The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
Cnidarians and the evolutionary origin of the nervous system
Open accessAbstract
Cnidarians are widely regarded as one of the first organisms in animal evolution possessing a nervous system. Conventional histological and electrophysiological studies have revealed a considerable degree of complexity of the cnidarian nervous system. Thanks to expressed sequence tags and genome projects and the availability of functional assay systems in cnidarians, this simple nervous system is now genetically accessible and becomes particularly valuable for understanding the origin and evolution of the genetic control mechanisms underlying its development. In the present review, the anatomical and physiological features of the cnidarian nervous system and the interesting parallels in neurodevelopmental mechanisms between Cnidaria and Bilateria are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Though at least 600 million years of evolution separate cnidarians from bilaterians [9–16], many aspects of the nervous system are conserved, including neuropeptides and neurotransmitters [15–20].”
From The Jellyfish Cassiopea Exhibits a Sleep-like State (2017) · cites this paper as [18]
In the citing paper
“The publication of several cnidarian genomes has shown that much of the molecular architecture underlying neurogenesis and neuron functioning is conserved between bilaterians and cnidarians [17,47–51].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [51]
In the citing paper
“Nerve net-like arrangements of neurons cover the almost entire ectoderm in cnidarians and ctenophores [61,129,130–136].”
From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [136]
In the citing paper
“The presence of a well-developed nerve net correlates with the presence of basiepithelial muscle fibres directly innervated by nerve net neurons, in cnidarians and in ctenophores [61,67,128,132,133,135,136,138–142].”
From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [136]
In the citing paper
“In the cerianthids, a basal cnidarian lineage, the nerve net appears to be of purely ectodermal nature [128], which suggests that the evolution of inner layer neurons occurred independently in ctenophore, cnidarian and bilaterian lineages [136].”
From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [136]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Microscopic anatomy of invertebrates
Harrison, F. W. (1991) · Wiley-Liss eBooks · Cited by 2,736
Broad phylogenomic sampling improves resolution of the animal tree of life
Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921 · cited 2×
“Anthozoa is considered to be a representative of the basal group within the Cnidaria (Bridge et al. 1995; Medina et al. 2001; Collins 2002; Dunn et al. 2008).”
BackgroundSea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555
CLIP Identifies Nova-Regulated RNA Networks in the Brain
Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science · doi:10.1126/science.1090095 · Cited by 1,120
Structure of a Molluscan Cardioexcitatory Neuropeptide
Price, D. A., & Greenberg, M. J. (1977) · Science · doi:10.1126/science.877582 · Cited by 1,064
McMahon, J. A., Takada, S., Zimmerman, L. B., Fan, C., Harland, R. M., & McMahon, A. P. (1998) · Genes & Development · doi:10.1101/gad.12.10.1438 · Cited by 844
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS
De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671
Neural induction, the default model and embryonic stem cells
Muñoz-Sanjuán, I., & Brivanlou, A. H. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn786 · Cited by 645
Mash1regulates neurogenesis in the ventral telencephalon
Casarosa, S., Schuurmans, C. J., & Guillemot, F. (1999) · Development · doi:10.1242/dev.126.3.525 · Cited by 639
Settlement and metamorphosis of marine invertebrate larvae
Chia, F., & Rice, M. E. (1978) · Cited by 636
Research works printed but not linked: 6
- Laska G., 1982, Morphologie und Ultrastruktur der Lichtsinnesorgane von Tripedalia cystophora Conant (Cnidaria, Cubozoa), Zool. Jb. Anat, 108, 107
- 10.1016/S0006-8993(99)01972-1 · DOI
- 10.1006/dbio.1999.9360 · DOI
- Mackie G. O., 1984, FMRF‐amide‐like immunoreactivity in the neurons of medusae, Am. Zool, 24, 36A
- Müller W. A., 1969, Auslösung der Metamorphose durch Bakterien bei den Larven von Hydractinia echinata, Zool. Jb. Anat, 86, 84
- Widersten B., 1968, On the morphology and development in some cnidarian larvae, Zool. Bidr. Upps, 37, 139
Cited by
Sorted by citations
Invertebrate neurophylogeny: suggested terms and definitions for a neuroanatomical glossary
Richter, S., Loesel, R., Purschke, G., Schmidt‐Rhaesa, A., Scholtz, G., Stach, T., Vogt, L., Wanninger, A., Brenneis, G., Döring, C., et al. (2010) · Frontiers in Zoology · doi:10.1186/1742-9994-7-29 · Cited by 334
“The nervous system of Cnidaria and Ctenophora is typically organized as a plexus which functions as a nerve net [18,190,220,276,277].”
