Association of Optimism and Pessimism With Inflammation and Hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA)
Open accessAbstract
Objective: To investigate the association between optimism/pessimism and concentrations of seven inflammation and hemostasis markers. Optimism and pessimism are associated with cardiovascular disease mortality and progression; however, the biological mechanism remains unclear. Methods: This cross-sectional study used data from the Multi-Ethnic Study of Atherosclerosis (MESA), a study of 6814 persons aged 45 to 84 years with no history of clinical cardiovascular disease. The Life-Orientation Test-Revised (LOT-R) was used to measure dispositional optimism and pessimism. Regression analyses were used to estimate associations of optimism and pessimism with interleukin (IL)-6, C-reactive protein (CRP), fibrinogen, homocysteine, Factor VIII, D-dimer, and plasmin-antiplasmin, before and after adjustment for sociodemographics, depression, cynicism, health behaviors, body mass index (BMI), hypertension, and diabetes. Results: Higher scores on the LOT-R (positive disposition) were related to lower concentrations of IL-6 (p = .001), fibrinogen (p < .001), and homocysteine (p = .031). Associations were stronger for the pessimism subscale. After adjustment for demographics, the percentage differences in inflammatory markers corresponding to a 2-standard deviation increase in pessimism were 6.01% (p = .001) for IL-6, 10.31% (p = .001) for CRP, 2.47% (p < .0001) for fibrinogen, and 1.36% (p = .07) for homocysteine. Associations were attenuated but significant after adjustment for sociodemographics, depression, cynical distrust, and behaviors. Further adjustment for hypertension, BMI, and diabetes reduced associations for CRP and IL-6. Pessimism remained associated with a 1.36% (p = .02) increase in fibrinogen in the fully adjusted model. Factor VIII, D-dimer, and plasmin-antiplasmin were not associated with the LOT-R or subscales. Conclusions: Pessimism is related to higher levels of inflammation. Health behaviors, BMI, hypertension, and diabetes seem to play a mediating role. CVD = cardiovascular disease; CHD = coronary heart disease; MESA = Multi-Ethnic Study of Atherosclerosis; HTN = hypertension; BMI = body mass index; DM = diabetes mellitus; LOT-R = Life-Orientation Test-Revised; IL-6 = interleukin-6; CRP = C-reactive protein; CES-D = Center for Epidemiologic Studies Depression scale; HPA = hypothalamic-pituitary-adrenal; MI = myocardial infarction; SD = standard deviation.
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Optimism appears linked to lower levels of inflammatory markers.
“In addition to, or possibly because of the coping advantage it confers, optimism appears linked to lower level of ambulatory blood pressure [102] and lower levels of inflammatory markers [103].”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [103]
Previous studies have found significant associations of inflammation with higher levels of pessimism and neuroticism in other conditions characterized by chronic low-grade inflammatory state (aging and obesity).
“previous studies have found significant associations of inflammation with higher levels of pessimism and neuroticism in other conditions characterized by a chronic low-grade inflammatory state, i.e., aging and obesity (Capuron et al. 2011; Ikeda et al. 2011; Roy et al. 2010).”
From Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults (2016) · cites this paper as Roy et al. 2010
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- Authors
- Roy, B., Diez-Roux, A. V., Seeman, T., Ranjit, N., Shea, S., & Cushman, M.
- Affiliations
- University of Michigan (US)
- University of Vermont (US)
- Venue
- Psychosomatic Medicine
- Published
- 2010-02
- Volume
- 72
- Issue
- 2
- Pages
- 134-140
- ISSN
- 0033-3174 (ISSN-L)
- PMC
- PMC2842951
- OpenAlex
- W2121889121
- Cited by
- 187
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 17 · 2021: 12 · 2020: 18 · 2019: 9 · 2018: 9 · 2017: 14 · 2016: 20 · 2015: 12 · 2014: 20 · 2013: 9 · 2012: 12
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (n01hc95165-34-0-1, n01hc095169-003, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01-HC095169, N01 HC95165, N01-HC-095159, R01 HL07683, R01HL076831, N01 HC95169)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD047861)
- Topics
- Social Sciences › Psychology › Applied Psychology › Optimism, Hope, and Well-being
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- pessimism, optimism, dispositional optimism, inflammation, hemostasis, interleukin-6, C-reactive protein, fibrinogen, homocysteine, cardiovascular risk, depression, cynicism, health behavior, body mass index, hypertension, diabetes mellitus, Life Orientation Test-Revised, cardiovascular biomarkers, coronary artery disease, stroke, cardiovascular mortality
- MeSH terms
- Adaptation, Psychological, Adult, Aged, Aged, 80 and over, Attitude to Health, C-Reactive Protein, Cardiovascular Diseases, Cross-Sectional Studies, Diabetes Mellitus, Ethnicity, Female, Fibrinogen, Hemostasis, Humans, Hypertension, Inflammation, Male, Middle Aged, Personality, Risk Factors, Biomarkers, Health Behavior, Interleukin-6, Body Mass Index, Atherosclerosis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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