Cited by 152Neurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormonesSexual Differentiation and Disorders

Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction

Andersen, S·2002·Psychoneuroendocrinology

Abstract

Males, but not females, overproduce dopamine receptors in the striatum of rats across the periadolescent period followed by their elimination during young adulthood. In order to investigate the role that gonadal hormones play in this pubertal process, rats were castrated or ovariectomized at postnatal day (P) 28 when estrogen and testosterone levels are beginning to surge. Dopamine D1 and D2 striatal receptor density was then determined with autoradiography at P40 (adolescence) and P80 (young adulthood) to determine if either testosterone stimulates the overproduction of receptors in males or if estrogen inhibits this process in females. Neither castration nor ovariectomy altered dopamine receptor density, although enhanced testosterone levels increased D1 receptor binding 4.2% and 19.5% in males and females, respectively. The results of this study suggest that the endogenous rise in gonadal steroid hormones during puberty is not responsible for the overproduction of receptors in males or the lack of overproduction in females.

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Crossref · 10.1016/s0306-4530(01)00069-5

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27 of 27 references verified0 citation errors · 0 not checkable

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  • Castration or testosterone injections during mid to late adolescence (p45-p60) alter various markers of dopaminergic function in male rats, though gonadal hormones are not necessary for male-specific peaks in striatal dopamine receptor expression.

    “For example, castration or testosterone injections during mid to late adolescence (p45-p60) alter various markers of dopaminergic function in male rats (Purves-Tyson et al., 2014), though gonadal hormones are not necessary for male-specific peaks in striatal dopamine receptor expression (Andersen et al., 2002).”

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Authors
Andersen, S.
Affiliations
Harvard University (US)
Corresponding author
Andersen, S
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2002-08
Volume
27
Issue
6
Pages
683-691
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2041464048
Cited by
152
References
27
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2022: 12 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 10
FWCI
2.79
Type
journal article
Language
en
Open access
closed
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Tourette Association of America
  • National Institute of Mental Health (NIMH-43473)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
puberty, gonadal hormones, dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, striatum, castration, ovariectomy, testosterone, estrogen, sex differences, adolescence, early adulthood, receptor density
MeSH terms
Aging, Animals, Autoradiography, Corpus Striatum, Estrogens, Female, Male, Orchiectomy, Ovariectomy, Receptors, Dopamine, Sex Characteristics, Sexual Maturation, Testosterone, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats

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