BackgroundFrom nerve net to nerve ring, nerve cord and brain — evolution of the nervous system
Arendt, D., Tosches, M. A., & Marlow, H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.15 · Cited by 279
The Jellyfish Cassiopea Exhibits a Sleep-like State
Nath, R. D., Bedbrook, C. N., Abrams, M. J., Basinger, T., Bois, J. S., Prober, D. A., Sternberg, P. W., Gradinaru, V., & Goentoro, L. (2017) · Current Biology · doi:10.1016/j.cub.2017.08.014 · Cited by 260
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232
Dixson, D. L., Abrego, D., & Hay, M. E. (2014) · Science · doi:10.1126/science.1255057 · Cited by 216
RetractedTryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor
Wei, G. Z., Martin, K. A., Xing, P. Y., Agrawal, R., Whiley, L., Wood, T. K., Hejndorf, S., Ng, Y. Z., Low, J. Z. Y., Rossant, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021091118 · Cited by 220
“That is, nerve cells appeared before the mesoderm layer, which, among many different cell types, control blood cells and adaptive immunity (1).”
BackgroundNakanishi, N., Renfer, E., Technau, U., & Rentzsch, F. (2012) · Development · doi:10.1242/dev.071902 · Cited by 188
“Interstitial cells can give rise to neurons, cnidocytes (stinging cells), gland cells and, in some species, also epithelial cells (Bosch et al., 2010; Bosch and David, 1987; David and Murphy, 1977; Muller et al., 2004; Watanabe et al., 2009).”
BackgroundWhat nervous systems do: early evolution, input–output, and the skin brain thesis
Keijzer, F., van Duijn, M., & Lyon, P. (2013) · Adaptive Behavior · doi:10.1177/1059712312465330 · Cited by 181
The Bilaterian Head Patterning Gene six3/6 Controls Aboral Domain Development in a Cnidarian
Sinigaglia, C., Busengdal, H., Leclère, L., Technau, U., & Rentzsch, F. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001488 · Cited by 169
“In contrast, despite regional differences in neuron density, neither Nematostella nor other cnidarian planulae or polyps display a comparable brain-like centralization of the nervous system at the oral or aboral end [83,85,101,102].”
BackgroundThe neuropeptide complement of the marine annelid Platynereis dumerilii
Conzelmann, M., Williams, E. A., Krug, K., Franz-Wachtel, M., Macek, B., & Jékely, G. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-906 · Cited by 165
“Neuropeptides represent by far the largest group of neurotransmitters and neuromodulators [1] and are considered the oldest neuronal signaling molecules in metazoans [2].”
BackgroundLayden, M. J., Rentzsch, F., & Röttinger, É. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.222 · Cited by 148
“Most agree that the nervous systems of bilaterians (the central and peripheral nervous systems) are derived from a nerve net-like ancestral nervous system.(98,99) Thus, better understanding development of nerve nets in Nematostella and other cnidarians will inform us about the structure and molecular make up of the an…”
BackgroundEvolution of sodium channels predates the origin of nervous systems in animals
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106363108 · Cited by 149
“Some medusozoans have concentrated nerve clusters and complex sense organs, which likely emerged convergently with the bilaterian central nervous system, as such nerve concentration is absent in anthozoans (34).”
BackgroundChemical transmission in the sea anemone Nematostella vectensis: a genomic perspective
Anctil, M. (2009) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2009.07.001 · Cited by 139
“A blast search apparently yielded Hydra genes for muscarinic receptors (Watanabe et al., 2009), but none is identified and there is no evidence that the gene sequences were subjected to scrutiny for functional domains.”
BackgroundNeuropeptides regulate swimming depth of Platynereis larvae
Conzelmann, M., Offenburger, S.-L., Asadulina, A., Keller, T., Münch, T. A., & Jékely, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109085108 · Cited by 136
“Neuropeptides are considered the oldest neuronal signaling molecules in animals (26).”
BackgroundInteroception and the origin of feelings: A new synthesis
Carvalho, G. B., & Damasio, A. (2021) · BioEssays · doi:10.1002/bies.202000261 · Cited by 132
Richards, G. S., & Rentzsch, F. (2014) · Development · doi:10.1242/dev.112029 · Cited by 110
“At the molecular level, Nematostella possesses many genes related to conserved bilaterian neural genes (Putnam et al., 2007; Watanabe et al., 2009), and subsets of its nervous system have been examined using antibodies against conserved neuropeptide precursor molecules [e.”
