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Cited by 540

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Vitamin C Intake and Mortality among a Sample of the United States Population

Enstrom,, James E., Kanim, Linda E., Klein, Morton A.·1992·Epidemiology
DOI 10.1097/00001648-199205000-00003
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Abstract

We examined the relation between vitamin C intake and mortality in the First National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study cohort. This cohort is based on a representative sample of 11,348 noninstitutionalized U.S. adults age 25-74 years who were nutritionally examined during 1971-1974 and followed up for mortality (1,809 deaths) through 1984, a median of 10 years. An index of vitamin C intake has been formed from detailed dietary measurements and use of vitamin supplements. The relation of the standardized mortality ratio (SMR) for all causes of death to increasing vitamin C intake is strongly inverse for males and weakly inverse for females. Among those with the highest vitamin C intake, males have an SMR (95% confidence interval) of 0.65 (0.52-0.80) for all causes, 0.78 (0.50-1.17) for all cancers, and 0.58 (0.41-0.78) for all cardiovascular diseases; females have an SMR of 0.90 (0.74-1.09) for all causes, 0.86 (0.55-1.27) for all cancers, and 0.75 (0.55-0.99) for all cardiovascular diseases. Comparisons are made relative to all U.S. whites, for whom the SMR is defined to be 1.00. There is no clear relation for individual cancer sites, except possibly an inverse relation for esophagus and stomach cancer among males. The relation with all causes of death among males remains after adjustment for age, sex, and 10 potentially confounding variables (including cigarette smoking, education, race, and disease history).

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Metadata

Authors
Enstrom, Kanim, L. E., & Klein, M. A.
Venue
Epidemiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1992-05
Volume
3
Issue
3
Pages
194-202
ISSN
1044-3983 (ISSN-L)
DOI
10.1097/00001648-199205000-00003
OpenAlex
W1968168087
Cited by
540
References
0
FWCI
34.90
Type
journal article
Language
en
Open access
closed

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