Intergenerational Metabolic Syndrome and Neuronal Network Hyperexcitability in Autism

Rivell, Aileen; Mattson, Mark P.

doi:10.1016/j.tins.2019.08.006

Cited by 50Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesGenetics and Neurodevelopmental Disorders

Intergenerational Metabolic Syndrome and Neuronal Network Hyperexcitability in Autism

Open access

Rivell, Aileen, Mattson, Mark P.·2019·Trends in Neurosciences

DOI 10.1016/j.tins.2019.08.006PMC PMC6779523

Open this paper in CoChat — free account

Abstract

We review evidence that suggests a role for excessive consumption of energy-dense foods, particularly fructose, and consequent obesity and insulin resistance (metabolic syndrome) in the recent increase in prevalence of autism spectrum disorders (ASD). Maternal insulin resistance, obesity, and diabetes may predispose offspring to ASD by mechanisms involving chronic activation of anabolic cellular pathways and a lack of metabolic switching to ketosis resulting in a deficit in GABAergic signaling and neuronal network hyperexcitability. Metabolic reprogramming by epigenetic DNA and chromatin modifications may contribute to alterations in gene expression that result in ASD. These mechanistic insights suggest that interventions that improve metabolic health such as intermittent fasting and exercise may ameliorate developmental neuronal network abnormalities and consequent behavioral manifestations in ASD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tins.2019.08.006

