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The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
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Summary: While many women with polycystic ovary syndrome (PCOS) are overweight, obese or centrally obese, the effect of excess weight on the outcomes of PCOS is inconsistent. The review aimed to assess the effects of overweight, obesity and central obesity on the reproductive, metabolic and psychological features of PCOS. MEDLINE, EMBASE, CINAHL, C ochrane C entral R egister of C ontrolled T rials (CENTRAL) and PSYCINFO were searched for studies reporting outcomes according to body mass index categories or body fat distribution. Data were presented as mean difference or risk ratio (95% confidence interval). This review included 30 eligible studies. Overweight or obese women with PCOS had decreased sex hormone‐binding globulin (SHBG), increased total testosterone, free androgen index, hirsutism, fasting glucose, fasting insulin, homeostatic model assessment‐insulin resistance index and worsened lipid profile. Obesity significantly worsened all metabolic and reproductive outcomes measured except for hirsutism when compared to normal weight women with PCOS. Overweight women had no differences in total testosterone, hirsutism, total‐cholesterol and low‐density lipoprotein‐cholesterol compared to normal weight women and no differences in SHBG and total testosterone compared to obese women. Central obesity was associated with higher fasting insulin levels. These results suggest that prevention and treatment of obesity is important for the management of PCOS.
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In the citing paper
“Obesity further exacerbates hormonal and clinical reproductive, metabolic and psychological features of PCOS (Lim et al. , 2013).”
From Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis (2015) · cites this paper as Lim et al., 2013
Experimental — accuracy not yet measuredIn the citing paper
“Weight gain and obesity further worsen insulin resistance and consequently the overall features of PCOS [9].”
From Providing lifestyle advice to women with PCOS: an overview of practical issues affecting success (2021) · cites this paper as [9]
In the citing paper
“Moreover, overweight as well as obesity negatively affect reproductive and metabolic features (Lim et al., 2013;Glueck and Goldenberg, 2019).”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Lim et al., 2013
In the citing paper
“The severity of the presentation of PCOS characteristics is positively correlated with BMI (Lim et al., 2013;Glueck and Goldenberg, 2019), and a lifestyle intervention to achieve weight reduction is currently the first-line treatment (Teede”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Lim et al., 2013
In the citing paper
“This is particularly important as weight is a primary concern for women with PCOS 51 because weight gain and obesity exacerbate insulin resistance and increase the risk of type 2 diabetes and cardiometabolic diseases in women with PCOS.52”
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Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
(2014) · Medical Entomology and Zoology · Cited by 17,633
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Barlow, S. E., & and the Expert Committee (2007) · Pediatrics · doi:10.1542/peds.2007-2329c · Cited by 4,497
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,090
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967
March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I. W., Norman, R. J., & Davies, M. J. (2010) · Human Reproduction · doi:10.1093/humrep/dep399 · Cited by 1,799
Self-citationKnochenhauer, E. S., Key, T. J., Kahsar-Miller, M., Waggoner, W., Boots, L. R., & Azziz, R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5090 · Cited by 1,759
Legro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508
Asunción, M., Calvo, R. M., Millán, J. L. S., Sancho, J., Ávila, S., & Escobar-Morreale, H. F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6682 · Cited by 1,328
Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
Ehrmann, D. A., Barnes, R. B., Rosenfield, R. L., Cavaghan, M. K., & Imperial, J. (1999) · Diabetes Care · doi:10.2337/diacare.22.1.141 · Cited by 1,257
Knochenhauer, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3078 · Cited by 1,134
Moran, L. J., Misso, M. L., Wild, R. A., & Norman, R. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq001 · Cited by 1,108
Self-citationDiamanti‐Kandarakis, E., Kouli, C., Bergiele, A. T., Filandra, F. A., Tsianateli, T. C., Spina, G., Zapanti, E. D., & Bartzis, M. I. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6148 · Cited by 1,107
Andrology: Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients
Balen, A. H., Conway, G. S., Kaltsas, G., Techatraisak, K., Manning, P. J., West, C., & Jacobs, H. S. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136243 · Cited by 1,060
Weight, Weight Change, and Coronary Heart Disease in Women: Risk Within the 'Normal' Weight Range
Willett, W. C. (1995) · JAMA · doi:10.1001/jama.1995.03520300035033 · Cited by 924
Kiddy, D. S., Hamilton‐Fairley, D., Bush, A., Short, F., Anyaoku, V., Reed, M. J., & Franks, S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02909.x · Cited by 921
Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119628 · Cited by 898 · cited 1×
“We report here a dose-dependent relationship between adiposity and surrogate measures of insulin resistance consistent with previous findings (69,70).”
