old newborns Enterococcus and Streptococcus were the microorganisms most frequently isolated, from 10 days of age until 3 months bifidobacteria become the predominant group. In breast-milk, Streptococcus was the genus most frequently isolated and Lactobacillus and Bifidobacterium were also obtained. Breast-milk contains viable lactobacilli and bifidobacteria that might contribute to the initial establishment of the microbiota in the newborn.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human milk harbors a unique microbial community, including commensal, mutualistic, and probiotic bacteria, some of which can be found as first colonizers of the neonatal gut.
“Human milk harbors a unique microbial community, including commensal, mutualistic, and probiotic bacteria, some of which can be found as first colonizers of the neonatal gut (258, 259).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [259]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232 · see citing works
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255 · see citing works
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859 · see citing works
Human milk is a source of lactic acid bacteria for the infant gut
Martín, R., Langa, S., Reviriego, C., Jimínez, E., Marín, M. L., Xaus, J., Fernández, L., & Rodríguez, J. M. (2003) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.09.028 · Cited by 792 · see citing works
Intestinal microflora in early infancy: composition and development
Fanaro, S., Chierici, R., Guerrini, P., & Vigi, V. (2003) · Acta Paediatrica · doi:10.1111/j.1651-2227.2003.tb00646.x · Cited by 738 · see citing works
Martı́n, R., Jiménez, E., Heilig, H. G. H. J., Fernández, L., Marín, M. L., Zoetendal, E. G., & Rodríguez, J. M. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02063-08 · Cited by 434 · see citing works
Breast Milk: A Source of Bifidobacteria for Infant Gut Development and Maturation?
Gueimonde, M., Laitinen, K., Salminen, S., & Isolauri, E. (2007) · Neonatology · doi:10.1159/000100088 · Cited by 273 · see citing works
Self-citationGueimonde, M., Delgado, S., Mayo, B., Ruas‐Madiedo, P., Margollés, A., & Reyes‐Gavilán, C. G. D. L. (2004) · Food Research International · doi:10.1016/j.foodres.2004.04.006 · Cited by 228 · see citing works
Self-citationStaphylococcus epidermidis: A differential trait of the fecal microbiota of breast-fed infants
Jiménez, E., Delgado, S., Maldonado‐Barragán, A., Arroyo, R., Albújar, M., García, N., Jariod, M., Fernández, L., Gómez, A., & Rodríguez, J. M. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-143 · Cited by 170 · see citing works
Genetic heterogeneity and functional properties of intestinal bifidobacteria
Mättö, J., Malinen, E., Suihko, M. ‐., Alander, M., Palva, A., & Saarela, M. (2004) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02340.x · Cited by 121 · see citing works
Fecal microflora of Greek healthy neonates
Mitsou, E. K., Kirtzalidou, E., Oikonomou, I., Liosis, G., & Kyriacou, A. (2007) · Anaerobe · doi:10.1016/j.anaerobe.2007.11.002 · Cited by 86 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [5][5] Martín R, Jiménez E, Heilig H, et al. Isolation of bifidobacteria from breast milk and 3 assessment of the bifidobacterial population by PCR-DGGE and qRTi-PCR. Appl Environ 4 Microbiol 2009;In press. 5
Cited by
Sorted by citations
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950 · see citing works
Self-citationThe first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182 · see citing works
Breast milk, a source of beneficial microbes and associated benefits for infant health
Lyons, K. E., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Nutrients · doi:10.3390/nu12041039 · Cited by 613 · see citing works
Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort
Hill, C. J., Lynch, D. B., Murphy, K., Ulaszewska, M., Jeffery, I. B., O’Shea, C. A., Watkins, C., Dempsey, E., Mattivi, F., Tuohy, K., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0213-y · Cited by 573 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Role of priority effects in the early-life assembly of the gut microbiota