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Maternal metabolic disorders including diabetes and obesity can pose another threat to the unborn child as placental dysfunctioning alters the prenatal exposure to nutrients and toxins.
“Maternal metabolic disorders including diabetes and obesity can pose another threat to the unborn child as placental dysfunctioning alters the prenatal exposure to nutrients and toxins [312–314].”
From Development of prefrontal cortex (2022) · cites this paper as [314]
The “Maternal Metabolic Syndrome and ASD” section (page not provided) says that a fetus of a mother with metabolic syndrome is exposed to elevated glucose, insulin, and pro-inflammatory cytokines, and it links maternal obesity and diabetes to risks for offspring. It does not say that placental dysfunction alters exposure to nutrients and toxins; its discussion of prenatal toxicants does not connect them to maternal metabolic disorders or placental dysfunction. (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Untitled work
(1943) · The Nervous child · Cited by 8,870 · see citing works
Autistic disturbances of affective contact.
Kanner, L. (1968) · PubMed · Cited by 2,273 · see citing works
Die „Autistischen Psychopathen” im Kindesalter
Asperger, H. (1944) · Archiv für Psychiatrie und Nervenkrankheiten · doi:10.1007/bf01837709 · Cited by 2,163 · see citing works
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597 · see citing works
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420 · see citing works
Obesity and pregnancy: Mechanisms of short term and long term adverse consequences for mother and child
Catalano, P. M., & Shankar, K. (2017) · BMJ · doi:10.1136/bmj.j1 · Cited by 1,306 · see citing works
Most genetic risk for autism resides with common variation
Gaugler, T., Klei, L., Sanders, S. J., Bodea, C. A., Goldberg, A. P., Lee, A. B., Mahajan, M., Manaa, D., Pawitan, Y., Reichert, J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3039 · Cited by 1,239 · see citing works
Fast-spiking, parvalbumin + GABAergic interneurons: From cellular design to microcircuit function
Hu, H., Gan, J., & Jonas, P. (2014) · Science · doi:10.1126/science.1255263 · Cited by 1,197 · see citing works
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168 · see citing works
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163 · see citing works
Origins of lifetime health around the time of conception: causes and consequences
Fleming, T. P., Watkins, A. J., Velazquez, M. A., Mathers, J. C., Prentice, A. M., Stephenson, J., Barker, M., Saffery, R., Yajnik, C. S., Eckert, J. J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30312-x · Cited by 1,147 · see citing works
Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
Tang, G., Gudsnuk, K., Kuo, S.-H., Cotrina, M. L., Rosoklija, G., Sosunov, A., Sonders, M. S., Kanter, E., Castagna, C., Yamamoto, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.040 · Cited by 1,146 · see citing works
Early brain development in infants at high risk for autism spectrum disorder
The IBIS Network, Hazlett, H. C., Gu, H., Munsell, B. C., Kim, S. H., Styner, M., Wolff, J. J., Elison, J. T., Swanson, M. R., Zhu, H., et al. (2017) · Nature · doi:10.1038/nature21369 · Cited by 1,128 · see citing works
Evidence of Brain Overgrowth in the First Year of Life in Autism
Courchesne, E. (2003) · JAMA · doi:10.1001/jama.290.3.337 · Cited by 1,120 · see citing works
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Donohoe, D. R., Collins, L. B., Wali, A., Bigler, R., Sun, W., & Bultman, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.033 · Cited by 993 · see citing works
Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder
Sgritta, M., Dooling, S. W., Buffington, S. A., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019) · Neuron · doi:10.1016/j.neuron.2018.11.018 · Cited by 865 · see citing works
Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works
Diet‐induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle‐aged rats
Stranahan, A., Norman, E., Lee, K., Cutler, R., Telljohann, R., Egan, J., & Mattson, M. P. (2008) · Hippocampus · doi:10.1002/hipo.20470 · Cited by 755 · see citing works
Self-citation
Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota
Kang, D.-W., Adams, J. B., Coleman, D. M., Pollard, E. L., Maldonado, J., McDonough-Means, S., Caporaso, J. G., & Krajmalnik-Brown, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-42183-0 · Cited by 749 · see citing works
Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011-2012.
Blumberg, S. J., Bramlett, M. D., Kogan, M. D., Schieve, L. A., Jones, J. R., & Lu, M. C. (2013) · PubMed · Cited by 726 · see citing works
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
Parikshak, N. N., Swarup, V., Belgard, T. G., Irimia, M., Ramaswami, G., Gandal, M. J., Hartl, C., Leppa, V., Ubieta, L. D. L. T., Huang, J., et al. (2016) · Nature · doi:10.1038/nature20612 · Cited by 685 · see citing works
Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders
Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2583 · Cited by 675 · see citing works
Activity-dependent neuronal signalling and autism spectrum disorder
Ebert, D. H., & Greenberg, M. E. (2013) · Nature · doi:10.1038/nature11860 · Cited by 666 · see citing works
Haploinsufficiency of NSD1 causes Sotos syndrome
Kurotaki, N., Imaizumi, K., Harada, N., Masuno, M., Kondoh, T., Nagai, T., Ohashi, H., Naritomi, K., Tsukahara, M., Makita, Y., et al. (2002) · Nature Genetics · doi:10.1038/ng863 · Cited by 647 · see citing works
Intermittent metabolic switching, neuroplasticity and brain health
Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.156 · Cited by 624 · see citing works
Self-citation
PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders
Ferguson, B. R., & Gao, W.-J. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00037 · Cited by 594 · see citing works
Mutations causing syndromic autism define an axis of synaptic pathophysiology
Auerbach, B. D., Osterweil, E. K., & Bear, M. F. (2011) · Nature · doi:10.1038/nature10658 · Cited by 592 · see citing works
Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M. L., et al. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-15 · Cited by 584 · see citing works
Added Sugars and Cardiovascular Disease Risk in Children: A Scientific Statement From the American Heart Association
Vos, M. B., Kaar, J. L., Welsh, J. A., Horn, L. V., Feig, D. I., Anderson, C. A. M., Patel, M. J., Muños, J. C., Krebs, N. F., Xanthakos, S. A., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000439 · Cited by 584 · see citing works
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development
Yockey, L. J., & Iwasaki, A. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.017 · Cited by 567 · see citing works
Fructose metabolism and metabolic disease
Hannou, S. A., Haslam, D. E., McKeown, N. M., & Herman, M. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96702 · Cited by 561 · see citing works
Dysregulation of mTOR signaling in fragile X syndrome
Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557 · see citing works
Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes
Vucetic, Z., Kimmel, J. N., Totoki, K., Hollenbeck, E., & Reyes, T. M. (2010) · Endocrinology · doi:10.1210/en.2010-0505 · Cited by 556 · see citing works
The Effects of Short-Chain Fatty Acids on Human Colon Cancer Cell Phenotype Are Associated with Histone Hyperacetylation
Hinnebusch, B. F., Meng, S., Wu, J. T., Archer, S. Y., & Hodin, R. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.1012 · Cited by 546 · see citing works
The microbiota-gut-brain axis in obesity.
Torres-Fuentes, C., Schellekens, H., Dinan, T., & Cryan, J. (2017) · The Lancet Gastroenterology and Hepatology · doi:10.1016/s2468-1253(17)30147-4 · Cited by 506 · see citing works
Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits
Neufer, P. D., Bamman, M. M., Muoio, D. M., Bouchard, C., Cooper, D. M., Goodpaster, B. H., Booth, F. W., Kohrt, W. M., Gerszten, R. E., Mattson, M. P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.011 · Cited by 474 · see citing works
Self-citation
NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718819115 · Cited by 472 · see citing works
Self-citation
Environmental toxicants and autism spectrum disorders: a systematic review
Rossignol, D. A., Genuis, S. J., & Frye, R. E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.4 · Cited by 458 · see citing works
Impact of prenatal exercise on neonatal and childhood outcomes: a systematic review and meta-analysis
Davenport, M. H., Meah, V. L., Ruchat, S.-M., Davies, G., Skow, R. J., Barrowman, N., Adamo, K. B., Poitras, V. J., Gray, C. E., Garcia, A. J., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099836 · Cited by 444 · see citing works
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434 · see citing works
Self-citation
Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome
Aagaard-Tillery, K. M., Grove, K. L., Bishop, J. M., Ke, X., Fu, Q., McKnight, R. A., & Lane, R. H. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0025 · Cited by 433 · see citing works
The anterior insula in autism: Under-connected and under-examined
Uddin, L. Q., & Menon, V. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.002 · Cited by 424 · see citing works
Effects of physical exercise on Autism Spectrum Disorders: A meta-analysis
Sowa, M., & Meulenbroek, R. (2012) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2011.09.001 · Cited by 386 · see citing works
Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges
Cheng, A., Yang, Y., Zhou, Y., Maharana, C., Lu, D., Peng, W., Liu, Y., Wan, R., Marosi, K., Misiak, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.013 · Cited by 371 · see citing works
Self-citation
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
Kashiwaya, Y., Bergman, C., Lee, J.-H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P., & Veech, R. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.023 · Cited by 363 · see citing works
Self-citation
Default Mode Network in Childhood Autism: Posteromedial Cortex Heterogeneity and Relationship with Social Deficits
Lynch, C. J., Uddin, L. Q., Supekar, K., Khouzam, A., Phillips, J. M., & Menon, V. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.013 · Cited by 357 · see citing works
The emerging field of epigenetics in neurodegeneration and neuroprotection
Hwang, J.-Y., Aromolaran, K. A., & Zukin, R. S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.46 · Cited by 343 · see citing works
Irrelevant and metaphorical language in early infantile autism
KANNER, L. (1946) · American Journal of Psychiatry · doi:10.1176/ajp.103.2.242 · Cited by 343 · see citing works
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
McCarthy, S. E., Gillis, J., Kramer, M., Lihm, J., Yoon, S. C., Berstein, Y., Mistry, M., Pavlidis, P., Solomon, R., Ghiban, E., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.29 · Cited by 332 · see citing works
A systematic review of the behavioural outcomes following exercise interventions for children and youth with autism spectrum disorder
Bremer, E., Crozier, M., & Lloyd, M. (2016) · Autism · doi:10.1177/1362361315616002 · Cited by 332 · see citing works
Reduced GABAergic Action in the Autistic Brain
Robertson, C. E., Ratai, E.-M., & Kanwisher, N. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.019 · Cited by 327 · see citing works
Current Perspectives on Physical Activity and Exercise Recommendations for Children and Adolescents With Autism Spectrum Disorders
Srinivasan, S. M., Pescatello, L. S., & Bhat, A. N. (2014) · Physical Therapy · doi:10.2522/ptj.20130157 · Cited by 322 · see citing works
The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism
Hashemi, E., Ariza, J., Rogers, H., Noctor, S. C., & Martínez-Cerdeño, V. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw021 · Cited by 322 · see citing works
GABA A Receptor Subtypes: Therapeutic Potential in Down Syndrome, Affective Disorders, Schizophrenia, and Autism
Rudolph, U., & Möhler, H. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135947 · Cited by 319 · see citing works
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
Wang, X., Bey, A. L., Katz, B. M., Badea, A., Kim, N., David, L. K., Duffney, L. J., Kumar, S., Mague, S. D., Hulbert, S. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms11459 · Cited by 318 · see citing works
High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice
Arnold, S. E., Lucki, I., Brookshire, B. R., Carlson, G. C., Browne, C. A., Kazi, H., Bang, S., Choi, B., Chen, Y., McMullen, M. F., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.011 · Cited by 315 · see citing works
Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation
Gogolla, N., Takesian, A. E., Feng, G., Fagiolini, M., & Hensch, T. K. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.033 · Cited by 310 · see citing works
Maternal obesity and neurodevelopmental and psychiatric disorders in offspring
Edlow, A. G. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4932 · Cited by 310 · see citing works
Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders
Foss‐Feig, J. H., Adkinson, B. D., Ji, J. L., Yang, G., Srihari, V. H., McPartland, J. C., Krystal, J. H., Murray, J. D., & Anticevic, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.005 · Cited by 310 · see citing works
Histone Acetylome-wide Association Study of Autism Spectrum Disorder
Sun, W., Poschmann, J., Cruz-Herrera del Rosario, R., Parikshak, N. N., Hajan, H. S., Kumar, V., Ramasamy, R., Belgard, T. G., Elanggovan, B., Wong, C. C. Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.031 · Cited by 306 · see citing works
Branched-chain amino acids in disease
White, P. J., & Newgard, C. B. (2019) · Science · doi:10.1126/science.aav0558 · Cited by 303 · see citing works
The effect of physical activity interventions on youth with autism spectrum disorder: A meta‐analysis
Healy, S., Nacario, A., Braithwaite, R. E., & Hopper, C. A. (2018) · Autism Research · doi:10.1002/aur.1955 · Cited by 298 · see citing works
The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders
Braat, S., & Kooy, R. F. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.042 · Cited by 294 · see citing works
Anatomical Abnormalities in Autism?
Haar, S., Berman, S., Behrmann, M., & Dinstein, I. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhu242 · Cited by 292 · see citing works
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
Schafer, S. T., Paquola, A. C. M., Stern, S., Gosselin, D., Ku, M., Pena, M., Kuret, T. J. M., Liyanage, M., Mansour, A. A., Jaeger, B. N., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0295-x · Cited by 288 · see citing works
DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways
Nardone, S., Sharan Sams, D., Reuveni, E., Getselter, D., Oron, O., Karpuj, M., & Elliott, E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.70 · Cited by 266 · see citing works
Reduced GABA and altered somatosensory function in children with autism spectrum disorder
Puts, N. A. J., Wodka, E. L., Harris, A. D., Crocetti, D., Tommerdahl, M., Mostofsky, S. H., & Edden, R. A. E. (2016) · Autism Research · doi:10.1002/aur.1691 · Cited by 264 · see citing works
Inhibitory Interneurons Regulate Temporal Precision and Correlations in Cortical Circuits
Cardin, J. A. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.07.015 · Cited by 254 · see citing works
The Role of Epigenetic Change in Autism Spectrum Disorders
Loke, Y. J., Hannan, A. J., & Craig, J. M. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00107 · Cited by 250 · see citing works
Neurobiological bases of autism–epilepsy comorbidity: a focus on excitation/inhibition imbalance
Bozzi, Y., Provenzano, G., & Casarosa, S. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13595 · Cited by 250 · see citing works
Lancet retracts 12-year-old article linking autism to MMR vaccines
Eggertson, L. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.109-3179 · Cited by 249 · see citing works
3‐Hydroxybutyrate regulates energy metabolism and induces <scp>BDNF</scp> expression in cerebral cortical neurons
Marosi, K., Kim, S. W., Moehl, K., Scheibye‐Knudsen, M., Cheng, A., Cutler, R., Camandola, S., & Mattson, M. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13868 · Cited by 242 · see citing works
