A three-dimensional self-opening intraneural peripheral interface (SELINE)
Open accessAbstract
OBJECTIVE: In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible peripheral neural interface. APPROACH: This polyimide-based electrode has a three-dimensional structure that provides an anchorage system to the nerve and confers stability after implant. This geometry has been achieved by means of the plastic deformation of polyimide. Mechanical and electrochemical characterizations have been performed to prove the integrity of the electrode with very good results. Functionality of SELINEs for fascicular stimulation has been tested during in vivo acute experiments in the rat. Chronic implants were made to test the biocompatibility of the device. MAIN RESULTS: Results showed that SELINEs significantly improve mechanical anchorage to the nerve. Stimulation stability is considerably enhanced compared to common planar transversal electrodes and stimulation selectivity is increased for some motor fascicles. Chronic experimental results showed that SELINEs neither produce changes in the fascicular organization of sciatic nerves nor signs of nerve degeneration. SIGNIFICANCE: The presented three-dimensional electrode provides an effective anchorage system to the nervous tissue that can improve the stability of the implant for acute and chronic studies.
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Implantation of SELINE in a rat sciatic nerve showed good selectivity and enhanced stability, despite an encapsulating layer caused by fibrotic scarring.
“Implantation in a rat sciatic nerve showed good selectivity and enhanced stability, despite an encapsulating layer caused by fibrotic scarring of tissue [29].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [29]
The paper reports SELINE implantation in rat sciatic nerves (§2.3.3) and improved stimulation selectivity and stability in in-vivo tests (Abstract; §4, Discussion and conclusions). The Discussion describes fibrous encapsulation as a tissue reaction to implants, but does not report observing an encapsulating layer around these SELINE implants or show that the measured selectivity and stability persisted despite one. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn a rat study comparing stability and stimulation selectivity of SELINE and TIME, SELINE stimulated more neural subfascicles, and its stability indices were higher than those of TIME, validating the impact of open wings in preventing displacement.
“In a rat study comparing the stability and stimulation selectivity of the SELINE and TIME, SELINE was found to stimulate more neural subfascicles, and its stability indices were higher than the stability indices of TIME, validating the impact of open wings in preventing displacement [105].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [105]
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- Authors
- Cutrone, A., Valle, J. D., Santos, D., Badia, J., Filippeschi, C., Micera, S., Navarro, X., & Bossi, S.
- Affiliations
- Scuola Superiore Sant'Anna (IT)
- Universitat Autònoma de Barcelona (ES)
- Italian Institute of Technology (IT)
- National Agency for New Technologies, Energy and Sustainable Economic Development (IT)
- Corresponding author
- Bossi, S
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2015-01-21
- Volume
- 12
- Issue
- 1
- Pages
- 016016
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- OpenAlex
- W2028925130
- Cited by
- 82
- References
- 25
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 14 · 2017: 11 · 2016: 1
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- ENEA Open Archive (National Agency for New Technologies, Energy and Sustainable Economic Development) (submittedVersion)
- Funders
- European Commission (280778)
- FP7 Nanosciences, Nanotechnologies, Materials and new Production Technologies
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- peripheral nerve interfaces, three-dimensional electrodes, polyimide electrodes, sciatic nerve, chronic implantation, biocompatibility, stimulation selectivity, rat model
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Gold, Materials Testing, Resins, Synthetic, Sciatic Nerve, Sensitivity and Specificity, Stress, Mechanical, Tensile Strength, Reproducibility of Results, Electric Impedance, Rats, Sprague-Dawley, Rats, Elastic Modulus, Neurophysiological Monitoring
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