The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Subchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys
Abstract
This study was conducted to determine the earliest measurable response of primates to low-level perfluorooctanesulfonate (PFOS) exposure and to provide information to reduce uncertainty in human health risk assessment. Groups of male and female monkeys received 0, 0.03, 0.15, or 0.75 mg/kg/day potassium PFOS orally for 182 days. Recovery animals from each group, except the 0.03 mg/kg/day dose group, were monitored for one year after treatment. Significant adverse effects occurred only in the 0.75 mg/kg/day dose group and included compound-related mortality in 2 of 6 male monkeys, decreased body weights, increased liver weights, lowered serum total cholesterol, lowered triiodothyronine concentrations (without evidence of hypothyroidism), and lowered estradiol levels. Decreased serum total cholesterol occurred in the 0.75 mg/kg/day dose group at serum PFOS levels > 100 ppm. Hepatocellular hypertrophy and lipid vacuolation were present at term in the 0.75 mg/kg/day dose group. No peroxisomal (palmitoyl CoA oxidase) or cell proliferation (proliferating cell nuclear antigen immunohistochemistry) was detected. Complete reversal of clinical and hepatic effects and significant decreases in serum and liver PFOS occurred within 211 days posttreatment. Liver-to-serum PFOS ratios were comparable in all dose groups, with a range of 1:1 to 2:1. Serum concentrations associated with no adverse effects (0.15 mg/kg/day) were 82.6 +/- 25.2 ppm for males and 66.8 +/- 10.8 ppm for females. Comparison of serum PFOS concentrations associated with no adverse effect in this study to those reported in human blood samples (0.028 +/- 0.014 ppm) indicated an adequate margin of safety.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“exposure to PFAS, primarily PFOS and PFOA, can lead to decreased food consumption and decreased weight gain in adult animals”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Seacat, 2002
Citations
Cites
Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
Robust tests for equality of variances
Levene, H. (1961) · Medical Entomology and Zoology · Cited by 3,271
New Tables for Multiple Comparisons with a Control
Dunnett, C. W. (1964) · Biometrics · doi:10.2307/2528490 · Cited by 3,105
Biostatistics: A Foundation for Analysis in the Health Sciences.
Rosenfeld, B., & Daniel, W. W. (1984) · Journal of the American Statistical Association · doi:10.2307/2288760 · Cited by 2,841
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750
Ingbar, S. H. (1965) · Archives of Internal Medicine · doi:10.1001/archinte.1965.03870060154035 · Cited by 1,745
Oliver, W. R., Shenk, J. L., Snaith, M. R., RUSSELL, C. S., Plunket, K. D., Bodkin, N. L., Lewis, M. C., Winegar, D. A., Sznaidman, M. L., Lambert, M. H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091021198 · Cited by 1,060
Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices
Hansen, K. J., Clemen, L. A., Ellefson, M. E., & Johnson, H. O. (2001) · Environmental Science & Technology · doi:10.1021/es001489z · Cited by 923
Dangerous dogmas in medicine: the nonthyroidal illness syndrome
De Groot, L. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5364 · Cited by 505
Interactions of flurochemicals with rat liver fatty acid-binding protein
Luebker, D. J., Hansen, K. J., Bass, N. M., Butenhoff, J. L., & Seacat, A. M. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00081-1 · Cited by 398
Self-citation
Cited by
Sorted by citations
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049
Self-citationThe Developmental Toxicity of Perfluoroalkyl Acids and Their Derivatives
Lau, C., Butenhoff, J. L., & Rogers, J. M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.031 · Cited by 867
Accumulation of perfluorinated alkyl substances (PFAS) in agricultural plants: A review
