Reward-related processing in the human brain: developmental considerations
Abstract
The pursuit of rewarding experiences motivates everyday human behavior, and can prove beneficial when pleasurable, positive consequences result (e.g., satisfying hunger, earning a paycheck). However, reward seeking may also be maladaptive and lead to risky decisions with potentially negative long-term consequences (e.g., unprotected sex, drug use). Such risky decision making is often observed during adolescence, a time in which important structural and functional refinements occur in the brain's reward circuitry. Although much of the brain develops before adolescence, critical centers for goal-directed behavior, such as frontal corticobasal ganglia networks, continue to mature. These ongoing changes may underlie the increases in risk-taking behavior often observed during adolescence. Further, typical development of these circuits is vital to our ability to make well-informed decisions; atypical development of the human reward circuitry can have severe implications, as is the case in certain clinical and developmental conditions (e.g., attention-deficit/hyperactivity disorder). This review focuses on current research probing the neural correlates of reward-related processing across human development supporting the current research hypothesis that immature or atypical corticostriatal circuitry may underlie maladaptive behaviors observed in adolescence.
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The ventral striatum primarily contains the nucleus accumbens and projects to regions of the PFC implicated in emotion and motivation.
“The ventral striatum primarily contains the nucleus accumbens and projects to regions of the PFC implicated in emotion and motivation (Fareri et al., 2008).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Fareri et al., 2008
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Somerville, L. H., Jones, R. M., & Casey, B. J. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.07.003 · Cited by 1,025 · see citing works
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A behavioral scientist looks at the science of adolescent brain development
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“Theories abound to explain these patterns, most of which suggest that adolescent behavior patterns are attributable to changes in brain maturation during this period of the lifespan (Casey et al., 2008; Fareri et al., 2008; Steinberg, 2008).”
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Does sleep help prevent forgetting rewarded memory representations in children and adults?
Prehn-Kristensen, A., Böhmig, A., Schult, J., Pedersen, A., Wiesner, C. D., & Baving, L. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00924 · Cited by 14 · see citing works
- Authors
- Fareri, D. S., Martin, L. N., & Delgado, M. R.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Delgado, Mauricio R.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008
- Volume
- 20
- Issue
- 4
- Pages
- 1191-1211
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- OpenAlex
- W2136095705
- Cited by
- 141
- References
- 158
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 1 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 10
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA022998, R03DA022998)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- reward processing, adolescent brain development, corticostriatal circuits, risky decision making, risk-taking, attention deficit hyperactivity disorder, maladaptive behavior, goal-directed behavior, neural correlates of reward
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Basal Ganglia, Brain, Child, Child Development, Corpus Striatum, Decision Making, Hemodynamics, Humans, Learning, Magnetic Resonance Imaging, Punishment, Reward, Risk-Taking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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