BackgroundFurness, J. B., & Stebbing, M. J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13234 · Cited by 128
Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
Senatore, A., Reese, T. S., & Smith, C. L. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.162396 · Cited by 113
“Many sensory neurosecretory cells in cnidarians and bilaterians are peptidergic (Spencer, 1989; Scharrer, 1990; Cazzamali and Grimmelikhuijzen, 2002; Grimmelikhuijzen et al., 2002; Plickert and Schneider, 2004; Kass-Simon and Pierobon, 2007; Watanabe et al., 2009; Conzelmann et al., 2011; Grimmelikhuijzen and Hauser,…”
BackgroundGastric pouches and the mucociliary sole: setting the stage for nervous system evolution
Arendt, D., Benito-Gutierrez, E., Brunet, T., & Marlow, H. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0286 · Cited by 112
Jager, M., Chiori, R., Alié, A., Dayraud, C., Quéinnec, E., & Manuel, M. (2011) · Journal of Experimental Zoology Part B: Molecular and Developmental Evolution · doi:10.1002/jez.b.21386 · Cited by 107
“& 2010 WILEY-LISS, INC. several homologues of bilaterian neural genes in cnidarian neuro-sensory cells (reviews in Galliot et al., 2009; Watanabe et al., 2009).”
BackgroundDo jellyfish have central nervous systems?
Satterlie, R. A. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.043687 · Cited by 113
“In comparison to neurons of bilateral animals, they contain close to a complete set of signaling molecules that are involved in nervous system development, maintenance and communication (see Watanabe et al., 2009).”
BackgroundThe chemical brain hypothesis for the origin of nervous systems
Jékely, G. (2021) · Philosophical Transactions of the Royal Society B · doi:10.1098/rstb.2019.0761 · Cited by 108
Layden, M. J., Boekhout, M., & Martindale, M. Q. (2012) · Development · doi:10.1242/dev.073221 · Cited by 98
“Additionally, FGF signaling and the closely related epidermal growth factor (EGF) signaling provide crucial instructive cues during bilaterian central nervous system development (Stern, 2005; Watanabe et al., 2009).”
BackgroundAncestral state reconstruction of ontogeny supports a bilaterian affinity for Dickinsonia
Gold, D. A., Runnegar, B., Gehling, J. G., & Jacobs, D. K. (2015) · Evolution & Development · doi:10.1111/ede.12168 · Cited by 99
The cellular and molecular basis of cnidarian neurogenesis
Rentzsch, F., Layden, M. J., & Manuel, M. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.257 · Cited by 96
“Molecularly, genes encoding for several of the major receptor-ligand pairs involved in bilaterian neurite guidance (Semaphorin and Plexin, Ephrin and Eph, Wnt and Ryk, Netrin and Neogenin/DCC, Unc5, RGM) are present in the Nematostella genome.(48) Interestingly, Netrin and RGM are expressed in different subdomains in…”
BackgroundImmortality and the base of multicellular life: Lessons from cnidarian stem cells
Watanabe, H., Hoang, V. T., Mättner, R. A., & Holstein, T. W. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.09.008 · Cited by 98
“The importance of cnidarians as a model for understanding the evolutionary origin of the nervous system in metazoan evolution has been recently revised elsewhere [9,68,69]).”
BackgroundSelf-citationEvolution of eumetazoan nervous systems: insights from cnidarians
Kelava, I., Rentzsch, F., & Technau, U. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0065 · Cited by 84
Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis
Watanabe, H., Kuhn, A., Fushiki, M., Agata, K., Özbek, S., Fujisawa, T., & Holstein, T. W. (2014) · Nature Communications · doi:10.1038/ncomms6536 · Cited by 79
Self-citationKrishnan, A., & Schiöth, H. B. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110312 · Cited by 81
“…glutamate, γaminobutyric acid (GABA), glycine, epinephrine, norepinephrine, Th e Jo ur na l o f E xp er im en ta l B io lo gy dopamine and serotonin transmitters, as well as neuropeptides, are involved in cnidarian neurotransmission (Kass-Simon and Pierobon, 2007; Watanabe et al., 2009) (Fig.”
BackgroundInfluentialRegulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
Richards, G. S., & Rentzsch, F. (2015) · Development · doi:10.1242/dev.123745 · Cited by 80
“Indeed, genomic comparisons have shown that cnidarians possess many orthologues to key bilaterian neural-related genes (Chapman et al., 2010; Galliot et al., 2009; Putnam et al., 2007; Watanabe et al., 2009), but a functional characterisation of the majority of these candidates is lacking.”
Dufour, S., Quérat, B., Tostivint, H., Pasqualini, C., Vaudry, H., & Rousseau, K. (2019) · Physiological Reviews · doi:10.1152/physrev.00009.2019 · Cited by 88
Tournière, O., Dolan, D., Richards, G. S., Sunagar, K., Columbus-Shenkar, Y. Y., Moran, Y., & Rentzsch, F. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.031 · Cited by 74
Keijzer, F. (2015) · Biology & Philosophy · doi:10.1007/s10539-015-9483-1 · Cited by 78
“Keywords Early nervous systems Skin brain thesis Sensorimotor organization Embodiment Input–output view Coordination view F. Keijzer (&) Department of Theoretical Philosophy, University of Groningen, Oude Boteringestraat 52, 9712 GL Groningen, The Netherlands e-mail: f.a.keijzer@rug.nl”
BackgroundEvolution of the bilaterian mouth and anus
Nielsen, C., Brunet, T., & Arendt, D. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0641-0 · Cited by 70
Convergent Evolution of Sodium Ion Selectivity in Metazoan Neuronal Signaling
Gur Barzilai, M., Reitzel, A. M., Kraus, J. E. M., Gordon, D., Technau, U., Gurevitz, M., & Moran, Y. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.016 · Cited by 76
Convergence of ion channel genome content in early animal evolution
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501195112 · Cited by 76
Lu, T.-M., Luo, Y., & Yu, J. (2012) · Development · doi:10.1242/dev.073833 · Cited by 75
“Although cnidarians typically have a diffuse nerve net, some regionalization patterns of neurons and their neurites have been identified in several types of cnidarians (Galliot et al., 2009; Watanabe et al., 2009).”
BackgroundArendt, D. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0347 · Cited by 75
The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation
Kim, H., Weber, J. A., Lee, N., Park, S. G., Cho, Y. S., Bhak, Y., Lee, N., Jeon, Y., Jeon, S., Luria, V., et al. (2019) · BMC Biology · doi:10.1186/s12915-019-0643-7 · Cited by 66
“3b; Additional file 5: Tables S34–S37); consistent with the anatomy of jellyfish tentacles, which contain the sensory cells and a loose plexus of the neuronal subpopulation at the base of the ectoderm [21].”
BackgroundAranda, M., Banaszak, A. T., Bayer, T., Luyten, J. R., Medina, M., & Voolstra, C. R. (2011) · Molecular Ecology · doi:10.1111/j.1365-294x.2011.05153.x · Cited by 62
“Compromised neurogenesis could consequently impair larval behaviour such as locomotion and settlement (Katsukura et al. 2004; Plickert & Schneider 2004; Watanabe et al. 2009), resulting in reduced motility and decreased settlement rates at later stages.”
BackgroundStrader, M. E., Aglyamova, G. V., & Matz, M. V. (2018) · BMC Genomics · doi:10.1186/s12864-017-4392-0 · Cited by 61
“Although a role of FGF signaling in sensory cell development has not been fully substantiated in cnidarians [103], it is possible that the role of FGF signaling in anthozoans without an apical organ is the development of other sensory cells that are critical in detection of environmental stimulus prior to settlement.”
Complex neural architecture in the diploblastic larva of Clava multicornis (Hydrozoa, Cnidaria)
Piraino, S., Zega, G., Di Benedetto, C., Leone, A., Dell'Anna, A., Pennati, R., Candia Carnevali, D., Schmid, V., & Reichert, H. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22614 · Cited by 56
“…are thought to represent important internal signals for the coordination of the metamorphic process in cnidarians (Schwoerer-Böhning et al., 1990; Leitz, 1993; Schmich et al., 1998a,b; Plickert et al., 2003) as well as for the synaptic transmission of neuronal activity (Watanabe et al., 2009).”
