Salivary Oxytocin and Vasopressin Levels in Police Officers With and Without Post‐Traumatic Stress Disorder
Open accessAbstract
Post‐traumatic stress disorder (PTSD) is characterised by symptoms associated with maladaptive fear and stress responses, as well as with social detachment. The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) have been associated with both regulating fear and neuroendocrine stress responsiveness and social behaviour. However, there is only limited evidence for dysregulated peripheral OT and AVP levels in PTSD patients. The present study aimed to investigate basal salivary OT and AVP levels in trauma‐exposed male and female police officers with and without PTSD. Saliva samples were collected during rest and OT and AVP levels were determined using a radioimmunoassay. Men and women were analysed separately, having adjusted for differences in trauma history, and for hormonal contraception use in women. The results showed that male PTSD patients had lower basal salivary OT levels, and did not differ in AVP levels compared to male trauma‐exposed healthy controls after adjusting for childhood emotional abuse. There were no significant differences in basal salivary OT and AVP levels in women. Our findings indicate potential dysfunctioning of the OT system in male PTSD patients. Future studies are needed to replicate these findings and to further unravel the relationship between the OT and AVP systems, sex, trauma history and PTSD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a steady state, unbound oxytocin and vasopressin should distribute in extravascular fluids, and measurements in saliva might be useful for estimating steady-state secretion.
“In a steady‐state, unbound oxytocin and vasopressin should distribute in extravascular fluids, and measurements in saliva might be useful for estimating steady‐state secretion 119, 130, 131.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [131]
Male PTSD patients had lower salivary OT levels than male trauma-exposed controls in the same sample.
“The notion that OT system functioning may be affected in PTSD patients is supported by our observation of lower salivary OT levels in male PTSD patients compared with male trauma-exposed controls (Frijling et al, 2015), in the same sample reported in this manuscript.”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Frijling et al, 2015
OT system functioning may be affected in PTSD patients.
“The notion that OT system functioning may be affected in PTSD patients is supported by our observation of lower salivary OT levels in male PTSD patients compared with male trauma-exposed controls (Frijling et al, 2015), in the same sample reported in this manuscript.”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Frijling et al, 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
The development of a Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995) · Journal of Traumatic Stress · doi:10.1002/jts.2490080106 · Cited by 5,024 · see citing works
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · see citing works
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339 · see citing works
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Self-citationPlasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728 · see citing works
DSM‐IV‐TR: Diagnostic and Statistical Manual of Mental Disorders
Chao, R., & Manita, J. (2013) · The Encyclopedia of Cross‐Cultural Psychology · doi:10.1002/9781118339893.wbeccp180 · Cited by 683 · see citing works
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620 · see citing works
Self-citationFries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504767102 · Cited by 570 · see citing works
Psychometric properties of the Early Trauma Inventory-Self Report
Bremner, J. D., Bolus, R., & Mayer, E. A. (2007) · Journal of Nervous & Mental Disease · doi:10.1097/01.nmd.0000243824.84651.6c · Cited by 550 · see citing works
Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518 · see citing works
Morris, M. C., Compas, B. E., & Garber, J. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.02.002 · Cited by 466 · see citing works
Oxytocin, vasopressin, and social recognition in mammals
Bielsky, I. F., & Young, L. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.019 · Cited by 460 · see citing works
Quantitative meta-analysis of neural activity in posttraumatic stress disorder