ResultThe Insulin-Related Ovarian Regulatory System in Health and Disease
Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0374 · Cited by 852
Obesity and the polycystic ovary syndrome
Gambineri, A., Pelusi, C., Vicennati, V., Pagotto, U., & Pasquali, R. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801994 · Cited by 841
Asuncion, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.7.2434 · Cited by 791
Lifestyle changes in women with polycystic ovary syndrome
Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725
Self-citationPrevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome
Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., & Ghazzi, M. N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1329 · Cited by 703
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693
Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome
Legro, R. S., Kunselman, A. R., & Dunaif, A. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00948-2 · Cited by 622
Cameron, A. J., Zimmet, P., Dunstan, D. W., Dalton, M., Shaw, J. E., Welborn, T. A., Owen, N. G., Salmon, J., & Jolley, D. (2003) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2003.tb05283.x · Cited by 595
Dunaif, A., Xia, J., Book, C. B., Schenker, E., & Tang, Z. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118126 · Cited by 561
Adolescent body mass index and infertility caused by ovulatory disorder
Rich-Edwards, J. W., Goldman, M. B., Willett, W. C., Hunter, D. J., Stampfer, M. J., Colditz, G. A., & Manson, J. E. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(94)90465-0 · Cited by 560
Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome
Dunaif, A. E., Segal, K. R., Shelley, D., Green, G., Dobrjansky, A., & Licholai, T. (1992) · Diabetes · doi:10.2337/diab.41.10.1257 · Cited by 544
Cameron, A. J., Zimmet, P., Dunstan, D. W., Dalton, M. F., Shaw, J. E., Welborn, T. A., Owen, N. G., Salmon, J., & Jolley, D. (2004) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2004.tb05998.x · Cited by 537
Moran, L. J., Noakes, M., Clifton, P. M., Tomlinson, L., & Norman, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020815 · Cited by 530
Self-citationStener-Victorin, E., Teede, H., Norman, R. J., Legro, R., Goodarzi, M. O., Dokras, A., Laven, J., Hoeger, K., & Piltonen, T. T. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00511-3 · Cited by 495
Self-citationLipid Levels in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis
Wild, R. A., Rizzo, M., Clifton, S., & Carmina, E. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.12.027 · Cited by 477
Dunaif, A. E., & Finegood, D. T. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772555 · Cited by 457
Morales, A. J., Laughlin, G. A., Bützow, T. L., Maheshwari, H., Baumann, G., & Yen, S. S. C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768842 · Cited by 453
Broekmans, F. J., Knauff, E. A. H., Valkenburg, O., Laven, J. S. E., Eijkemans, M. J. C., & Fauser, B. C. J. M. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01008.x · Cited by 445
Holte, J., Bergh, T., Berne, C., Wide, L., & Lithell, H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.9.7673399 · Cited by 435
Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome
Conway, G. S., Agrawal, R., Betteridge, D. J., & Jacobs, H. S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02295.x · Cited by 423
Impact of Obesity on the Risk for Polycystic Ovary Syndrome
Yildiz, B. O., Knochenhauer, E. S., & Azziz, R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1834 · Cited by 401
Haffner, S. M., D, M. P. S. M., Mitchell, B. D., Hazuda, H. P., & Patterson, J. K. (1990) · Diabetes · doi:10.2337/diab.39.3.283 · Cited by 397
de Groot, P. C. M., Dekkers, O. M., Romijn, J. A., Dieben, S. W. M., & Helmerhorst, F. M. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr001 · Cited by 394
Willis, D., Mason, H., Gilling-Smith, C., & Franks, S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.1.8550768 · Cited by 371
