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Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the ‘‘right stuff’’?
Abstract
There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper, we will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome. In addition to surveying the number of replicated findings and tallying box scores of results, we will approach the review of the studies in a more thorough and empirical manner by applying a meta-analysis. Lastly, we will discuss what we see as a key limitation of this literature, specifically, the relatively narrow selection of predictor measures. This limitation has constrained identification of mediating variables that may explain the mechanisms for these relationships.
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“Cognition determines, to a considerable extent, one's social and professional success and the ability to live independently (Audet, Hebert, Dubois, Rochette, & Mercier, 2007; Benedict & Zivadinov, 2006; Green, Kern, Braff, & Mintz, 2000).”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Green, Kern, Braff, & Mintz, 2000
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“These impairments have been shown to be associated with various impaired functional outcomes.4,5”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [4]
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GOFF, D. C., Lamberti, J. S., Leon, A. C., Green, M. F., Miller, A. L., Patel, J. K., Manschreck, T. C., Freudenreich, O., & Johnson, S. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301444 · Cited by 181
Self-citationThe potential role of dopamine D3 receptor neurotransmission in cognition
Nakajima, S., Gerretsen, P., Takeuchi, H., Caravaggio, F., Chow, T. W., Foll, B. L., Mulsant, B. H., Pollock, B. G., & Graff‐Guerrero, A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.05.006 · Cited by 179
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Combination Antipsychotic Therapy in Clinical Practice
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A meta-analysis of cognitive functioning in older adults with PTSD
Schuitevoerder, S., Rosen, J. W., Twamley, E. W., Ayers, C. R., Sones, H. M., Lohr, J. B., Goetter, E. M., Fonzo, G. A., Holloway, K. J., & Thorp, S. R. (2013) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2013.01.001 · Cited by 190
Metadata
- Authors
- Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J.
- Affiliations
- University of California, Los Angeles (US)
- University of California San Diego (US)
- Corresponding author
- Green, M. F.
- ORCID
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 26
- Issue
- 1
- Pages
- 119-136
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2150174494
- Cited by
- 2,999
- References
- 62
- Citations by year
- 2026: 49 · 2025: 50 · 2024: 85 · 2023: 77 · 2022: 89 · 2021: 111 · 2020: 120 · 2019: 146 · 2018: 132 · 2017: 143 · 2016: 146 · 2015: 180 · 2014: 146 · 2013: 180 · 2012: 183
- FWCI
- 31.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- schizophrenia, neurocognitive impairment
- MeSH terms
- Cognition Disorders, Humans, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Social Adjustment, Comorbidity, Cognitive Behavioral Therapy, Treatment Outcome
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