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-9 · Cited by 452 · see citing works
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416 · see citing works
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · see citing works
The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands
de Vries, G., & Olff, M. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20429 · Cited by 390 · see citing works
Self-citationHeinrichs, M., Meinlschmidt, G., Neumann, I., Wagner, S., Kirschbaum, C., Ehlert, U., & Hellhammer, D. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7919 · Cited by 386 · see citing works
Self-citationVan IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.008 · Cited by 365 · see citing works
Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin
Szeto, A., McCabe, P. M., Nation, D. A., Tabak, B. A., Rossetti, M. A., McCullough, M. E., Schneiderman, N., & Mendez, A. J. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31821df0c2 · Cited by 330 · see citing works
Plasma Levels of Arginine Vasopressin Elevated in Patients with Major Depression
van Londen, L. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00054-7 · Cited by 306 · see citing works
Veenema, A. H., Bredewold, R., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.008 · Cited by 263 · see citing works
Self-citationWotjak, C. T., Kubota, M., Liebsch, G., Montkowski, A., Holsboer, F., Neumann, I. D., & Landgraf, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07725.1996 · Cited by 231 · see citing works
Self-citationSalonia, A., Nappi, R. E., Pontillo, M., Daverio, R., Smeraldi, A., Briganti, A., Fabbri, F., Zanni, G. E., Rigatti, P., & Montorsi, F. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.10.002 · Cited by 229 · see citing works
Evidence of dysregulated peripheral oxytocin release among depressed women
Cyranowski, J. M., Hofkens, T. L., Frank, E., Seltman, H., Cai, H.-M., & Amico, J. A. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318188ade4 · Cited by 220 · see citing works
Kagerbauer, S. M., Martin, J., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12038 · Cited by 212 · see citing works
Oxytocin facilitates the extinction of conditioned fear in humans
Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T. E., Grinevich, V., Kendrick, K. M., Maier, W., & Hurlemann, R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.015 · Cited by 210 · see citing works
Carson, D. S., Berquist, S. W., Trujillo, T. H., Garner, J. P., Hannah, S. L., Hyde, S. A., Sumiyoshi, R. D., Jackson, L. P., Moss, J. K., Strehlow, M. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.132 · Cited by 196 · see citing works
Brain oxytocin in social fear conditioning and its extinction: involvement of the lateral septum
Zoicas, I., Slattery, D. A., & Neumann, I. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.156 · Cited by 189 · see citing works
Self-citationReduced plasma oxytocin levels in female patients with borderline personality disorder
Bertsch, K., Schmidinger, I., Neumann, I. D., & Herpertz, S. C. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.013 · Cited by 189 · see citing works
Self-citationThe effects of vasopressin on human facial responses related to social communication
Thompson, R. R., Gupta, S., Miller, K., Mills, S. D., & Orr, S. P. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00133-6 · Cited by 184 · see citing works
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179 · see citing works
Cardoso, C., Kingdon, D., & Ellenbogen, M. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.014 · Cited by 171 · see citing works
Özsoy, S., Eşel, E., & Kula, M. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.034 · Cited by 168 · see citing works
Hierarchy of cortical responses underlying binocular rivalry
Lee, S., Blake, R., & Heeger, D. J. (2007) · Nature Neuroscience · doi:10.1038/nn1939 · Cited by 154 · see citing works
Acheson, D., Feifel, D., de Wilde, S., Mckinney, R., Lohr, J., & Risbrough, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3099-4 · Cited by 141 · see citing works
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135 · see citing works
Self-citationToth, I., Neumann, I. D., & Slattery, D. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2702-4 · Cited by 107 · see citing works
Self-citationYuen, K. W., Garner, J. P., Carson, D. S., Keller, J., Lembke, A., Hyde, S. A., Kenna, H. A., Tennakoon, L., Schatzberg, A. F., & Parker, K. J. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.012 · Cited by 99 · see citing works
