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PreprintCited by 1,960Gut microbiota and healthOral microbiology and periodontitis researchGenetic factors in colorectal cancer

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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

Open access
Kostic, Aleksandar D., Gevers, Dirk, Pedamallu, Chandra Sekhar, Michaud, Monia, Duke, Fujiko, Earl, Ashlee M., Ojesina, Akinyemi I., Jung, Joonil, Bass, Adam J., Tabernero, Josep, Baselga, José, Liu, Chen, Shivdasani, Ramesh A., Ogino, Shuji, Birren, Bruce W., Huttenhower, Curtis, Garrett, Wendy S., Meyerson, Matthew·2012·Genome Research
DOI 10.1101/gr.126573.111PMC PMC3266036
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Abstract

The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to carcinogenesis; however, the role of the microbiota is the least well understood. We have characterized the composition of the microbiota in colorectal carcinoma using whole genome sequences from nine tumor/normal pairs. Fusobacterium sequences were enriched in carcinomas, confirmed by quantitative PCR and 16S rDNA sequence analysis of 95 carcinoma/normal DNA pairs, while the Bacteroidetes and Firmicutes phyla were depleted in tumors. Fusobacteria were also visualized within colorectal tumors using FISH. These findings reveal alterations in the colorectal cancer microbiota; however, the precise role of Fusobacteria in colorectal carcinoma pathogenesis requires further investigation.

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Metadata

Authors
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., Baselga, J., Liu, C., Shivdasani, R. A., Ogino, S., Birren, B. W., Huttenhower, C., Garrett, W. S., & Meyerson, M.
Affiliations
  • Broad Institute (US)
  • Harvard University (US)
  • Universitat Autònoma de Barcelona (ES)
  • University of Florida Health (US)
  • Dana-Farber Cancer Institute (US)
  • Brigham and Women's Hospital (US)
ORCID
Venue
Genome Research
Publisher
Cold Spring Harbor Laboratory
Published
2011-10-18
Volume
22
Issue
2
Pages
292-298
ISSN
1088-9051 (ISSN-L)
DOI
10.1101/gr.126573.111
PMC
PMC3266036
OpenAlex
W2107097628
Cited by
1,960
References
2
Citations by year
2026: 101 · 2025: 146 · 2024: 163 · 2023: 162 · 2022: 172 · 2021: 194 · 2020: 175 · 2019: 164 · 2018: 143 · 2017: 122 · 2016: 108 · 2015: 88 · 2014: 92 · 2013: 84 · 2012: 37
Type
posted content
Language
en
Open access
Locations
  • Genome Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Damon Runyon Cancer Research Foundation
  • Albert J. Ryan Foundation
  • University of Guelph
  • Broad Institute (U54HG003067)
  • National Institutes of Health (UL1TR000064)
  • Natural Sciences and Engineering Research Council of Canada
  • National Human Genome Research Institute (U54HG003067)
  • National Cancer Institute (P50CA127003, K08CA134931, RC2CA148317, R01CA154426)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
Fusobacterium, colorectal cancer, tumor microbiome, gut microbiota, tumor microenvironment, carcinogenesis, colorectal cancer pathogenesis
MeSH terms
Fusobacterium, Humans, Intestine, Large, Phylogeny, RNA, Ribosomal, 16S, Colorectal Neoplasms, Genome, Bacterial, Sequence Analysis, DNA, Metagenome

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