Ghisi, R., Vamerali, T., & Manzetti, S. (2019) · Environmental Research · doi:10.1016/j.envres.2018.10.023 · Cited by 705
Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)
Steenland, K., Fletcher, T., & Savitz, D. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901827 · Cited by 660
Binding of perfluorinated fatty acids to serum proteins
Jones, P. D., Hu, W., Coen, W. D., Newsted, J. L., & Giesy, J. P. (2003) · Environmental Toxicology and Chemistry · doi:10.1897/02-553 · Cited by 628
Apelberg, B. J., Witter, F. R., Herbstman, J. B., Calafat, A. M., Halden, R. U., Needham, L. L., & Goldman, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10334 · Cited by 630
Kelly, B. C., Ikonomou, M. G., Blair, J. D., Surridge, B. D., Hoover, D., Grace, R., & Gobas, F. A. P. C. (2009) · Environmental Science & Technology · doi:10.1021/es9003894 · Cited by 582
Exposure to Perfluorooctane Sulfonate during Pregnancy in Rat and Mouse. II: Postnatal Evaluation
Lau, C., Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Stanton, M. E., Butenhoff, J. L., & Stevenson, L. A. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg122 · Cited by 549
Nelson, J. W., Hatch, E. E., & Webster, T. F. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901165 · Cited by 538
(EFSA), E. F. S. A. (2008) · EFSA Journal · doi:10.2903/j.efsa.2008.653 · Cited by 549
Estimating Consumer Exposure to PFOS and PFOA
Trudel, D., Horowitz, L., Wormuth, M., Scheringer, M., Cousins, I. T., & Hungerbühler, K. (2008) · Risk Analysis · doi:10.1111/j.1539-6924.2008.01017.x · Cited by 514
(CONTAM), E. P. O. C. I. T. F. C., Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B. J., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5194 · Cited by 549
Johansson, N., Fredriksson, A., & Eriksson, P. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2007.10.008 · Cited by 463
Inoue, K., Okada, F., Ito, R., Kato, S., Sasaki, S., 中島そのみ, Uno, A., Saijo, Y., Sata, F., Yoshimura, Y., et al. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6864 · Cited by 460
Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Barbee, B. D., Richards, J. H., Butenhoff, J. L., Stevenson, L. A., & Lau, C. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg121 · Cited by 445
Toxicology of perfluorinated compounds
Stahl, T., Mattern, D., & Brunn, H. (2011) · Environmental Sciences Europe · doi:10.1186/2190-4715-23-38 · Cited by 432
Haug, L. S., Huber, S., Becher, G., & Thomsen, C. (2011) · Environment International · doi:10.1016/j.envint.2011.01.011 · Cited by 433
Toxicological relevance of emerging contaminants for drinking water quality
Schriks, M., Heringa, M. B., van der Kooi, M. M. E., de Voogt, P., & van Wezel, A. P. (2009) · Water Research · doi:10.1016/j.watres.2009.08.023 · Cited by 409
Olsen, G. W., Church, T. R., Miller, J. P., Burris, J. M., Hansen, K. J., Lundberg, J. K., Armitage, J. B., Herron, R., Medhdizadehkashi, Z., Nobiletti, J. B., et al. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6316 · Cited by 401
Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
Seacat, A. M., Thomford, P. J., Hansen, K. J., Clemen, L. A., Eldridge, S. R., Elcombe, C. R., & Butenhoff, J. L. (2003) · Toxicology · doi:10.1016/s0300-483x(02)00511-5 · Cited by 399
Self-citationMoody, C. A., Hebert, G. N., Strauss, S. H., & Field, J. A. (2003) · Journal of Environmental Monitoring · doi:10.1039/b212497a · Cited by 358
Liu, C., YU, K., SHI, X., Wang, J., Lam, P. K. S., Wu, R. S. S., & Zhou, B. S. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.02.006 · Cited by 367
Synthesis of environmentally relevant fluorinated surfactants—a review
Lehmler, H. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2004.11.078 · Cited by 375
Olsen, G. W., Burris, J. M., Burlew, M., & Mandel, J. H. (2003) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000052958.59271.10 · Cited by 362
