Effect of Chronic Restraint Stress and Western-Diet Feeding on Colonic Regulatory Gene Expression in Mice
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BACKGROUND: Diet-induced obesity (DIO) and psychological stress are significant independent regulators of gastrointestinal physiology; however, our understanding of how these two disorders influence the host-microbe interface is still poorly characterized. The aim of this study was to assess the combined influences of diet-induced obesity and psychological stress on microbiome composition and colonic gene expression. METHODS: C57BL/6J mice (n = 48) were subject to a combination of 22 weeks of Western diet (WD) feeding and a chronic restraint stressor (CRS) for the last 4 weeks of feeding. At the end of the combined intervention, microbiome composition was determined from cecal contents, and colonic tissue gene expression was assessed by multiplex analysis using NanoString nCounter System and real-time qPCR. RESULTS: WD feeding induced a DIO phenotype with increased body weight, worsened metabolic markers, and alterations to microbiome composition. CRS reduced body weight in both dietary groups while having differential effects on glucose metabolism. CRS improved the Firmicutes/Bacteroidetes ratio in WD-fed animals while expanding the Proteobacteria phyla. Significantly lower expression of colonic Tlr4 (p = 0.008), Ocln (p = 0.004), and Cldn3 (p = 0.004) were noted in WD-fed animals compared to controls with no synergistic effects observed when combined with CRS. No changes to colonic expression of downstream inflammatory mediators were observed. Interestingly, higher levels of expression of Cldn2 (p = 0.04) and bile acid receptor Nr1h4 (p = 0.02) were seen in mice exposed to CRS. CONCLUSION: Differential but not synergistic effects of WD and CRS were noted at the host-microbe interface suggesting multifactorial responses that require further investigation.
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Acute stressors, such as exposure to a natural predator, significantly increase fearful and anxious behaviors in rats, accompanied by a robust activation of the amygdala and increased expression of somatostatin receptor 2 (sst2) mRNA.
“Acute stressors, such as exposure to a natural predator, significantly increase fearful and anxious behaviors in rats, accompanied by a robust activation of the amygdala and increased expression of somatostatin receptor 2 (sst2) mRNA.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [28]
Chronic restraint stress (CRS) in mice results in higher expression levels of genes like Cldn2 and Nr1h4.
“Similarly, chronic restraint stress (CRS) in mice results in higher expression levels of genes like Cldn2 and Nr1h4, reflecting widespread changes in gene expression associated with sustained stress.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [28]
A study on the long-term effects of a single exposure to immobilization stress shows that stress-induced changes in anorexigenic and orexigenic factors in the hypothalamus and dorsal vagal complex (DVC) can lead to compensatory mechanisms that abolish stress-induced anorexia.
“A study on the long-term effects of a single exposure to immobilization stress shows that stress-induced changes in anorexigenic and orexigenic factors in the hypothalamus and dorsal vagal complex (DVC) can lead to compensatory mechanisms that abolish stress-induced anorexia.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [28]
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Glutamine alters the response to stress in mice with diet-induced obesity in a sex-dependent mannerPreprint
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- Authors
- Hatton‐Jones, K. M., du Toit, E. F., & Cox, A. J.
- Affiliations
- Griffith University (AU)
- School of Medical Science Griffith University Southport Queensland Australia
- Corresponding author
- Hatton‐Jones, Kyle M.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2021-11-26
- Volume
- 34
- Issue
- 4
- Pages
- e14300-e14300
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W3215522655
- Cited by
- 5
- References
- 108
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- chronic restraint stress, Western diet, diet-induced obesity, gut microbiota, colonic gene expression, TLR4, occludin, claudin-3, claudin-2, farnesoid X receptor, bile acid receptors, Firmicutes/Bacteroidetes ratio, Proteobacteria, glucose metabolism, intestinal barrier
- MeSH terms
- Gastrointestinal Microbiome, Animals, Body Weight, Mice, Inbred C57BL, Obesity, Gene Expression, Mice, Diet, High-Fat, Diet, Western
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