On the Reliability of Chronically Implanted Thin-Film Electrodes in Human Arm Nerves for Neuroprosthetic Applications
Open accessAbstract
Direct stimulation of peripheral nerves can successfully provide sensory feedback to amputees while using hand prostheses. Recent clinical studies have addressed this important limitation of current prostheses solutions using different implantable electrode concepts. Longevity of the electrodes is key to success. We have improved the long-term stability of the polyimide-based transverse intrafascicular multichannel electrode (TIME) that showed promising performance in clinical trials by integration of silicon carbide adhesion layers. The TIMEs were implanted in the median and ulnar nerves of three trans-radial amputees for up to six months. Here, we present the characterization of the electrical properties of the thin-film metallization as well as material status post explantationem for the first time. The TIMEs showed reliable performance in terms of eliciting sensation and stayed within the electrochemical safe limits maintaining a good working range with respect to amplitude modulation. After termination of the trials and explantation of the probes, no signs of corrosion or morphological change to the thin-film metallization was observed by means of electrochemical and optical analysis. Damage to the metallization was assigned exclusively to mechanical impacts during explantation and handling. The results indicate that thin-film metallization on polymer substrates is applicable in permanent implant system.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
More recent studies with transradial amputees have shown the feasibility of TIME implantation in the median and ulnar nerves for 6 months.
“More recent studies with transradial amputees have shown the feasibility of TIME implantation in the median and ulnar nerves for 6 months [104, 177].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [177]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neural Stimulation and Recording Electrodes
Cogan, S. F. (2008) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.10.061807.160518 · Cited by 2,243 · see citing works
Upper limb prosthesis use and abandonment
Biddiss, E. A., & Chau, T. T. (2007) · Prosthetics and Orthotics International · doi:10.1080/03093640600994581 · Cited by 1,123 · see citing works
Restoring natural sensory feedback in real-time bidirectional hand prostheses
Raspopovic, S., Capogrosso, M., Petrini, F. M., Bonizzato, M., Rigosa, J., Di Pino, G., Carpaneto, J., Controzzi, M., Boretius, T., Fernandez, E., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3006820 · Cited by 1,001 · see citing works
Self-citationA neural interface provides long-term stable natural touch perception
Tan, D. W., Schiefer, M. A., Keith, M. W., Anderson, J. R., Tyler, J., & Tyler, D. J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008669 · Cited by 751 · see citing works
Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates
Barrese, J. C., Rao, N., Paroo, K., Triebwasser, C., Vargas-Irwin, C., Franquemont, L., & Donoghue, J. P. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/6/066014 · Cited by 600 · see citing works
Consumer design priorities for upper limb prosthetics
Biddiss, E., Beaton, D., & Chau, T. (2007) · Disability and Rehabilitation: Assistive Technology · doi:10.1080/17483100701714733 · Cited by 519 · see citing works
Ortiz-Catalan, M., Håkansson, B., & Brånemark, R. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008933 · Cited by 484 · see citing works
A transverse intrafascicular multichannel electrode (TIME) to interface with the peripheral nerve
Boretius, T., Badia, J., Pascual-Font, A., Schuettler, M., Navarro, X., Yoshida, K., & Stieglitz, T. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.05.010 · Cited by 470 · cited 1× · see citing works
“In terms of spatial selectivity polyimide (PI) based transverse intrafascicular multichannel electrodes (TIME) [33] are very promising [24,34], as they are pulled through the nerve and can address as well the inner fascicles maintaining a steady contact-to-fascicle relationship in time.”
BackgroundSelf-citationA spiral nerve cuff electrode for peripheral nerve stimulation
Naples, G. G., Mortimer, J. T., Scheiner, A., & Sweeney, J. D. (1988) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.8670 · Cited by 415 · see citing works
Functionally selective peripheral nerve stimulation with a flat interface nerve electrode
Tyler, D. J., & Durand, D. M. (2002) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2002.806840 · Cited by 398 · cited 1× · see citing works
“To overcome this drawback Tyler & Durand developed the flat interface nerve electrode (FINE, manufactured with silicone rubber molding and spot welding) [25], which flattens and re-arranges the nerve .”