KIDDY, D. S., SHARP, P. S., WHITE, D. M., SCANLON, M. F., MASON, H. D., BRAY, C. S., POLSON, D. W., REED, M. J., & FRANKS, S. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb00857.x · Cited by 364
Review article: The impact of obesity on reproduction in women with polycystic ovary syndrome
Pasquali, R., Gambineri, A., & Pagotto, U. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00990.x · Cited by 359
Weyer, C., Tataranni, P. A., Bogardus, C., & Pratley, R. E. (2001) · Diabetes Care · doi:10.2337/diacare.24.1.89 · Cited by 358
Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis
Barry, J. A., Kuczmierczyk, A. R., & Hardiman, P. J. (2011) · Human Reproduction · doi:10.1093/humrep/der197 · Cited by 336
Lifestyle changes in women with polycystic ovary syndrome
Moran, L. J., Hutchison, S. K., Norman, R. J., & Teede, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub3 · Cited by 292
Self-citationCorbould, A., Kim, Y.-B., Youngren, J. F., Pender, C., Kahn, B. B., Lee, A., & Dunaif, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2004 · Cited by 283
Overweight Women with Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease
Meyer, C., McGrath, B. P., & Teede, H. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0011 · Cited by 273
Depression and Body Image among Women with Polycystic Ovary Syndrome
Himelein, M. J., & Thatcher, S. S. (2006) · Journal of Health Psychology · doi:10.1177/1359105306065021 · Cited by 248
Anxiety and depression in polycystic ovary syndrome: a comprehensive investigation
Deeks, A. A., Gibson-Helm, M. E., & Teede, H. J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.09.018 · Cited by 246
Kahn, S. E., Prigeon, R. L., Schwartz, R. S., Fujimoto, W. Y., Knopp, R. H., Brunzell, J. D., & Porte, D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.354s · Cited by 240
Polycystic Ovary Syndrome and Mental Health: A Review
Himelein, M. J., & Thatcher, S. S. (2006) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000243772.33357.84 · Cited by 239
Janssen, İ., Powell, L. H., Kazlauskaite, R., & Dugan, S. A. (2009) · Obesity · doi:10.1038/oby.2009.251 · Cited by 237
Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome
Yıldızhan, R., Kurdoğlu, M., Adalı, E., Kolusarı, A., Yıldızhan, B., Şahin, H. G., & Kamacı, M. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-0958-7 · Cited by 232
Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene
Selva, D. M., Hogeveen, K. N., Innis, S. M., & Hammond, G. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32249 · Cited by 232 · cited 1×
“Alternatively, the regulation of SHBG may occur independent of insulin (59) with dietary influences such as monosaccharide-induced lipogenesis also attenuating SHBG levels (60).”
BackgroundWeiner, C. L., Primeau, M., & Ehrmann, D. A. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000127871.46309.fe · Cited by 231
Morin-Papunen, L. C., Vauhkonen, I., Koivunen, R. M., Ruokonen, A., & Tapanainen, J. S. (2000) · Human Reproduction · doi:10.1093/humrep/15.6.1266 · Cited by 226
Holte, J., Bergh, T., Berne, C., & Lithell, H. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02577.x · Cited by 215
Depression in women with polycystic ovary syndrome: clinical and biochemical correlates
Rasgon, N., Rao, R. C., Hwang, S., Altshuler, L. L., Elman, S., Zuckerbrow-Miller, J., & Korenman, S. G. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00117-9 · Cited by 210
Rates of weight change for black and white Americans over a twenty year period
Sheehan, T. J., Dubrava, S., DeChello, L. M., & Fang, Z. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802263 · Cited by 208
Thomson, R. L., Buckley, J. D., Lim, S. S., Noakes, M., Clifton, P. M., Norman, R. J., & Brinkworth, G. D. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.11.001 · Cited by 207
Self-citationAdiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study
Escobar-Morreale, H. F. (2006) · Human Reproduction · doi:10.1093/humrep/del146 · Cited by 200
Rosenzweig, J. L., Ferrannini, E., Grundy, S. M., Haffner, S. M., Heine, R. J., Horton, E. S., & Kawamori, R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0222 · Cited by 197