BackgroundMethodInfluentialPredation and the Origin of Neurones
Monk, T., & Paulin, M. G. (2014) · Brain Behavior and Evolution · doi:10.1159/000368177 · Cited by 55
“Molecular evidence indicates that all nervous systems share a degree of genetic conservation [Ghysen, 2003; Gomez-Skarmeta et al., 2003; Ball et al., 2004; Matus et al., 2006; Denes et al., 2007; Jacobs et al., 2007; Arendt et al., 2008; Watanabe et al., 2009; Hirth, 2010], but some nervous systems are more closely re…”
BackgroundInfluentialSemmler, H., Chiodin, M., Bailly, X., Martı́nez, P., & Wanninger, A. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2010.01207.x · Cited by 55
“Some medusoid adults have unequally distributed ring-shaped or longitudinal neurites and regions with condensed neuronal cell bodies along the body axis, but until now it remains unclear whether these have been carried over from the larval stage or form de novo in adults (Watanabe et al. 2009).”
BackgroundKrishnan, A., Dnyansagar, R., Almén, M. S., Williams, M. J., Fredriksson, R., Manoj, N., & Schiöth, H. B. (2014) · BMC Evolutionary Biology · doi:10.1186/s12862-014-0270-4 · Cited by 57
“In Nematostella, an ectodermal and endodermal nerve net constituting of a simple and diffuse nervous system runs throughout the animal’s body [23,24].”
BackgroundThe role of cnidarian developmental biology in unraveling axis formation and Wnt signaling
Holstein, T. W. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.04.005 · Cited by 54
Self-citationBosch, T. C. G., Adamska, M., Augustin, R., Domazet‐Lošo, T., Forêt, S., Fraune, S., Funayama, N., Grasis, J. A., Hamada, M., Hatta, M., et al. (2014) · BioEssays · doi:10.1002/bies.201400065 · Cited by 52
Pagán, O. R. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0383 · Cited by 54
Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation
Pascual-Torner, M., Carrero, D., Pérez-Silva, J. G., Álvarez-Puente, D., Roiz‐Valle, D., Bretones, G., Rodríguez, D., Maeso, D., Mateo-González, E., Español, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118763119 · Cited by 50
Hayakawa, E., Watanabe, H., Menschaert, G., Holstein, T. W., Baggerman, G., & Schoofs, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215185 · Cited by 47
“A previous study showed a highly conserved set of genes in the Nematostella vectensis genome, including molecules involved in neurotransmission [28,89].”
BackgroundInfluentialSelf-citationThe Xenopus doublesex-related gene Dmrt5 is required for olfactory placode neurogenesis
Parlier, D., Moers, V., Campenhout, C. V., Preillon, J., Leclère, L., Saulnier, A., Sirakov, M., Busengdal, H., Kricha, S., Marine, J., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.10.003 · Cited by 47
GABAergic Synaptic Plasticity during a Developmentally Regulated Sleep-Like State inC. elegans
Dabbish, N., & Raizen, D. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0742-11.2011 · Cited by 42
“Nervous system remodeling is an ancient, widespread phenomenon seen in animals ranging from cnidarians to vertebrates (Nakanishi et al., 2008; Watanabe et al., 2009).”
Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale
Schlosser, G. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.008 · Cited by 45
A Non-sulfated Chondroitin Stabilizes Membrane Tubulation in Cnidarian Organelles
Adamczyk, P., Zenkert, C., Balasubramanian, P. G., Yamada, S., Murakoshi, S., Sugahara, K., Hwang, J. S., Gojobori, T., Holstein, T. W., & Özbek, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107904 · Cited by 40
Self-citationCharacterization of NvLWamide-like neurons reveals stereotypy in Nematostella nerve net development
Havrilak, J. A., Faltine-Gonzalez, D. Z., Wen, Y., Fodera, D. M., Simpson, A. C., Magie, C. R., & Layden, M. J. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.08.028 · Cited by 37
Microfluidics for electrophysiology, imaging, and behavioral analysis of Hydra
Badhiwala, K. N., Gonzales, D. L., Vercosa, D. G., Avants, B. W., & Robinson, J. T. (2018) · Lab on a Chip · doi:10.1039/c8lc00475g · Cited by 36
Vidal, B., Gülez, B., Cao, W. X., Leyva‐Díaz, E., Reilly, M. B., Tekieli, T., & Hobert, O. (2022) · eLife · doi:10.7554/elife.76003 · Cited by 44
“Pharyngeal neurons combine sensory, inter- and motor neuron features and are also not localized to ganglia but rather diffusely localized, resembling the architecture of more ancient nerve nets (Albertson and Thomson, 1976; Watanabe et al., 2009).”
