Cited by 141Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral Economics

Reward-related processing in the human brain: developmental considerations

Fareri, Dominic S., Martin, Laura N., Delgado, Mauricio R.·2008·Development and Psychopathology

Abstract

The pursuit of rewarding experiences motivates everyday human behavior, and can prove beneficial when pleasurable, positive consequences result (e.g., satisfying hunger, earning a paycheck). However, reward seeking may also be maladaptive and lead to risky decisions with potentially negative long-term consequences (e.g., unprotected sex, drug use). Such risky decision making is often observed during adolescence, a time in which important structural and functional refinements occur in the brain's reward circuitry. Although much of the brain develops before adolescence, critical centers for goal-directed behavior, such as frontal corticobasal ganglia networks, continue to mature. These ongoing changes may underlie the increases in risk-taking behavior often observed during adolescence. Further, typical development of these circuits is vital to our ability to make well-informed decisions; atypical development of the human reward circuitry can have severe implications, as is the case in certain clinical and developmental conditions (e.g., attention-deficit/hyperactivity disorder). This review focuses on current research probing the neural correlates of reward-related processing across human development supporting the current research hypothesis that immature or atypical corticostriatal circuitry may underlie maladaptive behaviors observed in adolescence.

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Crossref · 10.1017/s0954579408000576

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Authors
Fareri, D. S., Martin, L. N., & Delgado, M. R.
Affiliations
Rutgers, The State University of New Jersey (US)
Corresponding author
Delgado, Mauricio R.
Venue
Development and Psychopathology
Published
2008
Volume
20
Issue
4
Pages
1191-1211
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
OpenAlex
W2136095705
Cited by
141
References
158
Citations by year
2026: 7 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 1 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 10
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA022998, R03DA022998)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords
reward processing, adolescent brain development, corticostriatal circuits, risky decision making, risk-taking, attention deficit hyperactivity disorder, maladaptive behavior, goal-directed behavior, neural correlates of reward
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Basal Ganglia, Brain, Child, Child Development, Corpus Striatum, Decision Making, Hemodynamics, Humans, Learning, Magnetic Resonance Imaging, Punishment, Reward, Risk-Taking

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