Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases
Abstract
Neurons in the mature human central nervous system (CNS) perform a wide range of motor, sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output requires a great diversity of CNS neuronal and non-neuronal populations. Metabolomics encompasses the study of the complete set of metabolites/low-molecular-weight intermediates (metabolome), which are context-dependent and vary according to the physiology, developmental state, or pathologic state of the cell, tissue, organ, or organism. Therefore, the use of metabolomics can help to unravel the diversity-and to disclose the specificity-of metabolic traits and their alterations in the brain and in fluids such as cerebrospinal fluid and plasma, thus helping to uncover potential biomarkers of aging and neurodegenerative diseases. Here, we review the current applications of metabolomics in studies of CNS aging and certain age-related neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis. Neurometabolomics will increase knowledge of the physiologic and pathologic functions of neural cells and will place the concept of selective neuronal vulnerability in a metabolic context.
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Attempts to discover new biomarkers for the diagnosis of early stages of the disease are ongoing.
“Attempts to discover new biomarkers for the diagnosis of early stages of the disease are ongoing [134–136].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [134]
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Self-citationA plasma metabolomic signature discloses human breast cancer
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Self-citationA Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine
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Self-citationStatus of Metabolomic Measurement for Insights in Alzheimer’s Disease Progression—What Is Missing?
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Self-citationChanges in Brain Metallome/Metabolome Pattern due to a Single i.v. Injection of Manganese in Rats
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- Authors
- Jové, M., Portero-Otín, M., Naudí, A., Ferrer, I., & Pamplona, R.
- Affiliations
- Universitat de Lleida (ES)
- Corresponding author
- Pamplona, Reinald
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-07
- Volume
- 73
- Issue
- 7
- Pages
- 640-657
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W2317167530
- Cited by
- 195
- References
- 215
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 13 · 2023: 15 · 2022: 12 · 2021: 21 · 2020: 19 · 2019: 18 · 2018: 20 · 2017: 22 · 2016: 19 · 2015: 20 · 2014: 3
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- brain aging, age-related neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, cerebrospinal fluid metabolites, plasma metabolites, aging biomarkers, selective neuronal vulnerability, central nervous system metabolism
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Energy Metabolism, Female, Humans, Male, Neurons, Parkinson Disease, Species Specificity, Biomarkers, Neurodegenerative Diseases, Metabolomics
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