Cordner, A., De La Rosa, V. Y., Schaider, L. A., Rudel, R. A., Richter, L., & Brown, P. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0099-9 · Cited by 363
Weiss, J. M., Andersson, P. L., Lamoree, M. H., Leonards, P. E. G., van Leeuwen, S. P. J., & Hamers, T. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp055 · Cited by 373
Neuroendocrine Effects of Perfluorooctane Sulfonate in Rats
Austin, M. E., Kasturi, B. S., Barber, M., Kannan, K., MohanKumar, P. S., & MohanKumar, S. M. J. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6128 · Cited by 347
Perfluorinated Compounds in Tap Water from China and Several Other Countries
Mak, Y. L., Taniyasu, S., Yeung, L. W. Y., Lu, G.-H., Jin, L. N., Yang, Y., Lam, P. K. S., Kannan, K., & Yamashita, N. (2009) · Environmental Science & Technology · doi:10.1021/es900637a · Cited by 342
Olsen, G. W., Huang, H.-Y., Helzlsouer, K. J., Hansen, K. J., Butenhoff, J. L., & Mandel, J. H. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7544 · Cited by 325
Luebker, D. J., York, R. G., Hansen, K. J., Moore, J. A., & Butenhoff, J. L. (2005) · Toxicology · doi:10.1016/j.tox.2005.07.019 · Cited by 314
Occurrence of Perfluoroalkyl Surfactants in Water, Fish, and Birds from New York State
Sinclair, E., Mayack, D. T., Roblee, K. J., Yamashita, N., & Kannan, K. (2006) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-005-1188-z · Cited by 322
Roth, K., Yang, Z., Agarwal, M., Liu, W. J., Peng, Z., Long, Z., Birbeck, J. A., Westrick, J. A., Liu, W., & Petriello, M. C. (2021) · Environment International · doi:10.1016/j.envint.2021.106843 · Cited by 322
Olsen, G. W., & Zobel, L. R. (2007) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-007-0213-0 · Cited by 307
Wolf, C. J., Takacs, M. L., Schmid, J. E., Lau, C. S., & Abbott, B. D. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn166 · Cited by 302
Kuklenyik, Z., Reich, J. A., Tully, J. S., Needham, L. L., & Calafat, A. M. (2004) · Environmental Science & Technology · doi:10.1021/es040332u · Cited by 297
Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth
Washino, N., Saijo, Y., Sasaki, S., Kato, S., Ban, S., Konishi, K., Ito, R., Nakata, A., Iwasaki, Y., Saito, K., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11681 · Cited by 300
Huang, H., Huang, C., Wang, L., Ye, X., Bai, C., Simonich, M. T., Tanguay, R. L., & Dong, Q. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.02.003 · Cited by 283
Harada, K. H., Inoue, K., Morikawa, A., Yoshinaga, T., Saito, N., & Koizumi, A. (2005) · Environmental Research · doi:10.1016/j.envres.2004.12.003 · Cited by 293
Sonne, C. (2010) · Environment International · doi:10.1016/j.envint.2010.03.002 · Cited by 278
Suppression of Humoral Immunity in Mice following Exposure to Perfluorooctane Sulfonate
Peden‐Adams, M. M., Keller, J. M., EUDALY, J. G., Berger, J., Gilkeson, G. S., & Keil, D. E. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn059 · Cited by 281
Two-generation reproduction and cross-foster studies of perfluorooctanesulfonate (PFOS) in rats
Luebker, D. J., Case, M. T., York, R. G., Moore, J. A., Hansen, K. J., & Butenhoff, J. L. (2005) · Toxicology · doi:10.1016/j.tox.2005.07.018 · Cited by 274
Alterations in cell membrane properties caused by perfluorinated compounds
Hu, W., Jones, P. D., DeCoen, W., King, L. E., Fraker, P. J., Newsted, J. L., & Giesy, J. P. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(03)00043-7 · Cited by 264
Lopez-Espinosa, M.-J., Fletcher, T., Armstrong, B., Genser, B., Dhatariya, K., Mondal, D., Ducatman, A., & Leonardi, G. (2011) · Environmental Science & Technology · doi:10.1021/es1038694 · Cited by 262
Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
Bjork, J. A., Butenhoff, J. L., & Wallace, K. B. (2011) · Toxicology · doi:10.1016/j.tox.2011.06.012 · Cited by 266
Industrial Wastewater and Its Toxic Effects
