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The cross‐sectional associations between objectively measured sedentary time and cardiometabolic health markers in adults – a systematic review with meta‐analysis component

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Powell, C., Herring, M. P., Dowd, K. P., Donnelly, A. E., Carson, B. P.·2018·Obesity Reviews

Abstract

Summary: Sedentary time is viewed as an independent risk factor for adverse cardiometabolic health (CMH). No systematic review and meta‐analysis on the cross‐sectional associations between objectively measured sedentary time and CMH markers has been conducted. PubMed, Scopus and Web of Science Core Collection were searched for papers that examined the cross‐sectional association between objectively measured sedentary time and CMH markers in adults. Forty‐six papers met the inclusion criteria. The included papers had a combined sample size of 70,576 and an age range of 18–87 years. To examine the effect of increased levels of sedentary time on CMH markers, data on effect sizes and moderators were extracted, where possible. By pooling the unadjusted data from the included papers, increased sedentary time was shown to have a significant detrimental association with fasting glucose (Δ = 0.12, 95% confidence interval [CI]: 0.02, 0.23), fasting insulin (Δ = 0.19, 95% CI: 0.06, 0.32), triglycerides (Δ = 0.25, 95% CI: 0.14, 0.37), high‐density lipoprotein cholesterol (Δ = −0.20, 95% CI: −0.28, −0.13) and waist circumference (Δ = 0.25, 95% CI: 0.15, 0.35). How sedentary time was quantified and the device used to measure sedentary time significantly influence the size of the effect reported. Future interventions focused on both decreasing sedentary time and increasing physical activity may be the most effective strategy to improve CMH.

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Crossref · 10.1111/obr.12642

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Authors
Powell, C., Herring, M. P., Dowd, K. P., Donnelly, A. E., & Carson, B. P.
Affiliations
  • University of Limerick (IE)
  • Athlone Institute of Technology (IE)
Corresponding author
Powell, C.
Venue
Obesity Reviews
Publisher
Wiley
Published
2017-11-27
Volume
19
Issue
3
Pages
381-395
ISSN
  • 1467-7881 (ISSN-L)
  • 1467-789X
OpenAlex
W2770878701
Cited by
66
References
97
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 12 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 6 · 2017: 1
FWCI
0.81
Type
journal article
Language
en
Open access
Locations
  • Obesity Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Research@THEA (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords
sedentary time, cardiometabolic health, fasting blood glucose, fasting insulin, triglycerides, HDL cholesterol, waist circumference, physical activity interventions, adults
MeSH terms
Adult, Cardiovascular Diseases, Cross-Sectional Studies, Health Status Indicators, Humans, Metabolic Diseases, Biomarkers, Exercise, Sedentary Behavior

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