Preliminary 6 month results from the argustm ii epiretinal prosthesis feasibility study
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The Argus II 60 channel epiretinal prosthesis has been developed in order to provide partial restoration of vision to subjects blinded from outer retinal degenerative disease. To date the device has been implanted in 21 subjects as part of a feasibility study. In 6 month post-implantation door finding and line tracking orientation and mobility testing, subjects have shown improvements of 86% and 73%, respectively, for system on vs. system off. In high-contrast Square Localization tests using a touch screen monitor 87% of tested subjects performed significantly better with the system on compared with off. These preliminary results show that the Argus II system provides some functional vision to blind subjects.
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Traditional computer vision approaches such as edge detection, contrast enhancement, and difference of Gaussians have been tested in retinal prostheses and proved limited usefulness in daily life.
“However, traditional computer vision approaches, such as edge detection, contrast enhancement, and difference of Gaussians, have been tested in retinal prostheses and proved limited usefulness in daily life [181][182][183].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [181]
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Sahel, J., & Marazova, K. (2014) · Springer eBooks · doi:10.1007/978-3-540-69466-3_53
Characterization and Development of potential molecular therapies for retinal photoreceptor disease
Pawar, A. S. (2012) · Figshare
A Coding Scheme for Optoelectronic/Optogenetic Retinal Prosthesis
Al‐Atabany, W., & Degenaar, P. A. (2013) · Biomedical Engineering · doi:10.2316/p.2013.791-018
Walter, P. (2016) · Spektrum der Augenheilkunde · doi:10.1007/s00717-016-0299-4
Ocular Manifestations of Pediatric Renal Diseases
Kurup, S. P., Keswani, M., & Enzenauer, R. W. (2017) · Springer eBooks · doi:10.1007/978-3-319-18389-3_19
Forensic optometry: A new era called bionic eye
Sharma, K., Rawat, A., Kausar, S., Madishetti, N. K., & Khan, M. (2024) · Indian Journal of Clinical and Experimental Ophthalmology · doi:10.18231/j.ijceo.2024.040
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Barnes, N. M., Petoe, M. A., Kolic, M., Baglin, E. K., Titchener, S. A., Habili, N., Kentler, W. G., Abbott, C. J., Allen, P. J., & Walker, J. G. (2026) · Translational Vision Science & Technology · doi:10.1167/tvst.15.10.21
- Authors
- Humayun, M. S., Dorn, J. D., Ahuja, A. K., Caspi, A., Filley, E., Dagnelie, G., Salzmann, J., Santos, A., Duncan, J., daCruz, L., Mohand-Said, S., Eliott, D., McMahon, M. J., & Greenberg, R. J.
- Affiliations
- Doheny Eye Institute (US)
- Second Sight Medical Products (US)
- Retina Foundation of the Southwest (US)
- Johns Hopkins University (US)
- University Hospital of Geneva (CH)
- University of California, San Francisco (US)
- Moorfields Eye Hospital (GB)
- Venue
- 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- Publisher
- IEEE
- Published
- 2009-09
- Volume
- 2009
- Pages
- 4566-4568
- ISSN
- 2375-7477 (ISSN-L)
- PMC
- PMC3337704
- OpenAlex
- W2097308611
- Cited by
- 100
- References
- 6
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 5 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 17 · 2012: 9
- FWCI
- 24.75
- Type
- conference paper
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Eye Institute (R29EY011888)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- Argus II, epiretinal prosthesis, retinal prosthesis, vision restoration, retinal degeneration, blindness, orientation and mobility, line tracking, visual localization, feasibility study
- MeSH terms
- Adult, Aged, Blindness, Feasibility Studies, Female, Humans, Locomotion, Male, Middle Aged, Orientation, Retina, Retinitis Pigmentosa, Prostheses and Implants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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