Ahmed, J., Thakur, A. R., & Goyal, A. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839165399-00001 · Cited by 250
Per- and polyfluoroalkyl substances (PFAS) in livestock and game species: A review
Death, C. E., Bell, C., Champness, D., Milne, C. M., Reichman, S. M., & Hagen, T. G. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144795 · Cited by 261
Human Donor Liver and Serum Concentrations of Perfluorooctanesulfonate and Other Perfluorochemicals
Olsen, G. W., Hansen, K. J., Stevenson, L. A., Burris, J. M., & Mandel, J. H. (2003) · Environmental Science & Technology · doi:10.1021/es020955c · Cited by 242
PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field
Bonato, M., Corrà, F., Bellio, M., Guidolin, L., Tallandini, L., Irato, P., & Santovito, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218020 · Cited by 243
Wilkinson, J. L., Hooda, P. S., Barker, J., Barton, S., & Swinden, J. (2015) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2015.1096876 · Cited by 235
Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes
Zhao, L., Teng, M., Zhao, X., Li, Y., Sun, J., Zhao, W., Ruan, Y., Leung, K., & Wu, F. (2023) · Environment International · doi:10.1016/j.envint.2023.107951 · Cited by 236
Du, Y., Shi, X., Liu, C., Yu, K., & Zhou, B. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.09.075 · Cited by 229
Determinants of Fetal Exposure to Polyfluoroalkyl Compounds in Baltimore, Maryland
Apelberg, B. J., Goldman, L. R., Calafat, A. M., Herbstman, J. B., Kuklenyik, Z., Heidler, J., Needham, L. L., Halden, R. U., & Witter, F. R. (2007) · Environmental Science & Technology · doi:10.1021/es0700911 · Cited by 226
Shi, X., Liu, C., Wu, G., & Zhou, B. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2009.07.074 · Cited by 221
Perfluorochemicals in Pooled Serum Samples from United States Residents in 2001 and 2002
Calafat, A. M., Kuklenyik, Z., Caudill, S. P., Reidy, J. A., & Needham, L. L. (2006) · Environmental Science & Technology · doi:10.1021/es0517973 · Cited by 219
Pizzurro, D. M., Seeley, M., Kerper, L. E., & Beck, B. D. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.05.008 · Cited by 206
Chang, S., Thibodeaux, J. R., Eastvold, M. L., Ehresman, D. J., Bjork, J. A., Froehlich, J. W., Lau, C. S., Singh, R. J., Wallace, K. B., & Butenhoff, J. L. (2007) · Toxicology · doi:10.1016/j.tox.2007.10.014 · Cited by 209
Andersen, M. E., M.A., H. J. C. I., Tan, Y., Butenhoff, J. L., & Olsen, G. W. (2006) · Toxicology · doi:10.1016/j.tox.2006.08.004 · Cited by 210
Neurotoxic Effects of Perfluoroalkylated Compounds: Mechanisms of Action and Environmental Relevance
Mariussen, E. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0822-6 · Cited by 204
Kuklenyik, Z., Needham, L. L., & Calafat, A. M. (2005) · Analytical Chemistry · doi:10.1021/ac050671l · Cited by 204
Butenhoff, J. L., Olsen, G. W., & Pfahles-Hutchens, A. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9060 · Cited by 201
Liu, C., Du, Y., & Zhou, B. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.09.009 · Cited by 203
Du, G., Hu, J., Huang, H., Qin, Y., Han, X., Wu, D., Song, L., Xia, Y., & Wang, X. (2012) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2034 · Cited by 210
Estimating the contribution of precursor compounds in consumer exposure to PFOS and PFOA
Vestergren, R., Cousins, I. T., Trudel, D., Wormuth, M., & Scheringer, M. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.08.011 · Cited by 194
Liu, Y., Wang, J., WEI, Y., Zhang, H., XU, M., & DAI, J. (2008) · Aquatic Toxicology · doi:10.1016/j.aquatox.2008.07.009 · Cited by 192
Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism
Yu, W., Liu, W., & Jin, Y. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-345.1 · Cited by 195
Thyroid disruption by perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA)
Coperchini, F., Awwad, O., Rotondi, M., Santini, F., Imbriani, M., & Chiovato, L. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0572-z · Cited by 192
