Cited by 195Metabolomics and Mass Spectrometry StudiesDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

Jové, Mariona, Portero-Otín, Manuel, Naudí, Alba, Ferrer, Isidre, Pamplona, Reinald·2014·Journal of Neuropathology & Experimental Neurology

Abstract

Neurons in the mature human central nervous system (CNS) perform a wide range of motor, sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output requires a great diversity of CNS neuronal and non-neuronal populations. Metabolomics encompasses the study of the complete set of metabolites/low-molecular-weight intermediates (metabolome), which are context-dependent and vary according to the physiology, developmental state, or pathologic state of the cell, tissue, organ, or organism. Therefore, the use of metabolomics can help to unravel the diversity-and to disclose the specificity-of metabolic traits and their alterations in the brain and in fluids such as cerebrospinal fluid and plasma, thus helping to uncover potential biomarkers of aging and neurodegenerative diseases. Here, we review the current applications of metabolomics in studies of CNS aging and certain age-related neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis. Neurometabolomics will increase knowledge of the physiologic and pathologic functions of neural cells and will place the concept of selective neuronal vulnerability in a metabolic context.

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Registry

Crossref · 10.1097/nen.0000000000000091

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211 of 211 references verified0 citation errors · 0 not checkable

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Authors
Jové, M., Portero-Otín, M., Naudí, A., Ferrer, I., & Pamplona, R.
Affiliations
Universitat de Lleida (ES)
Corresponding author
Pamplona, Reinald
Venue
Journal of Neuropathology & Experimental Neurology
Published
2014-07
Volume
73
Issue
7
Pages
640-657
ISSN
  • 0022-3069 (ISSN-L)
  • 1554-6578
OpenAlex
W2317167530
Cited by
195
References
215
Citations by year
2026: 5 · 2025: 8 · 2024: 13 · 2023: 15 · 2022: 12 · 2021: 21 · 2020: 19 · 2019: 18 · 2018: 20 · 2017: 22 · 2016: 19 · 2015: 20 · 2014: 3
FWCI
2.01
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuropathology & Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
brain aging, age-related neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, cerebrospinal fluid metabolites, plasma metabolites, aging biomarkers, selective neuronal vulnerability, central nervous system metabolism
MeSH terms
Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Energy Metabolism, Female, Humans, Male, Neurons, Parkinson Disease, Species Specificity, Biomarkers, Neurodegenerative Diseases, Metabolomics

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