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The immune system and psychiatric disease: a basic science perspective

Bennett, F C, Molofsky, A V·2019·Clinical & Experimental Immunology
DOI 10.1111/cei.13334
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Abstract

Summary: Mental illness exerts a major burden on human health, yet evidence-based treatments are rudimentary due to a limited understanding of the underlying pathologies. Clinical studies point to roles for the immune system in psychiatric diseases, while basic science has revealed that the brain has an active and multi-cellular resident immune system that interacts with peripheral immunity and impacts behavior. In this perspective, we highlight evidence of immune involvement in human psychiatric disease and review data from animal models that link immune signaling to neuronal function and behavior. We propose a conceptual framework for linking advances in basic neuroimmunology to their potential relevance for psychiatric diseases, based on the subtypes of immune responses defined in peripheral tissues. Our goal is to identify novel areas of focus for future basic and translational studies that may reveal the potential of the immune system for diagnosing and treating mental illnesses

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Metadata

Authors
Bennett, F. C., & Molofsky, A. V.
Affiliations
  • Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia , Philadelphia, PA,
  • Department of Psychiatry and Weill Institute of Neurosciences, University of California , San Francisco, CA,
ORCID
Molofsky, A V
Venue
Clinical & Experimental Immunology
Publisher
Oxford University Press (OUP)
Published
2019-06-09
Volume
197
Issue
3
Pages
294-307
ISSN
  • 1365-2249
  • 0009-9104
DOI
10.1111/cei.13334
Cited by
137
References
51
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor, 891 d)
Funders
  • Brain and Behavior Research Foundation
  • National Institute of Mental Health (K08 MH112120-01, DP2MH116507, R01MH119349)
  • Burroughs Wellcome Fund
  • Pew Charitable Trusts

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Bennett, F. C., & Molofsky, A. V. (2019). The immune system and psychiatric disease: a basic science perspective. Clinical & Experimental Immunology. https://doi.org/10.1111/cei.13334