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Origin and differentiation of vascular smooth muscle cells

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Wang, Gang, Jacquet, Laureen, Karamariti, Eirini, Xu, Qingbo·2015·The Journal of Physiology

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Abstract

image Vascular smooth muscle cells (SMCs), a major structural component of the vessel wall, not only play a key role in maintaining vascular structure but also perform various functions. During embryogenesis, SMC recruitment from their progenitors is an important step in the formation of the embryonic vascular system. SMCs in the arterial wall are mostly quiescent but can display a contractile phenotype in adults. Under pathophysiological conditions, i.e. vascular remodelling after endothelial dysfunction or damage, contractile SMCs found in the media switch to a secretory type, which will facilitate their ability to migrate to the intima and proliferate to contribute to neointimal lesions. However, recent evidence suggests that the mobilization and recruitment of abundant stem/progenitor cells present in the vessel wall are largely responsible for SMC accumulation in the intima during vascular remodelling such as neointimal hyperplasia and arteriosclerosis. Therefore, understanding the regulatory mechanisms that control SMC differentiation from vascular progenitors is essential for exploring therapeutic targets for potential clinical applications. In this article, we review the origin and differentiation of SMCs from stem/progenitor cells during cardiovascular development and in the adult, highlighting the environmental cues and signalling pathways that control phenotypic modulation within the vasculature.

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“Nonetheless, under pathophysiological conditions, such as vascular remodeling after endothelial dysfunction, or immunological and mechanical damage, vascular SMCs switch to a de-differentiated, proliferative, and secretory phenotype, which facilitates their ability to migrate to the intima and contribute to the develo…”
Background
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See all 299

Authors: Wang, G., Jacquet, L., Karamariti, E., & Xu, Q.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2015-06-09
Volume: 593
Issue: 14
Pages: 3013-3030
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jp270033
OpenAlex: W2129228205
Cited by: 299
References: 168
FWCI: 5.53
Type: journal article
Language: en
Open access: hybrid

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Origin and differentiation of vascular smooth muscle cells

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