The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Caffeine (1, 3, 7‐trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters
Abstract
ABSTRACT: Caffeine ranks as one of the top most commonly consumed dietary ingredients throughout the world. It is naturally found in coffee beans, cacao beans, kola nuts, guarana berries, and tea leaves including yerba mate. The total daily intake, as well as the major source of caffeine varies globally; however, coffee and tea are the 2 most prominent sources. Soft drinks are also a common source of caffeine as well as energy drinks, a category of functional beverages. Moderate caffeine consumption is considered safe and its use as a food ingredient has been approved, within certain limits, by numerous regulatory agencies around the world. Performance benefits attributed to caffeine include physical endurance, reduction of fatigue, and enhancing mental alertness and concentration. Caffeine has also been recently linked to weight loss and consequent reduction of the overall risks for developing the metabolic syndrome. However, the caloric contribution of caffeine‐sweetened beverages needs to be considered in the overall energy balance. Despite all these benefits the potential negative effects of excessive caffeine intake should also be considered, particularly in children and pregnant women.
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Cites
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199
Coffee and Health: A Review of Recent Human Research
Higdon, J. V., & Frei, B. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390500400009 · Cited by 1,090
Caffeinated energy drinks a growing problem
Reissig, C. J., Strain, E. C., & Griffiths, R. R. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.08.001 · Cited by 1,026
Effects of caffeine on human behavior
Smith, A. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00096-0 · Cited by 741
Barone, J. J., & Roberts, H. R. (1996) · Food and Chemical Toxicology · doi:10.1016/0278-6915(95)00093-3 · Cited by 705
Food sources and intakes of caffeine in the diets of persons in the United States
Frary, C. D., Johnson, R. K., & Wang, M. Q. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.10.027 · Cited by 681
Prospective Study of Caffeine Consumption and Risk of Parkinson’s Disease in Men and Women
Ascherio, A., Zhang, S. M., Hernán, M. A., Kawachi, I., Colditz, G. A., Speizer, F. E., & Willett, W. C. (2001) · Annals of Neurology · doi:10.1002/ana.1052 · Cited by 677
Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review
van Dam, R. M., & Hu, F. B. (2005) · JAMA · doi:10.1001/jama.294.1.97 · Cited by 662
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Functional Properties of Coffee and Coffee By-Products
Esquivel, P., & Jiménez, V. M. (2012) · Food Research International · doi:10.1016/j.foodres.2011.05.028 · Cited by 847
Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
Nehlig, A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014407 · Cited by 632
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613
Beverage caffeine intakes in the U.S.
Mitchell, D. C., Knight, C. A., Hockenberry, J., Teplansky, R., & Hartman, T. J. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.10.042 · Cited by 565
Coffee: Biochemistry and Potential Impact on Health
Ludwig, I. A., Clifford, M. N., Lean, M. E. J., Ashihara, H., & Crozier, A. (2014) · Food Funct. · doi:10.1039/c4fo00042k · Cited by 537
The effect of caffeine on subsequent sleep: A systematic review and meta-analysis
Gardiner, C., Weakley, J., Burke, L. M., Roach, G. D., Sargent, C., Maniar, N., Townshend, A., & Halson, S. L. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101764 · Cited by 357
“With its status as a socially acceptable drug, caffeine is consumed by approximately 80% of the world's population [12].”
BackgroundThe clinical toxicology of caffeine: A review and case study
Willson, C. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2018.11.002 · Cited by 289
Coffee, Caffeine, and Risk of Depression Among Women
Lucas, M. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.393 · Cited by 270
Trends in intake and sources of caffeine in the diets of US adults: 2001–2010
Fulgoni, V. L., Keast, D. R., & Lieberman, H. R. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.080077 · Cited by 266
Variations in Caffeine and Chlorogenic Acid Contents of Coffees: What Are We Drinking?
Ludwig, I. A., Mena, P., Calani, L., Cid, C., Del Rio, D., Lean, M. E. J., & Crozier, A. (2014) · Food Funct. · doi:10.1039/c4fo00290c · Cited by 226
Caffeine as an Attention Enhancer: Reviewing Existing Assumptions
Einöther, S. J. L., & Giesbrecht, T. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2917-4 · Cited by 215
Caffeine as a factor influencing the functioning of the human body-friend or foe?
Rodak, K., Kokot, I., & Kratz, E. M. (2021) · Nutrients · doi:10.3390/nu13093088 · Cited by 188
Cornelis, M. C., Kacprowski, T., Menni, C., Gustafsson, S., Pivin, E., Adamski, J., Artati, A., Eap, C. B., Ehret, G., Friedrich, N., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw334 · Cited by 175
Drewnowski, A., & Rehm, C. (2016) · Nutrients · doi:10.3390/nu8030154 · Cited by 139
Horn, S. R., Long, M. M., Nelson, B. W., Allen, N. B., Fisher, P. A., & Byrne, M. L. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.016 · Cited by 129
Salinero, J. J., Lara, B., Abian-Vicen, J., Gonzalez-Millán, C., Areces, F., Gallo-Salazar, C., Ruiz-Vicente, D., & Del Coso, J. (2014) · British Journal of Nutrition · doi:10.1017/s0007114514002189 · Cited by 131
What Should We Do about Habitual Caffeine Use in Athletes?