BackgroundDouble nerve intraneural interface implant on a human amputee for robotic hand control
Rossini, P. M., Micera, S., Benvenuto, A., Carpaneto, J., Cavallo, G., Citi, L., Cipriani, C., Denaro, L., Denaro, V., Di Pino, G., et al. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.01.001 · Cited by 396 · see citing works
Self-citationValle, G., Mazzoni, A., Iberite, F., D’Anna, E., Strauss, I., Granata, G., Controzzi, M., Clemente, F., Rognini, G., Cipriani, C., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.033 · Cited by 340 · see citing works
Self-citationOddo, C. M., Raspopović, S., Artoni, F., Mazzoni, A., Spigler, G., Petrini, F. M., Giambattistelli, F., Vecchio, F., Miraglia, F., Zollo, L., et al. (2016) · eLife · doi:10.7554/elife.09148 · Cited by 328 · see citing works
Self-citationA closed-loop hand prosthesis with simultaneous intraneural tactile and position feedback
D’Anna, E., Valle, G., Mazzoni, A., Strauss, I., Iberite, F., Patton, J., Petrini, F. M., Raspopovic, S., Granata, G., Di Iorio, R., et al. (2019) · Science Robotics · doi:10.1126/scirobotics.aau8892 · Cited by 321 · see citing works
Self-citationDavis, T. S., Wark, H. A. C., Hutchinson, D. T., Warren, D. J., O’Neill, K., Scheinblum, T., Clark, G. A., Normann, R. A., & Greger, B. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/3/036001 · Cited by 314 · see citing works
Schiefer, M., Tan, D., Sidek, S. M., & Tyler, D. J. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/1/016001 · Cited by 255 · see citing works
An interpretative phenomenological analysis of the embodiment of artificial limbs
Murray, C. D. (2004) · Disability and Rehabilitation · doi:10.1080/09638280410001696764 · Cited by 244 · see citing works
Badia, J., Boretius, T., Andreu, D., Azevedo-Coste, C., Stieglitz, T., & Navarro, X. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/3/036023 · Cited by 227 · see citing works
Self-citationCuff electrodes for chronic stimulation and recording of peripheral nerve activity
Loeb, G. E., & Peck, R. A. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00123-9 · Cited by 215 · see citing works
Six‐Month Assessment of a Hand Prosthesis with Intraneural Tactile Feedback
Petrini, F. M., Valle, G., Strauss, I., Granata, G., Di Iorio, R., D'Anna, E., Čvančara, P., Mueller, M., Carpaneto, J., Clemente, F., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25384 · Cited by 195 · see citing works
Self-citationHorch, K., Meek, S., Taylor, T. G., & Hutchinson, D. T. (2011) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2011.2162635 · Cited by 194 · see citing works
Dhillon, G. S., Krüger, T. B., Sandhu, J. S., & Horch, K. W. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00937.2004 · Cited by 183 · see citing works
Sensory feedback prosthesis reduces phantom limb pain: Proof of a principle
Dietrich, C., Walter-Walsh, K., Preißler, S., Hofmann, G. O., Witte, O. W., Miltner, W. H. R., & Weiß, T. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.068 · Cited by 181 · see citing works
Long-term usability and bio-integration of polyimide-based intra-neural stimulating electrodes
Wurth, S., Capogrosso, M., Raspopovic, S., Gandar, J., Federici, G., Kinany, N., Cutrone, A., Piersigilli, A., Pavlova, N., Guiet, R., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.014 · Cited by 176 · see citing works
Self-citationTan, D. W., Schiefer, M. A., Keith, M. W., Anderson, J. R., & Tyler, D. J. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/2/026002 · Cited by 175 · see citing works
Rognini, G., Petrini, F. M., Raspopović, S., Valle, G., Granata, G., Strauss, I., Solcà, M., Bello‐Ruiz, J., Herbelin, B., Mange, R., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-318570 · Cited by 148 · see citing works
Self-citationChronic Response of the Rat Sciatic Nerve to the Flat Interface Nerve Electrode
Tyler, D. J., & Durand, D. M. (2003) · Annals of Biomedical Engineering · doi:10.1114/1.1569263 · Cited by 144 · see citing works
Sputtered iridium oxide films (SIROFs) for low-impedance neural stimulation and recording electrodes
Cogan, S. F., Plante, T. D., & Ehrlich, J. (2005) · The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.2004.1404158 · Cited by 138 · see citing works
Thin films and microelectrode arrays for neuroprosthetics
Ordonez, J., Schuettler, M., Boehler, C., Boretius, T., & Stieglitz, T. (2012) · MRS Bulletin · doi:10.1557/mrs.2012.117 · Cited by 118 · see citing works
Self-citationValle, G., Petrini, F. M., Strauss, I., Iberite, F., D’Anna, E., Granata, G., Controzzi, M., Cipriani, C., Stieglitz, T., Rossini, P. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34910-w · Cited by 117 · see citing works
Self-citationSchiefer, M. A., Graczyk, E. L., Sidik, S. M., Tan, D. W., & Tyler, D. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207659 · Cited by 116 · see citing works
Neural interfaces for somatosensory feedback: bringing life to a prosthesis
Tyler, D. J. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000266 · Cited by 105 · see citing works
Badia, J., Boretius, T., Pascual-Font, A., Udina, E., Stieglitz, T., & Navarro, X. (2011) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2011.2153850 · Cited by 103 · see citing works
Self-citationBeing like everybody else: the personal meanings of being a prosthesis user
Murray, C. D. (2008) · Disability and Rehabilitation · doi:10.1080/09638280802240290 · Cited by 102 · see citing works
Clemente, F., Valle, G., Controzzi, M., Strauss, I., Iberite, F., Stieglitz, T., Granata, G., Rossini, P. M., Petrini, F. M., Micera, S., et al. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab059b · Cited by 100 · see citing works
Self-citationShould patients with brain implants undergo MRI?