Basic Infertility Including Polycystic Ovary Syndrome
Brassard, M., Ainmelk, Y., & Baillargeon, J. (2008) · Medical Clinics of North America · doi:10.1016/j.mcna.2008.04.008 · Cited by 189
Dyslipidaemia is associated with insulin resistance in women with polycystic ovaries
Robinson, S., Henderson, A. D., Gelding, S. V., Kiddy, D. S., Niththyananthan, R., Bush, A., Richmond, W., Johnston, D. G., & Franks, S. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.674495.x · Cited by 181
Barber, T. M., Golding, S. J., Alvey, C., Wass, J. A. H., Karpe, F., Franks, S., & McCarthy, M. I. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2117 · Cited by 179
Holte, J., Bergh, T., Gennarelli, G., & WIDE, L. E. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02578.x · Cited by 173
Lord, J., Thomas, R., Fox, B., Acharya, U., & Wilkin, T. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00973.x · Cited by 158
l’Allemand, D., Penhoat, A., Lebrethon, M. C., Ardèvol, R., Baehr, V., Oelkers, W., & Saez, J. M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923834 · Cited by 155
von Ruesten, A., Steffen, A., Floegel, A., van der A, D. L., Masala, G., Tjønneland, A. M., Halkjær, J., Palli, D., Wareham, N. J., Loos, R. J. F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027455 · Cited by 148
Moran, L. J., Noakes, M., Clifton, P. M., Wittert, G. A., Williams, G., & Norman, R. J. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.77 · Cited by 141
Self-citationJakubowicz, D. J., & Nestler, J. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3753 · Cited by 138
CAMPBELL, P. J., & Gerich, J. E. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-4-1114 · Cited by 137
Goverde, A. J., van Koert, A. J. B., Eijkemans, M. J., Knauff, E. A. H., Westerveld, H. E., Fauser, B. C. J. M., & Broekmans, F. J. (2008) · Human Reproduction · doi:10.1093/humrep/den433 · Cited by 135
Baglietto, L., English, D. R., Hopper, J. L., MacInnis, R. J., Morris, H. A., Tilley, W. D., Krishnan, K., & Giles, G. G. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0069-3 · Cited by 134
Crave, J. C., Lejeune, H., Brébant, C., Baret, C., & Pugeat, M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7536204 · Cited by 133
Pasquali, R., Vicennati, V., Bertazzo, D., Casimirri, F., Pascal, G., Tortelli, O., & Labate, A. M. M. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90159-1 · Cited by 130
Spranger, J., Möhlig, M., Wegewitz, U. E., Ristow, M., Pfeiffer, A. F. H., Schill, T., Schlösser, H. W., Brabant, G. E., & Schöfl, C. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02159.x · Cited by 130
Glintborg, D., Henriksen, J. E., Andersen, M., Hagen, C., Hangaard, J., Rasmussen, P. E., Schousboe, K., & Hermann, A. P. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.06.040 · Cited by 126
Reproductive endocrinologic alterations in female asymptomatic obesity
Wallach, E. E., & Azziz, R. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)61020-8 · Cited by 125
Pasquali, R., Casimirri, F., Venturoli, S., Antonio, M., Morselli, L., Reho, S., Pezzoli, A., & Paradisi, R. (1994) · Metabolism · doi:10.1016/0026-0495(94)90118-x · Cited by 119
Robins, S., Lyass, A., Zachariah, J., Massaro, J., & Vasan, R. (2011) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.219055 · Cited by 111
Li, Y., Li, Y., Ng, E. H. Y., Stener‐Victorin, E., Hou, L., Wu, T., Han, F., & Wu, X. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.072 · Cited by 110
The impact of obesity on hormonal parameters in hirsute and nonhirsute women
Bernasconi, D., Monte, P. D., Meozzi, M., Randazzo, M., Marugo, A., Badaracco, B., & Marugo, M. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90202-4 · Cited by 109
Cheung, L. P., Ma, R. C. W., Lam, P. M., Lok, I. H., Haines, C. J., So, W. Y., Tong, P. C. Y., Cockram, C. S., Chow, C. C., & Goggins, W. B. (2008) · Human Reproduction · doi:10.1093/humrep/den090 · Cited by 108
The prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria.