Self-citation
Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism
Filice, F., Vörckel, K. J., Sungur, A. Ö., Wöhr, M., & Schwaller, B. (2016) · Molecular Brain · doi:10.1186/s13041-016-0192-8 · Cited by 240 · see citing works
Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment
Lopresti, A. L., & Drummond, P. D. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.005 · Cited by 231 · see citing works
Metformin ameliorates core deficits in a mouse model of fragile X syndrome
Gantois, I., Khoutorsky, A., Popić, J., Aguilar‐Valles, A., Freemantle, E., Cao, R., Sharma, V. K., Pooters, T., Nagpal, A., Skalecka, A., et al. (2017) · Nature Medicine · doi:10.1038/nm.4335 · Cited by 230 · see citing works
Determinants of sugar‐sweetened beverage consumption in young children: a systematic review
Paes, V. M., Hesketh, K. R., O’Malley, C. L., Moore, H. J., Summerbell, C. D., Griffin, S. J., van Sluijs, E. M. F., Ong, K. K., & Lakshman, R. (2015) · Obesity Reviews · doi:10.1111/obr.12310 · Cited by 222 · see citing works
Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats: Adolescent Sugar Intake Impairs Spatial Memory
Hsu, T. M., Konanur, V. R., Taing, L., Usui, R., Kayser, B. D., Goran, M. I., & Kanoski, S. E. (2015) · Hippocampus · doi:10.1002/hipo.22368 · Cited by 217 · see citing works
Genome-wide characteristics of de novo mutations in autism
Yuen, R. K., Merico, D., Cao, H., Pellecchia, G., Alipanahi, B., Thiruvahindrapuram, B., Tong, X., Sun, Y., Cao, D., Zhang, T., et al. (2016) · npj Genomic Medicine · doi:10.1038/npjgenmed.2016.27 · Cited by 216 · see citing works
Patterns of Atypical Functional Connectivity and Behavioral Links in Autism Differ Between Default, Salience, and Executive Networks
Abbott, A. E., Nair, A., Keown, C. L., Datko, M., Jahedi, A., Fishman, I., & Müller, R. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv191 · Cited by 213 · see citing works
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
Ehninger, D., & Silva, A. J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.10.002 · Cited by 212 · see citing works
Diet, the Gut Microbiome, and Epigenetics
Hullar, M. A. J., & Fu, B. C. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000053 · Cited by 205 · see citing works
Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease
Codagnone, M. G., Spichak, S., O’Mahony, S. M., O’Leary, O. F., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.014 · Cited by 198 · see citing works
Epigenetic Signatures of Autism: Trimethylated H3K4 Landscapes in Prefrontal Neurons
Shulha, H. P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.151 · Cited by 196 · see citing works
Understanding environmental contributions to autism: Causal concepts and the state of science
Hertz‐Picciotto, I., Schmidt, R. J., & Krakowiak, P. (2018) · Autism Research · doi:10.1002/aur.1938 · Cited by 192 · see citing works
Multivariate Searchlight Classification of Structural Magnetic Resonance Imaging in Children and Adolescents with Autism
Uddin, L. Q., Menon, V., Young, C. B., Ryali, S., Chen, T., Khouzam, A., Minshew, N. J., & Hardan, A. Y. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.014 · Cited by 187 · see citing works
SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
Liu, Y., Cheng, A., Li, Y.-J., Yang, Y., Kishimoto, Y., Zhang, S., Wang, Y., Wan, R., Raefsky, S. M., Lu, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09897-1 · Cited by 176 · see citing works
Self-citation
Progress and roadblocks in the search for brain-based biomarkers of autism and attention-deficit/hyperactivity disorder
Uddin, L. Q., Dajani, D. R., Voorhies, W., Bednarz, H., & Kana, R. K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.164 · Cited by 173 · see citing works
Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
Kazdoba, T. M., Leach, P. T., Yang, M., Silverman, J. L., Solomon, M., & Crawley, J. N. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5003 · Cited by 172 · see citing works
Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring
Kang, S. S., Kurti, A., Fair, D. A., & Fryer, J. D. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0156-9 · Cited by 167 · see citing works
A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder
Lee, R. W. Y., Corley, M. J., Pang, A. P. S., Arakaki, G., Abbott, L., Nishimoto, M., Miyamoto, R. H., Lee, E., Yamamoto, S., Maunakea, A. K., et al. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.006 · Cited by 165 · see citing works
Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2
Gross, C., Yao, X., Pong, D. L., Jeromin, A., & Bassell, G. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6661-10.2011 · Cited by 161 · see citing works
Autism spectrum disorder: insights into convergent mechanisms from transcriptomics
Quesnel-Vallières, M., Weatheritt, R. J., Cordes, S. P., & Blencowe, B. J. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0066-2 · Cited by 160 · see citing works
Default mode network segregation and social deficits in autism spectrum disorder: Evidence from non-medicated children
Yerys, B. E., Gordon, E. M., Abrams, D. N., Satterthwaite, T. D., Weinblatt, R., Jankowski, K. F., Strang, J. F., Kenworthy, L. E., Gaillard, W. D., & Vaidya, C. J. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.07.018 · Cited by 158 · see citing works
Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus
Calvo‐Ochoa, E., Hernández‐Ortega, K., Ferrera, P., Morimoto, S., & Arias, C. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.48 · Cited by 158 · see citing works
A meta-analytic review of the efficacy of physical exercise interventions on cognition in individuals with autism spectrum disorder and ADHD
Tan, B. W. Z., Pooley, J. A., & Speelman, C. P. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2854-x · Cited by 157 · see citing works
Genetics and epigenetics of autism: A Review
Waye, M. M. Y., & Cheng, H. Y. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12606 · Cited by 153 · see citing works
Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome
Lam, C. W., YEUNG, W.-L., KO, C.-H., POON, P. M. K., TONG, S.-F., CHAN, K.-Y., Lo, I. F. M., CHAN, L. Y. S., HUI, J., WONG, V., et al. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.12.e41 · Cited by 149 · see citing works
Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches
Cheng, N., Rho, J. M., & Masino, S. A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00034 · Cited by 148 · see citing works
Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice
Yan, J., Porch, M. W., Court-Vazquez, B. L., Bennett, M. V. L., & Zukin, R. S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808247115 · Cited by 144 · see citing works
Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study.
Gardner, R. M., Lee, B. K., Magnusson, C., Rai, D., Frisell, T., Karlsson, H., Idring, S., & Dalman, C. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv081 · Cited by 141 · see citing works
Pinto Bean Consumption Changes SCFA Profiles in Fecal Fermentations, Bacterial Populations of the Lower Bowel, and Lipid Profiles in Blood of Humans3
Finley, J. W., Burrell, J. B., & Reeves, P. G. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2391 · Cited by 139 · see citing works
Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism
Cooper, R. A., Richter, F. R., Bays, P. M., Plaisted-Grant, K. C., Baron‐Cohen, S., & Simons, J. S. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw417 · Cited by 137 · see citing works
Dysregulation of Cortical Neuron DNA Methylation Profile in Autism Spectrum Disorder
Nardone, S., Sams, D. S., Zito, A., Reuveni, E., & Elliott, E. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx250 · Cited by 134 · see citing works
Maternal preconception body mass index and offspring cord blood DNA methylation: Exploration of early life origins of disease
Liu, X., Chen, Q., Tsai, H., Wang, G., Hong, X., Zhou, Y., Zhang, C., Liu, C., Liu, R., Wang, H., et al. (2013) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21827 · Cited by 131 · see citing works
Dendritic Arborization and Spine Dynamics Are Abnormal in the Mouse Model ofMECP2Duplication Syndrome
