Long-term functionality of transversal intraneural electrodes is improved by dexamethasone treatment
Open accessAbstract
Neuroprostheses aimed to restore lost functions after a limb amputation are based on the interaction with the nervous system by means of neural interfaces. Among the different designs, intraneural electrodes implanted in peripheral nerves represent a good strategy to stimulate nerve fibers to send sensory feedback and to record nerve signals to control the prosthetic limb. However, intraneural electrodes, as any device implanted in the body, induce a foreign body reaction (FBR) that results in the tissue encapsulation of the device. The FBR causes a progressive decline of the electrode functionality over time due to the physical separation between the electrode active sites and the axons to interface. Modulation of the inflammatory response has arisen as a good strategy to reduce the FBR and maintain electrode functionality. In this study transversal intraneural multi-channel electrodes (TIMEs) were implanted in the rat sciatic nerve and tested for 3 months to evaluate stimulation and recording capabilities under chronic administration of dexamethasone. Dexamethasone treatment significantly reduced the threshold for evoking muscle responses during the follow-up compared to saline-treated animals, without affecting the selectivity of stimulation. However, dexamethasone treatment did not improve the signal-to-noise ratio of the recorded neural signals. Dexamethasone treatment allowed to maintain more working active sites along time than saline treatment. Thus, systemic administration of dexamethasone appears as a useful treatment in chronically implanted animals with neural electrodes as it increases the number of functioning contacts of the implanted TIME and reduces the intensity needed to stimulate the nerve.
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Dexamethasone administered systemically has been shown to improve electrical stimulation properties using TIME implants over a 3-month implantation period.
“Dexamethasone administered systemically has also been shown to improve the electrical stimulation properties using TIME implants over a 3-month implantation period (Oliva et al., 2019).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Oliva et al., 2019
The Results report improved stimulation measures with dexamethasone-treated TIME implants, but state that electrophysiological comparisons were possible only through one month because some wiring systems were damaged. Animals were followed for three months, but the Conclusion limits the demonstrated stimulation benefit to the first month of implantation. (LLM, conf=0.93)
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Cited by
Sorted by citations
Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
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“Dexamethasone administered systemically has also been shown to improve the electrical stimulation properties using TIME implants over a 3-month implantation period (Oliva et al., 2019).”
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“A study with TIME electrodes showed positive effects of systemic dexamethasone administration on decreasing foreign body reaction, further ensuring the chronic functionality [190].”
Method
- Authors
- de la Oliva, N., del Valle, J., Delgado-Martinez, I., Mueller, M., Stieglitz, T., & Navarro, X.
- Affiliations
- University of Freiburg (DE)
- Universitat Autònoma de Barcelona (ES)
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2019-03
- Volume
- 27
- Issue
- 3
- Pages
- 457-464
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- OpenAlex
- W2911370961
- Cited by
- 26
- References
- 40
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 1
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- ddd.uab.cat
- Licence
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, public-domain)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, public-domain)
- Funders
- FP7 Information and Communication Technologies (FP7-611687, EPIONE (FP7-602547))
- European Union’s Horizon 2020 Graphene Flagship Core Project 2 (785219)
- H2020 Future and Emerging Technologies
- TERCEL (RD12/0019/0011)
- CIBERNED (CB06/05/1105)
- Instituto de Salud Carlos III
- Fundación Ramón Areces (CIVP18A3897)
- ICN2
- Ministerio de Economía y Competitividad (SEV-2013-0295)
- Generalitat de Catalunya
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- dexamethasone, foreign body reaction, peripheral nerve stimulation, neural recording, sciatic nerve, chronic implantation, neural prostheses, amputation, anti-inflammatory therapy, signal-to-noise ratio
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