Antiaggressive activity of central oxytocin in male rats
Calcagnoli, F., de Boer, S. F., Althaus, M., den Boer, J. A., & Koolhaas, J. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3124-7 · Cited by 90 · see citing works
Diurnal rhythms in neurohypophysial function
Forsling, M. L. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00022.x · Cited by 85 · see citing works
Elevated plasma arginine vasopressin levels in veterans with posttraumatic stress disorder
de Kloet, C. S., Vermetten, E. H. G. J. M., Geuze, E., Wiegant, V. M., & Westenberg, H. G. M. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.11.009 · Cited by 84 · see citing works
Mechanisms and the Current State of Deep Brain Stimulation in Neuropsychiatry
Greenberg, B. D., & Rezai, A. R. (2003) · CNS Spectrums · doi:10.1017/s109285290001899x · Cited by 76 · see citing works
Shalev, I., Israel, S., Uzefovsky, F., Gritsenko, I., Kaitz, M., & Ebstein, R. P. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.04.005 · Cited by 65 · see citing works
Plasma, salivary, and urinary oxytocin in anorexia nervosa: A pilot study
Hoffman, E. R., Brownley, K. A., Hamer, R. M., & Bulik, C. M. (2012) · Eating Behaviors · doi:10.1016/j.eatbeh.2012.02.004 · Cited by 55 · see citing works
Lucas-Thompson, R. G., & Holman, E. A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.02.015 · Cited by 51 · see citing works
Bhandari, R., Bakermans-Kranenburg, M. J., van der Veen, R., Parsons, C. E., Young, K. S., Grewen, K. M., Stein, A., Kringelbach, M. L., & van IJzendoorn, M. H. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.028 · Cited by 33 · see citing works
Seng, J. S., Miller, J. M., Sperlich, M. I., van de Ven, C. J. M., Brown, S. L., Carter, C. S., & Liberzon, I. (2013) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2012.694594 · Cited by 33 · see citing works
Marshall, A. D. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.02.014 · Cited by 24 · see citing works
Oxytocin, vasopressin and their interplay with gonadal steroids
Dhakar, M. B., Stevenson, E. L., & Caldwell, H. K. (2013) · Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior · doi:10.1017/cbo9781139017855.003 · Cited by 20 · see citing works
Environmental risk factors for psychopathology.
Schlossberg, K., Massler, A., & Zalsman, G. (2010) · PubMed · Cited by 13 · see citing works
Bœuf, B. J. L., & Allen, J. L. (1970) · Hormones and Behavior · doi:10.1016/0018-506x(70)90004-8 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Carlier I, Gersons B. Development of a scale for traumatic incidents in police work. Psychiatrica Fennica 1992; 23: 59-70.
- Picavet C. Zwangerschap en anticonceptie in Nederland. Tijdschrift voor Seksuologie 2012; 2: 121-128.
Cited by
Sorted by citations
Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
Leng, G., & Sabatier, N. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12413 · Cited by 237 · see citing works
Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review
Burback, L., Brémault‐Phillips, S., Nijdam, M. J., McFARLANE, A. C., & Vermetten, E. H. G. J. M. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230428091433 · Cited by 232 · see citing works
In the search for integrative biomarker of resilience to psychological stress
Walker, F. R., Pfingst, K., Carnevali, L., Sgoifo, A., & Nalivaiko, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.003 · Cited by 211 · see citing works
The Associations Between Oxytocin and Trauma in Humans: A Systematic Review
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00154 · Cited by 119 · see citing works
Ellis, B. J., Horn, A. J., Carter, C. S., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.101985 · Cited by 103 · see citing works
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99 · see citing works
Self-citationKoch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98 · see citing works
Self-citationOxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches
Matsushita, H., Latt, H. M., Koga, Y., Nishiki, T., & Matsui, H. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.046 · Cited by 92 · see citing works
Links between the neurobiology of oxytocin and human musicality
Harvey, A. R. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00350 · Cited by 85 · see citing works
