Cited by 361Gastrointestinal motility and disordersProbiotics and Fermented FoodsGut microbiota and health

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A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention

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KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., KORPELA, R.·2005·Alimentary Pharmacology & Therapeutics

DOI 10.1111/j.1365-2036.2005.02579.x

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Abstract

Summary: Background : Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear. Aim : To investigate whether a probiotic mixture containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS is effective in alleviating irritable bowel syndrome symptoms. Methods : A total of 103 patients fulfilling the Rome I or II criteria took part in this 6‐month, randomized, double‐blind placebo‐controlled trial. The patients received a probiotic capsule or a placebo capsule daily. Gastrointestinal symptoms and bowel habits were recorded. Results : At the end the total symptom score (abdominal pain + distension + flatulence + borborygmi) was 7.7 (95% CI: −13.9 to −1.6) points lower in the probiotic group (P = 0.015). This represents a median reduction of 42% in the symptom score of the probiotic group compared with 6% in the placebo group. In individual symptoms, borborygmi was milder in the probiotic group (P = 0.008), and for the rest of the symptoms there was a non‐significant trend. Conclusions : The results indicate that this probiotic mixture is effective in alleviating irritable bowel syndrome symptoms. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms could have positive public health consequences.

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Authors: KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R.
Affiliations: University of Helsinki (FI)
Valio (Finland) (FI)
Helsinki University Hospital (FI)
Corresponding author: KORPELA, R.
ORCID: POUSSA, T.
FÄRKKILÄ, M.
KORPELA, R.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2005-08-26
Volume: 22
Issue: 5
Pages: 387-394
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1111/j.1365-2036.2005.02579.x
OpenAlex: W2001065399
Cited by: 361
References: 37
Citations by year: 2026: 5 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 16 · 2015: 15 · 2014: 25 · 2013: 23 · 2012: 30
FWCI: 22.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: Valio
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: irritable bowel syndrome, probiotics, Lactobacillus rhamnosus GG, abdominal pain, abdominal distension, flatulence, borborygmi, bowel habits, Rome criteria
MeSH terms: Adult, Aged, Defecation, Double-Blind Method, Female, Humans, Lactobacillus, Life Style, Male, Medical Records, Middle Aged, Propionibacterium, Quality of Life, Surveys and Questionnaires, Probiotics, Irritable Bowel Syndrome

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A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention

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