Jiang, M., Ash, R. T., Baker, S. A., Suter, B., Ferguson, A., Park, J., Rudy, J., Torsky, S. P., Chao, H.-T., Zoghbi, H. Y., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1745-13.2013 · Cited by 129 · see citing works
Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders
Tappy, L. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.164202 · Cited by 126 · see citing works
The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Prefrontal Cortex in Autism
Hashemi, E., Ariza, J., Rogers, H., Noctor, S. C., & Martínez-Cerdeño, V. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhx063 · Cited by 123 · see citing works
Epigenetics of Autism Spectrum Disorder
Siu, M. T., & Weksberg, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_4 · Cited by 121 · see citing works
Autism and Metabolic Diseases
Manzi, B., Loizzo, A. L., Giana, G., & Curatolo, P. (2007) · Journal of Child Neurology · doi:10.1177/0883073807308698 · Cited by 119 · see citing works
Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards
LUO, S. H., Monterosso, J. R., Sarpelleh, K., & Page, K. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503358112 · Cited by 118 · see citing works
Carbotoxicity—Noxious Effects of Carbohydrates
Kroemer, G., López-Otı́n, C., Madeo, F., & de Cabo, R. (2018) · Cell · doi:10.1016/j.cell.2018.07.044 · Cited by 117 · see citing works
Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors
Bey, A. L., Wang, X., Yan, H., Kim, N., Passman, R. L., Yang, Y., Cao, X., Towers, A. J., Hulbert, S. W., Duffney, L. J., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0142-6 · Cited by 113 · see citing works
High Fat Diet and In Utero Exposure to Maternal Obesity Disrupts Circadian Rhythm and Leads to Metabolic Programming of Liver in Rat Offspring
Borengasser, S. J., Kang, P., Faske, J. B., Gómez-Acevedo, H., Blackburn, M. L., Badger, T. M., & Shankar, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084209 · Cited by 112 · see citing works
Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging
Calfa, G. D., Hablitz, J. J., & Pozzo‐Miller, L. D. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00800.2010 · Cited by 106 · see citing works
High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring
Saad, A. F., Dickerson, J., Kechichian, T. B., Yin, H., Gamble, P., Salazar, A. E., Patrikeev, I., Motamedi, M., Saade, G. R., & Costantine, M. M. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.03.038 · Cited by 103 · see citing works
Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome
Han, J. C., Thurm, A. E., Golden, C., Joseph, L. A., Zein, W. M., Brooks, B. P., Butman, J. A., Brady, S. M., Fuhr, S. R., Hicks, M. D., et al. (2013) · Cortex · doi:10.1016/j.cortex.2013.02.009 · Cited by 98 · see citing works
Irrelevant and metaphorical language in early infantile autism. 1946 [classical article]
Kanner, L. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.6.161 · Cited by 98 · see citing works
Tactile hypersensitivity and GABA concentration in the sensorimotor cortex of adults with autism
Sapey‐Triomphe, L., Lamberton, F., Sonié, S., Mattout, J., & Schmitz, C. (2019) · Autism Research · doi:10.1002/aur.2073 · Cited by 98 · see citing works
Altered brain response to drinking glucose and fructose in obese adolescents
Jastreboff, A. M., Sinha, R., Arora, J., Giannini, C., Kubat, J., Malik, S., Van Name, M. A., Santoro, N., Savoye, M., Duran, E. J., et al. (2016) · Diabetes · doi:10.2337/db15-1216 · Cited by 97 · see citing works
Exploring the relationship between cortical GABA concentrations, auditory gamma‐band responses and development in ASD: Evidence for an altered maturational trajectory in ASD
Port, R. G., Gaetz, W., Bloy, L., Wang, D., Blaskey, L., Kuschner, E. S., Levy, S. E., Brodkin, E. S., & Roberts, T. P. L. (2017) · Autism Research · doi:10.1002/aur.1686 · Cited by 94 · see citing works
Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders
Barnes, S. A., Pinto-Duarte, A., Kappe, A., Zembrzycki, A., Metzler, A., Mukamel, E. A., Lucero, J., Wang, X., Sejnowski, T. J., Markou, A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.113 · Cited by 92 · see citing works
R-Baclofen reverses cognitive deficits and improves social interactions in two lines of 16p11.2 deletion mice
Stoppel, L. J., Kazdoba, T. M., Schaffler, M. D., Preza, A. R., Heynen, A., Crawley, J. N., & Bear, M. F. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.236 · Cited by 92 · see citing works
An Evolutionary Perspective on Why Food Overconsumption Impairs Cognition
Mattson, M. P. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.003 · Cited by 91 · see citing works
Self-citation
The obesogenic effect of high fructose exposure during early development
Goran, M. I., Dumke, K. A., Bouret, S. G., Kayser, B. D., Walker, R. W., & Blumberg, B. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.108 · Cited by 90 · see citing works
In pursuit of neurophenotypes: The consequences of having autism and a big brain
Amaral, D. G., Li, D., Libero, L. E., Solomon, M., de Water, J. V., Mastergeorge, A. M., Naigles, L., Rogers, S. J., & Nordahl, C. W. (2017) · Autism Research · doi:10.1002/aur.1755 · Cited by 88 · see citing works
Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder
Jann, K., Hernandez, L. M., Beck‐Pancer, D., McCarron, R., Smith, R. X., Dapretto, M., & Wang, D. J. J. (2015) · Brain and Behavior · doi:10.1002/brb3.358 · Cited by 87 · see citing works
Lupin kernel fiber consumption modifies fecal microbiota in healthy men as determined by rRNA gene fluorescent in situ hybridization
Smith, S. C., Choy, R., Johnson, S. K., Hall, R. S., Wildeboer-Veloo, A. C. M., & Welling, G. W. (2006) · European Journal of Nutrition · doi:10.1007/s00394-006-0603-1 · Cited by 84 · see citing works
Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models
Patti, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1298-0 · Cited by 84 · see citing works
Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders
D'Cruz, A.-M., Mosconi, M. W., Ragozzino, M. E., Cook, E. H., & Sweeney, J. A. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.161 · Cited by 77 · see citing works
Ketogenic diets improve behaviors associated with autism spectrum disorder in a sex-specific manner in the EL mouse
Ruskin, D. N., Fortin, J. A., Bisnauth, S. N., & Masino, S. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.10.023 · Cited by 77 · see citing works
Maternal obese-type gut microbiota differentially impact cognition, anxiety and compulsive behavior in male and female offspring in mice
Bruce-Keller, A. J., Fernandez-Kim, S.-O., Townsend, R. L., Kruger, C., Carmouche, R., Newman, S., Salbaum, J. M., & Berthoud, H.-R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175577 · Cited by 76 · see citing works
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
Orr, M. E., Salinas, A., Buffenstein, R., & Oddo, S. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.006 · Cited by 75 · see citing works
Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring
Ear, P. H., Chadda, A., Gumusoglu, S. B., Schmidt, M. S., Vogeler, S., Malicoat, J., Kadel, J., Moore, M. M., Migaud, M. E., Stevens, H. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.007 · Cited by 72 · see citing works
Offspring DNA methylation of the aryl-hydrocarbon receptor repressor gene is associated with maternal BMI, gestational age, and birth weight
Burris, H. H., Baccarelli, A., Byun, H., Cantoral, A., Just, A. C., Pantic, I., Solano-González, M., Svensson, K., Tamayo‐Ortiz, M., Zhao, Y., et al. (2015) · Epigenetics · doi:10.1080/15592294.2015.1078963 · Cited by 68 · see citing works
High-fat diet exacerbates cognitive rigidity and social deficiency in the BTBR mouse model of autism
Zilkha, N., Kuperman, Y., & Kimchi, T. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.070 · Cited by 68 · see citing works
Rapamycin improves sociability in the BTBR T+Itpr3/J mouse model of autism spectrum disorders
Burket, J. A., Benson, A. D., Tang, A., & Deutsch, S. I. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.11.005 · Cited by 67 · see citing works
Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability
