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Regulation of lipid peroxidation and ferroptosis in diverse species
Open accessAbstract
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q 10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
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![Figure 2. Transgenic studies of GPX4 in mice reveal which tissues are, in principle, sensitive to undergoing ferroptosis. A myriad of transgenic studies performed in mice have pinpointed which cells and tissues depend on a functional glutathione/GPX4 system and thus in general are susceptible to ferroptotic cell death. A number of knockout studies with systemic deletion of the Gpx4 gene showed that loss of GPX4 causes early embryonic lethality around the gastrulation stage (i.e., embryonic day 7.5 [E7.5]). Beyond its requirement in early embryogenesis, several conditional deletion approaches of Gpx4 in different neuronal subpopulations revealed its necessity for a number of different neurons, such as pyramidal cells in the hippocampus, glutamatergic neurons in the cerebral cortex, cerebellar Purkinje cells, and motor neurons. Tamoxifen-inducible whole-body deletion of Gpx4 showed that kidney epithelial tubular cells are the limiting factor for survival of adult mice. Loss of GPX4 in hepatocytes and endothelial cells showed that in some tissues, Gpx4 deficiency can be compensated for by dietary vitamin E supplementation. Additional tissue-specific knockout studies for Gpx4 pinpointed that reticulocytes, certain T cells, photoreceptor cells, and male germ cells do depend on a functional GSH/GPX4 system. For further details, see the text.](/paper-figures/5776dc1fc34d4d5f96b745f4bb4f0468/regulation-of-lipid-peroxidation-and-ferroptosis-in-diverse-species-figure-2.jpg)
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“Mitochondrial damage has been found to be involved in lipid peroxidation and imbalance of iron homeostasis in neurodegenerative diseases such as AD and PD [34].”
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Metadata
- Authors
- Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R.
- Affiliations
- Helmholtz Munich (DE)
- University of Pittsburgh (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Oregon State University (US)
- Columbia University (US)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2018-05-01
- Volume
- 32
- Issue
- 9-10
- Pages
- 602-619
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC6004068
- OpenAlex
- W2804102163
- Cited by
- 544
- References
- 224
- Citations by year
- 2026: 53 · 2025: 65 · 2024: 73 · 2023: 95 · 2022: 80 · 2021: 82 · 2020: 52 · 2019: 37 · 2018: 6
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Genes & Development (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Site cant be reached (submittedVersion, cc-by-nc)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health (R35CA209896, P01CA087497, U19AI068021, NS076511, NS061817)
- Deutsche Forschungsgemeinschaft (CO 291/2-3, CO 291/5-1)
- Human Frontier Science Program (RGP0013)
- Agencia Nacional de Promoción Científica y Tecnológica
- Proyectos de Investigación Científica y Tecnológica (2013-1372, PICT 2016-0110)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- lipid peroxidation, ferroptosis, antioxidant defense, GPX4, vitamin E, coenzyme Q10, peroxy radicals, lipid hydroperoxides, non-apoptotic cell death, iron metabolism
- MeSH terms
- Animals, Antioxidants, Biological Evolution, Humans, Iron, Species Specificity, Lipid Peroxidation, Cell Death, Reactive Oxygen Species
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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