Erhardt, J. B., Fuhrer, E., Gruschke, O. G., Leupold, J., Wapler, M. C., Hennig, J., Stieglitz, T., & Korvink, J. G. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aab4e4 · Cited by 98 · see citing works
Self-citationParadigms for restoration of somatosensory feedback via stimulation of the peripheral nervous system
Pasluosta, C. F., Kiele, P., & Stieglitz, T. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.12.027 · Cited by 97 · see citing works
Self-citationRaspopović, S., Petrini, F. M., Żelechowski, M., & Valle, G. (2016) · Proceedings of the IEEE · doi:10.1109/jproc.2016.2600560 · Cited by 84 · see citing works
Self-citationKundu, A., Harreby, K. R., Yoshida, K., Boretius, T., Stieglitz, T., & Jensen, W. (2014) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2013.2267936 · Cited by 83 · see citing works
Self-citationClark, G. A., Wendelken, S., Page, D. M., Davis, T., Wark, H. A. C., Normann, R. A., Warren, D. J., & Hutchinson, D. T. (2014) · 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/embc.2014.6944001 · Cited by 78 · see citing works
User demands for sensory feedback in upper extremity prostheses
Lewis, S., Russold, M., Dietl, H., & Kaniušas, E. (2012) · IEEE International Symposium on Medical Measurements and Applications (MeMeA) · doi:10.1109/memea.2012.6226669 · Cited by 70 · see citing works
"Microflex" - A New Assembling Technique for Interconnects
Stieglitz, T., Beutel, H., & Meyer, J.-U. (2000) · Journal of Intelligent Material Systems and Structures · doi:10.1106/r7bv-511b-21rj-r2fa · Cited by 67 · see citing works
Self-citationImproved polyimide thin-film electrodes for neural implants
Ordonez, J. S., Boehler, C., Schüettler, M., & Stieglitz, T. (2012) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2012.6347149 · Cited by 56 · see citing works
Self-citationChristensen, M. B., Wark, H. A. C., & Hutchinson, D. T. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.012 · Cited by 49 · see citing works
Visual prostheses based on direct interfaces with the visual system.
Hambrecht, F. T. (1995) · PubMed · Cited by 46 · see citing works
Widehammar, C., Pettersson, I., Janeslätt, G. K., & Hermansson, L. (2017) · Prosthetics and Orthotics International · doi:10.1177/0309364617704801 · Cited by 44 · see citing works
Granata, G., Iorio, R. D., Romanello, R., Iodice, F., Raspopović, S., Petrini, F. M., Strauss, I., Valle, G., Stieglitz, T., Čvančara, P., et al. (2018) · Clinical Neurophysiology · doi:10.1016/j.clinph.2018.02.138 · Cited by 40 · see citing works
Self-citationBoretius, T., Yoshida, K., Badia, J., Harreby, K., Kundu, A., Navarro, X., Jensen, W., & Stieglitz, T. (2012) · 2012 4th IEEE RAS & EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) · doi:10.1109/biorob.2012.6290787 · Cited by 39 · see citing works
Self-citationKrähenbühl, S. M., Čvančara, P., Stieglitz, T., Bonvin, R., Michetti, M., Flahaut, M., Durand, S., Deghayli, L., Applegate, L. A., & Raffoul, W. (2017) · Medicine · doi:10.1097/md.0000000000007528 · Cited by 39 · see citing works
Self-citationA 232-channel retinal vision prosthesis with a miniaturized hermetic package
Ordonez, J. S., Schüettler, M., Ortmanns, M., & Stieglitz, T. (2012) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2012.6346545 · Cited by 28 · see citing works
Self-citationHarreby, K. R., Kundu, A., Yoshida, K., Boretius, T., Stieglitz, T., & Jensen, W. (2014) · Artificial Organs · doi:10.1111/aor.12347 · Cited by 14 · see citing works
Self-citationThe influence of hot-steam sterilization on hydrated sputtered iridium oxide films
Boretius, T., & Stieglitz, T. (2013) · International IEEE/EMBS Conference on Neural Engineering · doi:10.1109/ner.2013.6695926 · Cited by 5 · see citing works
