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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Open accessAbstract
The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to carcinogenesis; however, the role of the microbiota is the least well understood. We have characterized the composition of the microbiota in colorectal carcinoma using whole genome sequences from nine tumor/normal pairs. Fusobacterium sequences were enriched in carcinomas, confirmed by quantitative PCR and 16S rDNA sequence analysis of 95 carcinoma/normal DNA pairs, while the Bacteroidetes and Firmicutes phyla were depleted in tumors. Fusobacteria were also visualized within colorectal tumors using FISH. These findings reveal alterations in the colorectal cancer microbiota; however, the precise role of Fusobacteria in colorectal carcinoma pathogenesis requires further investigation.
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“Two independent studies reported increased levels of Fusobacterium DNA and RNA sequences in tumor compared with non-tumor specimens.21, 22”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [22]
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Metadata
- Authors
- Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., Baselga, J., Liu, C., Shivdasani, R. A., Ogino, S., Birren, B. W., Huttenhower, C., Garrett, W. S., & Meyerson, M.
- Affiliations
- Broad Institute (US)
- Harvard University (US)
- Universitat Autònoma de Barcelona (ES)
- University of Florida Health (US)
- Dana-Farber Cancer Institute (US)
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-10-18
- Volume
- 22
- Issue
- 2
- Pages
- 292-298
- ISSN
- 1088-9051 (ISSN-L)
- PMC
- PMC3266036
- OpenAlex
- W2107097628
- Cited by
- 1,960
- References
- 2
- Citations by year
- 2026: 101 · 2025: 146 · 2024: 163 · 2023: 162 · 2022: 172 · 2021: 194 · 2020: 175 · 2019: 164 · 2018: 143 · 2017: 122 · 2016: 108 · 2015: 88 · 2014: 92 · 2013: 84 · 2012: 37
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- Albert J. Ryan Foundation
- University of Guelph
- Broad Institute (U54HG003067)
- National Institutes of Health (UL1TR000064)
- Natural Sciences and Engineering Research Council of Canada
- National Human Genome Research Institute (U54HG003067)
- National Cancer Institute (P50CA127003, K08CA134931, RC2CA148317, R01CA154426)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- Fusobacterium, colorectal cancer, tumor microbiome, gut microbiota, tumor microenvironment, carcinogenesis, colorectal cancer pathogenesis
- MeSH terms
- Fusobacterium, Humans, Intestine, Large, Phylogeny, RNA, Ribosomal, 16S, Colorectal Neoplasms, Genome, Bacterial, Sequence Analysis, DNA, Metagenome
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