Qian, Y., Ducatman, A., Ward, R., Leonard, S., Bukowski, V., Lan Guo, N., Shi, X., Vallyathan, V., & Castranova, V. (2010) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/15287391003689317 · Cited by 191
Yeung, L. W. Y., Miyake, Y., Taniyasu, S., Wang, Y., Yu, H., So, M. K., Jiang, G., Wu, Y., Li, J., Giesy, J. P., et al. (2008) · Environmental Science & Technology · doi:10.1021/es800631n · Cited by 196
Fragki, S., Dirven, H. A. A. M., Fletcher, T., Grasl‐Kraupp, B., Gützkow, K. B., Hoogenboom, L. A. P., Kersten, S., Lindeman, B., Louisse, J., Peijnenburg, A., et al. (2021) · Critical Reviews in Toxicology · doi:10.1080/10408444.2021.1888073 · Cited by 196
Wolf, C. J., Fenton, S., Schmid, J., Calafat, A., Kuklenyik, Z., Bryant, X. A., Thibodeaux, J. R., Das, K., White, S., Lau, C., et al. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl159 · Cited by 199
Haug, L. S., Thomsen, C., & Becher, G. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.10.113 · Cited by 188
Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility
Alexander, B. H., Olsen, G. W., Burris, J. M., Mandel, J. H., & Mandel, J. S. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.10.722 · Cited by 179
Benskin, J. P., Silva, A. O. D., & Martin, J. W. (2010) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4419-6880-7_2 · Cited by 187
Sheng, N., Pan, Y., Guo, Y., Sun, Y., & Dai, J. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b01714 · Cited by 176
Perfluorinated Alkyl Substances
Grandjean, P., & Clapp, R. (2015) · NEW SOLUTIONS A Journal of Environmental and Occupational Health Policy · doi:10.1177/1048291115590506 · Cited by 189
Sun, Q., Zong, G., Valvi, D., Nielsen, F., Coull, B. A., & Grandjean, P. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2619 · Cited by 186
Lam, J. C. W., Lyu, J., Kwok, K. Y., & Lam, P. K. S. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b06076 · Cited by 176
Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys
Sundström, M., Chang, S., Noker, P. E., Gorman, G. S., Hart, J. A., Ehresman, D. J., Bergman, Å., & Butenhoff, J. L. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.07.004 · Cited by 178
Comparison on gestation and lactation exposure of perfluorinated compounds for newborns
Liu, J., Li, J., Liu, Y., Chan, H. M., Zhao, Y., Cai, Z., & Wu, Y. (2011) · Environment International · doi:10.1016/j.envint.2011.05.001 · Cited by 174
Guruge, K. S., Taniyasu, S., Yamashita, N., Wijeratna, S. R., Mohotti, K. M., Seneviratne, H. R., Kannan, K., Yamanaka, N., & Miyazaki, S. (2005) · Journal of Environmental Monitoring · doi:10.1039/b412532k · Cited by 171
Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys
Chang, S., Noker, P. E., Gorman, G. S., Gibson, S. J., Hart, J. A., Ehresman, D. J., & Butenhoff, J. L. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.07.002 · Cited by 181
trans-Activation of PPAR and Induction of PPAR Target Genes by Perfluorooctane-Based Chemicals
Shipley, J. M. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh130 · Cited by 168
Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review
Bach, C. C., Vested, A., Jørgensen, K. T., Bonde, J. P., Henriksen, T. B., & Toft, G. V. (2016) · Critical Reviews in Toxicology · doi:10.1080/10408444.2016.1182117 · Cited by 172
Sznajder‐Katarzyńska, K., Surma, M., & Cieślik, I. (2019) · Journal of Chemistry · doi:10.1155/2019/2717528 · Cited by 181
Grandjean, P., & Budtz–Jørgensen, E. (2013) · Environmental Health · doi:10.1186/1476-069x-12-35 · Cited by 173
Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166
“It has been reported in many studies that exposure to PFAS, primarily PFOS and PFOA, can lead to decreased food consumption and decreased weight gain in adult animals (Seacat, 2002; Austin et al., 2003; Thibodeaux et al., 2003; Fang et al., 2008; Butenhoff et al., 2009a, 2012).”