BackgroundNeuronal cell death during metamorphosis of Hydractina echinata (Cnidaria, Hydrozoa)
Seipp, S., Schmich, J., Will, B., Schetter, E., Plickert, G., & Leitz, T. (2010) · Invertebrate Neuroscience · doi:10.1007/s10158-010-0109-7 · Cited by 36
“…1300 Morris Park Ave., Chanin Building, Room 606, New York, NY 10461, USA E. Schetter G. Plickert Biozentrum der Universität, Institut für Zoologie, Universität zu Köln, Zülpicher Str. 47b, 50674 Köln, Germany Westfall 1995; Koizumi and Bode 1991; Watanabe et al. 2009 for a recent review).”
Modern genomic tools reveal the structural and cellular diversity of cnidarian nervous systems
Rentzsch, F., Juliano, C. E., & Galliot, B. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.12.004 · Cited by 37
Evo-devo of non-bilaterian animals
Lanna, E. (2015) · Genetics and Molecular Biology · doi:10.1590/s1415-475738320150005 · Cited by 34
“It has already been shown that some neural bHLH transcription factors are expressed in developing neurons in hydrozoans (Grens et al., 1995; Seipel et al., 2004; reviewed in Watanabe et al., 2009).”
BackgroundInfluentialGenomics and development of Nematostella vectensis and other anthozoans
Rentzsch, F., & Technau, U. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.024 · Cited by 32
Effect of neurotoxic compounds on ephyrae of Aurelia aurita jellyfish
Costa, E., Gambardella, C., Piazza, V., Greco, G., Lavorano, S., Beltrandi, M., Bongiovanni, E., Gnone, G., Faimali, M., & Garaventa, F. (2015) · Hydrobiologia · doi:10.1007/s10750-015-2284-3 · Cited by 34
“Moreover, a role of neuronal control has been proved to regulate the periodic contractions of A. aurita body, in order to generate ring-vortices of the surrounding medium (Satterlie, 2002; Watanabe et al., 2009).”
BackgroundResultA myxozoan genome reveals mosaic evolution in a parasitic cnidarian
Guo, Q., Atkinson, S. D., Xiao, B., Zhai, Y., Bartholomew, J. L., & Gu, Z. (2022) · BMC Biology · doi:10.1186/s12915-022-01249-8 · Cited by 31
“Primitive nervous system? While free-living cnidarians have simple nerve nets [85], there is no evidence that similar nerves are present in myxozoans even though they can sense proximity of hosts and can have motile, multi-cellular stages [56].”
BackgroundBusengdal, H., & Rentzsch, F. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.08.021 · Cited by 35
A new look at the architecture and dynamics of the Hydra nerve net
Keramidioti, A., Schneid, S., Busse, C., von Laue, C. C., Bertulat, B., Salvenmoser, W., Heß, M., Alexandrova, O., Glauber, K. M., Steele, R. E., et al. (2023) · eLife · doi:10.7554/elife.87330.3 · Cited by 34
Self-citationEvolution of the Pax-Six-Eya-Dach network: the calcisponge case study
Fortunato, S., Leininger, S., & Adamska, M. (2014) · EvoDevo · doi:10.1186/2041-9139-5-23 · Cited by 32
“ciliatum express SoxB [24], a transcription factor involved in bilaterian neurogenesis [34,35] and expressed in cnidarian neurosensory cells [36].”
BackgroundPhylostratigraphic Profiles in Zebrafish Uncover Chordate Origins of the Vertebrate Brain
Šestak, M. S., & Domazet‐Lošo, T. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu319 · Cited by 29
“These increases might be expected, given that the first nervous system emerged in this evolutionary range (Koizumi 2007; SchmidtRhaesa 2007; Galliot et al. 2009; Watanabe et al. 2009).”
BackgroundFortunato, S. A. V., Adamski, M., & Adamska, M. (2015) · Marine Genomics · doi:10.1016/j.margen.2015.07.008 · Cited by 31
Zieger, E., & Schubert, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.09.001 · Cited by 32
Insights into the evolution of digestive systems from studies of Trichoplax adhaerens
Smith, C. L., & Mayorova, T. D. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03057-z · Cited by 29
Organization of the ectodermal nervous structures in jellyfish: scyphomedusae
Satterlie, R. A., & Eichinger, J. M. (2014) · The Biological Bulletin · doi:10.1086/bblv226n1p29 · Cited by 30
“In a more general sense, various forms of tubulin antibodies have been used to stain neurons in cnidarians (Groger and Schmid, 2001; Galliot et al., 2009; Watanabe et al., 2009; Nakanishi et al., 2009, 2010), as have RFamide antibodies (Grimmelikhuijzen et al., 1996, 2002).”