Helpman, L., Zhu, X., Suarez-Jimenez, B., Lazarov, A., Monk, C., & Neria, Y. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0854-y · Cited by 82 · see citing works
Hypothalamus and Post-Traumatic Stress Disorder: A Review
Raise‐Abdullahi, P., Meamar, M., Vafaei, A. A., Alizadeh, M., Dadkhah, M., Shafia, S., Ghalandari-Shamami, M., Naderian, R., Samaei, A., & Rashidy‐Pour, A. (2023) · Brain Sciences · doi:10.3390/brainsci13071010 · Cited by 80 · see citing works
Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw123 · Cited by 72 · see citing works
Self-citationKraaijenvanger, E. J., He, Y., Spencer, H., Smith, A. K., Bos, P. A., & Boks, M. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.016 · Cited by 57 · see citing works
Swaab, D. F., & Bao, A. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00023-0 · Cited by 56 · see citing works
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 49 · see citing works
Self-citationMalikowska‐Racia, N., & Sałat, K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.001 · Cited by 46 · see citing works
Ferreira, A. C., & Osório, F. D. L. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110561 · Cited by 47 · see citing works
Female psychopharmacology matters! Towards a sex-specific psychopharmacology
Bolea-Alamanac, B. M., Bailey, S., Lovick, T. A., Scheele, D., & Valentino, R. J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117747578 · Cited by 44 · see citing works
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 40 · see citing works
Lushchak, O. V., Strilbytska, O. M., Koliada, A. K., & Storey, K. B. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1094076 · Cited by 39 · see citing works
Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls
Nawijn, L., Krzyzewska, I. M., van Zuiden, M., Henneman, P., Koch, S. B. J., Mul, A. N. P. M., Frijling, J. L., Veltman, D. J., Mannens, M. M. A. M., & Olff, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.10.006 · Cited by 38 · see citing works
Self-citationKim, S., & Strathearn, L. (2017) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2016.1277897 · Cited by 35 · see citing works
Decreased Plasma Oxytocin Levels in Patients With PTSD
Carmassi, C., Marazziti, D., Mucci, F., Vecchia, A. D., Barberi, F. M., Baroni, S., Giannaccini, G., Palego, L., Massimetti, G., & Dell’Osso, L. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.612338 · Cited by 36 · see citing works
Oxytocin attenuates social and non-social avoidance: Re-thinking the social specificity of Oxytocin
Harari-Dahan, O., & Bernstein, A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.04.005 · Cited by 34 · see citing works
Bina, R. W., & Langevin, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00300 · Cited by 35 · see citing works
Marvar, P. J., Andero, R., Hurlemann, R., Lago, T. R., Zelikowsky, M., & Dabrowska, J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1647-20.2020 · Cited by 29 · see citing works
Witteveen, A. B., Stramrood, C. A. I., Henrichs, J., Flanagan, J. C., van Pampus, M. G., & Olff, M. (2019) · Archives of Women s Mental Health · doi:10.1007/s00737-019-00994-0 · Cited by 29 · see citing works
Self-citationReijnen, A., Geuze, E., & Vermetten, E. H. G. J. M. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.06.010 · Cited by 29 · see citing works
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease
Aulinas, A., & Lawson, E. A. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf008 · Cited by 30 · see citing works
Circulating levels of oxytocin may be elevated in complicated grief: a pilot study
Bui, É., Hellberg, S. N., Hoeppner, S. S., Rosencrans, P. L., Young, A., Ross, R., Hoge, E. A., & Simon, N. M. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1646603 · Cited by 26 · see citing works
Danan, D., Todder, D., Zohar, J., & Cohen, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116050 · Cited by 26 · see citing works
Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic‐Pituitary‐Adrenal Axis
Borrow, A. P., Stranahan, A. M., Suchecki, D., & Yunes, R. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12403 · Cited by 26 · see citing works
Woodward, S. H., Jamison, A. L., Gala, S., & Holmes, T. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179912 · Cited by 21 · see citing works
Birze, A., LeBlanc, V. R., Regehr, C., Paradis, E., & Einstein, G. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00604 · Cited by 19 · see citing works
Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders
Marazziti, D., Carter, C. S., Carmassi, C., Vecchia, A. D., Mucci, F., Pagni, G., Carbone, M. G., Baroni, S., Giannaccini, G., Palego, L., et al. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100165 · Cited by 18 · see citing works
Novel Pharmacological Targets of Post-Traumatic Stress Disorders
Marazziti, D., Carmassi, C., Cappellato, G., Chiarantini, I., Massoni, L., Mucci, F., Arone, A., Violi, M., Palermo, S., Iorio, G. D., et al. (2023) · Life · doi:10.3390/life13081731 · Cited by 18 · see citing works
Neuroendocrinological treatment targets for posttraumatic stress disorder
Yoon, S., & Kim, Y. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.021 · Cited by 18 · see citing works
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16 · see citing works
Exploring the hormonal and neural correlates of paternal protective behavior to their infants
Lotz, A. M., Verhees, M. W. F. T., Horstman, L. I., Riem, M. M. E., van IJzendoorn, M. H., Bakermans‐Kranenburg, M. J., & Buisman, R. S. M. (2020) · Developmental Psychobiology · doi:10.1002/dev.22055 · Cited by 15 · see citing works
Vasopressin and post-traumatic stress disorder
Sipos, E., Török, B., Barna, I., Engelmann, M., & Zelena, D. (2020) · Stress · doi:10.1080/10253890.2020.1826430 · Cited by 15 · see citing works
Severe PTSD is marked by reduced oxytocin and elevated vasopressin
Horn, A. J., Cole, S., Nazarloo, H. P., Nazarloo, P., Davis, J. M., Carrier, D. R., Bryan, C. J., & Carter, C. S. (2024) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2024.100236 · Cited by 14 · see citing works
Peripheral Biomarker Candidates of Posttraumatic Stress Disorder
Kang, H. J., Yoon, S. J., & Lyoo, I. K. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.3.186 · Cited by 14 · see citing works
Social desirability, stress and health in police officers: preliminary results
Habersaat, S., Abdellaoui, S., & Wolf, J. M. (2020) · Policing An International Journal · doi:10.1108/pijpsm-08-2020-0133 · Cited by 12 · see citing works
Watson, I., Brüne, M., & Bradley, A. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.010 · Cited by 13 · see citing works
Augmenting Treatment for Posttraumatic Stress Disorder and Co-Occurring Conditions with Oxytocin
Flanagan, J. C., & Mitchell, J. (2019) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-019-00171-1 · Cited by 10 · see citing works
Asla, Q., Garrido, M., Urgell, E., Terzan, S., Vives, A. S., Varghese, N., Atila, C., Biagetti, B., Plessow, F., Christ‐Crain, M., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf201 · Cited by 8 · see citing works
Yamaguchi, S., Watanabe, K., Sugimura, N., Shishido, I., Konya, I., Fujita, T., Yoshimitsu, Y., Kato, S., Ito, Y. M., & Yano, R. (2022) · Healthcare · doi:10.3390/healthcare10081416 · Cited by 10 · see citing works
Bruti, G., & Foggetti, P. (2024) · Biomedicines · doi:10.3390/biomedicines12081744 · Cited by 8 · see citing works
Oxytocin and Vasopressin Blood Levels in People with Post-Traumatic Stress Disorder
Zayman, E. P., Karabulut, A. B., Özdemir, S., & Kartalcı, Ş. (2023) · ALPHA PSYCHIATRY · doi:10.5152/alphapsychiatry.2023.21628 · Cited by 7 · see citing works
Persike, D. S., & Alkass, S. Y. (2020) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2020-0037 · Cited by 7 · see citing works
Kaźmierczak, M., Pawlicka, P., Anikiej‐Wiczenbach, P., Łada‐Maśko, A., Kiełbratowska, B., Rybicka, M., Kotłowska, A., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094815 · Cited by 7 · see citing works
Sippel, L. M., King, C. E., Wahlquist, A. E., & Flanagan, J. C. (2020) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001226 · Cited by 7 · see citing works
Chacko, T. P., Toole, J. T., Richman, S., Spink, G. L., Reinhard, M. J., Brewster, R. C., Costanzo, M. E., & Broderick, G. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.941019 · Cited by 6 · see citing works
Salivary oxytocin after oxytocin administration: Examining the moderating role of childhood trauma
Fragkaki, I., Glennon, J. C., & Cima, M. (2020) · Biological Psychology · doi:10.1016/j.biopsycho.2020.107903 · Cited by 6 · see citing works
Kázmierczak, M., van IJzendoorn, M. H., & Bakermans-Kranenburg, M. (2022) · Attachment & Human Development · doi:10.1080/14616734.2022.2063911 · Cited by 5 · see citing works
van Sleeuwen, C., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., Olff, M., & Nawijn, L. (2023) · European Journal of Psychotraumatology · doi:10.1080/20008066.2023.2281187 · Cited by 6 · see citing works