BackgroundGestational Exposure to Perfluorooctane Sulfonate Suppresses Immune Function in B6C3F1 Mice
Keil, D. E., Mehlmann, T., Butterworth, L. F., & Peden‐Adams, M. M. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn015 · Cited by 168
Wang, Y., Rogan, W. J., Chen, P.-C., Lien, G.-W., Chen, H.-Y., Tseng, Y.-C., Longnecker, M. P., & Wang, S.-L. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1306925 · Cited by 162
Concentrations of PFOS, PFOA and other perfluorinated alkyl acids in Australian drinking water
Thompson, J., Eaglesham, G. K., & Mueller, J. F. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.04.017 · Cited by 170
Perfluorinated chemicals in selected residents of the American continent
Calafat, A. M., Needham, L. L., Kuklenyik, Z., Reidy, J. A., Tully, J. S., Aguilar-Villalobos, M., & Naeher, L. P. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.08.028 · Cited by 166
Henry, N. D., & Fair, P. A. (2011) · Journal of Applied Toxicology · doi:10.1002/jat.1736 · Cited by 160
Wolf, C. J., Schmid, J. E., Lau, C. S., & Abbott, B. D. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.09.009 · Cited by 160
Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1 offspring
Wang, M., Chen, J., Lin, K., Chen, Y., Hu, W. M., Tanguay, R. L., Huang, C., & Dong, Q. (2011) · Environmental Toxicology and Chemistry · doi:10.1002/etc.594 · Cited by 169
Avian Toxicity Reference Values for Perfluorooctane Sulfonate
Newsted, J. L., Jones, P. D., Coady, K. K., & Giesy, J. P. (2005) · Environmental Science & Technology · doi:10.1021/es050989v · Cited by 160
Ammonium Perfluorooctanoate Production and Occupational Mortality
Lundin, J. I., Alexander, B. H., Olsen, G. W., & Church, T. R. (2009) · Epidemiology · doi:10.1097/ede.0b013e3181b5f395 · Cited by 156
Yuan, G., Peng, H., Huang, C., & Hu, J. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03806 · Cited by 158
Bijland, S., Rensen, P. C. N., Pieterman, E. J., Maas, A. C. E., van der Hoorn, J. W., van Erk, M. J., Havekes, L. M., van Dijk, K. W., Chang, S., Ehresman, D. J., et al. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr142 · Cited by 159
Egeghy, P. P., & Lorber, M. (2010) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2009.73 · Cited by 153
Effects of perfluorooctanoate and perfluorooctane sulfonate exposure on hepatoma Hep G2 cells
Hu, X., & Hu, D. (2009) · Archives of Toxicology · doi:10.1007/s00204-009-0441-z · Cited by 152
Metadata
- Authors
- Seacat, A. M.
- Affiliations
- 3M (United States) (US)
- Corresponding author
- Seacat, A. M.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-07-01
- Volume
- 68
- Issue
- 1
- Pages
- 249-264
- ISSN
- 1096-0929 (ISSN-L)
- OpenAlex
- W2127286660
- Cited by
- 564
- References
- 36
- Citations by year
- 2026: 6 · 2025: 25 · 2024: 16 · 2023: 18 · 2022: 12 · 2021: 25 · 2020: 27 · 2019: 23 · 2018: 31 · 2017: 17 · 2016: 25 · 2015: 31 · 2014: 24 · 2013: 24 · 2012: 35
- FWCI
- 12.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- PFOS, subchronic toxicity, Macaca fascicularis, hepatocyte hypertrophy, total cholesterol, triiodothyronine, estradiol, recovery after treatment, safety margin, human health risk assessment, peroxisomal function, cell proliferation
- MeSH terms
- Administration, Oral, Animals, Body Weight, Cell Division, Dose-Response Relationship, Drug, Female, Fluorocarbons, Immunohistochemistry, Liver, Longevity, Macaca fascicularis, Male, Organ Size, Remission Induction, Alkanesulfonic Acids, Toxicity Tests, Proliferating Cell Nuclear Antigen, Peroxisomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review