Mehrabian, F., Khani, B., Kelishadi, R., & Ghanbari, E. (2011) · PubMed · Cited by 104
Lundgren, H., Bengtsson, C., Blohmé, G., Lapidus, L., & Waldenström, J. (1990) · Diabetic Medicine · doi:10.1111/j.1464-5491.1990.tb01415.x · Cited by 103
Carmina, E., Bucchieri, S., Mansueto, P., Rini, G., Ferin, M., & Løbo, R. A. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.007 · Cited by 103
Obesity, body composition and metabolic disturbances in polycystic ovary syndrome
Svendsen, P. F., Nilas, L., Nørgaard, K., Jensen, J. B., & Madsbad, S. (2008) · Human Reproduction · doi:10.1093/humrep/den211 · Cited by 103
Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women
Liou, T.-H., Yang, J.-H., Hsieh, C.-H., Lee, C.-Y., Hsu, C.-S., & Hsu, M.-I. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.003 · Cited by 100
Faloia, E., Canibus, P., Gatti, C., Frezza, F., Santangelo, M., Garrapa, G., & Boscaro, M. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03345285 · Cited by 96
Mukherjee, S., Shaikh, N. J., Khavale, S., Shinde, G., Meherji, P. K., Shah, N. S., & Maitra, A. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0932 · Cited by 94
Body mass index and metabolic risk factors for coronary heart disease in women
Ashton, W. D. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2469 · Cited by 90
Cupisti, S., Kajaia, N., Dittrich, R., Duezenli, H., Beckmann, M. W., & Mueller, A. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0515 · Cited by 86
FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome
Attaoua, R., Ait-El-Mkadem, S., Radian, S., Fica, S. V., Hanzu, F. A., Albu, A. I., Gheorghiu, M. L., Coculescu, M., & Grigorescu, F. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.039 · Cited by 85
Weight Characteristics and Height in Relation to Risk of Gestational Diabetes Mellitus
Rudra, C. B., Sorensen, T. K., Leisenring, W. M., Dashow, E. E., & Williams, M. A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk007 · Cited by 83
Prevalence of the Metabolic Syndrome in German Women with Polycystic Ovary Syndrome
Hahn, S., Tan, S., Sack, S., Kimmig, R., Quadbeck, B., Mann, K., & Janssen, O. E. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-967093 · Cited by 80
Demirel, F., Bıdecı, A., Cınaz, P., Çamurdan, M. O., Biberoğlu, G., Yeşilkaya, E., & Hasanoğlu, A. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02849.x · Cited by 78
Pasquali, R., Casimirri, F., Cantobelli, S., Labate, A. M. M., Venturoli, S., Paradisi, R., & Zannarini, L. (2008) · Hormone Research · doi:10.1159/000182732 · Cited by 78
Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome
Essah, P. A., Nestler, J. E., & Carmina, E. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03345564 · Cited by 74
Slowinska-Srzednicka, J., Zgliczyński, S., Wierzbicki, M., Srzednicki, M., Stopińska-Głuszak, U., Zgliczyński, W., Soszynski, P. A., Chotkowska, E., Bednarska, M., & Sadowski, Z. (1991) · Journal of Endocrinological Investigation · doi:10.1007/bf03346870 · Cited by 70
Tolino, A., Gambardella, V., Caccavale, C., D’Ettore, A., Giannotti, F., D’Antò, V., & De Falco, C. L. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.06.043 · Cited by 69
Obesity and insulin resistance associated with lower plasma vitamin B12 in PCOS
Kaya, C., Cengiz, S. D., & Şatıroğlu, H. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.06.005 · Cited by 67
Yücel, A., Noyan, V., & Sağsöz, N. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.11.012 · Cited by 61
Hudecova, M., Holte, J., Olovsson, M., Larsson, A., Berne, C., & Sundstrom-Poromaa, I. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.08.006 · Cited by 61 · cited 1×
“Women with PCOS have increased risk of metabolic syndrome (12), type 2 diabetes (13–15), and cardiovascular diseases including coronary heart disease and stroke (16,17).”
