A transverse intrafascicular multichannel electrode (TIME) to treat phantom limb pain — Towards human clinical trials
Abstract
Over the last three years, a novel type of intrafascicular electrode was developed to serve as a corrective neural prosthetic interface to be placed in the peripheral nerve stumps of upper limb amputees who suffer from phantom limb pain (PLP). In general, the presented interface is an advancement of the thin-film LIFE electrode that was successfully used in amputees a couple of years ago. Although the LIFE concept proved to be effective, the longitudinal orientation of the implant prevented distribution of spatial selective sites in more than one fascicle. Therefore, a transversal approach was developed. The work presented was developed within the European project “TIME” and will be implanted in the median and ulnar nerves of an amputee subject in Rome later this year (2012). The present paper will outline the design, assembly technologies and full electrochemical characterization of the TIME-3H electrode for sub-chronic (<;30 days) human implants.
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Intra-neural devices such as LIFE, TIME, and USEA balance the trade-off between selectivity and invasiveness.
“The trade-off between selectivity and invasiveness is more balanced with intra-neural devices such as longitudinal intrafascicular electrodes (LIFE), which are implanted parallel to nerves [25], as well as transverse intra-fascicular multi-channel electrodes (TIME) and Utah slanted electrode arrays (USEA), which penetrate nerves at varying depths [26], [27].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [26]
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- Authors
- Boretius, T., Yoshida, K., Badia, J., Harreby, K., Kundu, A., Navarro, X., Jensen, W., & Stieglitz, T.
- Affiliations
- University of Freiburg (DE)
- Purdue University in Indianapolis (US)
- Aalborg University (DK)
- Universitat Autònoma de Barcelona (ES)
- Venue
- 2012 4th IEEE RAS & EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob)
- Publisher
- IEEE
- Published
- 2012-06
- Pages
- 282-287
- ISSN
- 2155-1774 (ISSN-L)
- OpenAlex
- W1975092334
- Cited by
- 39
- References
- 11
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 4 · 2017: 8 · 2016: 1 · 2014: 3 · 2013: 3
- FWCI
- 7.34
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- phantom limb pain, intrafascicular electrodes, upper limb amputation, median nerve, ulnar nerve, thin film electrodes, electrochemical characterization, neuroprosthetics
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