Golden, C. E. M., Buxbaum, J. D., & Rubeis, S. D. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.11.006 · Cited by 67 · see citing works
Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter
Yamazaki, M., Yamada, H., Munetsuna, E., Ishikawa, H., Mizuno, G., Mukuda, T., Mouri, A., Nabeshima, T., Saito, K., Suzuki, K. A. O., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700783rr · Cited by 66 · see citing works
Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation
Ohja, K., Gozal, E., Fahnestock, M. L., Cai, L., Cai, J., Freedman, J. H., Switala, A., El-Baz, A. S., & Barnes, G. N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8488-8 · Cited by 65 · see citing works
Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose
Burmeister, M. A., Ayala, J., Drucker, D. J., & Ayala, J. E. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2012 · Cited by 64 · see citing works
Association between parental body mass index and autism spectrum disorder: a systematic review and meta-analysis
Lei, X., Li, Y., Ou, J.-J., & Li, Y. (2018) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-018-1259-0 · Cited by 61 · see citing works
GABA A receptor availability is not altered in adults with autism spectrum disorder or in mouse models
Horder, J., Andersson, M., Mendez, M. A., Singh, N., Tangen, Ä., Lundberg, J., Gee, A., Halldin, C., Veronese, M., Bölte, S., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam8434 · Cited by 60 · see citing works
Voltage-Independent SK-Channel Dysfunction Causes Neuronal Hyperexcitability in the Hippocampus of Fmr1 Knock-Out Mice
Deng, P., Carlin, D., Oh, Y. M., Myrick, L. K., Warren, S. T., Cavalli, V., & Klyachko, V. A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1593-18.2018 · Cited by 60 · see citing works
Fetal DNA methylation of autism spectrum disorders candidate genes: association with spontaneous preterm birth
Behnia, F., Parets, S. E., Kechichian, T. B., Yin, H., Dutta, E. H., Saade, G. R., Smith, A. K., & Menon, R. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.02.011 · Cited by 59 · see citing works
Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies
Brondino, N., Fusar‐Poli, L., Panisi, C., Damiani, S., Barale, F., & Politi, P. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2619-y · Cited by 58 · see citing works
Region-specific impairments in parvalbumin interneurons in social isolation-reared mice
Ueno, H., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Okamoto, M., Matsumoto, Y., & Ishihara, T. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.016 · Cited by 56 · see citing works
Neuroepigenomics in Aging and Disease
Delgado‐Morales, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1 · Cited by 55 · see citing works
Increased Male Offspring’s Risk of Metabolic-Neuroendocrine Dysfunction and Overweight after Fructose-Rich Diet Intake by the Lactating Mother
Alzamendi, A., Castrogiovanni, D. C., Gaillard, R. C., Spinedi, E., & Giovambattista, A. (2010) · Endocrinology · doi:10.1210/en.2009-1353 · Cited by 54 · see citing works
Concise Review: Fragile X Proteins in Stem Cell Maintenance and Differentiation
Li, Y., & Zhao, X. (2014) · Stem Cells · doi:10.1002/stem.1698 · Cited by 52 · see citing works
The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders
Nuttall, J. R. (2015) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1103437 · Cited by 52 · see citing works
Epigenetic modulation of mechanisms involved in inflammation: Influence of selected polyphenolic substances on histone acetylation state
Kiss, A. K., Granica, S., Stolarczyk, M., & Melzig, M. F. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.09.109 · Cited by 49 · see citing works
Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain
Hester, M. S., Hosford, B. E., Santos, V. R., Singh, S. P., Rolle, I. J., LaSarge, C. L., Liska, J. P., Garcia‐Cairasco, N., & Danzer, S. C. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.015 · Cited by 47 · see citing works
Dietary interventions for autism spectrum disorder: New perspectives from the gut-brain axis
Doenyas, C. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.07.014 · Cited by 46 · see citing works
Placental Expression of Glucose Transporter Proteins in Pregnancies Complicated by Gestational and Pregestational Diabetes Mellitus
Stanirowski, P. J., Szukiewicz, D., Pazura, M., Sawicki, W., & Cendrowski, K. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.04.008 · Cited by 45 · see citing works
Transgenerational Epigenetic Mechanisms in Adipose Tissue Development
Lecoutre, S., Petrus, P., Rydén, M., & Breton, C. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.07.004 · Cited by 45 · see citing works
Responses of the embryonic epigenome to maternal diabetes
Salbaum, J. M., & Kappen, C. (2012) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.23035 · Cited by 43 · see citing works
Conceptualizing the Autism Spectrum in Terms of Natural Selection and Behavioral Ecology: The Solitary Forager Hypothesis
Reser, J. E. (2011) · Evolutionary Psychology · doi:10.1177/147470491100900209 · Cited by 41 · see citing works
Ketogenic diet restores aberrant cortical motor maps and excitation-to-inhibition imbalance in the BTBR mouse model of autism spectrum disorder
Smith, J. D., Rho, J. M., & Teskey, G. C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.02.015 · Cited by 40 · see citing works
Reduced Cortical Excitability, Neuroplasticity, and Salivary Cortisol in 11–13-Year-Old Children Born to Women with Gestational Diabetes Mellitus
Dam, J. M. V., Garrett, A. J., Schneider, L. A., Hodyl, N. A., Goldsworthy, M. R., Coat, S., Rowan, J., Hague, W. M., & Pitcher, J. B. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.04.011 · Cited by 40 · see citing works
Memory of fearful events: the role of fibroblast growth factor-2 in fear acquisition and extinction
Graham, B. M., & Richardson, R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.041 · Cited by 37 · see citing works
Inductions of histone H3 acetylation at lysine 9 on SGLT1 gene and its expression by feeding mice a high carbohydrate/fat ratio diet
Honma, K., Mochizuki, K., & Goda, T. (2008) · Nutrition · doi:10.1016/j.nut.2008.07.006 · Cited by 33 · see citing works
Hierarchical cortical transcriptome disorganization in autism
Lombardo, M. V., Courchesne, E., Lewis, N. E., & Pramparo, T. (2017) · Molecular Autism · doi:10.1186/s13229-017-0147-7 · Cited by 33 · see citing works
Beneficial Effects of GLP-1 Agonist in a Male With Compulsive Food-Related Behavior Associated With Autism
Järvinen, A. M., Laine, M. K., Tikkanen, R., & Castrén, M. L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00097 · Cited by 31 · see citing works
Decreased levels of serum fibroblast growth factor-2 in children with autism spectrum disorder
Esnafoğlu, E., & Ayyıldız, S. N. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.07.028 · Cited by 30 · see citing works
Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice
Cabral‐Costa, J. V., Andreotti, D. Z., de Mello, N. P., Scavone, C., Camandola, S., & Kawamoto, E. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-26814-6 · Cited by 27 · see citing works
Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain
Dasuri, K., Zhang, L., Kim, S. O. K. F., Bruce‐Keller, A. J., & Keller, J. N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.002 · Cited by 26 · see citing works
TSC2 c.1864C>T variant associated with mild cases of tuberous sclerosis complex
Farach, L. S., Gibson, W. T., Sparagana, S. P., Nellist, M. D., Schrander-Stumpel, C. T. R. M., Hietala, M., Friedman, E. R., Pearson, D. A., Creighton, S. P., Wagemans, A. M. A., et al. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38083 · Cited by 24 · see citing works
Maternal pre‐pregnancy weight and autistic‐like traits among offspring in the general population
Varcin, K. J., Newnham, J. P., & Whitehouse, A. (2018) · Autism Research · doi:10.1002/aur.1973 · Cited by 21 · see citing works
Deriving and validating biomarkers associated with autism spectrum disorders from a large-scale resting-state database
Chen, C.-M., Yang, P., Wu, M., Chuang, T., & Huang, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-45465-9 · Cited by 20 · see citing works

