Cited by 174Diabetes Management and EducationDiabetes Management and ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Diabetes‐specific emotional distress mediates the association between depressive symptoms and glycaemic control in Type 1 and Type 2 diabetes

Van Bastelaar, K. M. P., Pouwer, F., Geelhoed‐Duijvestijn, P. H. L. M., Tack, C. J., Bazelmans, E., Beekman, A. T., Heine, R. J., Snoek, F. J.·2010·Diabetic Medicine

Abstract

Diabet. Med. 27, 798–803 (2010) Objectives To investigate whether diabetes‐specific emotional distress mediates the relationship between depression and glycaemic control in patients with Type 1 and Type 2 diabetes. Research design and methods Data were derived from the baseline assessment of a depression in diabetes screening study carried out in three tertiary diabetes clinics in the Netherlands. Most recent glycated haemoglobin (HbA 1c) measurement was obtained from medical records. The Centre for Epidemiologic Studies Depression Scale (CES‐D) and Problem Areas in Diabetes scale (PAID) were used to measure depression and diabetes‐specific emotional distress respectively. Linear regression was performed to examine the mediating effect of diabetes–distress. Results Complete data were available for 627 outpatients with Type 1 (n = 280) and Type 2 (n = 347) diabetes. Analyses showed that diabetes–distress mediated the relation between depression and glycaemic control and not differently for both disease types. Post‐hoc analyses revealed that patients depressed and distressed by their diabetes were in significantly poorer glycaemic control relative to those not depressed nor distressed (HbA 1c 8.7 ± 1.7 vs. 7.6 ± 1.2% in those without depressive symptoms, 7.6 ± 1.1% in depressed only and 7.7 ± 1.1% in the distressed only, P < 0.001). Depressed patients without elevated diabetes‐distress did not show a significantly increased risk of elevated HbA 1c. Conclusions In explaining the association between depression and glycaemic control, diabetes‐specific emotional distress appears to be an important mediator. Addressing diabetes‐specific emotional problems as part of depression treatment in diabetes patients may help improve glycaemic outcomes.

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Crossref · 10.1111/j.1464-5491.2010.03025.x

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Authors
Van Bastelaar, K. M. P., Pouwer, F., Geelhoed‐Duijvestijn, P. H. L. M., Tack, C. J., Bazelmans, E., Beekman, A. T., Heine, R. J., & Snoek, F. J.
Affiliations
  • Tilburg University (NL)
  • Radboud University Medical Center (NL)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
  • Amsterdam Public Health (NL)
Venue
Diabetic Medicine
Publisher
Wiley
Published
2010-06-30
Volume
27
Issue
7
Pages
798-803
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
OpenAlex
W2111199807
Cited by
174
References
30
Citations by year
2026: 3 · 2025: 7 · 2024: 13 · 2023: 17 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 20 · 2014: 10 · 2013: 14 · 2012: 7
FWCI
6.97
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetic Medicine (publishedVersion)
  • Research portal (Tilburg University) (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • VU Research Portal (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
diabetes distress, depression, depressive symptoms, glycemic control, HbA1c, type 1 diabetes, type 2 diabetes, mediation
MeSH terms
Depressive Disorder, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Male, Middle Aged, Netherlands, Stress, Psychological

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