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Cited by 176

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men

Zarotsky, V., Huang, M.‐Y., Carman, W., Morgentaler, A., Singhal, P. K., Coffin, D., Jones, T. H.·2014·Andrology
DOI 10.1111/andr.274
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Abstract

Summary: The objective of this review was to summarize the literature on the risk factors, comorbidities, and consequences of male hypogonadism, which is defined as a syndrome complex that includes biochemical confirmation of low testosterone (T) and the consistent symptoms and signs associated with low T. A systematic literature search was performed in PubMed/MEDLINE, EMBASE, Cochrane Library for articles published in the last 10 years on risk factors, comorbidities, and consequences of male hypogonadism. Of the 53 relevant studies identified, nine examined potential risk factors, 14 examined potential comorbidities, and 30 examined potential consequences of male hypogonadism. Based on studies conducted in Asia, Australia, Europe, and North & South America, the important factors that predicted and correlated with hypogonadism were advanced age, obesity, a diagnosis of metabolic syndrome (MetS), and a poor general health status. Diabetes mellitus was correlated with hypogonadism in most studies, but was not established as a risk factor. Although diseases, such as coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with incident low T. The data reviewed on potential consequences suggest that low T levels may be linked to earlier all‐cause and cardiovascular related mortality among men. This literature review suggests that men with certain factors, such as advanced age, obesity, MetS, and poor general health, are more likely to have and develop hypogonadism. Low levels of T may have important long‐term negative health consequences.

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Metadata

Authors
Zarotsky, V., Huang, M. ‐., Carman, W., Morgentaler, A., Singhal, P. K., Coffin, D., & Jones, T. H.
Venue
Andrology
Publisher
Wiley
Published
2014-10
Volume
2
Issue
6
Pages
819-834
ISSN
  • 2047-2919 (ISSN-L)
  • 2047-2927
DOI
10.1111/andr.274
OpenAlex
W2011443000
Cited by
176
References
22
FWCI
2.08
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Merck & Co., Inc.

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.