Self-citationČvančara, P., Boretius, T., López-Álvarez, V. M., Maciejasz, P., Andreu, D., Raspopović, S., Petrini, F. M., Micera, S., Granata, G., Fernández, E., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/644914 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Boehler, C., Carli, S., Fadiga, L., Stieglitz, T., & Asplund, M. (2020) · Nature Protocols · doi:10.1038/s41596-020-0389-2 · Cited by 311 · see citing works
Self-citationBioelectronics for electrical stimulation: materials, devices and biomedical applications
Huang, Y., Yao, K., Zhang, Q., Huang, X., Chen, Z., Zhou, Y., & Yu, X. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00413b · Cited by 166 · see citing works
Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review
Yildiz, K. A., Shin, A. Y., & Kaufman, K. R. (2020) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-020-00667-5 · Cited by 113 · see citing works
“More recent studies with transradial amputees have shown the feasibility of TIME implantation in the median and ulnar nerves for 6 months [104, 177].”
BackgroundValle, G., Katic, N., Eggemann, D., Gorskii, O., Pavlova, N., Petrini, F. M., Čvančara, P., Stieglitz, T., Евгеньевич, М. П., Bumbaširević, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45190-6 · Cited by 75 · see citing works
Self-citationMultifaceted understanding of human nerve implants to design optimized electrodes for bioelectronics
Valle, G., Aiello, G., Ciotti, F., Čvančara, P., Martinović, T., Kravic‐Stevovic, T., Navarro, X., Stieglitz, T., Bumbaširević, M., & Raspopović, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121874 · Cited by 44 · see citing works
Self-citationSchulte, J., Vajari, D. A., & Stieglitz, T. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202310130 · Cited by 23 · see citing works
Self-citationCiotti, F., Cimolato, A., Valle, G., & Raspopović, S. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011184 · Cited by 16 · see citing works
Self-citationPeripheral neurostimulation for encoding artificial somatosensations
Valle, G. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15822 · Cited by 16 · see citing works
Self-citationConnecting residual nervous system and prosthetic legs for sensorimotor and cognitive rehabilitation
Valle, G., Preatoni, G., & Raspopović, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822828-9.00007-1 · Cited by 7 · see citing works
Self-citationValle, G., Carpaneto, J., & Micera, S. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_27 · Cited by 3 · see citing works
Self-citationGozzi, N., & Valle, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18498-7.00014-4 · Cited by 2 · see citing works
Self-citation
- Authors
- Čvančara, P., Valle, G., Müller, M., Guiho, T., Hiairrassary, A., Petrini, F., Raspopovic, S., Strauss, I., Granata, G., Fernandez, E., Rossini, P. M., Barbaro, M., Yoshida, K., Jensen, W., Divoux, J.-L., Guiraud, D., Micera, S., & Stieglitz, T.
- Affiliations
- University of Freiburg (DE)
- Scuola Superiore Sant'Anna (IT)
- Institut national de recherche en sciences et technologies du numérique (FR)
- École Polytechnique Fédérale de Lausanne (CH)
- Università Cattolica del Sacro Cuore (IT)
- University of Cagliari (IT)
- Indiana University – Purdue University Indianapolis (US)
- Aalborg University (DK)
- Corresponding author
- Čvančara, P.
- ORCID
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2019-05-29
- OpenAlex
- W2946884562
- Cited by
- 12
- References
- 53
- Citations by year
- 2024: 2 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 2
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Funders
- Fondation Bertarelli
- European Commission (2007–2013, 602547, FP7 2007-2013, FP7/2007, 611687, HEALTH-2013)
- FP7 Health (FP7/2007-2013, FP7-HEALTH-2013-INNOVATIO-1 602547)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- thin film electrodes, chronically implanted electrodes, neuroprosthetics, sensory feedback, transradial amputation, prosthetic hand, polyimide electrodes, thin film metallization, explantation, corrosion, median nerve, ulnar nerve, amplitude modulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