BackgroundKarabulut, A., Yaylali, G. F., Demirlenk, S., Sevket, O., & Acun, A. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.589929 · Cited by 61
Once fat was fat and that was that : our changing perspectives on adipose tissue
Ferris, W. F., & Crowther, N. J. (2011) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2010-083 · Cited by 56
Lee, H., Oh, J. Y., Sung, Y., Chung, H., & Cho, W. Y. (2009) · Endocrine · doi:10.1007/s12020-009-9226-7 · Cited by 55
Mozzanega, B., Mioni, R., Granzotto, M., Chiarelli, S. M., Xamin, N., Zuliani, L., Sicolo, N., Marchesoni, D., & Vettor, R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.038 · Cited by 55
Body fat composition and distribution in women with polycystic ovary syndrome
Çoşar, E., Üçok, K., Akgün, L., Köken, G., Şahin, F. K., Arıöz, D. T., & Baş, O. (2008) · Gynecological Endocrinology · doi:10.1080/09513590802234253 · Cited by 54
Insulin enhances ACTH-stimulated androgen and glucocorticoid metabolism in hyperandrogenic women
Tosi, F., Negri, C., Brun, E., Castello, R., Faccini, G., Bonora, E., Muggeo, M., Toscano, V., & Moghetti, P. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0782 · Cited by 53
Economou, F., Xyrafis, X., Livadas, S., Androulakis, I. I., Argyrakopoulou, G., Christakou, C. D., Kandaraki, E., Palioura, E., & Diamanti‐Kandarakis, E. (2009) · HORMONES · doi:10.14310/horm.2002.1236 · Cited by 51
Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism
Castelo‐Branco, C., Steinvarcel, F., Osorio, A., Ros, C., & Balasch, J. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.481025 · Cited by 49
Mackie, A. D. R., Doddridge, M., Gamsu, H. R., Brudenell, J. M., Nicolaides, K. H., & Drury, P. (1996) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199601)13:1 · Cited by 47
Tissue insulin sensitivity and body weight in polycystic ovary syndrome
Marsden, P. J., Murdoch, A. P., & Taylor, R. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01303.x · Cited by 47
Strowitzki, T., Halser, B., & Demant, T. (2002) · Gynecological Endocrinology · doi:10.1080/gye.16.1.45.51 · Cited by 39
Cupisti, S., Dittrich, R., Binder, H., Kajaia, N., Hoffmann, I., Maltaris, T., Beckmann, M. W., & Mueller, A. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-970163 · Cited by 38
Buffington, C. K., & Kitabchi, A. E. (1994) · Metabolism · doi:10.1016/0026-0495(94)90029-9 · Cited by 38
Abdominal fat distribution and insulin resistance in Indian women with polycystic ovarian syndrome
Kalra, P., Bansal, B., Nag, P., Singh, J. K., Gupta, R. K., Kumar, S., Rathore, R. K. S., Bhatia, V., & Bhatia, E. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.037 · Cited by 37
Targher, G., Solagna, E., Tosi, F., Castello, R., Spiazzi, G., Zoppini, G., Muggeo, M., Day, C., & Moghetti, P. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03345743 · Cited by 37
Penaforte, F. R. O., Japur, C. C., Diez-Garcia, R. W., & Chiarello, P. G. (2011) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2010.01130.x · Cited by 35
Godoy‐Matos, A. F., Vaisman, F., Pedrosa, A. P., Farias, M. L. F., de Mendonça, L. M. C., & Pinheiro, M. F. M. C. (2009) · Gynecological Endocrinology · doi:10.3109/09513590903015528 · Cited by 33
Buyalos, R. P., Pekonen, F., Halme, J. K., Judd, H. L., & Rutanen, E. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90024-1 · Cited by 31
Skeletal Muscle Insulin Resistance in Morbid Obesity: The Role of Interleukin-6 and Leptin
Mitrou, P., Lambadiari, V., Maratou, E., Boutati, E. I., Komesidou, V., Papakonstantinou, A., Raptis, S., & Dimitriadis, G. (2011) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0030-1269846 · Cited by 25
The counterregulatory response to hypoglycaemia in women with the polycystic ovary syndrome
Gennarelli, G., Holte, J., Stridsberg, M., Niklasson, F., Berne, C., & Bäckström, T. C. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.1070915.x · Cited by 22
Impact of body mass index on blood pressure levels in patients with polycystic ovary syndrome
Barcellos, C. R. G., Rocha, M. P., Hayashida, S. A. Y., Mion, D., Lage, S. G., & Marcondes, J. A. M. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000700013 · Cited by 21