Flagged first, then by citations

Sorted by citations

Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Maternal Nutrition and Neurodevelopment: A Scoping Review
Cortés-Albornoz, M. C., García-Guáqueta, D. P., Vélez-van-Meerbeke, A., & Talero‐Gutiérrez, C. (2021) · Nutrients · doi:10.3390/nu13103530 · Cited by 244 · see citing works
Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders
Tappy, L. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.164202 · Cited by 126 · see citing works
Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors
Bey, A. L., Wang, X., Yan, H., Kim, N., Passman, R. L., Yang, Y., Cao, X., Towers, A. J., Hulbert, S. W., Duffney, L. J., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0142-6 · Cited by 113 · see citing works
The gut microbiota–brain axis in neurological disorders
You, M., Chen, N., Yang, Y., Cheng, L., He, H., Cai, Y., Liu, Y., Liu, H., & Hong, G. (2024) · MedComm · doi:10.1002/mco2.656 · Cited by 107 · see citing works
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy
Chen, Z., Zhao, X., Wang, S., Cai, R., Liu, Q., Ye, H., Wang, M.-J., Peng, S., Xue, W., Zhang, Y.-X., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01979-2 · Cited by 87 · see citing works
Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children
Lahti‐Pulkkinen, M., Girchenko, P. V., Tuovinen, S., Sammallahti, S., Reynolds, R. M., Lahti, J. M. T., Heinonen, K., Lipsanen, J. O., Hämäläinen, E. K., Villa, P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14140 · Cited by 81 · see citing works
The hormesis principle of neuroplasticity and neuroprotection
Mattson, M. P., & Leak, R. K. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.022 · Cited by 75 · see citing works
Self-citation
Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter
Yamazaki, M., Yamada, H., Munetsuna, E., Ishikawa, H., Mizuno, G., Mukuda, T., Mouri, A., Nabeshima, T., Saito, K., Suzuki, K. A. O., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700783rr · Cited by 66 · see citing works
VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction
Usui, N., Iwata, K., Miyachi, T., Takagai, S., Wakusawa, K., Nara, T., Tsuchiya, K. J., Matsumoto, K., Kurita, D., Kameno, Y., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102917 · Cited by 45 · see citing works
Prenatal and perinatal metabolic risk factors for autism: a review and integration of findings from population-based studies
Katz, J., Reichenberg, A., & Kolevzon, A. L. (2020) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000673 · Cited by 34 · see citing works
Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction
Li, Y., Jiang, T., Du, M., He, S., Huang, N., Cheng, B., Yan, C., Tang, W., Gao, W., Guo, H., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01112-y · Cited by 32 · see citing works
Influence of Nutritional Ketosis Achieved through Various Methods on Plasma Concentrations of Brain Derived Neurotropic Factor
Kackley, M. L., Buga, A., Crabtree, C. D., Sapper, T. N., McElroy, C. A., Focht, B. C., Kraemer, W. J., & Volek, J. S. (2022) · Brain Sciences · doi:10.3390/brainsci12091143 · Cited by 18 · see citing works
Dysregulation of Serum Exosomal Lipid Metabolism in Schizophrenia: A Biomarker Perspective
Xu, C.-X., Huang, W., Shi, X., Du, Y., Liang, J., Fang, X., Chen, H.-Y., & Cheng, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04477-x · Cited by 16 · see citing works
Associations Between Sex Hormone Levels and Autistic Traits in Infertile Patients With Polycystic Ovary Syndrome and Their Offspring
Jiang, L., Tian, L., Yuan, J., Xu, X., Qu, F., Zhang, R., & Wang, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.789395 · Cited by 16 · see citing works
Rewiring of the glymphatic landscape in metabolic disorders
Chen, B., Meseguer, D., Lenck, S., Thomas, J., & Schneeberger, M. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.005 · Cited by 15 · see citing works
Impaired social cognition caused by perinatal protein malnutrition evokes neurodevelopmental disorder symptoms and is intergenerationally transmitted
Fesser, E. A., Gianatiempo, O., Berardino, B. G., Alberca, C. D., Urrutia, L., Falasco, G., Sonzogni, S. V., Chertoff, M., & Cánepa, E. T. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113911 · Cited by 14 · see citing works
Abnormalities in both stimulus-induced and baseline MEG alpha oscillations in the auditory cortex of children with Autism Spectrum Disorder
Arutiunian, V., Arcara, G., Buianova, I., Fedorov, M., Юрьевна, Д. Е., Станиславаовна, П. Д., Sorokin, A. B., Анатольевна, Т. С., Mamokhina, U. A., Касимовна, Д. К., et al. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02802-7 · Cited by 12 · see citing works
Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice
Zilkha, N., Chuartzman, S. G., Fishman, R., Ben‐Dor, S., & Kimchi, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-70062-w · Cited by 12 · see citing works
Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism
Dai, L., Weiss, R. B., Dunn, D. M., Ramirez, A., Paul, S., & Korenberg, J. R. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab041 · Cited by 10 · see citing works
The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study
Shirayama, Y., Matsumoto, K., Osone, F., Hara, A., Guan, S., Hamatani, S., Muneoka, K., Sato, K., Okada, A., & Yokokawa, T. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05778-7 · Cited by 10 · see citing works
Alpha-linolenic acid enhances the facilitation of GABAergic neurotransmission in the BLA and CA1
Pidoplichko, V. I., Figueiredo, T. H., Braga, M. F. M., Pan, H., & Marini, A. M. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231165010 · Cited by 9 · see citing works
Lipid peroxidation and neuroinflammation: A possible link between maternal fructose intake and delay of acquisition of neonatal reflexes in Wistar female rats
Spalm, F. H. P., Sánchez, M. L. C., Furland, N. E., & Vallés, A. S. (2023) · Developmental Neurobiology · doi:10.1002/dneu.22921 · Cited by 8 · see citing works
Limited contextual memory and transcriptional dysregulation in the medial prefrontal cortex of mice exposed to early protein malnutrition are intergenerationally transmitted
Fesser, E. A., Gianatiempo, O., Berardino, B. G., Ferroni, N. M., Cambiasso, M. Y., Fontana, V. A., Calvo, J. C., Sonzogni, S. V., & Cánepa, E. T. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.041 · Cited by 8 · see citing works
Restoration of nNOS Expression Rescues Autistic-Like Phenotypes Through Normalization of AMPA Receptor-Mediated Neurotransmission
Wang, X., Zhang, Y., Luo, S., Zhao, K., Gao, C., Mei, D., Duan, Y., & Hu, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03997-w · Cited by 6 · see citing works
Microglia eliminate inhibitory synapses and drive neuronal hyperexcitability in epilepsy
(2025) · Nature Neuroscience · doi:10.1038/s41593-025-01983-6 · Cited by 5 · see citing works
Pathophysiologic similarities between autism spectrum disorder and Alzheimer's disease: therapeutic possibilities
Phillips, W. T., Sheesley, A. P., & Schwartz, J. G. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1737007 · Cited by 5 · see citing works
Sculptor and Destroyer
Mattson, M. P. (2023) · The MIT Press eBooks · doi:10.7551/mitpress/14422.001.0001 · Cited by 4 · see citing works
Self-citation
Vocal communication in asocial BTBR mice is more malleable by a ketogenic diet in juveniles than adults
Möhrle, D., Murari, K., Rho, J. M., & Cheng, N. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.001 · Cited by 4 · see citing works
Parallel paths: A narrative review exploring autism and its co-occurring conditions
Hasan, H., Hagerman, R. J., Say, D. S., Nguyen, A. P., Babata, K., Oyegbile-Chidi, T. O., Herrera-Guerra, A., Torrents, C., Silver, C. E., & Restrepo, B. (2025) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v14.i4.111641 · Cited by 3 · see citing works
Applying available knowledge and resources to alleviate familial and sporadic neurodegenerative disorders
Mattson, M. P. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.09.001 · Cited by 3 · see citing works
Self-citation
Effects of fructose consumption during pregnancy in murine models (Review)
Urrego, A. L., Urrutia, C., González, J. D. R., & Vargas, J. A. G. (2025) · Biomedical Reports · doi:10.3892/br.2025.1965 · Cited by 2 · see citing works
Association between the Healthy Eating Index-2015 and Developmental Disabilities in Children: A Cross-Sectional Analysis
Gui, J., Wang, L., Han, Z., Ding, R., Yang, X., Yang, J., Luo, H., Huang, D., Liu, J., & Jiang, L. (2023) · Brain Sciences · doi:10.3390/brainsci13091353 · Cited by 2 · see citing works
Bezdomność jako problem społeczny i indywidualny-możliwości profilaktyki
Piechowicz, M. (2012) · Resocjalizacja Polska · Cited by 2 · see citing works
From maternal metabolism to offspring brain: how high-fructose diets shape neurodevelopment
Vallés, A. S., Spalm, F. H. P., & Sánchez, M. L. C. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.03.006 · Cited by 1 · see citing works
Does metabolic syndrome during pregnancy really a risk to autism spectrum disorder?
Abraham, D. A., & Rajanandh, M. G. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.08.006 · Cited by 1 · see citing works
Mitochondrial Dysfunction and mTOR in Autism Spectrum Disorders
SELAMET, E., & Usta, M. B. (2023) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.1205786 · Cited by 1 · see citing works
Cellular Adaptations to Intermittent Fasting with Emphasis on the Brain
Mattson, M. P. (2024) · Springer eBooks · doi:10.1007/978-3-031-49622-6_7 · Cited by 2 · see citing works
Self-citation
Ketogenic Diet, Social Behavior, and Autism
Cheng, N., Masino, S. A., & Rho, J. M. (2022) · doi:10.1093/med/9780197501207.003.0016 · Cited by 1 · see citing works
How Different Health-Related Interventions Improve Metabolic Impairments in Individuals with Autism Spectrum Disorder
(2022) · International Journal of Diabetes & Metabolic Disorders · doi:10.33140/ijdmd.07.02.16 · Cited by 1 · see citing works
Editorial: Developmental Neuropsychiatry dyslexia, animal models, prenatal and perinatal risk for autism, neuroimaging, and syndrome updates
Harris, J. C. (2020) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000676
Neurology
Hoffmann, M. W., Cywes, R., Childers, A. M., Kossoff, M. M., Kossoff, E. H., Perlmutter, D., Phillips, M. C. L., Edes, G., Berger, A., Stanton, A. A., et al. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821617-0.00006-1
Protecting axons in grandchildren
Sural, S. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.09.005
Association and predictive value of blood branched-chain and excitatory amino acids with autism spectrum disorder severity
Li, J., Wang, Y. S., Bi, L., Yang, X., Yang, Y., Zhang, Q., Mei, X., Dang, W., Feng, G., Zhang, X., et al. (2026) · BMC Pediatrics · doi:10.1186/s12887-025-06501-y
Mapping evidence on maternal metabolic conditions and child neurodevelopment in the Caribbean: a scoping review
Mabie, A., Cleave, A. V., Foley, O. A., Gray, C. J., Tauseef, A., Beste, J., & Jiménez, M. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1686158
Direct Reprogramming of glial cell into functional GABAergic neurons : a new avenue to epileptic seizure relief
Lentini, C. (2019) · doi:10.70675/6816666az3fdfz41c0zb106zc7d30c1931eb
Autism spectrum disorders with comorbidities – A detailed profiling of risk factors and temperamental characteristics - Insights from a tertiary care center
Sinha, U., Shenoy, S., Amrtavarshini, R., & Bhandary, R. P. (2026) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2026.102364
The role of ucOCN in aerobic exercise induced amelioration of autism spectrum disorder phenotypes
Shi, Y., Zhu, T., Wang, S., Sun, Y., Liu, Y., Chen, S., Qiao, W., Zhou, D., Wang, Z., Fan, L., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116541
Neuromodulatory roles of the sigma-1 receptor in behavior and drug sensitization during development
Yang, Q., Xiao, J.-H., Li, J., Yu, Z., Qin, P., Zhu, Y., Ye, N., Li, X.-H., Zhang, S., Sun, Y., et al. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01903-9
Metabolic Dysregulation and Metabolite-Targeted Interventions in Autism Spectrum Disorder: Mechanisms and Translational Perspectives
Fang, Y., Dou, Z., Liu, Y., Zong, Y., Wang, S., Li, S., He, N., & Li, N. (2026) · Metabolites · doi:10.3390/metabo16100749