Pickering, C., & Kiely, J. (2019) · Sports Medicine · doi:10.1007/s40279-018-0980-7 · Cited by 127
Iranpour, S., & Sabour, S. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.004 · Cited by 115
Jee, H. J., Lee, S. G., Bormate, K. J., & Jung, Y.-S. (2020) · Nutrients · doi:10.3390/nu12103080 · Cited by 111
“Caffeine (1,3,7-trimethylxanthine), a type of methylxanthine series alkaloid [1], is commonly found in coffee, tea, and soft drinks, and also exists in cocoa, chocolate, and a number of dietary supplements [2].”
BackgroundFood and Gastroesophageal Reflux Disease
Surdea-Blaga, T., Negrutiu, D. E., Palage, M., & Dumitrascu, D. L. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867324666170515123807 · Cited by 101
Arab, L., Biggs, M. L., O'Meara, E. S., Longstreth, W. T., Crane, P. K., & Fitzpatrick, A. L. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110431 · Cited by 98
Ahluwalia, N., & Herrick, K. (2015) · Advances in Nutrition · doi:10.3945/an.114.007401 · Cited by 84
Assessing caffeine intake in the United Kingdom diet
Fitt, E., Pell, D., & Cole, D. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2012.07.092 · Cited by 74
Effect of Green Tea Phytochemicals on Mood and Cognition
Dietz, C., & Dekker, M. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170105151800 · Cited by 70
Insights on the Health Benefits of the Bioactive Compounds of Coffee Silverskin Extract
Fernandez-Gomez, B., Lezama, A., Amigo-Benavent, M., Ullate, M., Herrero, M., Martín, M. Á., Mesa, M. D., & del Castillo, M. D. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.06.001 · Cited by 58
The impact of daily caffeine intake on nighttime sleep in young adult men
Weibel, J., Lin, Y.-S., Landolt, H.-P., Kistler, J., Rehm, S., Rentsch, K. M., Slawik, H., Borgwardt, S., Cajochen, C., & Reichert, C. F. (2021) · Scientific Reports · doi:10.1038/s41598-021-84088-x · Cited by 52
Ruxton, C. H. S. (2014) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12172 · Cited by 49
Benjamim, C. J. R., Kliszczewicz, B., Garner, D. M., Cavalcante, T. C. F., da Silva, A. A. M., Santana, M. D. R., & Valenti, V. E. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2019.1705201 · Cited by 39
Soares, R. N., Schneider, A., Valle, S. C., & Schenkel, P. C. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.03.002 · Cited by 35
Silva, A. M., Júdice, P. B., Matias, C. N., Santos, D. A., Magalhães, J. P., St-Onge, M.-P., Gonçalves, E. M., Armada-da-Silva, P., & Sardinha, L. B. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0253 · Cited by 32
Lane, S., Palmer, J., Christie, B., Ehlting, J., & Le, C. (2017) · The Arbutus Review · doi:10.18357/tar81201716816 · Cited by 26
An, S. M., Park, J. S., & Kim, S. H. (2014) · Journal of Exercise Nutrition and Biochemistry · doi:10.5717/jenb.2014.18.1.31 · Cited by 24
Abbas-Hashemi, S. A., Hosseininasab, D., Rastgoo, S., Shiraseb, F., & Asbaghi, O. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.09.923 · Cited by 19
Butler, J. M., Frampton, C. M., Moore, G., Barclay, M. L., & Jardine, D. L. (2023) · Clinical Autonomic Research · doi:10.1007/s10286-023-00967-5 · Cited by 17
Souza, D., Casonatto, J., Poton, R., Willardson, J., & Polito, M. (2014) · Research in Sports Medicine · doi:10.1080/15438627.2014.915832 · Cited by 16
Effects of Dietary Coffee on Feeding Parameters and Growth of Terrestrial Isopod, Porcellio laevis
Mohammad, W., & El-Wakeil, K. (2021) · Egyptian Academic Journal of Biological Sciences, B. Zoology · doi:10.21608/eajbsz.2021.203498 · Cited by 1
Metadata
- Authors
- Heckman, M. A., Weil, J., & De Mejia, E. G.
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 75
- Issue
- 3
- Pages
- R77-87
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W2120114161
- Cited by
- 908
- References
- 27
- FWCI
- 20.91
- Type
- journal article
- Language
- en
- Open access
- closed
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