Importance of eye position on spatial localization in blind subjects wearing an Argus II retinal prosthesis
Abstract
PURPOSE: With a retinal prosthesis connected to a head-mounted camera (camera-connected prosthesis [CC-P]), subjects explore the visual environment through head-scanning movements. As eye and camera misalignment might alter the spatial localization of images generated by the device, we investigated if such misalignment occurs in blind subjects wearing a CC-P and whether it impacts spatial localization, even years after the implantation. METHODS: We studied three subjects blinded by retinitis pigmentosa, fitted with a CC-P (Argus II) 4 years earlier. Eye/head movements were video recorded as subjects tried to localize a visual target. Pointing coordinates were collected as subjects were requested to orient their gaze toward predetermined directions, and to point their finger to the corresponding perceived spot locations on a touch screen. Finally, subjects were asked to give a history of their everyday behavior while performing visually controlled grasping tasks. RESULTS: Misaligned head and gaze directions occurred in all subjects during free visual search. Pointing coordinates were collected in two subjects and showed that median pointing directions shifted toward gaze direction. Reportedly all subjects were unable to accurately determine their eye position, and they developed adapted strategies to perform visually directed movements. CONCLUSIONS: Eye position affected perceptual localization of images generated by the Argus II prosthesis, and consequently visuomotor coordination, even 4 years following implantation. Affected individuals developed strategies for visually guided movements to attenuate the impact of eye and head misalignment. Our observations provide indications for rehabilitation procedures and for the design of upcoming retinal prostheses. (ClinicalTrials.gov number, NCT00407602.).
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In prostheses with a head-mounted camera, misalignment between the camera orientation and the pupillary axes can induce localization problems.
“Therefore, in prostheses with a head-mounted camera, misalignment between the camera orientation and the pupillary axes can induce localization problems (Caspi et al., 2018; Paraskevoudi and Pezaris, 2018; Sabbah et al., 2014; Schmidt et al., 1996).”
From Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses (2024) · cites this paper as Sabbah et al., 2014
In blind patients implanted with retinal prostheses, the brain shifts the location of electrically-elicited percepts based on eye position.
“In blind patients implanted with retinal prostheses, the brain shifts the location of electrically-elicited percepts based on the eye position [12,13].”
From Eye movements and the perceived location of phosphenes generated by intracranial primary visual cortex stimulation in the blind (2021) · cites this paper as [13]
Phosphene shape variation across trials could also have been affected by perceptual adaptation and gaze direction.
“Phosphene shape variation across trials also could have been influenced by perceptual adaptation (Pérez Fornos et al. 2012) and gaze direction (Barry and Dagnelie 2016; Sabbah et al. 2014; Caspi et al. 2017; 2021).”
From Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only (2022) · cites this paper as Sabbah et al. 2014
Mislocalization may be due to eye movements affecting phosphene location or to inconsistencies in phosphene size and brightness.
“Mislocalization can be attributed to eye movements that influence the location of the phosphene (Sabbah et al. 2014; Caspi et al. 2017; 2021), or inconsistencies in phosphene size and brightness.”
From Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only (2022) · cites this paper as Sabbah et al. 2014
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“Therefore, in prostheses with a head-mounted camera, misalignment between the camera orientation and the pupillary axes can induce localization problems ( Caspi et al., 2018 ; Paraskevoudi and Pezaris, 2018 ; Sabbah et al., 2014 ; Schmidt et al., 1996 ).”
BackgroundResultRetinotopic to spatiotopic mapping in blind patients implanted with the Argus II retinal prosthesis
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Advances in neuroscience, not devices, will determine the effectiveness of visual prostheses
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Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only
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- Authors
- Sabbah, N., Authie, C. N., Sanda, N., Mohand-Said, S., Sahel, J.-A., & Safran, A. B.
- Affiliations
- Institut de la Vision (FR)
- University of Geneva (CH)
- Corresponding author
- Safran, A. B.
- Venue
- Investigative Ophthalmology & Visual Science
- Published
- 2014-11-20
- Volume
- 55
- Issue
- 12
- Pages
- 8259-8266
- ISSN
- 0146-0404 (ISSN-L)
- OpenAlex
- W2327843290
- Cited by
- 45
- References
- 28
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-IDEX-0004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- Argus II retinal prosthesis, spatial localization, retinitis pigmentosa, blind subjects, visuomotor coordination, visually guided grasping, adaptation strategies, head scanning
- MeSH terms
- Blindness, Calibration, Eye Movements, Humans, Male, Middle Aged, Motor Skills, Movement, Retinitis Pigmentosa, Space Perception, Head Movements, Visual Prosthesis
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