Self-citationMoshfeghinia, R., Sanaei, E., Kavari, K., Barzegari, A. M., Ahmadzadeh, A. M., Bafrani, M. A., Habibzadeh, A., Boroon, M., & Shalbafan, M. (2025) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-00996-y · Cited by 4 · see citing works
Hu, H., Lee, Y., Tillman, A. N., Ballard, E. D., Waldman, L. R., Yuan, P., Johnston, J. N., Peng, S., Kvarta, M. D., Verbalis, J. G., et al. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70133 · Cited by 3 · see citing works
Oxytocin enhances creativity specifically in approach-motivated individuals
Yang, C., Guo, Z., & Cheng, L. (2025) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaf004 · Cited by 3 · see citing works
Targeting exercise triggered irisin for therapeutic intervention of autism-associated social anxiety
Tatode, A., Gupta, T., Qutub, M., Umekar, M. J., Taksande, B. G., & Premchandani, T. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.11.027 · Cited by 2 · see citing works
Podtschaske, A. H., Martin, J., Ulm, B., Jungwirth, B., & Kagerbauer, S. M. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00757-1 · Cited by 2 · see citing works
The Effects of Bioactive Compounds on PTSD Treatment
Strilbytska, O. M., Koliada, O., Lushchak, V. I., & Lushchak, O. V. (2024) · Current Neuropharmacology · doi:10.2174/011570159x333438240927103741 · Cited by 2 · see citing works
Comparison of ELISA and RIA methods to quantify arginine vasopressin hormone levels in cell culture
Türkmen, M. Ö., Karaduman, T., & Mergen, H. (2022) · Biologia · doi:10.1007/s11756-022-01301-6 · Cited by 2 · see citing works
Reading the mind in the eyes in PTSD: Limited Moderation by the presence of a service dog
Woodward, S. H., Jamison, A. L., Khan, C. T., Gala, S., Bhowmick, C., Villasenor, D., Tamayo, G. C., Puckett, M., & Parker, K. J. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.09.012 · Cited by 1 · see citing works
Salivary Bioscience in Clinical Psychology and Psychiatry
Kuhlman, K. R., Lopez‐Duran, N. L., & Mousavi, Z. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-35784-9_20 · Cited by 1 · see citing works
Oxytocin and Social Behavior—Based on Social Salience and Situation Strength
Cao, S. (2019) · Advances in Psychology · doi:10.12677/ap.2019.91013
Yan, H., Huang, B., Huang, S., Zhuang, Y., Chen, Q., Lan, Q., Zhou, P., Peng, S., & Zhang, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-09217-2
Kapteijn, C. M., Vinke, C. M., van Lith, H. A., Endenburg, N., Rodenburg, T. B., & Rault, J. (2025) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2025.106826
Biomarkers for complex post-traumatic stress disorder: translational and evolutionary perspectives
Rajkumar, R. P. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1786811
Miquel, A., Chan, W., Rouquet, C., MISON, J., JOLLY, M., Coutan, M., Ferhani, O., Trousselard, M., & Duffaud, A. M. (2026) · MethodsX · doi:10.1016/j.mex.2026.103924
Circuit logic of oxytocin and vasopressin complementary actions
Jeanneteau, F. D., Chakraborty, P., Petitjean, H., & Charlet, A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1875731
Li, X., Zhu, Y., Ji, Y., Yao, X., Qi, L., & Sun, H. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118359
魏百慧, Li, X., & Che, X. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107050
- Authors
- Frijling, J. L., van Zuiden, M., Nawijn, L., Koch, S. B. J., Neumann, I. D., Veltman, D. J., & Olff, M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Department of Psychiatry Academic Medical Center Amsterdam The Netherlands
- University of Regensburg (DE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Frijling, J. L.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2015-09-21
- Volume
- 27
- Issue
- 10
- Pages
- 743-751
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2130631553
- Cited by
- 74
- References
- 55
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 2
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (Ne465/21)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, oxytocin, vasopressin, salivary biomarkers, police officers, trauma exposure, sex differences, childhood emotional abuse, fear regulation, social behavior, stress response
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Oxytocin, Saliva, Stress Disorders, Post-Traumatic, Vasopressins, Case-Control Studies, Police
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
