A Review of Treating Depression in Diabetes: Emerging Findings
Open accessAbstract
Background Depression in patients with diabetes is associated with poorer adherence and worse health outcomes, however treating depression may help improve these outcomes.Objective The present systematic review identified published papers to evaluate treatments for depression in patients with diabetes.Results Seventeen studies that met criteria were identified, indicating that psychosocial interventions, particularly cognitive-behavior therapy, anti-depressant medications, and collaborative care are effective in the treatment of depression in patients with diabetes.Conclusion Evidence for the efficacy of these interventions in improving glycemic control was mixed. No study targeted adherence to treatment or health behaviors in addition to depression, which may be necessary to maximize improvement in diabetes outcomes such as glycemic control.
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Interventions have failed to show compelling evidence that amelioration of major depressive disorder leads to improved diabetes management or glycemic control.
“Moreover, they have failed to show compelling evidence that amelioration of MDD leads to improved diabetes management or glycemic control (9).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [9]
Numerous treatment studies have shown positive effects for the improvement of major depressive disorder in diabetic patients.
“Numerous treatment studies have shown positive effects for the improvement of MDD in diabetic patients, but evidence for resulting glycemic benefit is, at best, weak (9).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [9]
Evidence for glycemic benefit from treating major depressive disorder in diabetic patients is, at best, weak.
“Numerous treatment studies have shown positive effects for the improvement of MDD in diabetic patients, but evidence for resulting glycemic benefit is, at best, weak (9).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [9]
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Dieter, T., & Lauerer, J. (2017) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12203 · Cited by 19 · see citing works
Ding, X., Rong, S., Wang, Y., Li, D., Wen, L., Zou, B., Zang, D., Feng, K., Liang, Y., Wang, F., et al. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s343926 · Cited by 19 · see citing works
Depression in Medically Ill Children and Adolescents
Malas, N., Plioplys, S., & Pao, M. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.02.005 · Cited by 18 · see citing works
Symptoms of depression among patients attending a diabetes care clinic in rural western Kenya
Shirey, K., Manyara, S. M., Atwoli, L., Tomlin, R., Gakinya, B. N., Cheng, S. W., Kamano, J. H., Laktabai, J., & Pastakia, S. D. (2015) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2015.02.002 · Cited by 18 · see citing works
Psychische Erkrankungen und Diabetes mellitus
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Self-citationNaicker, K., Manuel, D. G., Øverland, S. N., Skogen, J. C., Johnson, J. A., Sivertsen, B., & Colman, I. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0387-5 · Cited by 18 · see citing works
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Self-citationNovel Challenges in Aging with Type 1 Diabetes
Bispham, J. A., Hughes, A. S., Driscoll, K. A., & McAuliffe‐Fogarty, A. H. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01298-9 · Cited by 17 · see citing works
Abrahamian, H., Hofmann, Kinzl, & Toplak (2012) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s33679 · Cited by 15 · see citing works
- Authors
- Markowitz, S. M., Gonzalez, J. S., Wilkinson, J. L., & Safren, S. A.
- Affiliations
- Harvard University (US)
- Albert Einstein College of Medicine (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Markowitz, Sarah M.
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 52
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0033-3182 (ISSN-L)
- PMC
- PMC3043600
- OpenAlex
- W1992579306
- Cited by
- 230
- References
- 108
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 18 · 2021: 10 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 19 · 2016: 24 · 2015: 28 · 2014: 20 · 2013: 22 · 2012: 11
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1r01mh078571-01)
- National Institute of Mental Health (1R01MH078571-01, R01 MH-078571)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- depression, diabetes mellitus, depression treatment, psychosocial interventions, cognitive behavioral therapy, antidepressants, collaborative care, glycemic control, medication adherence
- MeSH terms
- Adolescent, Adult, Antidepressive Agents, Child, Cooperative Behavior, Depressive Disorder, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Health Education, Humans, Mental Health Services, Patient Education as Topic, Psychotherapy, Self Care, Cognitive Behavioral Therapy, Treatment Outcome
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