BackgroundEv, R., & Raikova, O. I. (2015) · Zoology · doi:10.1016/j.zool.2015.11.004 · Cited by 30
Formery, L., Orange, F., Formery, A., Yaguchi, S., Lowe, C. J., Schubert, M., & Croce, J. C. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25012 · Cited by 30
Cephalopods: Ambassadors for rethinking cognition
Schnell, A. K., & Clayton, N. S. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.062 · Cited by 33
Do epidermal keratinocytes have sensory and information processing systems?
Denda, M., & Nakanishi, S. (2021) · Experimental Dermatology · doi:10.1111/exd.14494 · Cited by 31
Tournière, O., Gahan, J. M., Busengdal, H., Bartsch, N., & Rentzsch, F. (2022) · Science Advances · doi:10.1126/sciadv.abi7109 · Cited by 25
Hydraulic and electric control of cell spheroids
Duclut, C., Prost, J., & Jülicher, F. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021972118 · Cited by 26
The synapsin gene family in basal chordates: evolutionary perspectives in metazoans
Candiani, S., Moronti, L., Pennati, R., de Bernardi, F. L., Benfenati, F., & Pestarino, M. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-32 · Cited by 28
“Thus, the emergence of E domain appears to be correlated with the beginning of the genesis of nervous organization, since the simplest metazoans known to possess a nervous system are those of the phylum Cnidaria [39].”
Hou, X., Qin, Z., Wei, M., Fu, Z., Liu, R., Lu, L., Bai, S., Ma, Y., & Zhang, Z. (2020) · BMC Genomics · doi:10.1186/s12864-020-07312-4 · Cited by 25
Structure and evolution of neuronal wiring receptors and ligands
Cortés, E. C., Pak, J. S., & Özkan, E. (2022) · Developmental Dynamics · doi:10.1002/dvdy.512 · Cited by 25
“DCC homologs have been identified in bilaterians as common receptors that guide commissural projections but are also present in cnidarians(15): For example, the anthozoan model organism Nematostella vectensis (starlet sea anemone) is known to have a complete set of Netrin, DCC, and Unc5-like proteins.(15) In vertebrat…”
BackgroundMedusa: A Review of an Ancient Cnidarian Body Form
Ames, C. L. (2018) · Results and problems in cell differentiation · doi:10.1007/978-3-319-92486-1_7 · Cited by 27
Oren, M., Brickner, I., Appelbaum, L., & Levy, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093832 · Cited by 24
“The first appearance of functional nervous systems in animal evolution is attributed to the coelenterates, including the ctenophores (comb jellies) and the cnidarians [5].”
BackgroundTran, C., & Hadfield, M. G. . (2012) · Biological Bulletin · doi:10.1086/bblv222n2p128 · Cited by 24
Cnidarian Nerve Nets and Neuromuscular Efficiency
Satterlie, R. A. (2015) · Integrative and Comparative Biology · doi:10.1093/icb/icv067 · Cited by 25
Clark, E., Kanauchi, D., Kano, T., Aonuma, H., Briggs, D. E. G., & Ishiguro, A. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.192104 · Cited by 22
“Other examples of decentralized nervous control in the animal kingdom include the diffused nerve nets of cnidarians (Watanabe et al., 2009) and other bilaterians such as xenacoelomorphs and hemichordates (Martín-Durán et al.”
BackgroundCapasso, L., Ganot, P., Planas-Bielsa, V., Tambutté, S., & Zoccola, D. (2021) · BMC Molecular and Cell Biology · doi:10.1186/s12860-021-00353-x · Cited by 20
Wong, E., Mölter, J., Anggono, V., Degnan, B. M., & Degnan, B. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-51282-x · Cited by 20
PHYRN: A Robust Method for Phylogenetic Analysis of Highly Divergent Sequences
Bhardwaj, G., Ko, K. D., Hong, Y., Zhang, Z., Ho, N. L., Chintapalli, S. V., Kline, L. A., Gotlin, M. J., Hartranft, D. N., Patterson, M. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034261 · Cited by 17
“580 million years ago), which are some of the first organisms known to have a developed neural net, radial axis of symmetry, muscle cells, and stem cells [49,50].”