Metabolic Dysregulation and Metabolite-Targeted Interventions in Autism Spectrum Disorder: Mechanisms and Translational Perspectives
Fang, Y., Dou, Z., Liu, Y., Zong, Y., Wang, S., Li, S., He, N., & Li, N. (2026) · Metabolites · doi:10.3390/metabo16100749
Editorial: Metabolic Disorders Associated With Autism Spectrum Disorders: Approaches for Intervention
Gaspar, J. M., Carvalho, H. M., & Camacho‐Morales, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.809978 · Cited by 4 · see citing works
Maternal obesity and autism spectrum disorders in offspring
Agrawal, R., Agrawal, A., & Mandumpala, J. J. (2022) · Indian Journal of Child Health · doi:10.32677/ijch.v9i10.3690 · Cited by 2 · see citing works
Autism spectrum disorders: let’s talk about glucose?
Hoirisch-Clapauch, S., & Nardi, A. E. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0370-4 · Cited by 44 · see citing works
Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder
Currais, A. J. M., Farrokhi, C. B., Dargusch, R., Goujon-Svrzic, M., & Maher, P. A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.64 · Cited by 39 · see citing works

Authors: Rivell, A., & Mattson, M. P.
Affiliations: National Institute on Aging (US)
Johns Hopkins University (US)
Corresponding author: Mattson, Mark P.
ORCID: Rivell, Aileen
Mattson, Mark P.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2019-10
Volume: 42
Issue: 10
Pages: 709-726
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2019.08.006
PMC: PMC6779523
OpenAlex: W2972003441
Cited by: 50
References: 170
Citations by year: 2026: 8 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 3 · 2012: 1
FWCI: 0.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, metabolic syndrome, maternal obesity, insulin resistance, fructose consumption, energy-dense diet, ketosis, GABAergic neurotransmission, DNA methylation, chromatin modification, metabolic reprogramming, intermittent fasting, physical activity, anabolic signaling
MeSH terms: Animals, Autistic Disorder, Brain, Energy Metabolism, Humans, Nerve Net, Neurons, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intergenerational Metabolic Syndrome and Neuronal Network Hyperexcitability in Autism

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks