Cited by 2,999Schizophrenia research and treatmentMental Health and PsychiatryDementia and Cognitive Impairment Research

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Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the ‘‘right stuff’’?

Green, M. F., Kern, R. S., Braff, D. L., Mintz, J.·2000·Schizophrenia Bulletin

DOI 10.1093/oxfordjournals.schbul.a033430

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Abstract

There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper, we will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome. In addition to surveying the number of replicated findings and tallying box scores of results, we will approach the review of the studies in a more thorough and empirical manner by applying a meta-analysis. Lastly, we will discuss what we see as a key limitation of this literature, specifically, the relatively narrow selection of predictor measures. This limitation has constrained identification of mediating variables that may explain the mechanisms for these relationships.

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Authors: Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J.
Affiliations: University of California, Los Angeles (US)
University of California San Diego (US)
Corresponding author: Green, M. F.
ORCID: Kern, R. S.
Mintz, J.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2000-01-01
Volume: 26
Issue: 1
Pages: 119-136
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/oxfordjournals.schbul.a033430
OpenAlex: W2150174494
Cited by: 2,999
References: 62
Citations by year: 2026: 49 · 2025: 50 · 2024: 85 · 2023: 77 · 2022: 89 · 2021: 111 · 2020: 120 · 2019: 146 · 2018: 132 · 2017: 143 · 2016: 146 · 2015: 180 · 2014: 146 · 2013: 180 · 2012: 183
FWCI: 31.16
Type: journal article
Language: en
Open access: closed
Locations: Schizophrenia Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: schizophrenia, neurocognitive impairment
MeSH terms: Cognition Disorders, Humans, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Social Adjustment, Comorbidity, Cognitive Behavioral Therapy, Treatment Outcome

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Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the ‘‘right stuff’’?

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