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Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
Open accessAbstract
Cancer remains one of the leading causes of death, albeit enormous efforts to cure the disease. To overcome the major challenges in cancer therapy, we need to have a better understanding of the tumour microenvironment (TME), as well as a more effective means to screen anti-cancer drug leads; both can be achieved using advanced technologies, including the emerging tumour-on-a-chip technology. Here, we review the recent development of the tumour-on-a-chip technology, which integrates microfluidics, microfabrication, tissue engineering and biomaterials research, and offers new opportunities for building and applying functional three-dimensional in vitro human tumour models for oncology research, immunotherapy studies and drug screening. In particular, tumour-on-a-chip microdevices allow well-controlled microscopic studies of the interaction among tumour cells, immune cells and cells in the TME, of which simple tissue cultures and animal models are not amenable to do. The challenges in developing the next-generation tumour-on-a-chip technology are also discussed.
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“These tumor-on-chip systems are expected to increase the effective identification of new and better cancer therapies while minimizing non-specific toxicity [13,14,15,16,17].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [14]
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“Tumor-on-chip models based on these organ-on-chip systems can recreate human tumor microenvironments and now hold great promise as a new resource for cost-effective and higher-throughput screening of anticancer drugs [13,14,15,16,17] and powerful enablers of precision medicine [18].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [14]
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“Tumor-on-chip models based on these organ-on-chip systems can recreate human tumor microenvironments and now hold great promise as a new resource for cost-effective and higher-throughput screening of anticancer drugs [13,14,15,16,17] and powerful enablers of precision medicine [18].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [14]
In the citing paper
“Ideally, tumor-on-a-chip platforms have the ability to recreate many cardinal TME features and show great promise as a novel technology for studying the mechanisms of tumor evolution, screening anticancer drugs and cancer therapies, and enabling precision medicine14,112,117–122.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [14]
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Metadata
- Authors
- Tsai, H.-F., Trubelja, A., Shen, A. Q., & Bao, G.
- Affiliations
- Okinawa Institute of Science and Technology Graduate University (JP)
- Rice University (US)
- Corresponding author
- Shen, Amy Q.
- Bao, Gang
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2017-06
- Volume
- 14
- Issue
- 131
- Pages
- 20170137
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- PMC
- PMC5493797
- OpenAlex
- W2695955856
- Cited by
- 214
- References
- 209
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 26 · 2023: 26 · 2022: 25 · 2021: 18 · 2020: 28 · 2019: 44 · 2018: 20 · 2017: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of The Royal Society Interface (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Okinawa Institute of Science and Technology Graduate University (Okinawa Institute of Science and Technology Graduate University) (submittedVersion, cc-by-nc-nd)
- Funders
- Cancer Prevention and Research Institute of Texas (RR140081)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor microenvironment, anticancer drug screening, tumor growth, tumor morphology, immunotherapy, tissue engineering, biomaterials, microfabrication
- MeSH terms
- Humans, Models, Biological, Neoplasms, Tissue Engineering, Microfluidics, Microfluidic Analytical Techniques, Microtechnology
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