BackgroundSizemore, T. R., Jonaitis, J., & Dacks, A. M. (2023) · Nature Communications · doi:10.1038/s41467-023-41012-3 · Cited by 21
“isons test was used to determine if: (1) MIPergic LNs preferentially innervate based on the functional group found along the odorant that activates the given glomerulus’ odorant receptor; (2) SPR-GAL4::VP16 expression in antennae and maxillary palps significantly differs between males, mated females, and virgin female…”
Zheng, Y., Cong, X., Liu, H., Wang, Y., Storey, K. B., & Chen, M. (2022) · Biology · doi:10.3390/biology11101538 · Cited by 16
Extracellular matrix and morphogenesis in cnidarians: a tightly knit relationship
Bergheim, B. G., & Özbek, S. (2019) · Essays in Biochemistry · doi:10.1042/ebc20190021 · Cited by 16
Melatonin Distribution Reveals Clues to Its Biological Significance in Basal Metazoans
Roopin, M., & Levy, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052266 · Cited by 16
“Although a complete understanding of the cnidarian nervous system has not been obtained, potentially centralized elements, such as circular nerve ring structures, are believed to represent complex features of these presumably simple systems (reviewed in [50]) and have been demonstrated to functionally coordinate a wid…”
BackgroundTranscriptional characterisation of the Exaiptasia pallida pedal disc
Davey, P. A., Rodrigues, M., Clarke, J., & Aldred, N. (2019) · BMC Genomics · doi:10.1186/s12864-019-5917-5 · Cited by 18
Nielsen, S. K. D., Koch, T. L., Wiisbye, S. H., Grimmelikhuijzen, C. J. P., & Garm, A. L. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25133 · Cited by 14
“…nature of the neuronal inducers among cnidarians is still unclear, and increased knowledge here would provide important insights not only into the evolutionary origin of neural induction but also into the molecular evolution of the centralized nervous system in bilaterians (Watanabe et al., 2009).”
BackgroundB., L. Q. I., Bartsch, N., Kouzel, I. U., Busengdal, H., Richards, G. S., Steinmetz, P. R. H., & Rentzsch, F. (2023) · Nature Communications · doi:10.1038/s41467-023-39789-4 · Cited by 13
Reconciling Ontic and Epistemic Constraints on Mechanistic Explanation, Epistemically
van Eck, D. (2014) · Axiomathes · doi:10.1007/s10516-014-9243-x · Cited by 14
Zhang, R., Jin, L., Zhang, N., Petridis, A. K., Eckert, T., Scheiner‐Bobis, G., Bergmann, M., Scheidig, A. J., Schauer, R., Yan, M., et al. (2019) · Marine Drugs · doi:10.3390/md17080469 · Cited by 13
“Sialic acid molecules which play also a crucial role in developmental processes [90,91] were invented during the evolution in Echinodermata (e.”
BackgroundNoro, Y., Shimizu, H., Mineta, K., & Gojobori, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-89325-x · Cited by 15
Human transcriptome nexuses: Basic-eukaryotic and metazoan
Vinogradov, A. E. (2010) · Genomics · doi:10.1016/j.ygeno.2010.03.004 · Cited by 14
“The nervous system originated very early in the evolution of metazoans, just after the divergence of sponge and eumetazoan lineages [38,39].”
BackgroundThe histology of Nanomia bijuga (Hydrozoa: Siphonophora)
Church, S. H., Siebert, S., Bhattacharyya, P., & Dunn, C. W. (2015) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22629 · Cited by 14
Metadata
- Authors
- Watanabe, H., Fujisawa, T., & Holstein, T. W.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Watanabe, Hiroshi
- Holstein, Thomas W.
- Venue
- Development, Growth & Differentiation
- Publisher
- Wiley
- Published
- 2009-03-30
- Volume
- 51
- Issue
- 3
- Pages
- 167-183
- ISSN
- 0012-1592 (ISSN-L)
- 1440-169X
- OpenAlex
- W1636647670
- Cited by
- 206
- References
- 191
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 16 · 2023: 9 · 2022: 16 · 2021: 26 · 2020: 13 · 2019: 17 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 19 · 2014: 15 · 2013: 5 · 2012: 8
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development Growth & Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Toyobo Biotechnology Foundation
- Deutsche Forschungsgemeinschaft (SFB 488)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Cnidaria, nervous system evolution, brain development, Bilateria, comparative neuroanatomy
- MeSH terms
- Animals, Cnidaria, Biological Evolution, Nervous System, Phylogeny
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