Sprockett, D., Fukami, T., & Relman, D. A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.173 · Cited by 419 · see citing works
Rios-Covian, D., Gueimonde, M., Duncan, S. H., Flint, H. J., & de los Reyes-Gavilan, C. G. (2015) · FEMS Microbiology Letters · doi:10.1093/femsle/fnv176 · Cited by 371 · see citing works
Self-citationHuman milk: a source of more life than we imagine
Jeurink, P. V., van Bergenhenegouwen, J., Jiménez, E., Knippels, L. M. J., Fernández, L., Garssen, J., Knol, J., Rodríguez, J. M., & Martín, R. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0040 · Cited by 354 · see citing works
Sources, isolation, characterisation and evaluation of probiotics
Fontana, L., Bermudez-Brito, M., Plaza-Diaz, J., Muñoz-Quezada, S., & Gil, A. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512004011 · Cited by 348 · see citing works
Jost, T., Lacroix, C., Braegger, C., & Chassard, C. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu016 · Cited by 267 · see citing works
Irritable bowel syndrome, the microbiota and the gut-brain axis
Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243 · see citing works
Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients
de Steenhuijsen Piters, W. A. A., Huijskens, E. G. W., Wyllie, A. L., Biesbroek, G., van den Bergh, M. R., Veenhoven, R. H., Wang, X., Trzciński, K., Bonten, M. J., Rossen, J. W. A., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.99 · Cited by 235 · see citing works
A molecular basis for bifidobacterial enrichment in the infant gastrointestinal tract
Garrido, D., Barile, D., & Mills, D. A. (2012) · Advances in Nutrition · doi:10.3945/an.111.001586 · Cited by 149 · see citing works
Arboleya, S., Ruas-Madiedo, P., Margolles, A., Solís, G., Salminen, S., de los Reyes-Gavilán, C. G., & Gueimonde, M. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.10.036 · Cited by 139 · see citing works
Evaluation of probiotic properties of Lactobacillus plantarum WLPL04 isolated from human breast milk
Jiang, M., Zhang, F., Wan, C., Xiong, Y., Shah, N. P., Wei, H., & Tao, X. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10434 · Cited by 125 · see citing works
Immune Development and Intestinal Microbiota in Celiac Disease
Pozo-Rubio, T., Olivares, M., Nova, E., De Palma, G., Mujico, J. R., Ferrer, M. D., Marcos, A., & Sanz, Y. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/654143 · Cited by 82 · see citing works
Facultative to strict anaerobes ratio in the preterm infant microbiota: A target for intervention?
Arboleya, S., Solís, G., Fernández, N., de los Reyes-Gavilán, C. G., & Gueimonde, M. (2012) · Gut Microbes · doi:10.4161/gmic.21942 · Cited by 74 · see citing works
Self-citationArboleya, S., Stanton, C., Ryan, C. A., Dempsey, E., & Ross, P. R. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033151 · Cited by 41 · see citing works
Li, S., Li, N., Wang, C., Zhao, Y., Cao, J., Li, X., Zhang, Z., Li, Y., Yang, X., Wang, X., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.798403 · Cited by 26 · see citing works
- Authors
- Solís, G., de los Reyes-Gavilan, C. G., Fernández, N., Margolles, A., & Gueimonde, M.
- Affiliations
- Hospital Universitario De Cabueñes (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Gueimonde, M.
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 16
- Issue
- 3
- Pages
- 307-310
- ISSN
- 1075-9964 (ISSN-L)
- OpenAlex
- W2073795434
- Cited by
- 327
- References
- 11
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 21 · 2023: 14 · 2022: 24 · 2021: 23 · 2020: 33 · 2019: 19 · 2018: 26 · 2017: 25 · 2016: 21 · 2015: 25 · 2014: 17 · 2013: 22 · 2012: 20
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anaerobe (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- lactic acid bacteria, Bifidobacterium, breast milk, infant gut microbiota, Lactobacillus, Streptococcus, Enterococcus, breastfeeding
- MeSH terms
- Bifidobacterium, Breast Feeding, Female, Humans, Infant, Infant, Newborn, Lactobacillus, Milk, Human, Streptococcus, Colony Count, Microbial, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