Adalı, E., Yıldızhan, R., Kurdoğlu, M., Buğdaycı, G., Kolusarı, A., & Şahin, H. G. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.037 · Cited by 20
Decreased Adiponectin Levels in Polycystic Ovary Syndrome, Independent of Body Mass Index
Sharifi, F., Hajihosseini, R., Mazloomi, S., Amirmogaddami, H., & Nazem, H. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2009.0036 · Cited by 19
Effects of polycystic ovary syndrome on health-related quality of life
Upadhya, K. K., & Trent, M. (2007) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.7.6.597 · Cited by 17
Erel, C. T., Senturk, L. M., Kaleli, S., Gezer, A., Baysal, B., & Taşan, E. (2003) · Gynecological Endocrinology · doi:10.1080/gye.17.3.223.229 · Cited by 15
Siddiqui, I., Tamimi, W. G., Tamim, H., AlEisa, N., & Adham, M. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1124-y · Cited by 14
Ciampelli, M., Muzj, G., Leoni, F., Romualdi, D., Belosi, C., Cento, R. M., & Lanzone, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8060 · Cited by 12
Hypothalamic-pituitary-adrenal axis sensitivity to opioids in women with polycystic ovary syndrome
Ciampelli, M., Guido, M., Cucinelli, F., Cinque, B., Barini, A., & Lanzone, A. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00602-0 · Cited by 11
A pilot study of the long-term effects of acipimox in polycystic ovarian syndrome
Ciampelli, M., Leoni, F., Lattanzi, F., Guido, M., Apa, R., & Lanzone, A. (2002) · Human Reproduction · doi:10.1093/humrep/17.3.647 · Cited by 9
Plasma β-endorphin levels in obese and non-obese patients with polycystic ovary disease
Guisasola, J. M. M., Guerrero, M., Alonso, F., Dı́az, F., Cordero, J., & Ferrer, J. (2001) · Gynecological Endocrinology · doi:10.1080/gye.15.1.14.22 · Cited by 9
Evaluation of Biochemical Hyperandrogenemia and Body Mass Index in Women Presenting with Amenorrhea
Cupisti, S., Dittrich, R., Binder, H., Beckmann, M. W., & Mueller, A. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-973059 · Cited by 9
Marcondes, J. A. M., Minanni, S. L., Luthold, W., Lerário, A. C., Nery, M., Mendonca, B. B., WAJCHENBERG, B. L., & Kirschner, M. A. (1995) · Journal of Endocrinological Investigation · doi:10.1007/bf03349741 · Cited by 6
Research works printed but not linked: 12
- Zawadzki JK, 1992, Polycystic Ovary Syndrome, 377
- World Health Organisation, International Association for the Study of Obesity, International Obesity TaskForce, 2000, The Asia‐Pacific Perspective: Redefining Obesity and Its Treatment
- 10.1210/jc.80.4.1283 · DOI
- 10.1210/jc.81.11.3892 · DOI
- 10.1210/jc.81.1.302 · DOI · Paper page
- 10.1210/jc.81.8.2854 · DOI
- 10.1210/jc.81.3.942 · DOI
- 10.1080/713603251 · DOI
- 10.1210/jc.80.9.2586 · DOI · Paper page
- 10.1210/jc.82.2.556 · DOI
- 10.1210/jc.86.11.5324 · DOI
- 10.1055/s-2007-973059 · DOI
Cited by
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Self-citationLifestyle changes in women with polycystic ovary syndrome
Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725
Self-citation
Metadata
- Authors
- Lim, S. S., Norman, R. J., Davies, M. J., & Moran, L. J.
- Affiliations
- Deakin University (AU)
- The University of Adelaide (AU)
- Corresponding author
- Norman, R. J.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2012-10-31
- Volume
- 14
- Issue
- 2
- Pages
- 95-109
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W1943352132
- Cited by
- 539
- References
- 144
- Citations by year
- 2026: 31 · 2025: 32 · 2024: 50 · 2023: 45 · 2022: 57 · 2021: 60 · 2020: 38 · 2019: 36 · 2018: 42 · 2017: 30 · 2016: 32 · 2015: 38 · 2014: 31 · 2013: 15 · 2012: 2
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, obesity, overweight, abdominal obesity, body mass index, sex hormone-binding globulin, total testosterone, free androgen index, hirsutism, insulin resistance, insulin, lipid profile, fasting blood glucose, body fat distribution
- MeSH terms
- Adult, Blood Glucose, Body Composition, Female, Humans, Insulin, Insulin Resistance, Lipids, Obesity, Polycystic Ovary Syndrome, Reproduction, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index
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