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Cited by 78Neuroscience and Neural EngineeringMuscle activation and electromyography studiesEEG and Brain-Computer Interfaces

Using multiple high-count electrode arrays in human median and ulnar nerves to restore sensorimotor function after previous transradial amputation of the hand

Clark, Gregory A., Wendelken, Suzanne, Page, David M., Davis, Tyler, Wark, Heather A. C., Normann, Richard A., Warren, David J., Hutchinson, Douglas T.·2014·2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
DOI 10.1109/embc.2014.6944001
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Abstract

Peripheral nerve interfaces that can record from and stimulate large numbers of different nerve fibers selectively and independently may help restore intuitive and effective motor and sensory function after hand amputation. To this end, and extending previous work in two subjects, two 100-electrode Utah Slanted Electrode Arrays (USEAs) were implanted for four weeks in the residual ulnar and median nerves of a 50-year-old male whose left, dominant hand had been amputated 21 years previously. Subsequent experiments involved 1) recording from USEAs for real-time control of a virtual prosthetic hand; 2) stimulation to evoke somatosensory percepts; and 3) closed-loop sensorimotor control. Overall, partial motor control and sensation were achieved using USEAs. 1) Isolated action potentials recorded from nerve motor fibers, although sparse at these distal implant sites, were activated during fictive movements of the phantom hand. Unlike in our previous two subjects, electromyographic (EMG) activity contributed to most online recordings and decodes, but was reduced in offline analyses using common average referencing. Online and offline Kalman-filter decodes of thresholded neural or EMG spikes independently controlled different digits of the virtual hand with one or two degrees of freedom. 2) Microstimulation through individual electrodes of the two USEAs evoked up to 106 different percepts, covering much of the phantom hand. The subject discriminated among five perceived stimulus locations, and between two somatosensory submodalities at a single location. 3) USEA-evoked percepts, mimicking contact with either a near or distal virtual target, were used to terminate movements of the virtual hand controlled with USEA recordings comprised wholly or mostly of EMG. These results further indicate that USEAs can help restore sensory and motor function after hand loss.

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Crossref · 10.1109/embc.2014.6944001

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  • USEA and LIFEs have been used successfully in short-term (less than a month) experiments in humans.

    “However, the USEA and LIFEs have been used successfully in short-term (less than a month) experiments in humans [7–9, 12, 14].”

    From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [12]

  • Patients have been shown to reliably distinguish a small number of different contact points depending on which electrode was stimulated.

    “Indeed, patients have been shown to reliably distinguish a small number of different contact points depending on which electrode was stimulated (Clark et al., 2014;Tan et al., 2015).”

    From Biomimetic approaches to bionic touch through a peripheral nerve interface (2015) · cites this paper as Clark et al., 2014

  • Stimulation of the nerve has been shown to induce a variety of sensations with complex qualities, such as tapping on the skin, vibration, tingling, stinging, brushing, and itch.

    “Stimulation of the nerve has been shown to induce a variety of sensations with complex qualities, such as tapping on the skin, vibration, tingling, stinging, brushing, and itch (Clark et al., 2014;Tan et al., 2015;2014).”

    From Biomimetic approaches to bionic touch through a peripheral nerve interface (2015) · cites this paper as Clark et al., 2014

  • Stimulation of the nerve can also occasionally evoke proprioceptive sensations, for example sensations of movement of a finger or a joint or a specific hand configuration.

    “Stimulation of the nerve can also occasionally evoke proprioceptive sensations, for example sensations of movement of a finger or a joint or a specific hand configuration (Clark et al., 2014;Dhillon and Horch, 2005;Tan et al., 2015;2014), though the quality and gradedness of these sensations has not been systematically explored.”

    From Biomimetic approaches to bionic touch through a peripheral nerve interface (2015) · cites this paper as Clark et al., 2014

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Authors
Clark, G. A., Wendelken, S., Page, D. M., Davis, T., Wark, H. A. C., Normann, R. A., Warren, D. J., & Hutchinson, D. T.
Affiliations
University of Utah (US)
ORCID
Venue
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Publisher
IEEE
Published
2014-08
Volume
2014
Pages
1977-1980
ISSN
2375-7477 (ISSN-L)
DOI
10.1109/embc.2014.6944001
OpenAlex
W2334234243
Cited by
78
References
9
Citations by year
2025: 1 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 13 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 3
FWCI
29.86
Type
conference paper
Language
en
Open access
closed
Licence
Locations
  • Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
peripheral nerve interfaces, median nerve, ulnar nerve, transradial amputation, prosthetic hand, sensorimotor control, somatosensory feedback, microstimulation, phantom hand
MeSH terms
Action Potentials, Amputation, Traumatic, Artificial Limbs, Electrodes, Humans, Male, Middle Aged, Motor Activity, Prosthesis Design, Ulnar Nerve, Neural Prostheses

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